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Synthesis and bio-evaluation of phenothiazine derivatives as new antituberculosis agents

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Chinese Chemical Letters 2015年第8期26卷 951-954页

作者： Chun-Xian He Hui meng Xiang Zhang Hua-Qing Cui da-Li Yin State Key Laboratory of Bioactive Substances and Functions of Natural medicines Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences College of Pharmacy Shandong University of Traditional Chinese Medicine Department of medicinal Chemistry Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Sciences

Two series of phenothiazine derivatives were designed and synthesized. All compounds were tested for anti-tuberculosis activities against mycobacterium tuberculosis H37RV. In comparison with mother compound of chlorpromazine, compound 6e shows promising anti-tuberculosis activity and much less mammalian cell cytotoxicity, compound 6e merits to be further explored as new anti-tuberculosis agents.

关键词： tuberculosis mother mycobacterium cytotoxicity dimethylamino likely moiety mammalian alkyl phenoxy

Different risk factors influence peptic ulcer disease development in a Brazilian population

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World Journal of Gastroenterology 2012年第38期18卷 5404-5411页

作者： Rodrigo Buzinaro Suzuki Rodrigo Faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da Silva André Eterovic márcia Aparecida Sperana Department of Genotyping Hemocenter Marilia Medical School Marilia 17519-030 So Paulo Brazil Center for Natural and Human Sciences Universidade Federal do ABC Santo André 09210-170 So Paulo Brazil Department of molecular Biology Marilia Medical School Marilia 17519-030 So Paulo Brazil Department of Pathology Marilia Medical School Marilia 17519-030 So Paulo Brazil

AIm: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic *** submitted to upper gastroscopy at Hospital das Clinicas of marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori dia.nosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori dia.nosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P metaplasia (OR = 1.0520, P iated with decreasing age (OR = 0.9827, P m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and G

关键词： Helicobacter pylori Gastric ulcer disease Duodenal ulcer disease Gastric atrophy Helicobacter pylori vacuolating cytotoxin A medium region mosaicism

Progress in development of electrocatalyst for CO2 conversion to selective CO2 production

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Carbon Energy 2020年第1期2卷 72-98页

作者： dang Le Tri Nguyen Younghye Kim Yun Jeong Hwang da Hye Won Clean Energy Research Center Korea Institute of Science and TechnologySeoulRepublic of Korea Division of Energy and Environmental Technology KIST SchoolKorea University of Science and TechnologySeoulRepublic of Korea Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoulRepublic of Korea

The conversion of carbon dioxide(CO2)to valuable fuels and chemicals offers a new pathway for sustainable and clean carbon ***,the focus has been on electrochemical CO2 reduction on heterogeneous electrode catalysts,leading to remarkable achievements in the reaction *** date,CO2 to carbon monoxide(CO)conversion is considered as the most promising candidate reaction for the industrial market,owing to its high efficiency and reasonable technoeconomic ***,CO has been proposed as a key intermedia.e species for further reduced hydrocarbons,which can pave the way for various fuel *** study sets out to describe recent progress on the electrochemical CO2 reduction to CO in a heterogeneously catalyzed *** review includes understanding of the catalytic material employed and engineering strategies implemented by adjusting the binding energy of key *** material design approaches,such as nanostructuring,alloying,doping,and so forth,have pioneered breakouts in the intrinsic catalytic nature of transition metal ***,recent advances in systematic design are summarized,with focus on practical industrial ***,perspectives on the design of electrocatalyst materials for CO production by electrochemical CO2 reduction are presented.

关键词： CO production CO2 reduction reaction electrocatalyst

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软土地区深基坑地下连续墙变形机制方法研究

建筑技术开发 2024年第7期51卷 161-163页

作者：黄毅覃峰吴华达李港司林军宁波市轨道交通集团有限公司浙江宁波315101 中铁十四局集团有限公司济南250000 华北水利水电大学郑州450045

随着城市化进程的加速和地下空间利用的增加,不同土质环境下深基坑工程中维护结构的变形性状及稳定性控制存在差异,如何精确评估和预测软土地区深基坑工程中地下连续墙的变形行为是关键挑战之一。通过回顾近年来对软土地区深基坑工程中... 详细信息

随着城市化进程的加速和地下空间利用的增加,不同土质环境下深基坑工程中维护结构的变形性状及稳定性控制存在差异,如何精确评估和预测软土地区深基坑工程中地下连续墙的变形行为是关键挑战之一。通过回顾近年来对软土地区深基坑工程中地下连续墙的变形机理研究,综合分析软土土质特性对深基坑地下连续墙位移变形的影响,总结不同案例中的变形规律,探讨有效的预测模型规律和策略。

关键词：软土地区深基坑地下连续墙变形特性

压密注浆技术在临海闸站除险加固工程中的应用

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海河水利 2024年第10期 108-111页

作者：姚达张玉婷谢明王昊楠江苏省工程勘测研究院有限责任公司江苏扬州225000 江苏鸿基水源科技股份有限公司江苏扬州225000

以某临海闸站除险加固工程为例,论述了压密注浆技术用于闸站底板下部填充加固的原理、可行性、施工参数和施工流程;通过施工过程中一系列的监控手段和技术控制,确保了压密注浆技术在闸站除险加固中的应用效果;结合工程实例总结了压密注... 详细信息

以某临海闸站除险加固工程为例,论述了压密注浆技术用于闸站底板下部填充加固的原理、可行性、施工参数和施工流程;通过施工过程中一系列的监控手段和技术控制,确保了压密注浆技术在闸站除险加固中的应用效果;结合工程实例总结了压密注浆施工注意事项。研究结果表明,压密注浆技术可有效解决闸室底板沉降过大、局部脱空、裂缝等问题,可在同类工程中推广应用。

关键词：压密注浆沉降脱空浆液扩散注浆压力控制

Building Simulation to be published monthly from 2022

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Building Simulation 2022年第1期15卷 1-1页

作者： da Yan Department of Building Science School of ArchitectureTsinghua UniversityBeijing 100084China

It is my honor to be the Editor-in-Chief of Building Simulation,succeeding Professor Xudong Yang,the founding *** Journal is undergoing rapid growth in many *** meet the increasing demand from both our readers and authors,the Journal has decided to change the publishing frequency from bi-monthly to monthly,effective Issue 1,Vol.15(2022).We will now publish approximately 120 articles annually.

关键词： annually founding Building

Drift-free localisation using prior cross-source map for indoor low-light environments

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IET Cyber-Systems and Robotics 2023年第1期5卷 122-131页

作者： Junyi Tao Weichen dai da Kong Jiayan Wan Bin He Yu Zhang State Key Laboratory of Industrial Control Technology College of Control Science and EngineeringZhejiang UniversityHangzhouChina School of Computer Science Hangzhou Dianzi UniversityHangzhouChina Key Laboratory of Collaborative Sensing and Autonomous Unmanned Systems of Zhejiang Province HangzhouChina

In this study,a localisation system without cumulative errors is ***,depth odometry is achieved only by using the depth information from the depth *** the point cloud cross-source map registration is realised by 3D particle filtering to obtain the pose of the point cloud relative to the ***,we fuse the odometry results with the point cloud to map registration results,so the system can operate effectively even if the map is *** effectiveness of the system for long-term localisation,localisation in the incomplete map,and localisation in low light through multiple experiments on the self-recorded dataset is *** with other methods,the results are better than theirs and achieve high indoor localisation accuracy.

关键词： indoor positioning robots

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激素及pH对大蒜愈伤组织诱导研究

安徽农业科学 2024年第19期52卷 41-44,49页

作者：于大胜马琳郑泽荣刘世琦莱芜职业技术学院山东济南271100 山东农业大学山东泰安271018

探讨大蒜愈伤组织诱导及增殖分化的影响因素,建立大蒜愈伤组织诱导、增殖及器官分化的培养体系。结果表明,适合大蒜愈伤组织诱导及增殖的培养基激素浓度及pH为2 mg/L NAA,2 mg/L 6-BA,1 mg/L 2,4-D和pH 5.8;苍山蒜愈伤组织出芽分化的最... 详细信息

探讨大蒜愈伤组织诱导及增殖分化的影响因素,建立大蒜愈伤组织诱导、增殖及器官分化的培养体系。结果表明,适合大蒜愈伤组织诱导及增殖的培养基激素浓度及pH为2 mg/L NAA,2 mg/L 6-BA,1 mg/L 2,4-D和pH 5.8;苍山蒜愈伤组织出芽分化的最佳培养基激素浓度及pH为1 mg/L NAA,3 mg/L 6-BA,pH 5.8;苏联蒜愈伤组织出芽分化的最佳培养基激素浓度及pH为2 mg/L NAA,2 mg/L 6-BA,pH 6.1;苍山蒜和苏联蒜愈伤组织生根分化的最佳培养基激素浓度及pH均为1 mg/L NAA,pH 5.8,表明高浓度的2,4-D有利于大蒜愈伤组织的诱导,但并不利于其分化。

关键词：大蒜组织培养愈伤组织激素 pH

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minimizing Ratio of monotone Non-submodular Functions

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Journal of the Operations Research Society of China 2019年第3期7卷 449-459页

作者： Yi-Jing Wang da-Chuan Xu Yan-Jun Jiang Dong-mei Zhang Department of Information and Operations Research College of Applied SciencesBeijing University of TechnologyBeijing 100124China School of mathematics and Statistics Science Ludong UniversityYantai 264025ShandongChina School of Computer Science and Technology Shandong Jianzhu UniversityJinan 250101China

In this paper,we investigate the problem of minimizing the ratio of normalized non-negative monotone non-submodular set function f and normalized non-negative monotone set function *** take advantage of the greedy technique and get a per-formance guarantee depending on the generalized curvature and inverse generalized curvature of f,as well as the submodularity ratio of *** results generalize the works of Bai et al.(Algorithms for optimizing the ratio of submodular ***:Proceedings of the 33rd International Conference on machine L earning,2016)and Qian et al.(Optimizing ratio of monotone set ***:Proceedings of the 26th International Joint Conference on Artificial Intelligence,2017).

关键词： Non-submodular Set functions minimizing ratio Greedy algorithm