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elucidating regulatory processes of intense physical activity by multi-omics analysis

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Military Medical Research 2024年第4期11卷 479-499页

作者： ernesto S.Nakayasu Marina A.gritsenko Young-Mo Kim Jennifer e.Kyle Kelly g.Stratton Carrie D.Nicora Nathalie Munoz Kathleen M.Navarro daniel Claborne Yuqian gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes Kathleen A.Clark grant Tietje Justin Teeguarden Kristin e.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

酪蛋白胶束-果胶复合物微胶囊对大黄素的负载作用

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食品与发酵工业 2024年第12期50卷 24-31页

作者：杨敏瓦文强梁慧光季伟李茜甘肃农业大学理学院甘肃兰州730070

大黄素(emodin,e)是大黄中的主要活性成分,是一种疏水性分子。酪蛋白胶束(micellar casein,MC)是乳中酪蛋白的天然存在形态。该文采用荧光分析法研究了不同果胶(pectin,P)添加量下酪蛋白胶束与大黄素的结合作用,解析了果胶-酪蛋白胶束@... 详细信息

大黄素(emodin,e)是大黄中的主要活性成分,是一种疏水性分子。酪蛋白胶束(micellar casein,MC)是乳中酪蛋白的天然存在形态。该文采用荧光分析法研究了不同果胶(pectin,P)添加量下酪蛋白胶束与大黄素的结合作用,解析了果胶-酪蛋白胶束@大黄素(P-MC@e)复合物粒径及结构,评价了复合物的DPPH自由基和ABTS阳离子自由基清除活性,并通过模拟胃肠消化实验分析了复合物中大黄素的释放状况。结果显示,P-MC复合体系中,当果胶与酪蛋白胶束比例为0∶10~5∶5时,酪蛋白胶束与大黄素的结合作用均为疏水作用,二者结合常数大于103。随着果胶添加量的增加,P-MC@e复合物粒径逐渐增大,但其红外谱图没有显著变化。另外,复合物的DPPH自由基和ABTS阳离子自由基清除活性较游离大黄素显著提升,且随果胶添加量的增加而显著增大。与P-MC形成复合物后,大黄素的胃肠模拟消化释放率降低。研究结果可为大黄素的负载和递送提供参考依据。

关键词：大黄素酪蛋白胶束果胶结合机理抗氧化性

Surgical Treatment of Hemorrhoidal Disease at Brazzaville University Hospital Center

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Surgical Science 2024年第3期15卷 159-168页

作者： Murielle etiennette Julie Note Madzele Pierlesky elion Ossibi Rody Stéphane Ngami Dida.e Massamba Miabaou Clausina Philestine Mikolele Ahoui Apendi Noé Henschel Motoula Latou Bhodeho Medy Monwongui giresse Bienvenu Tsouassa wa Ngono Prude Pertinie Avala Carmich Nzaka Moukala Cédrick Du Bonheur Alima Koya Blaise Irénée Atipo-Ibara Digestive Surgery Department Brazzaville University Hospital Center Brazzaville Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo gastroenterology and Internal Medicine Department Brazzaville University Hospital Center Brazzaville Congo

Introduction: Hemorrhoidal disease is a common pathology and its surgical treatment is based, among other things, on pedicular resection after failure of medical and instrumental treatment. The aim of this study is to analyze the epidemiological, clinical, therapeutic and evolving aspects of hemorrhoidal disease at the stage of surgical treatment at the University Hospital Center of Brazzaville. Patients and Methods: We conducted a retrospective and descriptive study carried out from January 2020 to December 2021, a 24 months period, in the Digestive surgery department of the University Hospital Center of Brazzaville. It concerned patients who underwent a surgical procedure for hemorrhoidal disease. Results: 21 cases were collected, representing a hospital frequency of 2.3%, with a sex ratio of 4.3 in favor of men. The average age of patients was 42.2 ± 11.9 years. The symptoms were mainly proctalgia, mass sensation and rectal bleeding. We recorded five cases (19.1%) of hemorrhoidal thrombosis and 16 cases (80.9%) of hemorrhoidal prolapse including 12 cases requiring manual integration (goligher grade III) and four irreducible permanent cases (goligher grade IV). The grade III prolapse was associated with a polyp in one patient and with posterior anal fissure in another patient. Out of the 21 patients, 14 underwent a tripedicular hemorrhoidectomy according to Milligan and Morgan. Two patients underwent mono- and bipedicular hemorrhoidectomy with resection of associated lesions and five patients underwent emergency thrombectomy. The outcome was favorable for all our patients. The average length of hospital stay was 1.5 ± 2.1 days. Conclusion: In the event of failure of medical and instrumental treatment, the hemorrhoidal cure according to Milligan and Morgan is the surgical treatment of reference for hemorrhoidal disease at the University Hospital Center of Brazzaville.

关键词： Hemorrhoidal Disease Surgery Milligan and Morgan

Application of Shear wave elastography and Contrast-enhanced Ultrasound in Transrectal Prostate Biopsy

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Current Medical Science 2022年第2期42卷 447-452页

作者： gao-wa SHAReN Jun ZHANg Department of Ultrasound Affiliated Hospital of Inner Mongolia Medical UniversityHohhot010050China Department of Urology Affiliated Hospital of Inner Mongolia Medical UniversityHohhot010050China

Objective To explore the clinical value of ultrasound shear wave elastography(SWe)and contrast-enhanced ultrasound(CeUS)in transrectal prostate *** A total of 54 patients(average age:67.79±12.01 years)in the experimental group underwent transrectal prostate biopsy under the guidance of SWe,while 46 patients(average age:69.22±11.54 years)in the control group underwent transrectal prostate biopsy guided by *** There were a total of 451 needles,with an average of 8.35±1.67 needles per patient in the experimental group,and a total of 462 needles,with an average of 10.04±1.33 needles per patient in the control *** difference in puncture times between the two groups was statistically significant(Pere was no significant difference in the positive detection rate,sensitivity or specificity between the two groups(P>0.05),but there was a significant difference in the diagnostic accuracy between the two groups(Pe e_(mean)and e_(max)of prostate cancer were significantly higher in the experimental group than in benign prostatic hyperplasia(Pe receiver operating characteristic curve(ROC)analysis showed that the area under the ROC curve(AUC)of e_(mean)was 0.752(S.e.=0.072,95%CI=0.611-0.894,P=0.007),and the best cutoff value was 47.005 *** In summary,both SWe-and CeUS-guided transrectal prostate biopsy can help find the focus and guide the puncture,and improve the positive detection rate.

关键词： prostate puncture ultrasonic shear wave elastography contrast-enhanced ultrasound biopsy analysis

Nanostructured Catalyst for Fischer-Tropsch Synthesis

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Chinese Journal of Chemistry 2018年第9期36卷 798-808页

作者： wa.gao Qingshan Zhu Ding Ma College of Chemistry and Molecular engineering and College of engineering Peking University Beijing 100871 China Fritz-Haber-Institut der Max-Planck-gesellschaft Faradayweg 4-6 D-14195 Berlin Germany

Fischer-Tropsch synthesis （FTS） is a heterogeneous catalytic process for the production of fuels or chemicals from synthesis gas （CO ＋ H2）, which can be derived from nonpetroleum feedstocks such as natural gas, coal, or biomass. Co, Ru, Fe and Ni are all active in FTS, but only cheaper Fe and Co based catalysts are used in industry because the price of Ru is relatively high. However, the industrial Fe- and Co-based FTS catalysts normally work at a relatively high temperature range of 493--623 K in order to get a reasonable space time yield. Moreover, the product selectivity of FTS is governed by the law of polymerization, i.e., a so-called Anderson-Schulz-FIory distribution holds, which restricts its industrial application. In this account, we highlight some of our progress toward the design/fabrication of nanostructured Fe, Co and Ru catalysts to improve FTS activity at the low temperature and to change the product selectivity and confine the product distribution into a certain range.

关键词： catalyst Fischer-Tropsch synthesis nanostructure

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editorial

Science China(Physics,Mechanics & Astronomy) 2009年第12期52卷 1813-1814页

作者： Ping JinSong Qian ZhiHan Fung Lai-wa Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai200030China

Since the 1990s, a new round of lunar exploration missions have aroused profound interest of such big aerospace nations as U.S., Japan, europe, China and India in broad-based active participation. In

关键词： VLBI editorial Ce

抗-e、抗-c、抗-M、抗-S多重抗体分析

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中国输血杂志 2024年第5期37卷 511-515,533页

作者：高娃李冰班凤禹王秋实中国医科大学附属盛京医院输血科辽宁沈阳110004

目的对1例存在多重抗体的肾积水伴输尿管结石合并休克老年患者进行抗体特异性鉴定。方法微柱凝胶法进行红细胞不规则抗体筛查和抗体鉴定,酶法,抗体吸收法协助判断患者的抗体特异性;盐水试管法检测患者ABO血型鉴定、Rh血型鉴定、MNS血型... 详细信息

目的对1例存在多重抗体的肾积水伴输尿管结石合并休克老年患者进行抗体特异性鉴定。方法微柱凝胶法进行红细胞不规则抗体筛查和抗体鉴定,酶法,抗体吸收法协助判断患者的抗体特异性;盐水试管法检测患者ABO血型鉴定、Rh血型鉴定、MNS血型。结果患者血型:O、CCDee、NNss,患者体内检测出抗-e、抗-c、抗-M、抗-S联合抗体。结论反复输血可能引起患者存在1种或者多种意外抗体,体内多种或高频率抗体的患者,可能引起鉴定困难和用血延迟。

关键词：多重抗体抗体鉴定

A Model to Describe the Fracture of Porous Polygranular graphite Subject to Neutron damage and Radiolytic Oxidation

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Computers, Materials & Continua 2016年第3期51卷 163-185页

作者： g.Smith e.Schlangen P.e.J.Flewitt A.g.Crocker A.Hodgkins Interface Analysis Centre School of PhysicsUniversity of BristolBristolBS81TLUK Faculty of Civil engineering and geosciences Delft University of TechnologyDelftNetherlands HH Wills Physics Laboratory School of PhysicsUniversity of BristolBristolBS81TLUK Physics Department University of SurreyGuildfordGU27XH AMeC Clean energy now AMEC Foster-WheelerWalton House404 Faraday StreetBirchwood ParkWarringtonCheshireWA36GAUK

Two linked models have been developed to explore the relationship between the amount of porosity arising in service from both radiolytic oxidation and fast neutron damage that influences both the strength and the force-displacement(load-displacement)behaviour and crack propagation in pile grade A graphite used as a nuclear reactor moderator *** models of the microstructure of the porous graphite for both unirradiated and irradiated graphite are *** form the input for the second stage,simulating fracture in lattice-type finite element models,which predicts force(load)-displacement and crack propagation *** comprising aligned filler particles,typical of needle coke,in a porous matrix have been *** purpose was to isolate the contributions of filler particles and porosity to fracture strength and crack paths and consider their implications for the overall failure of reactor core graphite.

关键词： Reactor core graphite Modelling microstructure Fe lattice model Fracture strength Crack path

青藏高原尕斯库勒盐湖可培养嗜盐耐盐微生物的群落结构与分离方法对比研究

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海洋与湖沼 2024年第4期55卷 916-930页

作者：马欣马想蓉朱德锐李轩领沈国平邢江娃青海大学医学院基础医学研究中心青海西宁810016

嗜盐耐盐微生物在生物医药、生物酶等领域有着重要的应用潜力。为更好地利用青藏高原的盐湖微生物资源,以青藏高原尕斯库勒盐湖为研究对象,借助Illumina MiSeq测序平台分析盐湖微生物的群落组成,并采用寡营养培养、富集培养和梯度稀释... 详细信息

嗜盐耐盐微生物在生物医药、生物酶等领域有着重要的应用潜力。为更好地利用青藏高原的盐湖微生物资源,以青藏高原尕斯库勒盐湖为研究对象,借助Illumina MiSeq测序平台分析盐湖微生物的群落组成,并采用寡营养培养、富集培养和梯度稀释等方法对嗜盐耐盐微生物进行大规模分离与培养。结果表明,高通量测序获得明确分类地位的细菌有30门50纲81目162科417属,古菌6门7纲9目15科39属。细菌优势属类群以矿生菌属(Fodinibius)和纤维单胞菌属(gracilimonas)为主。古菌优势属类群以盐红菌属(Halorubrum)为主;纯培养法共获得502株嗜盐耐盐微生物,其中嗜盐耐盐细菌472株,分布在4门5纲7目9科13属,优势属为芽孢杆菌属(Bacillus)和盐单胞菌属(Halomonas),其中巴纽尔斯菌(Balneolota)门Fodinibius属可培养细菌是首次从盐湖中分离得到;嗜盐古菌30株,分布在1门1纲1目3科5属,优势属为Halorubrum。对比不同培养条件下的分离结果发现,1/2 TSA培养基和1/2 RCA培养基更有利于嗜盐耐盐细菌的分离,最佳富集天数为7天和30天,稀释梯度10-1和10-2可与未稀释样本互为补充来增加可培养嗜盐耐盐细菌的多样性;1/102216e培养基更适合于古菌的分离,最佳富集天数为7天和14天,且样本不稀释分离效果更好。研究结果可为青藏高原盐湖可培养微生物的分离方案优化提供理论依据和数据支撑。

关键词：尕斯库勒盐湖嗜盐耐盐微生物分离培养生物多样性高盐环境