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Pro-apoptotic effects of tectorigenin on human hepatocellular carcinoma HepG2 cells

World Journal of Gastroenterology 2012年第15期18卷 1753-1764页

作者： Chun-Ping Jiang Hui Ding da-hua shi Yu-Rong Wang Er-Guang Li Jun-hua Wu The First Clinical Medical College NanjingUniversity of Chinese Medicine Nanjing 210046 Jiangsu Province China Department of Hepatobiliary Surgery The Affiliated Drum Tower Hospital Medical School Nanjing University Nanjing 210008 Jiangsu Province China Jiangsu Key Laboratory of Molecular Medicine State Key Laboratory of Pharmaceutical Biotechnology Medical School Nanjing University Nanjing 210093 Jiangsu Province China

AIM:To investigate the effects of tectorigenin on human hepatocellular carcinoma(HCC)HepG2 ***:Tectorigenin,one of the main components of rhizome of Iris tectorum,was prepared by simple methods,such as extraction,filtration,concentration,precipitation and ***2 cells were incubated with tectorigenin at different concentrations,and their viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** was detected by morphological observation of nuclear change,agarose gel electrophoresis of DNA ladder,and flow cytometry with Hoechst 33342,Annexin V-EGFP and propidium iodide *** of reactive oxygen species was quantified using *** Ca2+was monitored by Fura *** membrane potential was monitored using Rhodamine *** of cytochrome c from mitochondria to cytosol was detected by Western *** of caspase-3,-8 and-9 were investigated by Caspase Activity Assay ***:The viability of HepG2 cells treated by tectorigenin decreased in a concentration-and timedependent *** concentration that reduced the number of viable HepG2 cells by 50%(IC50)after 12,24 and 48 h of incubation was 35.72 mg/L,21.19 mg/L and 11.06 mg/L,***,treatment with tectorigenin at 20 mg/L resulted in a very slight cytotoxicity to L02 cells after incubation for 12,24 or 48 *** at a concentration of 20 mg/L greatly inhibited the viability of HepG2 cells and induced the condensation of chromatin and fragmentation of *** induced apoptosis of HepG2 cells in a time-and dose-dependent *** with the viability rate,induction of apoptosis was the main mechanism of the anti-proliferation effect of tectorigenin in HepG2 ***,tectorigenininduced apoptosis of HepG2 cells was associated with the generation of reactive oxygen species,increased intracellular[Ca2+]i,loss of mitochondrial membrane potential,transloca

关键词： Tectorigenin Iris tectorum maxim Apop-tosis Hepatocellular carcinoma HepG2 Mitochondria Liver cancer

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Low‑Temperature Oxidation Induced Phase Evolution with Gradient Magnetic Heterointerfaces for Superior Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 191-204页

作者： Zizhuang He Lingzi shi Ran Sun Lianfei Ding Mukun He Jiaming Li hua Guo Tiande Gao Panbo Liu School of Chemistry and Chemical Engineering Northwestern Polytechnical UniversityXi’an 710129People’s Republic of China School of Marine Science and Technology Northwestern Polytechnical UniversityXi’an 710072People’s Republic of China

Gradient magnetic heterointerfaces have injected infinite vitality in optimizing impedance matching,adjusting dielectric/magnetic resonance and promoting electromagnetic(EM)wave absorption,but still exist a significant challenging in regulating local phase ***,accordion-shaped Co/Co_(3)O_(4)@N-doped carbon nanosheets(Co/Co_(3)O_(4)@NC)with gradient magnetic heterointerfaces have been fabricated via the cooperative high-temperature carbonization and lowtemperature oxidation *** results indicate that the surface epitaxial growth of crystal Co_(3)O_(4) domains on local Co nanoparticles realizes the adjustment of magnetic-heteroatomic components,which are beneficial for optimizing impedance matching and interfacial ***,gradient magnetic heterointerfaces simultaneously realize magnetic coupling,and long-range magnetic ***,the synthesized Co/Co_(3)O_(4)@NC absorbents display the strong electromagnetic wave attenuation capability of−53.5 dB at a thickness of 3.0 mm with an effective absorption bandwidth of 5.36 GHz,both are superior to those of single magnetic domains embedded in carbon *** design concept provides us an inspiration in optimizing interfacial polarization,regulating magnetic coupling and promoting electromagnetic wave absorption.

关键词： Magnetic heterointerfaces Phase evolution Interfacial polarization Magnetic coupling Electromagnetic wave absorption

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Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang Guo Di Lan Zirui Jia Zhenguo Gao Xuetao shi Mukun He hua Guo Guanglei Wu Pengfei Yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection

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含孔洞CoCrNiFeCu高熵合金纳米压入的分子动力学模拟

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原子与分子物理学报 2025年第3期42卷 141-148页

作者：史银花施琴江苏联合职业技术学院镇江分院镇江212016

高熵合金具有优异的力学性能、耐磨耐蚀耐高温等性能,成为未来最有发展潜力的新型材料之一.因此,本文通过分子动力学模拟的方法探究了孔洞对CoCrNiFeCu高熵合金模型纳米压痕力学性能和位错演化的影响.结果表明,屈服点、载荷、杨氏模量... 详细信息

高熵合金具有优异的力学性能、耐磨耐蚀耐高温等性能,成为未来最有发展潜力的新型材料之一.因此,本文通过分子动力学模拟的方法探究了孔洞对CoCrNiFeCu高熵合金模型纳米压痕力学性能和位错演化的影响.结果表明,屈服点、载荷、杨氏模量和硬度等力学参数随着孔洞深度D的增加呈现先增加后稳定的趋势.孔洞的存在显著影响了位错形核的位置,随着孔洞深度的增加,初始位错优先在孔洞与表面之间形成,随后集中在模型表面形成,且位错环由平面圆环状转变为“翼状”.在孔洞深度较小时(D<40A),位错环沿(110)面水平扩展,随着孔洞深度的增加,位错环开始向下扩展.此外,在压痕深度为30?时,位错密度随着孔洞深度的增加逐渐增加.

关键词： CoCrNiFeCu 分子动力学纳米压入力学性能位错演变

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Advanced Functional Electromagnetic shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-Micro Letters 2025年第1期17卷 98-134页

作者： Yang shi Mingjun Wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin hua Qiu Jinxuan Jiang Yazeed M.Asiri Runzhou huang hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu Xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding *** concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding Micro-nano structure interface control Conductivity

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Contact theory and algorithm

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Science China(Technological Sciences) 2021年第8期64卷 1775-1790页

作者： shi Gen-hua University of Chinese Academy of Sciences Beijing100049China Dda-NMM Company Beijing100026China School of Qilu Transportation Shandong UniversityJinan250100China

In discontinuous computations,contacts between two general blocks A and B are common and represent a fundamental *** paper presents a mathematically proven theory and algorithm to address this *** the proposed approach,a reference point a0 is selected from block A,and the contacts between blocks A and B are transferred to the contact of the reference point a0 and the entrance block E(A,B).Discontinuity related computations DEM,Dda,and FEM can use this mathematically proven theory and algorithm directly.

关键词： contact discontinuity entrance block computational geometry

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Determination of inter-satellite relative position using X-ray pulsars

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第2期14卷 133-142页

作者： da-jun FENG Lu-ping XU hua ZHANG shi-bin SONG School of Electronic Engineering Xidian University Institute of Astronautics and Aeronautics Xidian University

Pulsars are rapidly rotating neutron stars that generate pulsed electromagnetic radiation.A new method for intersatellite relative position determination between a global navigation satellite system(GNSS) and spacecraft using X-ray pulsars is proposed in this *** geometric model of this method is formulated,and two different resolution algorithms are introduced and *** phase cycle ambiguity resolution is investigated,and a new strategy is proposed and *** the direct vector parameters of the pulsar,geometric dilution of precision(GDOP) is *** is shown that this method has advantages of simplicity and efficiency,and is able to eliminate the clock *** analytical results are verified numerically via computer simulations.

关键词： Pulsar navigation Position determination Phase cycle ambiguity Geometric dilution of precision(GDOP)

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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

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Traditional Medicine Research 2025年第1期10卷 27-43页

作者： shi-Bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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JPEG stream soft-decoding technique based on autoregressive modeling

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The Journal of China Universities of Posts and Telecommunications 2012年第5期19卷 115-123页

作者： NIU Yi shi Guang-ming WANG Xiao-tian WANG Li-zhi GAO da-hua School of Electronic Engineering Xidian University Xi'an 710071 China ECE McMaster University Hamilton L8S 4KI Canada School of Science Air Force Engineering University Xi'an 710051 China

This paper introduces a new model-based soft decoding techniqt, e to restore the widely used joint photographic expert group （JPEG） streams. The image is modeled as a two dimensional （2D） piecewise stationary autoregressive process, and the decoding task is formulated as a constrained optimization problem. All the constraints are given by the quantization intervals which available at the decoder freely. The autoregressive model serves as an important regularization term of the objective function of the optimization, and the model parameters are solved on the decoded image locally using a weighted total least square method. In addition, a novel bilateral dualside weighting scheme is proposed to minimize the influence of the blocking artifact on the accuracy of parameter estimation. Extensive experimental results suggest that the proposed algorithm systematically improves the quality of JPEG images and also outperforms existing JPEG postprocessing algorithms in a wide bit-rate range both in terms of peak signal-to-noise ratio （PSNR） and subjective quality

关键词： image deblocking autoregressive modeling constrained optimization total least squares bilateral weighting

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Almost split sequences for symmetric non-semisimple Hopf algebras

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第6期7卷 1077-1083页

作者： shi Mei-hua Department of Mathematics Zhejiang Education Institute Hangzhou 310012 China

We first prove that for a finite dimensional non-semisimple Hopfalgebra H, the trivial H-module is not projective and so the almost split sequence ended with k exists. By this exact sequence, for all indecomposable H-module X, we can construct a special kind of exact sequence ending with it. The main aim of this paper is to determine when this special exact sequence is an almost split one. For this aim, we restrict H to be tmimodular and the square of its antipode to be an inner automorphism. As a special case, we give an application to the quantum double D（H）=（H^op）^＊∞ H） of any non-semisimple Hopf algebra.

关键词： Indecomposable Unimodular Almost split sequences Symmetric non-semisimple Hopfalgebras

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