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Baicalin Antagonizes Prostate Cancer Stemness via Inhibiting Notch1/NF-κB Signaling Pathway

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Chinese Journal of Integrative Medicine 2023年第10期29卷 914-923页

作者： WU Ming-hui WU Kun zhu Yuan-bing LI da-chuan YANG Huan ZENG Hong Department of Urology Hubei University of Traditional Chinese MedicineWuhan430065China Department of Urology Chongqing Jiangjin District Hospital of Chinese MedicineChongqing402260China

Objective To investigate the molecular mechanisms underlying the effect of baicalin on prostate cancer(PCa)progression both in vivo and in *** The in situ PCa stem cells(PCSCs)-injected xenograft tumor models were established in BALB/c nude *** volume and weight were respectively checked after baicalin(100 mg/kg)***-eosin(HE)staining was used to observe the growth arrest and cell *** expression levels of acetaldehyde dehydrogenase 1(ALDH1),CD44,CD133 and Notch1 were determined by reverse transcription-polymerase chain *** expression levels of ALDH1,CD44,CD133,Notch1,nuclear factorκB(NF-κB)P65 and NF-κB p-P65 were detected by Western *** and subcellular location of ALDH1,CD44,CD133,Notch1 and NF-κB p65 were detected by immunofluorescence *** vitro,cell cycle distribution and cell apoptosis of PC3 PCSCs was assessed by flow cytometry after baicalin(125µmol/L)*** migration and invasion abilities of PCSCs were assessed using Transwell *** electron microscopy scanning was utilized to observe the structure and autophagosome formation of baicalin-treated *** addition,PCSCs were infected with lentiviruses expressing human *** Compared with the control group,the tumor volume and weight were notably reduced in mice treated with 100 mg/kg baicalin(P<0.05 or P<0.01).Histopathological analysis showed that baicalin treatment significantly inhibited cell proliferation and promoted cell ***,baicalin treatment reduced mRNA and protein expression levels of CD44,CD133,ALDH1,and Notch1 as well as the protein expression of NF-κB p-P65 in the xenograft tumor(P<0.01).In vitro,the cell proliferation of PCSCs was significantly attenuated after treatment with 125µmol/L baicalin for 72 h(P<0.01).The cell migration and invasion rates were decreased following treatment with baicalin for 48 and 72 h(P<0.01).Baicalin notably induced cell apoptosis and seriously

关键词： baicalin prostate cancer cancer stemness Notch1/nuclear factorκB signaling

Ammonia-induced CuO/13X for H_(2)S removal from simulated blast furnace gas at low temperature

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Green Energy & Environment 2025年第1期10卷 139-149页

作者： Erping Cao Yuhua Zheng Hao Zhang Jianshan Wang Yuran Li Tingyu zhu Zhan-guo Zhang Guangwen Xu Yanbin Cui State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China State Key Laboratory of Vanadium and Titanium Resources Comprehensive Utilization PanGang Group Research Institute Co.Ltd.Panzhihua Sichuan617000China Shenyang University of Chemical Technology Shenyang110142China University of Chinese Academy of Sciences Beijing 100049China

Blast furnace gas(BFG)is an important by-product energy for the iron and steel industry and has been widely used for heating or electricity ***,the undesirable contaminants in BFG(especially H_(2)S)generate harmful environmental *** desulfurization of BFG is urgent for integrated steel plants due to the stringent ultra-low emission *** with other desulfurization materials,zeolite-based adsorbents represent a viable option with low costs and long service *** this study,an ammonia-induced CuO modified 13X adsorbent(NH3–CuO/13X)was prepared for H_(2)S removal from simulated BFG at low *** XRD,H_(2)-TPR and TEM analysis proved that smaller CuO particles were formed and the dispersion of Cu on the surface of 13X zeolite was improved via the induction of *** on H_(2)S adsorption performance of the adsorbent was carried out using simulated BFG,and the results showed that NH3–CuO/13X-3 has better breakthrough sulfur capacity,which was more than twice the sulfur capacity of CuO/*** is proposed that the enhanced desulfurization performance of NH3–CuO/13X is attributed to an abundant pore of 13X,and combined action of 13X and *** work provided an effective way to improve the sulfur capacity of zeolite-based adsorbents via impregnation method by ammonia induction.

关键词： Blast furnace gas Desulfurization Ammonia-induced CuO 13X zeolite

Buried interface bridging for inverted cesium-formamidinium triiodide perovskite solar cells with long operational stability

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Science China Chemistry 2025年第1期68卷 163-173页

作者： Chenhui Zhang Chunjun Liang Fulin Sun Ting zhu Xinghai Huang Yuzhu Guo Xinyu Guo Kunyang Ge dan Li Fangtian You Zhiqun He Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic TechnologyBeijing Jiaotong University Department of Physics School of Physical Science and Engineering Beijing Jiaotong University

In the field of perovskite solar cells(PSCs), the research on defects in the buried interface has been relatively limited due to its non-exposure; however, this interface significantly impacts the performance enhancement of inverted PSCs. This study employs phenylethylammonium chloride(PEACl) molecules as a buffer layer to modify the buried interface of p-i-n structured PSCs,aiming to enhance the uniformity of self-assembled monolayers(SAMs) and facilitate the uniform nucleation and growth of perovskite films on the substrate. Furthermore, the introduction of the PEACl buffer layer effectively passivates defects at the bottom of the perovskite layer and notably enhances the crystal quality of the perovskite film by mitigating residual stress,thereby reducing nonradiative recombination loss. Following these optimizations, the MA-free PSCs treated with PEACl achieve a power conversion efficiency(PCE) of 24.11%, with significant improvements in storage, thermal stability, and operational stability. Particularly noteworthy is the device's performance in an unencapsulated state, whereas after 1,500 hours of continuous light operation stability testing, it retains 97% of its original efficiency. This study not only enriches the systematic understanding of the characteristics of the buried interface in PSCs but also contributes significantly to advancing the commercial production of perovskite photovoltaic technology.

关键词： defect-induced recombination buried interfaces inverted perovskite solar cells crystallization lattice mismatch

BIVARIATE LAGRANGE-TYPE VECTOR VALUED RATIONAL INTERPOLANTS

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Journal of Computational Mathematics 2002年第2期20卷 207-216页

作者： chuan-qing Gu Gong-qing zhu Department of Mathematics Shanghai UniversityShanghai 200436China Department of Mathematics Hefei Polytechnic UniversityHefei 230009China

Focuses on a study that presented an axiomatic definition to bivariate vector valued rational interpolation on distinct plane interpolation points. Definition; Existence and uniqueness; Connection.

关键词： bivariate vector value rational interpolation determinantal formula

AQDS Enhances Degradation of BDE-47 by Promoting Shewanella oneidensis MR-1-mediated Fenton Reaction with Fe(III)-containing Minerals

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Journal of Earth Science 2025年

作者： Yongguang Jiang Siqi zhu Zhou Jiang Yiran Dong Liang Shi School of Environmental Studies， China University of Geosciences State Key Laboratory of Biogeology and Environmental Geology， China University of Geosciences Hubei Key Laboratory of Yangtze Catchment Environmental Aquatic Science， China University of Geosciences State Environmental Protection Key Laboratory of Source Apportionment and Control of Aquatic Pollution， Ministry of Ecology and Environment， China University of Geosciences(Wuhan)

Electron shuttles are widespread in the environments and play important role in microbe-mineral interaction. This study investigated the effects of a model electron shuttle (i.e.， anthraquinone-2， 6-disulfonate， AQDS) on Shewanella oneidensis MR-1-mediated Fenton reaction and subsequent degradation of 2， 2′， 4， 4′-tetrabrominated diphenyl ether (BDE-47). Three Fe(III)-containing minerals， namely， ferrihydrite， goethite and nontronite， were used as electron acceptors and Fe(II) sources. With each mineral， additions of 0.01 – 1 mM AQDS in the reactions significantly enhanced Fe(III) reduction by S. oneidensis MR-1 and increased the amounts of Fe(II) produced in anoxic phase. As a result， the amounts of cumulative ·OH formed in oxic phase were increased by 10% – 287%. Regression analysis revealed that ·OH cumulation has significant linear correlation with sorbed Fe(II) but not aqueous and structural Fe(II). This finding may be ascribed to the higher reactivity of sorbed Fe(II) in oxygenation than the latter two types of Fe(II). With more ·OH， the degradation efficiency of BDE-47 was elevated by 31% – 173%. Collectively， AQDS enhances ·OH formation and BDE-47 degradation by promoting production of Fe(II)， particularly sorbed Fe(II) in S. oneidensis MR-1-mediated Fenton reaction with Fe(III)-containing minerals.

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The potential mechanism and clinical application value of remote ischemic conditioning in stroke

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Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun zhu Xiaoguo Li Xingwei Lei Liuyang Tang daochen Wen Bo Zeng Xiaofeng Zhang Zichao Huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

Astragalus mongholicus ameliorates renal fibrosis by modulating HGF and TGF-β in rats with unilateral ureteral obstruction

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第5期10卷 380-390页

作者： chuan ZUO Xi-sheng XIE Hong-yu QIU Yao DENG da zhu Jun-ming FAN Department of Nephrology West China Hospital of Sichuan University Chengdu 610041 China

Astragalus mongholicus （AM） derived from the dry root ofAstragalus membranaceus Bge. var. mongolicus （Bge.） Hsiao is a widely used traditional Chinese medicine. The present study investigated the potential role of AM on renal fibrosis on a rat model of unilateral ureteral obstruction （UUO）. We divided 48 Sprague-dawley rats randomly into 4 groups： sham-operated group （Sham）, untreated UUO group, AM-treated （10 g/（kg.d）） UUO group, and losartan-treated （20 mg/（kg.d）） UUO group as positive control. Haematoxylin ＆ eosin （HE） and Masson staining were used to study the dynamic histological changes of the kidneys 7 and 14 d after operation. The expressions of fibronectin （FN）, type I collagen （coil）, hepatocyte growth factor （HGF）, transforming growth factor-β1 （TGF-β1）, and eL-smooth muscle actin （α-SMA） were analyzed by real-time polymerase chain reaction （PCR）, immunohistochemistry staining, and Western blot. Results show that, similar to losartan, AM alleviated the renal damage and decreased the deposition of FN and coil from UUO by reducing the expressions of TGF-β1 and α-SMA （P〈0.05）, whereas HGF increased greatly with AM treatment （P〈0.05）. Our findings reveal that AM could retard the progression of renal fibrosis. The renoprotective effect of AM might be related to inhibition ofmyofibroblast activation, inducing of HGF and reducing of TGF-β1 expression.

关键词： Astragalus mongholicus (AM) Myofibroblast Transforming growth factor-β1 (TGF-β1) Renal interstitial fibrosis,Hepatocyte growth factor (HGF)

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基于深度学习的高效率烤烟等级识别模型研究

西南大学学报（自然科学版） 2025年第1期47卷 213-225页

作者：冯川祝诗平黄华严森垚于丽敏西南大学工程技术学院重庆400715 山东农业工程学院信息科学与工程学院济南250110

烤烟的等级识别是烟草产业的一个关键环节,为了降低烟农烤烟分级劳动强度,减少主观因素,提高识别精度,需要实现烤烟的自动分级。研究了深度学习中多种卷积神经网络的多层特征提取方法,并基于ShuffleNetV2网络提出一种改进的网络模型(Shu... 详细信息

烤烟的等级识别是烟草产业的一个关键环节,为了降低烟农烤烟分级劳动强度,减少主观因素,提高识别精度,需要实现烤烟的自动分级。研究了深度学习中多种卷积神经网络的多层特征提取方法,并基于ShuffleNetV2网络提出一种改进的网络模型(ShuffleNetV2_FTC)。ShuffleNetV2_FTC网络是将ShuffleNetV2网络的主干单元进行更改,并引入CBAM(Convolutional Block Attention Module)注意力机制和SiLU激活函数。应用该模型对27种类别的烤烟图像进行识别分类。该模型的最佳测试准确率为93.09%,检测帧率达到每秒15.3张。相对原模型获得了0.24%(0.5×)、6.06%(1×)和4.73%(1.5×)的准确率提升,每秒检测12.3张图片到15.3张图片的检测帧率提升。ShuffleNetV2_FTC网络结合机器视觉技术可以很好地识别烤烟等级,为优化烤烟的收购、烘干和加工等流程奠定基础。

关键词：烤烟等级图像处理机器视觉深度学习 ShuffleNetV2网络

Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology

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Neural Regeneration Research 2025年第9期20卷 2655-2666页

作者： Yiyang Qin Wenzhen zhu Tingting Guo Yiran Zhang Tingting Xing Peng Yin Shihua Li Xiao-Jiang Li Su Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong–HongKong–Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina

Spinal and bulbar muscular atrophy is a neurodegenerative disease caused by extended CAG trinucleotide repeats in the androgen receptor gene,which encodes a ligand-dependent transcription facto *** mutant androgen receptor protein,characterized by polyglutamine expansion,is prone to misfolding and forms aggregates in both the nucleus and cytoplasm in the brain in spinal and bulbar muscular atrophy *** aggregates alter protein-protein interactions and compromise transcriptional *** this study,we reported that in both cultured N2a cells and mouse brain,mutant androgen receptor with polyglutamine expansion causes reduced expression of mesencephalic astrocyte-de rived neurotrophic *** n of mesencephalic astrocyte-derived neurotrophic factor amelio rated the neurotoxicity of mutant androgen receptor through the inhibition of mutant androgen receptor *** down endogenous mesencephalic astrocyte-derived neurotrophic factor in the mouse brain exacerbated neuronal damage and mutant androgen receptor *** findings suggest that inhibition of mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor is a potential mechanism underlying neurodegeneration in spinal and bulbar muscular atrophy.

关键词： androgen receptor mesencephalic astrocyte-derived neurotrophic factor mouse model neurodegeneration neuronal loss neurotrophic factor polyglutamine disease protein misfolding spinal and bulbar muscular atrophy transcription factor