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Effects of lower fluence pulsed dye laser irradiation on production of collagen and the mRNA expression of collagen relative gene in cultured fibroblasts in vitro

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Chinese Medical Journal 2006年第18期119卷 1543-1547页

作者： YU Hai-yan CHEN da-fang wang qi CHENG Hao Department of Dermatology Sir Run Run Shaw Hospital of Zhejiang University Hangzhou 310016 China

Background Lower fluence of 585-nm flashlamp-pumped pulsed dye laser has been successfully used as a nonablative technique in the treatment of wrinkles. The objective of this study was to evaluate the effect of the pulsed dye laser （585 nm） on the production of collagen and the mRNA expression of collagen related gene in fibroblasts in vitro. Methods Cultured fibroblasts were treated with a 585-nm flashlamp-pumped pulsed dye laser （ fluence 3 J/cm^2, 4 J/cm^2, spot size 7 mm, pulse duration 450 12s）. The production of collagen and the mRNA expression of transforming growth factor （TGF）-β1, SMAD2, SMAD3, SMAD4, SMAD7 and type Ⅰ procollagen α1, α2 in fibroblasts were investigated by colorimetry or real time polymerase chain reaction. Results The production of collagen was significantly up-regulated after treatment with a 585-nm flashlamp-pumped pulsed dye laser with a fluence of 3 J/cm^2 （P 〈0.001）. The mRNA expression of TGF- β1, SMAD2, SMAD3, SMAD4, SMAD7 and procollagen I was significantly up-regulated after treatment with a 585-nm flashlamp-pumped pulsed dye laser with a fluence of 3 J/cm^2 （P 〈0.001）. No significant difference of mRNA expression of SMAD2, SMAD3, SMAD4, SMAD7 and type Ⅰ procollagen was found between controls and fibroblasts treated with pulsed dye laser with a fluence of 4 J/cm^2 （P 〉0.05）. Conclusions Lower fluence （3 J/cm^2） pulsed dye laser increased the collagen production in fibroblasts by up-regulating TGF-β1, SMAD2, SMAD3, SMAD4, SMAD7 and type Ⅰ procollagen mRNA expression. These may be the reason it can be effectively used in the treatment of wrinkles.

关键词： pulsed dye laser fibroblasts procollagen SMADs

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Synthesis,characterization and cytotoxicity of fluorescent organotin complexes of terpyridine derivatives

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Chinese Chemical Letters 2014年第4期25卷 586-588页

作者： Peng-Fei Shi qin Jiang Hai-Chao Duan da-qi wang School of Chemistry Huaihai Institute of Technology School of Chemistry Liaocheng University

Five organotin complexes of terpyridine derivatives were synthesized and characterized. The mononuclear Sn（IV） complexes were six-coordinated adopting a distorted octahedral coordination geometry. A brief outline of... 详细信息

关键词： Organotin Terpyridine Antitumor

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Synthesis and Crystal Structure of a Binuclear Gadolinium（Ⅲ） Complex Bridged by Cucurbit[6]uril

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Chinese Chemical Letters 2006年第1期17卷 93-96页

作者： Gui Ling ZHANG Zhi Yong WU Yan Tuan LI da qi wang Jian Min DOU Marine Drug and Food Institute Ocean University of China Qingdao 266003 Department of Chemistry Liaocheng University Liaocheng 252059

A new cucurbit[6]uril bridsed binuclear complex {[Gd（H2O）6]2[Q6（H2O）]}C16·4H2O, where Q6 represents cucurbit[6]uril, has been synthesized and characterized by X-ray diffraction. The crystal structure shows that the complex has an extended cucurbit[6]uril-bridged structure consisting of two gadolinium（Ⅲ） ions, in which each gadolinium（Ⅲ） ion is coordinated with two neighboring carbonylic oxygen atoms of Q6 and six oxygen atoms of water molecules that leans toward one side of the portal. One disordered guest water molecule resides in the Q6 molecule cavity and occupies two different positions. Hydrogen bonds assemble the complcx to threedimensional supramolecular structure.

关键词： Cucurbituril binuclear gadolinium(Ⅲ) complex crystal structure

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The short and long-term effect of polystyrene nanoplastics on nitrifying sludge at high nitrite concentrations

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Journal of Environmental Sciences 2024年第1期135卷 222-231页

作者： Xiaolong wang Jialu Huang Zhiqiang qi Ruiqin Kang Chao Du da Li School of Chemical and Environmental Engineering Anyang Institute of TechnologyAnyang 455000China Henan Licheng Environmental Technology Co. Ltd.Anyang 455000China State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

The effect of nanoplastics(NPs)on nitrite oxidation bacteria(NOB)community in treating high-strength wastewater remains unclear,which seriously affects the stability of nitrogen removal *** this study,highly active nitrifying sludge was enriched and exposed to 50nm polystyrene NPs(PS-NPs)for short-term(1,100,500,and 1000 mg/L,1.5 hr)and long-term(1,10,100 mg/L,40 days)at high nitrite *** contrast to previous studies,our results showed that the exposures to PS-NPs had little effect on nitrifying *** long-term exposure,the protein/polysaccharide ratios in extracellular polymeric substances(EPS)were positively correlated with PS-NPs concentrations(0.78–0.99).The produced reactive oxygen species(ROS)were gradually removed,and PS-NPs higher than 10 mg/L caused damage to membrane ***-term exposure for 40 days increased the community diversity and caused significant differences between the control and exposed *** control group were dominated by Nitrobacter and Exiguobacterium,while the exposure group was dominated by Bacillus,Mycobacterium,and Nitrospira.A noticeable shift in the NOB community from Nitrobacter(26.5%to 3.4%)to Nitrospira(1.61%to 14.27%)was observed.A KEGG analysis indicated a decrease in cell growth and death,cell motility and energy *** appeared that NOB could adapt to PS-NPs stress through enhanced secretion and removal of oxidative ***,this study provided new insights into the response mechanism of NOB to PS-NPs exposure.

关键词： Nanoplastics Nitrifying activity Extracellular polymeric substance(EPS) Exposure Community analysis

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Understanding the spatial interaction of ultrasounds based on three-dimensional dual-frequency ultrasonic field numerical simulation

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China Foundry 2024年第1期21卷 29-43页

作者： Zhao-yang Yin qi-chi Le Yan-chao Jiang da-zhi Zhao qi-yu Liao qi Zou Key Lab of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China School of Materials Science and Engineering Northeastern UniversityShenyang 110819China

A transient 3D model was established to investigate the effect of spatial interaction of ultrasounds on the dual-frequency ultrasonic field in magnesium alloy *** effects of insertion depth and tip shape of the ultrasonic rods,input pressures and their ratio on the acoustic field distribution were discussed in ***,the spacing,angle,and insertion depth of two ultrasonic rods significantly affect the interaction between distinct *** a result,various acoustic pressure distributions and cavitation regions are *** spherical rods mitigate the longitudinal and transversal attenuation of acoustic pressure and expand the cavitation volume by 53.7%and 31.7%,respectively,compared to the plate and conical *** the input pressure will enlarge the cavitation region but has no effect on the acoustic pressure distribution *** acoustic pressure ratio significantly affects the pressure distribution and the cavitation region,and the best cavitation effect is obtained at the ratio of 2:1(P15:P20).

关键词： dual-frequency ultrasonic numerical model acoustic pressure spatial interaction magnesium alloy

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Renewable conversion of coal gangue to 13-X molecular sieve for Cd^(2+)-containing wastewater adsorption performance

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Rare Metals 2024年第2期43卷 702-710页

作者： Le Kang Si-Fan Liu da-Wei Yi Kai wang Hui-Ling Du Hao-qi Huang Peng Chen College of Materials Science and Engineering Xi’an University of Science and TechnologyXi’an710054China School of Electrical Engineering Weihai Innovation Research InstituteQingdao UniversityQingdao266000China School of Metallurgy Northeastern UniversityShenyang110819China School of Materials and Chemical Engineering Tongren UniversityTongren554300China

Using coal gangue(CG)as raw material,a new type of all solid-waste-based 13-X molecular sieve material was controllably prepared by alkali fusion-hydrothermal *** synthetic molecular sieve was used as a solid adsorbent to treat Cd^(2+)-containing wastewater,and its adsorption behavior on Cd^(2+)in aqueous solution was studied and *** microstructure and morphology of the molecular sieve were investigated by X-ray diffraction(XRD),field emission scanning electron microscopy(FESEM)and specific surface area *** results show that the synthesized 13-X molecular sieve has higher Brunauer–Emmett–Teller(BET)specific surface area with higher crystallinity and higher adsorption capacity for the heavy metal Cd^(2+).The adsorption process of Cd^(2+)by molecular sieve conforms to the Langmuir isotherm adsorption equation and Lagergren pseudo-second-order rate *** with thermodynamic calculation,it can be concluded that the adsorption process is physically monolayer,spontaneous and *** this study,a low-cost and naturally available synthesis method of 13-X molecular sieve is *** with its adsorption mechanism for Cd^(2+),it provides a feasible and general method for removing heavy metal ions from coal gangue and also provides a new way for the utilization of coal gangue with high added value.

关键词： Coal gangue Hydrothermal synthesis 13-X molecular sieve Adsorption Wastewater containing Cd^(2+)

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Extending the detection limit:innovations in infrared quantum dot photodetectors reaching up to 18μm

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Light(Science & Applications) 2024年第8期13卷 1445-1447页

作者： Chong Wu wang qi Jie wang Centre for OptoElectronics and Biophotonics School of Electrical and Electronic EngineeringNanyang Technological UniversitySingapore 639798Singapore Centre for Disruptive Photonic Technologies School of Physical and Mathematical SciencesNanyang Technological UniversitySingaporeSingapore

A regrowth method was used to synthesize large-sized colloidal quantum dots(CQDs).With the assistance of doping engineering,the synthesized CQD detectors demonstrate exceptional long-wavelength infrared detection performance,reaching up to 18μm,significantly extending the spectral response limit for CQD-based infrared *** detectors also achieve a reasonably high detectivity of 6.6×10^(8)Jones.

关键词： limit quantum sized

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Design optimization and testing of a morphing leading-edge with a variable-thickness compliant skin and a closed-chain mechanism

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Chinese Journal of Aeronautics 2024年第7期37卷 285-300页

作者： Zhigang wang Xiasheng SUN Yu YANG Wenjie GE daochun LI Jinwu XIANG Panpan BAO qi WU Andrea da RONCH School of Aeronautical Science and Engineering Beihang UniversityBeijing 100191China National Key Laboratory of Strength and Structural Integrity Aircraft Strength Research Institute of ChinaXi’an 710065China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China Faculty of Engineering and Physical Sciences University of SouthamptonSouthampton SO171JBUK

Climate warming and the increased demand in air travels motivate the aviation industry to urgently produce technological *** of the most promising innovations is based on the smoothly continuous morphing leading-edge *** study proposes a two-step process for the design of a morphing leading-edge,including the optimization of the outer variable-thickness composite compliant skin and the optimization of the inner kinematic *** the compliant skin design,an optimization of the variable thickness composite skin is proposed based on a laminate continuity model,with laminate continuity constraint and other manufacturing *** laminate continuity model utilizes a guiding sequence and a ply-drop sequence to describe the overall stacking sequence of plies in different thickness regions of the complaint *** the inner kinematic mechanism design,a coupled four-bar linkage system is proposed and optimized to produce specific trajectories at the actuation points on the stringer hats of the compliant skin,which ensures that the compliant skin can be deflected into the aerodynamically optimal ***,a morphing leading-edge is manufactured and *** results are compared with numerical predictions,confirming the feasibility of the morphing leading-edge concept and the overall proposed design approach.

关键词： Optimization Design Morphing wing Compliant skin Kinematics Leading-edge Control surfaces

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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

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Military Medical Research 2024年第4期11卷 543-566页

作者： Ying Chen Xing wang Sheng Tao qi wang Pan-qin Ma Zi-Biao Li Yun-Long Wu da-Wei Li Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology School of Pharmaceutical SciencesXiamen UniversityXiamen 361102FujianChina Beijing National Laboratory for Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100090China University of Chinese Academy of Sciences Beijing 100049China Senior Department of Orthopedics the Fourth Medical Center of Chinese PLA General HospitalBeijing 100091China Institute of Materials Research and Engineering A*STAR(Agency for ScienceTechnology and Research)Singapore 138634Singapore

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical *** reports have shown that hydrogel wound dressings might be an effective strategy for treating diabetic wounds due to their excellent hydrophilicity,good drug-loading ability and sustained drug release *** a typical example,hyaluronic acid dressing(Healoderm)has been demonstrated in clinical trials to improve wound-healing efficiency and healing rates for diabetic foot ***,the drug release and degradation behavior of clinically-used hydrogel wound dressings cannot be adjusted according to the wound *** to the intricacy of diabetic wounds,antibiotics and other medications are frequently combined with hydrogel dressings in clinical practice,although these medications are easily hindered by the hostile *** this case,scientists have created responsive-hydrogel dressings based on the microenvironment features of diabetic wounds(such as high glucose and low pH)or combined with external stimuli(such as light or magnetic field)to achieve controllable drug release,gel degradation,and microenvironment improvements in order to overcome these clinical *** responsive-hydrogel dressings are anticipated to play a significant role in diabetic therapeutic wound ***,we review recent advances on responsive-hydrogel dressings towards diabetic wound healing,with focus on hydrogel structure design,the principle of responsiveness,and the behavior of *** but not least,the advantages and limitations of these responsive-hydrogels in clinical applications will also be *** hope that this review will contribute to furthering progress on hydrogels as an improved dressing for diabetic wound healing and practical clinical application.

关键词： Responsive-hydrogel Diabetic wound Anti-inflammation Tissue remodeling

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A Fibonacci View on the Galois NFSR Used in Trivium

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Journal of Systems Science & Complexity 2024年第3期37卷 1326-1350页

作者： wang Hongyu ZHENG Qunxiong qi Wenfeng PLA Strategic Support Force Information Engineering University Zhengzhou 450001China

Trivium is an international standard of lightweight stream ciphers(ISO/IEC 29192-3:2012).In this paper,the Trivium-like NFSRs,a class of Galois NFSRs generalized from the Galois NFSR of Trivium,are studied from the perspective of Fibonacci *** is shown that an n-stage Trivium-like NFSR cannot be equivalent to an n-stage Fibonacci NFSR,which is proved by showing the existence of“collision initial states”.As an intermediate conclusion,a necessary and sufficient condition for a kind of linear degeneracy of a Trivium-like NFSR is obtained from the persepective of interleaved ***,the smallest stage number of a Fibonacci NFSR that can generate all the output sequences of an n-stage Trivium-like NFSR is shown to be greater than n-7 and this value is no less than 371=287+min{93,84,111}specifically for the 288-stage Galois NFSR used in *** results contradict the existence of a equivalent Fibonacci model of Trivium NFSR of small stage,which implies that Trivium algorithm possesses a fair degree of immunity against“structure attack”.

关键词： Fibonacci NFSR galois NFSR interleaved sequence linear degeneracy trivium

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