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Design optimization and testing of a morphing leading-edge with a variable-thickness compliant skin and a closed-chain mechanism

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Chinese Journal of Aeronautics 2024年第7期37卷 285-300页

作者： Zhigang WANG Xiasheng SUN Yu YANG Wenjie GE daochun LI Jinwu XIANG Panpan BAO Qi WU Andrea da RONCH School of Aeronautical Science and Engineering Beihang UniversityBeijing 100191China National Key Laboratory of Strength and Structural Integrity Aircraft Strength Research Institute of ChinaXi’an 710065China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China Faculty of Engineering and Physical Sciences University of SouthamptonSouthampton SO171JBUK

Climate warming and the increased demand in air travels motivate the aviation industry to urgently produce technological *** of the most promising innovations is based on the smoothly continuous morphing leading-edge *** study proposes a two-step process for the design of a morphing leading-edge,including the optimization of the outer variable-thickness composite compliant skin and the optimization of the inner kinematic *** the compliant skin design,an optimization of the variable thickness composite skin is proposed based on a laminate continuity model,with laminate continuity constraint and other manufacturing *** laminate continuity model utilizes a guiding sequence and a ply-drop sequence to describe the overall stacking sequence of plies in different thickness regions of the complaint *** the inner kinematic mechanism design,a coupled four-bar linkage system is proposed and optimized to produce specific trajectories at the actuation points on the stringer hats of the compliant skin,which ensures that the compliant skin can be deflected into the aerodynamically optimal ***,a morphing leading-edge is manufactured and *** results are compared with numerical predictions,confirming the feasibility of the morphing leading-edge concept and the overall proposed design approach.

关键词： Optimization Design Morphing wing Compliant skin Kinematics Leading-edge Control surfaces

Run-and-Tumble Dynamics and Mechanotaxis Discovered in Microglial Migration

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Research 2024年第2期2023卷 95-103页

作者： Yiyu Zhang da Wei Xiaochen Wang Boyi Wang Ming Li Haiping Fang Yi Peng Qihui Fan Fangfu Ye Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejang 325000China Songshan Lake Materials Laboratory DongguanGuangdong 523808China School of Science East China University of Science and TechnologyShanghai 200237China Oujang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)WenzhouZhejiang 325000China

Microglia are resident macrophage cells in the central nervous system that search for pathogens or abnormal neural activities and migrate to resolve the *** effective search and targeted motion of macrophages mean dearly to maintaining a healthy brain,yet little is known about their migration *** this work,we study microglial motion with and without the presence of external *** discover that the cells are promptly attracted by the applied forces(i.e.,mechanotaxis),which is a tactic behavior as yet unconfirmed in ***,in both the explorative and the targeted migration,microglia display dynamics that is strikingly analogous to bacterial run-and-tumble motion.A closer examination reveals that microglial run-and-tumble is more sophisticated,e.g.,they display a short-term memory when tumbling and rely on active steering during runs to achieve mechanotaxis,probably via the responses of mechanosensitive ion *** differences reflect the sharp contrast between microglia and bacteria cells(eukaryotes ***)and their environments(compact tissue ***).Further analyses suggest that the reported migration dynamics has an optimal search efficiency and is shared among a subset of immune cells(human monocyte and macrophage).This work reveals a fruitful analogy between the locomotion of 2 remote systems and provides a framework for studying immune cells exploring complex environments.

关键词： analogy closer prompt

Designing silver niobate-based relaxor antiferroelectrics for ultrahigh energy storage performance

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Journal of Advanced Ceramics 2024年第8期13卷 1282-1290页

作者： Zhengdong Hu Zhen Liu Bing Han Haonan Peng Kai da Zequan Xu Zhengqian Fu Zhigao Hu Genshui Wang Key Laboratory of Inorganic Functional Materials and Devices Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China School of Physics and Electronic Science East China Normal UniversityShanghai 200241China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China

AgNbO_(3)(AN)and modified AgNbO_(3) have been extensively investigated as promising lead-free antiferroelectric(AFE)energy storage *** studies have focused mainly on the use of an ion dopant at the A/B site to obtain a stabilized AFE phase;however,simultaneous improvements in the recoverable energy storage density(Wrec)and efficiency(n)are stll difficult to ***,we innovatively constructed a AgNbO_(3)-NaNbO_(3)-(Sr_(0.7)Bi_(0.2))TiO_(3)(AN-NN-SBT)ternary solid solution to achieve a relaxor AFE in AgNbO_(3)-based *** coexistence of antiferroelectric(M3)and paraelectric(O)phases in 0.8(0.7AgNbO_(3)-0.3NaNbO_(3))-0.2(Sro.7Bio.2)TiO_(3) confirms the successful realization of a relaxor AFE,attributed to multiple ion occupation at the A/B ***,a high Wrec of 7.53 ***^(-3) and n of 74.0% are acquired,together with superior stability against various temperatures,frequencies,and cycling ***,a high power density(298.7 MW·cm^(-3))and fast discharge speed(41.4 ns)are also demonstrated for the AgNbO_(3)-based relaxor *** work presents a promising energy storage AgNbO_(3)-based ternary solid solution and proposes a novel strategy for AgNbO_(3)-based energy storage via the design of relaxor AFE materials.

关键词： AgNbO_(3)(AN)-based ceramics relaxor antiferroelectric(RAFE) paraelectric(PE) energy storage performance

Effect of Plastic Deformation on Microstructure and Properties of Cu-(1 wt%-6 wt%) Ag Alloy

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 747-753页

作者：茹亚东 ZHANG Zhongyuan 高召顺 ZHANG Ling ZUO Tingting XUE Jiangli TANG Zhixiang da Bo LIU Yongsheng XIAO Liye Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China Department of Physics Shanghai University of Electric PowerShanghai 201306China University of Chinese Academy of Sciences Beijing 100190China International Joint Labora-tory for Light Alloys(MOE) College of Materials Science and EngineeringChongqing UniversityChongqing 400044China Research and Services Division of Materials data and Integrated System National Institute for Materials ScienceTsukuba 305-0047Japan

In the present study,the Cu-(1 wt%-6 wt%)Ag alloys were prepared by melting,forging and wire *** effects of plastic deformation on microstructure evolution and properties of the alloys were *** results show that non-equilibrium eutectic colonies exist in the Cu-(3 wt%-6 wt%)Ag alloy and no eutectic colonies in the 1 wt%-2 wt%Ag containing *** eutectic colonies are aligned along the drawing direction and refined with the increase of draw *** to the refinement of eutectic colonies,the Cu-Ag alloy exhibits higher strength with the increase of draw *** Cu-6Ag alloy exhibits excellent comprehensive properties with a strength of 930 MPa and a conductivity of 82%IACS when the draw ratio reaches 5.7.

关键词： Cu-Ag alloy high strength and high conductivity microstructure eutectic structure strengthening mechanism

Existence of long-range magnetic order in Heisenberg spin nanoribbons with edge modification

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Communications in Theoretical Physics 2024年第7期76卷 134-144页

作者： da-cheng Ma Ling-yi Cui Chu-xiao Sun Xiao-dan Chi Zheng-Nan XianYu An Du College of Science Northeastern UniversityShenyang 110819China Department of Basic Science Dalian Naval AcademyDalian 116018China Department of Physics College of SciencesShenyang University of Chemical TechnologyShenyang 110142China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityChina Key Laboratory of data Analytics and Optimization for Smart Industry(Northeastern University) Ministry of EducationChina

Long-range magnetic order appears on a side decorated Heisenberg spin nanoribbon at nonzero temperature,although no spontaneous magnetization exists in a one-or two-dimensional isotropic Heisenberg model at any nonzero temperature according to the Mermin-Wagner *** use of the spin Green's function method,we calculated the magnetizations of Heisenberg nanoribbons decorated by side spins with single-ion anisotropy and found that the system exhibits a nonzero transition temperature,whether the decorated edge spins of the system link together or separate from each *** the width of the nanoribbon achieves infinite limit,the transition temperatures of the system tend to the same finite constant eventually whether one edge or both edges are decorated by side spins in the *** results reveal that the magnetism of a low-dimensional spin system is different from that of a threedimensional spin *** the single-ion anisotropy of edge spins in a Heisenberg spin nanoribbon can be modulated by an electric field experimentally,various useful long-range magnetic orders of the system can be *** work can provide a detailed theoretical basis for designing and fabricating next-generation low-dimensional magnetic random-access memory.

关键词： Nanoribbon magnetic anisotropy long-range magnetic order Heisenberg model transition temperature

Malvidin Mitigates Sepsis-induced Cardiac Injury by Modulating the TLR4-iNOS-COX-2 Inflammatory Pathway and the Bax/Bcl-2/Cyto-C Mitochondrial Apoptosis Pathway in a p38 MAPK-dependent Manner

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Biomedical and Environmental Sciences 2024年第2期37卷 221-227页

作者： ZHANG Wei YUAN Si Long QIANG Jing Chao HUANG He LI da SUN Ying ZHANG Hong Gang Department of Vascular Surgery The First People’s Hospital of LianyungangLianyungang 222005JiangsuChina Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening College of PharmacyJiangsu Ocean UniversityLianyungang 222005JiangsuChina Jinzhou Medical University postgraduate training base(Lianyungang First People’s Hospital) Lianyungang 222005JiangsuChina

In critical care medicine,sepsis is a dangerous systemic condition that is highly prevalent and is associated with high morbidity and mortality rates^([1]).The high mortality rate associated with sepsis is closely related to multi-organ dysfunction,with heart injury being particularly critical and considered the starting point of multi-organ injury^([2]).

关键词： mortality Apoptosis TLR4

Exploring the relationship between red blood cell levels and emotional regulation through the miR191-Riok3-Mxi1 pathway

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 101-110页

作者： da Zhang Xiaoqing Zhang Li Yang Yan Zhao Xingang Hu School of Life Sciences Beijing University of Chinese MedicineBeijing 102488China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Dongfang Hospital Beijing University of Chinese MedicineBeijing 100078China

Objective:To assess emotional fluctuations,physical and mental health status,and indicators closely related to red blood cells,such as RIO kinase 3(Riok3),MAX interactor 1(Mxi1),and microRNA 191(miR191),in participants with different levels of red blood ***:Participants who underwent physical examinations at Dongfang Hospital between April and October 2019 were divided into healthy,blood deficiency,and anemia groups(30 individuals in the healthy and blood deficiency group respectively,and 13 in the anemia group).The physical and mental conditions of the participants were evaluated through questionnaires,and emotional fluctuations were assessed through an emotion-inducing experiment,in which participants watched video segments designed to induce specific *** expression levels of miR191,Riok3,and Mxi1 from venous blood samples were also ***:The main psychological factors identified in the anemia and blood deficiency groups were obsessive-compulsive symptoms,depression,anxiety,and other negative *** gene expression levels indicated that miR191 was upregulated and Riok3 and Mxi1 were downregulated in both the blood deficiency and anemia *** the emotional score of disgust on video stage,the main effect was significant(F=335.58,Pideos caused participants to have a dominant emotion,and there is a difference on group(F=5.35,P=.01),with higher disgust scores in the anemia and blood deficiency *** symptoms of blood deficiency and anemia,such as weakness in limbs were significantly negatively correlated with Riok3 and Mxi1 expression(r=-0.38 and-0.31 respectively),but was significantly positively correlated with miR191 expression(r=0.29).Conclusion:We determined that a close relationship exists between red blood cell levels and emotional *** findings suggest that individuals with anemia and blood deficiency are more likely to experience psychological pro

关键词： Anemia Blood deficiency Emotional regulation miR191-Riok3-Mxi1 pathway Emotion-inducing experiments

Research progress on semi-continuous casting of magnesium alloys under external field

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China Foundry 2024年第5期21卷 516-524页

作者： Qi-yu Liao Qi-chi Le da-zhi Zhao Lei Bao Tong Wang Yong-hui Jia Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China Key Laboratory of Lightweight Structural Materials Liaoning ProvinceNortheastern UniversityShenyang 110819China Key Laboratory of Light-weight Materials Nanjing Tech UniversityNanjing 210009China

High-performance magnesium alloys are moving towards a trend of being produced on a large scale and in an integrated *** foundational key to their successful production is the high-quality cast *** alloys produced through the conventional semi-continuous casting process inevitably contain casting defects,which makes it challenging to manufacture high-quality *** integration of external field assisted controlled solidification technology,which combines physical fields such as electromagnetic and ultrasonic fields with traditional semi-continuous casting processes,enables the production of high-quality magnesium alloy ingots characterized by a homogeneous microstructure and absence of *** article mainly summarizes the technical principles of those external field assisted casting *** focus is on elaborating the refinement mechanism of different types of electromagnetic fields,ultrasonic fields,and combined physical fields during the solidification of magnesium ***,the development prospects of producing highquality magnesium alloy ingots through semi-continuous casting under the external field were discussed.

关键词： semi-continuous casting electromagnetic field ultrasonic field magnesium alloys refinement mechanism

Tumor necrosis factor α deficiency promotes myogenesis and muscle regeneration

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Zoological Research 2024年第4期45卷 951-960页

作者： Yu Fu Jing-Ru Nie Peng Shang Bo Zhang da-Wei Yan Xin Hao Hao Zhang State Key Laboratory of Animal Biotech Breeding China Agricultural UniversityBeijing 100193China College of Animal Science Xizang Agricultural and Animal Husbandry UniversityLinzhiXizang 860000China College of Animal Science and Technology Yunnan Agricultural UniversityKunmingYunnan 650201China

Tumor necrosis factorα(TNFα)exhibits diverse biological functions;however,its regulatory roles in myogenesis are not fully *** the present study,we explored the function of TNFαin myoblast proliferation,differentiation,migration,and myotube fusion in primary myoblasts and C2C12 *** this end,we constructed TNFαmuscle-conditional knockout(TNFα-CKO)mice and compared them with flox mice to assess the effects of TNFαknockout on skeletal *** indicated that TNFα-CKO mice displayed phenotypes such as accelerated muscle development,enhanced regenerative capacity,and improved exercise endurance compared to flox mice,with no significant differences observed in major visceral organs or skeletal *** label-free proteomic analysis,we found that TNFα-CKO altered the distribution of several muscle development-related proteins,such as Hira,Casz1,Casp7,Arhgap10,Gas1,Diaph1,Map3k20,Cfl2,and Igf2,in the nucleus and *** set enrichment analysis(GSEA)further revealed that TNFαdeficiency resulted in positive enrichment in oxidative phosphorylation and MyoD targets and negative enrichment in JAK-STAT *** findings suggest that TNFα-CKO positively regulates muscle growth and development,possibly via these newly identified targets and pathways.

关键词： TNFα Muscle-conditional knockout Myogenesis Regeneration Muscle development