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Asymmetric Dimethylarginine Predicts One-year Recurrent Cardiovascular Events: Potential Biomarker of "Toxin Syndrome" in Coronary Heart Disease

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Chinese Journal of Integrative Medicine 2019年第5期25卷 327-333页

作者： XU Hao CHEN Zhuo SHANG Qing-hua GAO Zhu-ye YU Chang-an shi da-zhuo CHEN Ke-ji Cardiovascular Diseases Center Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China Department of Cardiology China-Japan Friendship HospitalBeijing(100029)China

Objective: To examine the prognostic value of serum levels of asymmetric dimethylarginine(ADMA)in patients with stable coronary heart disease(CHD) thus explore a potential biomarker of "toxin syndrome" in ***: In this prospective nested case-control study, 36 of 1,503 Chinese patients with stable CHD experienced at least 1 recurrent cardiovascular event(RCE) during 1-year fol ow-up. Serum levels of ADMA at the start of fol ow-up were compared between these 36 cases and 36 controls which matched to cases in terms of gender, age, history of hypertension, and myocardial infarction. Results: Based on the crude model, subjects in the 2 highest ADMA quartiles showed signi?cantly higher risk of developing RCE than those in the lowest ADMA quartile [odds ratio(OR) 4.09, 95%confidence interval(CI) 1.01 to 16.58; OR 6.76, 95% CI 1.57 to 29.07]. This association was also observed in the case-mix model(OR 5.51, 95% CI 1.23 to 24.61; OR 7.83, 95% CI 1.68 to 36.41) and multivariable model(OR 6.64,95% CI 1.40 to 31.49; OR 13.14, 95% CI 2.28 to 75.71) after adjusting for confounders. The multivariable model which combined ADMA and high-sensitivity C-reactive protein(hs CRP) showed better predictive power with areas under the receiver operator characteristic curves(0.779) than the model of either ADMA(0.694) or hs CRP(0.636). Conclusion:Serum ADMA level may be a potential biomarker of "toxin syndrome" in CHD which shows favorable prognostic value in predicting 1-year RCE in patients with stable CHD. [The registration number is Chi CTR-PRNRC-07000012]

关键词： asymmetric dimethylarginine recurrent cardiovascular event nested case-control study coronary heart disease toxin syndrome

Three novel missense germline mutations in different exons of MSH6 gene in Chinese hereditary non-polyposis colorectal cancer families

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World Journal of Gastroenterology 2007年第37期13卷 5021-5024页

作者： shi-Yan Yan Xiao-Yan Zhou Xiang Du Tai-Ming Zhang Yong-Ming Lu San-Jun Cai Xiao-Li Xu Bao-hua Yu Heng-hua Zhou da-Ren shi Department of Pathology Cancer Hospital/InstituteFudan University Department of Oncology Shanghai MedicalCollege Fudan University Shanghai 200032 China Department of Abdominal Surgery CancerHospital/Institute Fudan University Shanghai 200032 China

AIM: To investigate the germline mutations of MSH6 gene in probands of Chinese hereditary non-polyposis colorectal cancer (HNPCC) families fulfilling different clinical criteria. METHODS: Germline mutations of MSH6 gene were detected by PCR-based DNA sequencing in 39 unrelated HNPCC probands fulfilling different clinical criteria in which MSH2 and MLH1 mutations were excluded. To further investigate the pathological effects of detected missense mutations, we analyzed the above related MSH6 exons using PCR-based sequencing in 137 healthy persons with no family history. The clinicopathological features were collected from the Archive Library of Cancer Hospital, Fudan University and analyzed. RESULTS: Four germline missense mutations distributed in the 4th, 6th and 9th exons were observed. Of them, three were not found in international HNPCC databases and did not occur in 137 healthy controls, indicating that they were novel missense mutations. The remaining mutation which is consistent with the case H14 at c.3488A>T of exon 6 of MSH6 gene was also found in the controls, the rate was approximately 3.65% (5/137) and the type of mutation was not found in the international HNPCC mutational and SNP databases, suggesting that this missense mutation was a new SNP unreported up to date. CONCLUSION: Three novel missense mutations and a new SNP observed in the probands of Chinese HNPCC families, may play an important role in the development of HNPCC.

关键词： Hereditary non-polyposis colorectal cancer MSH6 Missense mutation Colorectal cancer

Significance of hepatitis B virus surface antigen, hepatitis C virus expression in hepatocellular carcinoma and pericarcinomatous tissues

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World Journal of Gastroenterology 2007年第12期13卷 1870-1874页

作者： shi-Ying Xuan Yong-Ning Xin hua Chen Guang-Jun shi hua-shi Guan Yang Li College of Medicine and Pharmaceutics Ocean University of China 5 Yushan Road Qingdao 266003 Shandong Province China Qingdao Municipal Hospital Qingdao University Medical College Qingdao 266021 Shandong Province China

AIM： To investigate the correlation between hepatitis B virus surface antigen （HBsAg）, hepatitis C virus （HCV） expression in hepatocellular carcinoma （HCC）, the HAI score of the noncancerous region of the liver and the serum Alpha fetoprotein （AFP） level. METHODS： The patterns of HBsAg and HCV in 100 cases of HCC and their surrounding liver tissues were studied on paraffin-embedded sections with immunohistochemistry, the histological status was determined by one pathologist and one surgeon simultaneously using the hepatitis activity index （HAIl score, and AFP was detected by radioimmunity. The study included 100 consecutive patients who underwent curative resection for HCC. Based on HBsAg and HCV expression, the patients were classified into 4 groups： patients positive for HBsAg （HBsAg group）, patients positive for HCV （HCV group）, patients negative for both HCV and HBsAg （NBNC group） and patients positive for both HBsAg and HCV （BC group）. RESULTS： The BC group had significantly higher HAI scores than the other three groups. （BC 〉 HCV 〉 HBsAg 〉 NBNC）. HBV and HCV virus infection was positively correlated with HAI （rs = 0.39, P = 0.00011. The positive rate of AFP （85.7%） and the value of AFP （541.2 ng/mL） in the group with HBV and HCV co-infection were the highest among the four groups. The positive rate （53.3%） of AFP and the value of AFP （ 53.3 ng/mL） in the group with none-infection of HBV and HCV were the lowest. HBV and HCV virus infection was positively correlated with AFP（rs = 0.38, P = 0.0001）. CONCLUSION： The AFP increase in patients with liver cancer was positively correlated with the infection of HBV and HCV. The-serum AFP elevation by the infection of HBV and HCV is one of mechanisms which lead to hepatocarcinogenesis, and the antivirus intervening treatment of hepatitis is significant for the prognosis of liver cancer. From our Spearman＇s rank correlation analysis, we can conclude that the severity of virally induced inflammation is correlated wit

关键词： Hepatitis B virus surface antigen Hepatitis C virus antigen Histological activity index Immunohistochemistry Hepatocellular carcinoma Alpha-fetoprotein.

Hydrothermal Synthesis and Crystal Structure of Inorganic-organic Hybrid Compound [H_3NC_2H_4NH_2]VOPO_4

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Chemical Research in Chinese Universities 2001年第3期17卷 249-252页

作者： ZHANG Dong shi Zhan FENG Shou-hua National Key Laboratory of Inorganic Synthesis&Preparative Chemistry Department of ChemistryJilin UniversityChangchun 130023P.R.China

An inorganic-organic hybrid compound, [H_3NC_2H_4NH_2]VOPO_4 was synthesized by means of the hydrothermal method. It was crystallized in a monoclinic system, a space group P2_1/c, with the crystal cell parameters: a=0.92285(11) nm, b=0.72994(9) nm, c=0.98495(11) nm, β=101.280(3)°, V=0.65067(13) nm^3, M_r=223.02 g/mol, D_c=2.277 g/cm^3, Z=4, R=0.0315, ωR=0.0865, GOF=1.085. The VO_5N octahedra chains are corner-linked by PO_4 tetrahedra; the VO_5N octahedra are all trans-linked with V—O bonds being alternately short and long. The monoprotonated ethylenediamine was intercalated between the layers with one end coordinating to V and the other end as an H-bond donor interacting with a terminal O atom of PO_4 from a neighboring sheet. The elementary analysis, infrared spectrum characters and thermal stability were also given.

关键词： Inorganic-organic hybrid material Hydrothermal synthesis Vanadium phosphate Crystal structure

Autophagy in plants: Physiological roles and post-translational regulation

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Journal of Integrative Plant Biology 2021年第1期63卷 161-179页

作者： hua Qi Fan-Nv Xia shi Xiao State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory of Plant ResourcesSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China

In eukaryotes, autophagy helps maintain cellular homeostasis by degrading and recycling cytoplasmic materials via a tightly regulated *** the past few decades, significant progress has been made towards understanding the physiological functions and molecular regulation of autophagy in plant cells. Increasing evidence indicates that autophagy is essential for plant responses to several developmental and environmental cues, functioning in diverse processes such as senescence, male fertility, root meristem maintenance, responses to nutrient starvation,and biotic and abiotic stress. Recent studies have demonstrated that, similar to nonplant systems,the modulation of core proteins in the plant autophagy machinery by posttranslational modifications such as phosphorylation, ubiquitination,lipidation, S-sulfhydration, S-nitrosylation, and acetylation is widely involved in the initiation and progression of autophagy. Here, we provide an overview of the physiological roles and posttranslational regulation of autophagy in plants.

关键词： autophagy physiological roles post-translational regulation

shift current response in elemental two-dimensional ferroelectrics

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npj Computational Materials 2023年第1期9卷 1675-1685页

作者： Zhuang Qian Jian Zhou hua Wang shi Liu Zhejiang University HangzhouZhejiang 310058China Key Laboratory for Quantum Materials of Zhejiang Province Department of PhysicsSchool of Science and Research Center for Industries of the FutureHangzhouZhejiang 310030China Center for Alloy Innovation and Design State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhouZhejiang 310024China

A bulk material without inversion symmetry can generate a direct current under *** interface-free current generation mechanism,referred to as the bulk photovoltaic effect(BPVE),does not rely on p-n ***,we explore the shift current generation,a major mechanism responsible for the BPVE,in single-element two-dimensional(2D)ferroelectrics represented by phosphorene-like monolayers of As,Sb,and *** strong covalency,small band gap,and large joint density of states afforded by these elemental 2D materials give rise to large shift currents,outperforming many state-of-the-art *** find that the shift current,due to its topological nature,depends sensitively on the details of the Bloch wave *** is crucial to consider the electronic exchange-correlation potential beyond the generalized gradient approximation as well as the spin-orbit interaction in density functional theory calculations to obtain reliable frequency-dependent shift current responses.

关键词： functions materials details

Effects of Rare Earth,Titanium,and Magnesium Additions on Microstructures and Properties of High-boron Medium-carbon Alloy

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Journal of Iron and Steel Research International 2016年第11期23卷 1226-1233页

作者： Xiao-li shi Ye-hua JIANG Rong ZHOU Faculty of Materials Science and Engineering Kunming University of Science and Technology

In order to improve the toughness and wear resistance of high-boron medium-carbon alloy （HBMCA）, a novel wear-resistant HBMCA comprising granular borocarbide was obtained by titanium, magnesium, and rare earth modifications. These modifications gave rise to greatly refined as-cast eutectic borocarbide structures and a less interconnected continuous borocarbide network. Heat treatment mostly produced broken and spheriodized borocarbides that tended to exist as isolated particles in modified HBMCA. The heat treated modified HBMCA exhibited enhanced hardness than pristine and impact toughness was improved significantly to 12.5 J/cm^2. In addition, it displayed 2.39 and 1.7 times greater wear resistance than high-speed steel （HSS） and high nickel-chromium alloy steel （Cr25） at high temperature （500℃）, respectively. Here, the modification mechanisms involving Re2O3, TiN, and MgO/ MgS heterogeneous nuclei were discussed.

关键词： modification eutectic borocarbide spheroidization toughness wear resistance

Distribution of platinum group elements in road dust in the Beijing metropolitan area, China

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Journal of Environmental Sciences 2007年第1期19卷 29-34页

作者： WANG Juan ZHU Ruo-hua shi Yan-zhi Department of Chemistry Capital Normal University Beijing 100037 China

Dust samples collected from the Beijing metropolitan area （China） were evaluated to determine the distribution and the concentration of platinum group elements （PGEs）. The dust particles that were smaller than 100 mesh size fraction （150 μm） were analyzed after aqua regia digestion. Concentrations ofPt, Rh, and Pd were found to be between 3.96 and 356.3 ng/g, 2.76 and 97.11 ng/g, and 0.1 and 124.9 ng/g, respectively, in the urban areas of Beijing, whereas for the background samples collected from the suburbs of Beijing, the concentrations of Pt, Pd, and Rh were very low and ranged from 0.1 to 0.9 ng/g, 0.5 to 1.4 ng/g, and 0.8 to 2.2 rig/g, respectively. The distributions of PGEs in road dust were an accurate reflection of the levels of pollution and were found to match with the local traffic conditions. A strong positive correlation was established among all the dements found in road dust. This suggests that emissions of abraded fragments from vehicle exhausts may be the source of the high concentration of Pt, Rh, and Pd in road dust along the main roads of Beijing.

关键词： platinum (Pt) palladium (Pd) rhodium (Rh) road dust distribution environmental pollution

NewBalance: Efficient data Space Management and Algorithmic Optimization for Large-Scale Storage Systems

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Chinese Journal of Electronics 2017年第3期26卷 493-501页

作者： XU Guangping LIN Sheng shi Kai ZHANG hua Tianjin Key Laboratory of Intelligence Computing and New Software Technology Computer and Communication Engineering School Tianjin University of Technology

Fragmentation usually occurs when data space of original storage nodes has to be reallocated to new added storage nodes during the scale-out evolution of the large-scale storage *** greatly influences its performance and becomes a challenge to manage the whole *** present an efficient space management framework,called New Balance,to reduce fragmentation with the minimum data movement while keeping the storage system load *** space management framework has two phases including the collection phase and the allocation *** the collection phase,we propose a novel algorithm,called the greedy bi-direction collector,which collects enough space for the new storage *** the allocation phase,we formally represent it as a variant of the bin packing problem and then utilize some bin packing heuristics including the first fitting and the best fitting to allocate collected intervals to new added storage *** experimental results show that the amount of intervals can be reduced by 20%;5%and our algorithmic optimization improves the data lookup performance by at least 10%and the scale-out performance by 2X;X.

关键词： Large-scale storage systems Space management Algorithmic optimization Performance evaluation