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Sesquiterpenes from Red Alga Laurencia tristicha

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Chinese Chemical Letters 2005年第12期16卷 1611-1614页

作者： Jie SUN Li Jun HAN da yong shi Xiao FAN Su Juan WANG Shuai LI yong Chun YANG Jian Gong shi Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 Graduate School of the Chinese Academy of Sciences Beijing 100039

Three naturally new sesquiterpenes named 10-hydroxyepiaplysin, 10-hydroxyaplysin and 10-hydroxybromoepiaplysin have been isolated from Laurencia tristicha. On the basis of the spectroscopic techniques their structures were elucidated as （3S, 3αR, 8βS）-（-）-2, 3, 3α, 8β3-tetra- hydro-7-bromo-3-hydroxy-3, 3α, 6,8β-tetramethyl-lH-cyclopenta[b]benzofuran, （3R, 3αR, 8βS）- （-）-2,3,3α, 8β-tetrahydro-7-bromo-3-hydroxy-3, 3α,6,8β-tetramethyl-lH-cyclopenta[b]benzofuran and （3S, 3αR, 8βS）-（-）-2, 3,3R, 8β-tetrahydro-3-hydroxy-3,3α,6,8β-tetramethyl-lH-cyclopenta[b]- benzofuran, respectively.

关键词： Red alga Laurencia tristicha sesquiterpenes

Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor

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Chinese Chemical Letters 2008年第11期19卷 1290-1292页

作者： Jing Li Shu Ju Guo Hua Su Li Jun Han da yong shi Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China

Protein tyrosine phosphatase 1B （PTP1B） plays an important role as a negative regulator and has been proved to be an effective target for the treatment of type 2 diabetes mellitus. Bis-（2,3-dibromo-4,5-dihydroxyphenyl）-methane 7 was first reported as a natural bromophenol with significant inhibition against PTP1B which was isolated from red algae Rhodomela conrervoides. Intrigued by its astonishing activity （IC50 = 2.4 μmol/L）, compound 7 was synthesized with the overall yield of 24% and evaluated for its PTPIB inhibitory activity compared with natural compound.

关键词： Bromophcnol Bis-(2,3-dibromo-4,5-dihydroxyphcnyl)-methane PTPIB inhibitor Total synthesis

Two new bromoindoles from red alga Laurencia similis

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Chinese Chemical Letters 2009年第4期20卷 456-458页

作者： Hua Su Zhao Hui Yuan Jing Li Shu Ju Guo Li Ping Deng Li Jun Han Xiao Bin Zhu da yong shi Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

Two new bromoindole alkaloids have been isolated from the ethanolic extract of the red alga Laurencia similis. On the basis of chemical and spectroscopic methods （including 1D and 2D NMR technique）, their structures have been elucidated as 2,2＇,5,5＇,6,6＇- sixibromo-3, 3＇-bi-lH-indole and 3, 5-dibromo-1-methylindole, respectively.

关键词： Laurencia similis Bromoindole alkaloid 2,2',5,5',6,6'-Sixibromo-3,3'-bi-lH-indole 3,5-Dibromo-l-methylindole

Preliminary Study of Brain Glucose Metabolism Changes in Patients with Lung Cancer of Different Histological Types

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Chinese Medical Journal 2015年第3期128卷 301-304页

作者： Wei-Ling Li Chang Fu Ang Xuan da-Peng shi yong-Ju Gao Jie Zhang Jun-Ling Xu Department of Nuclear Medicine Henan Provincial People's Hospital People's Hospital of Zhengzhou University Zhengzhou Henan 450003 China

Background： Cerebral glucose metabolism changes are always observed in patients suffering from malignant tumors. This preliminary study aimed to investigate the brain glucose metabolism changes in patients with lung cancer of different histological types. Methods： One hundred and twenty patients with primary untreated lung cancer, who visited People＇s Hospital of Zhengzhou University from February 2012 to July 2013, were divided into three groups based on histological types confirmed by biopsy or surgical pathology, which included adenocarcinoma （52 cases）, squamous cell carcinoma （43 cases）, and small-cell carcinoma （25 cases）. The whole body ^18F-fiuorodeoxyglucose （^18F-FDG） positron emission tomography （PET）/computed tomography （CT） of these cases was retrospectively studied. The brain PET data of three groups were analyzed individually using statistical parametric maps （SPM） software, with 50 age-matched and gender-matched healthy controls for comparison. Results： The brain resting glucose metabolism in all three lung cancer groups showed regional cerebral metabolic reduction. The hypo-metabolic cerebral regions were mainly distributed at the left superior and middle frontal, bilateral superior and middle temporal and inferior and middle temporal gyrus. Besides, the hypo-metabolic regions were also found in the right inferior parietal lobule and hippocampus in the small-cell carcinoma group. The area of the total hypo-metabolic cerebral regions in the small-cell carcinoma group （total voxel value 3255） was larger than those in the adenocarcinoma group （total voxel value 1217） and squamous cell carcinoma group （total voxel value 1292）. Conclusions： The brain resting glucose metabolism in patients with lung cancer shows regional cerebral metabolic reduction and the brain hypo-metabolic changes are related to the histological types of lung cancer.

关键词： ^18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Brain Glucose Metabolism Lung Cancer Statistical Parametric Mapping

Natural and Semisynthetic Protein Tyrosine Phosphatase 1B(PTP1B)Inhibitors as Anti-Diabetic Agents

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Natural and Semisynthetic Protein Tyrosine Phosphatase 1B(PT...

Natural and Semisynthetic Protein Tyrosine Phosphatase 1B(PTP1B)Inhibitors as Anti-Diabetic Agents

全国第二届海洋与陆地多糖多肽及天然创新药物研发学术会议

作者： Li-Jun Wang Bo Jiang NingWu Shuai-Yu Wang da-yong shi Institute of Oceanology Chinese Academy of Sciences

Diabetes mellitus,which includes both type 1 and type 2 diabetes mellitus(T2DM),is a major disease that threatens human health *** tyrosine phosphatase IB(PTPIB)is a promising molecular-level therapeutic target that is effective in the management of *** products with various skeletons and diverse bioactivities offer opportunities for the development of new drugs and lead compounds with potent inhibitory activity against PTPIB in vitro and in ***,a number of potent PTPIB inhibitors have been obtained from natural sources or prepared by synthesis/semi-synthesis,and they exhibit potential for the treatment of *** this review,we discuss the development of potent natural and semisynthetic PTPIB inhibitors with ICvalues under 10μM over the past six years(2009-2014),including their structural features,biological features,structure-activity relationships(SARs).We also discuss strategies for identifying potent PTPIB inhibitors from natural products to provide useful information for use by medicinal chemists in developing potent PTPIB inhibitors as T2DM treatments.

关键词： Diabetes mellitus protein tyrosine phosphatase 1B(PTP1B) type 2 diabetes mellitus(T2DM) natural PTP1B inhibitors synthesis structure-activity relationships(SARs) anti-diabetic agents

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Natural and Semisynthetic Protein Tyrosine Phosphatase 1B(PT...

Two novel gastric cancer-associated genes identified by differential display

全国第九届海洋生物技术与创新药物学术会议

作者： Li-Jun Wang Bo Jiang Ning Wu Shuai-Yu Wang da-yong shi Institute of Oceanology Chinese Academy of Sciences

Diabetes mellitus,including type 1 and type 2 diabetes mellitus(T2DM)is a kind of major diseases that threaten the human health in the *** tyrosine phosphatase 1B(PTP1B)is a promising molecular level legitimate therapeutic target,which was effectively management of *** products with various skeletons and diverse bioactivities offer more opportunities to develop new drugs and leading compounds with potent inhibitory activity against PTP1B in vitro and in ***,a number of potent PTP1B inhibitors have been obtained from natural sources or prepared by synthesis/semi-synthesis,which exhibited the potential ability in the treatment of *** this review will discuss the developments of the potent natural and semisynthetic PTP1B inhibitors with ICvalues under 10μM during the past five years(2009-2013)with their structural features,biological features,the structure-activity relationships(SARs)and strategies for searching potent PTP1B inhibitors from natural products in order to provide useful information for the medicinal chemist to develop potent PTP1B inhibitor as treating T2DM drugs.

关键词： Diabetes mellitus protein tyrosine phosphatase 1B(PTP1B) type 2 diabetes mellitus(T2DM) natural PTP1B inhibitors synthesis structure-activity relationships(SARs) anti-diabetic agents

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World Journal of Gastroenterology 1998年第4期4卷 62-64页

作者： YOU Han, XIAO Bing, CUI daXiang, shi yongQuan and FAN daiMingKeywords stomach neoplasms gene clone nucleotides sequence analysis in situ hybridization polymerase chain reaction RNA, messenger

AIM To clone novel gastric cancer-associated genes and investigate their roles in gastric cancer *** A method called differential display was used which allows the identification of differentially expressed genes by using PAGE to display PCR-amplified cDNA fragments between gastric cancer cells and normal gastric mucosa cells. These fragments were cloned into plasmid vector pUC18. Homology analysis was made after sequencing these *** Two novel genes were identified compared with sequences from GenBank. One was registered with the AD number AF 051783. In situ hybridization showed that these two novel genes expressed specifically in gastric cancer *** The two novel genes obtained by differential display were confirmed to be gastric cancer-associated genes using in situ hybridization.

关键词： differential identified genes display Two cancer-associated

Bi_4V_2O_(11)/石墨烯异质结光催化剂的制备及其在降解抗体污染物中应用（英文）

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应用化学 2018年第8期35卷 946-955页

作者：笪祖林赵勇施伟东江苏大学化学化工学院江苏镇江212013

发展和设计高效、廉价和稳定的光催化剂用于抗生素污染物降解仍然存在巨大的挑战。本文通过一种便捷的水热方法制备了Bi_4V_2O_(11)/石墨烯复合材料并用于可见光下抗生素污染物光催化降解。通过自由基追踪实验,确认了光催化降解过程中... 详细信息

发展和设计高效、廉价和稳定的光催化剂用于抗生素污染物降解仍然存在巨大的挑战。本文通过一种便捷的水热方法制备了Bi_4V_2O_(11)/石墨烯复合材料并用于可见光下抗生素污染物光催化降解。通过自由基追踪实验,确认了光催化降解过程中活性物质为h+和·OH基团。根据实验结果,提出了相应的反应机理。石墨烯的引入可以有效地促进光生电子-空穴对的分离,从而增强光催化活性。该复合催化剂展现出良好的活性和稳定性。该方法以石墨烯为载体制备了光催化降解材料,为高性能光催化剂的制备提供了参考。

关键词：光催化剂 Bi4V2O11 石墨烯机理

Correlation between anxiety, depression, and social stress in young patients with thoracolumbar spine fractures

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World Journal of Psychiatry 2025年第1期15卷 83-92页

作者： Bo Wang da shi Yin-Di Sun Bo Dong Joint Ward of Orthopedics Department of TCM Honghui HospitalXi'an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Pain Ward of Orthopedics Department of TCM Honghui HospitalXi'an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina

BACKGROUND Traumatic injuries,such as falling,car accidents,and crushing mostly cause spinal fractures in young and middle-aged people,and>50%of them are thoracolumbar *** kind of fracture is easily combined with serious injuries to peripheral nerves and soft tissues,which causes paralysis of the lower limbs if there is no timely rehabilitation *** patients with thoracolumbar fractures find it difficult to recover after the operation,and they are prone to depression,low self-esteem,and other negative *** To investigate the association between anxiety,depression,and social stress in young patients with thoracolumbar spine fractures and the effect on rehabilitation *** This study retrospectively analyzed 100 patients admitted to the orthopedic department of Honghui Hospital,Xi’an Jiaotong University who underwent thoracolumbar spine fracture surgery from January 2022 to June *** general data of the patients were assessed with the Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD),life events scale,and social support rating scale(SSRS)to identify the correlation between anxiety,depression scores,and social stress and social *** Japanese Orthopedic Association(JOA)was utilized to evaluate the rehabilitation outcomes of the patients and to analyze the effects of anxiety and depression scores on *** According to the scores of HAMD and HAMA in all patients,the prevalence of depression in patients was 39%(39/100),and the prevalence of anxiety was 49%(49/100).Patients were categorized into non-depression(n=61)and depression(n=39),non-anxiety(n=51),and anxiety(n=49)*** significant differences in gender,occupation,Pittsburgh Sleep Quality Index(PSQI)score,and monthly family income were observed between the non-depression and depression groups(P<0.05).A significant difference in occupation and PSQI score was found between the non-anxiety and anxiety *** depression(r=0

关键词： Patients with thoracolumbar fractures Anxiety Depression Social pressure Social support