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Changes in sensorimotor regions of the cerebral cortex in congenital amusia:a case-control study

Neural Regeneration Research 2021年第3期16卷 531-536页

作者： Jun-Jie Sun Xue-Qun Pan Ru Yang Zhi-Shuai Jin Yi-Hui Li Jun Liu da-xing wu Department of Radiology the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina Department of Radiology the Affiliated Zhuzhou Hospital of Xiangya College of MedicineCentral South UniversityZhuzhouHunan ProvinceChina Lister Hill National Center for Biomedical Communication National Library of MedicineBethesdaMDUSA Medical Psychological Center the Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Perceiving pitch is a central function of the human auditory system;congenital amusia is a disorder of pitch *** underlying neural mechanisms of congenital amusia have been actively ***,little attention has been paid to the changes in the motor rain within congenital *** this case-control study,17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed.A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control *** found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls,indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback *** found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia *** conclusion,our study identified novel,hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital *** evidence supports the view that sensorimotor coupling plays an important role in memory and musical *** study was approved by the Ethics Committee of the Second Xiangya Hospital,Central South University,China(***20180101GZ01)on February 9,2019.

关键词： congenital amusia degree centrality lifelong impairment local functional connectivity music discrimination primary motor area primary sensorimotor area primary sensory area resting-state functional magnetic resonance imaging voxel-based analysis

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Preliminary assessment of two non-destructive instrumental techniques for quality evaluation of Lobelia chinensis Lour.

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Journal of Pharmaceutical Analysis 2016年第3期6卷 203-206页

作者： Hong-Peng Chen Wen-jia Pan Nan Tang Yuan Zhang Mei-Ling Yu xing-da wu School of Information Engineering Guangdong Medical University Xincheng Road Dongguan 52380& China School of Pharmacy Guangdong Medical University Xincheng Road Dongguan 523808 China Department of Pharmacology Zhongshan School of Medicine Sun Yat-Sen University Guangzhou 510080 China Department of Pharmacy the First Affiliated Hospital of Bengbu Medical College Benghu 233004 China

Two non-destructive instrumental methods, infrared spectroscopy （IR） and X-ray diffraction （XRD）, were studied for qualiW evaluation of Lobelia chinensis Lour. （L chinensis）. We obtained the IR spectra and XRD patterns of L chinensis collected from different sources. The similarity of samples was analyzed by cal- culating the cosine coefficient. The cosine values were in the range of 0.83-0.90, indicating that the main components ofL chinensis samples are similar. Sample L1 and L6 showed a slightly lower similarity than that of L2, L3, L4, L5 detected by the two methods, which revealed that IR and XRD methods exhibited analogous detection ability for quality evaluation of L. chinensis. The two methods could be highly re- commended as simple and rapid detection means for quality evaluation of L. chinensis.

关键词： Lobelia chinensis Lour Infrared spectroscopy X-ray diffraction Quality evaluation

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Cell-cycle-dependent PC-PLC was Regulated by APCCdc20-mediated Ubiquitin Proteasome Pathway

Cell-cycle-dependent PC-PLC was Regulated by APCCdc20-mediat...

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2008年全国生物化学与分子生物学学术大会

作者： da Fu xing-zhong wu (Department of Biochemistry,Shanghai Medical Collgeg,Fudan University,Shanghai 200032,PR China)

Phosphatidylcholine-specific phospholipase C(PC-PLC)involved in the cell signal transduction,including cell proliferation and *** the mechanism is not fully understood,and a role of PC-PLC in cell cycle is also ***,We prepared the PC-PLC antibody and found that cell division cycle 2O homolog(Cdc20) and PC-PLC possible directly interact in CBRH-7919 *** co-localization,immunoprecipitation,two-

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Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie Liu Changqing Xu da-Jian wu Ying Cheng Xiao-Jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

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Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin xing Xuyun Hua Yuwen Zhang Xin Xue Jiajia wu Mouxiong Zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong xing Xinzhu Liu Xiandeng Li Mi Li Xian wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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青少年卵巢肿瘤的CT诊断

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实用放射学杂志 2007年第3期23卷 374-377页

作者：温大勇伍兴友银川市第一人民医院放射科银川市第一人民医院放射科宁夏银川750001

目的探讨青少年卵巢肿瘤的CT表现和诊断价值。方法回顾性分析经手术和病理证实的29例青少年卵巢肿瘤的CT表现,并与手术、病理结果对照。结果29例中良性肿瘤18例,恶性肿瘤11例,其中生殖细胞肿瘤19例,占65.5%,上皮性肿瘤5例,占17.2%,非赘... 详细信息

目的探讨青少年卵巢肿瘤的CT表现和诊断价值。方法回顾性分析经手术和病理证实的29例青少年卵巢肿瘤的CT表现,并与手术、病理结果对照。结果29例中良性肿瘤18例,恶性肿瘤11例,其中生殖细胞肿瘤19例,占65.5%,上皮性肿瘤5例,占17.2%,非赘生性囊肿3例,占10.3%。性索间质肿瘤2例,占7%。CT显示囊性肿物17个,囊实性肿物6个,实性肿物10个。肿瘤合并出血者6个,肿瘤蒂扭转者5个;囊性肿物多见于良性肿瘤(17/20个,占85%),恶性肿瘤以实性肿物居多(9/13个,占69.2%)。结论CT对青少年卵巢肿瘤具有很高的诊断价值。

关键词：卵巢肿瘤青少年体层摄影术,X线计算机

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采用感受野优化与渐进特征融合的图像超分辨率算法

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西安交通大学学报 2025年第1期59卷 136-147页

作者：吴洪伍盖绍彦达飞鹏东南大学自动化学院 210096南京东南大学复杂工程系统测量与控制教育部重点实验室 210096南京

针对现有基于深度学习的超分辨率方法存在参数冗余以及难以学习到全局上下文信息、重建图像高频特征能力欠佳的问题,提出一种基于感受野优化与渐进特征融合的超分辨率网络(RPSRnet),其在单幅图像重建方面实现了较高的性能。该网络采用... 详细信息

针对现有基于深度学习的超分辨率方法存在参数冗余以及难以学习到全局上下文信息、重建图像高频特征能力欠佳的问题,提出一种基于感受野优化与渐进特征融合的超分辨率网络(RPSRnet),其在单幅图像重建方面实现了较高的性能。该网络采用像素注意力机制与大感受野卷积相结合的方式,设计两条渐进路径将输入表征为不同层次的特征抽象,增强网络捕获上下文信息的能力,同时减少了网络参数冗余。通过分层卷积和多重感受野分支,在保持轻量卷积的前提下,于分层的多路径上学习不同尺度的融合特征,增强网络重建边缘细节和复杂纹理特征的能力。实验结果表明:相比于先进算法,所提算法在基准测试集Set5上的峰值信噪比达到32.47 dB,在测试集Set14上达到28.81 dB,优于现有的先进算法,且网络参数更少,实现了9%的参数缩减,从而验证了算法的有效性。

关键词：超分辨率注意力机制感受野优化特征融合

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螺旋CT血管成像对肝血管瘤并发周围型动-门静脉瘘的诊断价值

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实用放射学杂志 2008年第6期24卷 787-789页

作者：温大勇伍兴友杨晔银川市第一人民医院放射科银川市第一人民医院放射科宁夏银川750001

目的探讨肝血管瘤并发周围型肝动脉-门静脉瘘(APS)多层螺旋CT血管成像的影像表现和诊断价值。方法搜集12例经多层螺旋CT三期扫描确诊的肝血管瘤并发周围型APS,对肝动脉期CT血管成像进行回顾性分析。结果容积再现(VR)和最大密度投影(M IP... 详细信息

目的探讨肝血管瘤并发周围型肝动脉-门静脉瘘(APS)多层螺旋CT血管成像的影像表现和诊断价值。方法搜集12例经多层螺旋CT三期扫描确诊的肝血管瘤并发周围型APS,对肝动脉期CT血管成像进行回顾性分析。结果容积再现(VR)和最大密度投影(M IP)三维重建法均可较好地显示周围型APS和肝实质一过性强化。APS血管成像可分为4种类型,类型Ⅰ:瘤周可见早显的门静脉分支,多有肝动脉支伴行,有时可见'双轨'征;类型Ⅱ:自瘤体发出数条纤细的早显小门静脉支,呈细线或虚线状,无肝动脉支伴行,早显的小门静脉支多位于短暂肝实质强化区中;类型Ⅲ:同时具备类型Ⅰ和类型Ⅱ的影像表现;类型Ⅳ:瘤周无早显的门静脉分支,仅显示楔形或片状浓染区。肝实质一过性强化表现为瘤周片状浓染区。结论多层螺旋CT血管成像是诊断肝血管瘤并发周围型APS有效的检查手段。

关键词：肝脏肝血管瘤动-门静脉瘘体层摄影术,X线计算机

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Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

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Nano Research 2025年第1期18卷 618-627页

作者： Shuai wu Li Zhu Sheng Ni Xiong Zhao Meng Yan Yuan Zhong Karissa Kusuma Yi Liang Kaiwen Bao Kai Qu Xian Qin Kun Zhang wuquan Deng da Sun Wei wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

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