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Impact of gut–brain interaction in emerging neurological disorders

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World Journal of Clinical Cases 2023年第1期11卷 1-6页

作者： Muh-Shi Lin Yao-Chin Wang Wei-jung Chen woon-Man Kung Division of Neurosurgery Department of SurgeryKuang Tien General HospitalTaichung 43303Taiwan Department of Biotechnology and Animal Science College of BioresourcesNational Ilan UniversityYilan 26047Taiwan Department of Biotechnology College of Medical and Health CareHung Kuang UniversityTaichung 43302Taiwan Department of Health Business Administration College of Medical and Health CareHung Kuang UniversityTaichung 43302Taiwan Department of Emergency Min-Sheng General HospitalTaoyuan 33044Taiwan Graduate Institute of Injury Prevention and Control College of Public HealthTaipei Medical UniversityTaipei 11031Taiwan Division of Neurosurgery Department of SurgeryTaipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City 23142Taiwan Department of Exercise and Health Promotion College of Kinesiology and HealthChinese Culture UniversityTaipei 11114Taiwan

The central nervous system(CNS)is a reservoir of immune *** immune glial cells are responsible for maintenance and defense against foreign *** blood–brain barrier(BBB)prevents detrimental pathogens and potentially overreactive immune cells from entering the *** the double-edged neuroinflammatory response is overloaded,it no longer has the protective function of promoting ***,microbiota and its derivatives may emerge as pathogen-associated molecular patterns of brain pathology,causing microbiome–gut–brain axis dysregulation from the *** dysbiosis of the gastrointestinal flora leads to subsequent alterations in BBB permeability,peripheral immune cells are recruited to the *** results in amplification of neuroinflammatory circuits in the brain,which eventually leads to specific neurological *** treatment strategies for gastrointestinal disorders may protect against specific immune responses to gastrointestinal disorders,which can lead to potential protective effects in the ***,this study investigated the mutual effects of microbiota and the gut–brain axis,which may provide targeting strategies for future disease treatment.

关键词： Neuroinflammation Blood–brain barrier Microbiota Gut–brain axis Neurological disorders

Occurrence of human leukocyte antigen B51-related ankylosing spondylitis in a family:Two case reports

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World Journal of Clinical Cases 2022年第3期10卷 992-999页

作者： Mie Jin Lim Eul Noh Ro-woon Lee Kyong-Hee jung Won Park Rheumatology/Internal Medicine Inha UniversityIncheon 22332South Korea Radiology Inha UniversityIncheon 22332South Korea

BACKGROUND Ankylosing spondylitis(AS)is strongly associated with the human leukocyte antigen(HLA)B27 *** regions where conventional polymerase chain reaction for HLA typing is available for antigens such as HLA B27 or HLA B51,it is common to perform the HLA B27 test for evaluation of *** HLA B27-associated clustered occurrences of AS have been reported in families,we report the first case series of HLA B51-related occurrences of AS in a *** SUMMARY A father and his daughters were diagnosed with AS and did not have the HLA B27 *** they were positive for HLA B51,they exhibited no signs of Behçet’s disease(BD).Of the five daughters,one had AS,and three,including the daughter with AS,were positive for HLA *** two daughters with the HLA B51 haplotype(excluding the daughter with AS)exhibited bilateral grade 1 sacroiliitis,whereas the daughters without the HLA B51 haplotype did not have ***,this Korean family exhibited a strong association with the HLA B51 haplotype and clinical sacroiliitis,irrespective of the symptoms of *** It is advisable to check for HLA B51 positivity in patients with AS/spondyloarthropathy who test negative for HLA B27.

关键词： Ankylosing spondylitis Spondyloarthropathy Human leukocyte antigen B51 Human leukocyte antigen B27 Sacroiliitis Case report

Anaphylactic shock induced by polyethylene glycol after bowel preparation for the colorectal cancer surgery:A case report

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世界临床病例杂志 2023年第23期11卷 5589-5594页

作者： Go woon Park Nahyeon Park jung Cheol Kuk Eung Jin Shin dae Ro Lim Department of General Surgery Soonchunhyang Bucheon HospitalBucheon 14584South Korea

BACKGROUND Polyethylene glycol(PEG)is widely used as an additive because of its hydrophilic and chemically inert ***,there are been increasing reports of PEG allergies,including anaphylaxis,although they are still *** case report aims to raise awareness,that the commonly used bowel cleansing agent containing PEG can cause serious allergic *** SUMMARY Prior to surgery for sigmoid colon cancer,a 63-year-old man was prescribed a bowel cleansing agent containing *** 30 min of ingestion,he developed symptoms of anaphylactic shock and did not respond to initial intramuscular epinephrine *** diagnosis of anaphylaxis to PEG,he was stabilized with fluid hydration and continuous norepinephrine *** While allergic reactions to PEG are rare,they can be ***,it is crucial for clinicians to be aware of this possibility and to diagnose and resuscitate patients immediately.

关键词： Polyethylene glycol Anaphylaxis Sigmoid colon cancer Bowel preparation Case report

Ectopic peritoneal paragonimiasis mimicking tuberculous peritonitis:A care report

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World Journal of Clinical Cases 2022年第16期10卷 5359-5364页

作者： jung Woo Choi Chang Min Lee Seong Je Kim Se In Hah Ji Yoon Kwak Hyun Chin Cho Chang Yoon Ha woon Tae jung Ok Jae Lee Department of Internal Medicine Gyeongsang National University College of Medicine and Gyeongsang National University HospitalJinju 52727South Korea Institute of Health Sciences Gyeongsang National UniversityJinju 52828South Korea

BACKGROUND The most common site of paragonimiasis is in the *** migratory route passes through the duodenal wall,peritoneum,and diaphragm to the lungs;thus,the thoracic cavity and central nervous system,as well as the liver,intestine,and abdominal cavity may be ***,we present a case of intraperitoneal paragonimiasis without other organ involvement,mimicking tuberculous *** SUMMARY A 57-year-old man presented with recurrent abdominal pain for 4 *** examination revealed tenderness in the right lower *** findings showed complete blood counts within the normal range without *** reactive lymph nodes and diffuse peritoneal infiltration were noted on abdominal computed tomography(CT).There were no abnormalities on chest CT or *** findings of diagnostic laparoscopy for the differential diagnosis of tuberculous peritonitis and peritoneal carcinomatosis included multiple small whitish nodules and an abscess in the *** reports confirmed the presence of numerous eggs of Paragonimus westermani(***).A postoperative serum enzyme-linked immunosorbent assay revealed *** *** and repetitive history-taking led him to retrospectively recall the consumption of freshwater *** 3 d of treatment with praziquantel(1800 mg;25 mg/kg),he recovered from all *** In patients who require diagnostic laparoscopy for the differential diagnosis of tuberculous peritonitis and peritoneal carcinomatosis,repetitive history-taking and preoperative serologic antibody tests against Paragonimus may be helpful in diagnosing intraperitoneal paragonimiasis without other organ involvement.

关键词： Differential diagnoses Intraperitoneal abscess Paragonimiasis Paragonimus westermani Peritonitis Tuberculosis Case report

Translocator protein 18 kda(TSPO): old dogma, new mice, new structure, and new questions for neuroprotection

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Neural Regeneration Research 2015年第6期10卷 878-880页

作者： Eun-jung Kim Seong-woon Yu Department of Brain and Cognitive Science Daegu Gyeongbuk Institute of Science and Technology (DGIST)

The normal development and optimal functioning of the brain requires a vigilant immune surveillance system to detect and remove potential risk factors and prevent infection and tissue damage. Microglia are the resident immune cells and the frontline defenders responsible for the immune response of the brain. Resting microglia possess a ramified morphology with numerous thin processes that continuously sample the environment. In response to inflammatory signals, microglia become activated and transform their morphology into a thick, amoeboid-like shape. Activated microglia proliferate, tolerate to sites of iniurv,

关键词： TSPO old dogma Translocator protein 18 kda new mice new structure

Caenorhabditis elegans deep lipidome profiling by using integrative mass spectrometry acquisitions reveals significantly altered lipid networks

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Journal of Pharmaceutical Analysis 2022年第5期12卷 743-754页

作者： Nguyen Hoang Anh Young Cheol Yoon Young Jin Min Nguyen Phuoc Long Cheol woon jung Sun Jo Kim Suk Won Kim Eun Goo Lee daijie Wang Xiao Wang Sung Won Kwon College of Pharmacy Seoul National UniversitySeoul08826Republic of Korea School of Pharmaceutical Sciences Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan250014China Biological Engineering Technology Innovation Center of Shandong Province Heze Branch of Qilu University of Technology(Shandong Academy of Sciences)HezeShandong274000China

Lipidomics coverage improvement is essential for functional lipid and pathway construction.A powerful approach to discovering organism lipidome is to combine various data acquisitions,such as full scan mass spectrometry(full MS),data-dependent acquisition(Dda),and data-independent acquisition(DIA).Caenorhabditis elegans(***)is a useful model for discovering toxic-induced metabolism,highthroughput drug screening,and a variety of human disease *** determine the lipidome of *** and investigate lipid disruption from the molecular level to the system biology level,we used integrative data *** methyl-tert-butyl ether method was used to extract L4 stage *** after exposure to triclosan(TCS),perfluorooctanoic acid,and nanopolystyrene(nPS).Full MS,Dda,and DIA integrations were performed to comprehensively profile the *** lipidome by Q-Exactive Plus *** annotated lipids were then analyzed using lipid ontology and pathway *** annotated up to 940 lipids from 20 lipid classes involved in various functions and *** biological investigations revealed that when *** were exposed to nPS,lipid droplets were disrupted,whereas plasma membrane-functionalized lipids were likely to be changed in the TCS treatment *** nPS treatment caused a significant disruption in lipid ***,glycerophospholipid,and ether class lipids were those primarily hindered by ***,toxicant exposure frequently involved numerous lipid-related pathways,including the phosphoinositide 3-kinase/protein kinase B *** conclusion,an integrative data acquisition strategy was used to characterize the *** lipidome,providing valuable biological insights into hypothesis generation and validation.

关键词： Caenorhabditis elegans Lipidomics data-dependent acquisition data-independent acquisition

Surface effects of hybrid vibration-assisted femtosecond laser system for micro-hole drilling of copper substrate

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中国有色金属学会会刊：英文版 2012年第S3期22卷 801-807页

作者： jung-Kyu PARK Ji-woon YOON Myung-Chang KANG Sung-Hak CHO Nano Machining Laboratory Korea Institute of Machinery and Materials Department of Nano-Mechatronics University of Science and Technology National Core Research Center for Hybrid Materials Solution Pusan National University

The ultrafast laser based hybrid machining system was studied and a novel approach was demonstrated to improve laser machining quality on metals by vibrating the optical objective lens with a low frequency (500 Hz) and various displacements (0-16.5 μm) during a femtosecond laser machining *** laser used in this experiment is an amplified Ti:sapphire femtosecond (10-15 s) laser system that generates 100 femtosecond pulses having an energy of 3.5 mJ/pulse with a 5 kHz repetition rate at a central wavelength of 790 *** is found that both the wall surface finish of the machined structures and the aspect ratio obtained using the frequency vibration assisted laser machining are improved compared with those derived via laser machining without vibration assistance.

关键词： femtosecond laser hybrid machining vibration-assisted machining surface roughness aspect ratio

Effects of Wind Fences on the Wind Environment around Jang Bogo Antarctic Research Station

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Advances in Atmospheric Sciences 2017年第12期34卷 1404-1414页

作者： Jang-woon WANG Jae-Jin KIM Wonsik CHOI da-Som MUN jung-Eun KANG Hataek KWON Jin-Soo KIM Kyung-Soo HAN Department of Environmental Atmospheric Sciences Pukyong National University 45Yongso-ro Korea Polar Research Institute 26 Songdomirae-ro Yeonsu-gu Department of Spatial Information Engineering Pukyong National University 45Yongso-ro

This study investigated the flow characteristics altered by Jang Bogo Antarctic Research Station using computational fluid dynamics(CFD) modeling. The topography and buildings around Jang Bogo Station were constructed with computeraided-design data in the CFD model domain. We simulated 16 cases with different inflow directions, and compared the flow characteristics with and without Jang Bogo Station for each inflow direction. The wind data recorded by the site’s automatic weather station(AWS) were used for comparison. Wind rose analysis showed that the wind speed and direction after the construction of Jang Bogo Station were quite different from those before construction. We also investigated how virtual wind fences would modify the flow patterns, changing the distance of the fence from the station as well as the porosity of the fence. For westerly inflows, when the AWS was downwind of Jang Bogo Station, the decrease in wind speed was maximized(-81% for west-northwesterly). The wind speed reduction was also greater as the distance of the fence was closer to Jang Bogo Station. With the same distance, the fence with medium porosity(25%–33%) maximized the wind speed *** results suggest that the location and material of the wind fence should be selected carefully, or AWS data should be interpreted cautiously, for particular prevailing wind directions.

关键词： Jang Bogo Antarctic Research Station CFD model observation environment wind fence porosity

Single atom and defect engineering of CuO for efficient electrochemical reduction of CO_(2) to C_(2)H_(4)

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SmartMat 2022年第1期3卷 194-205页

作者： Senlin Chu Changwoo Kang woonghyeon Park Yu Han Song Hong Leiduan Hao Hao Zhang Tsz woon Benedict Lo Alex W.Robertson Yousung jung Buxing Han Zhenyu Sun State Key Laboratory of Organic‐Inorganic Composites Beijing University of Chemical TechnologyBeijingChina Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina Department of Physics University of WarwickCoventryUK Institute of Chemistry Chinese Academy of SciencesBeijingChina

Electrochemical CO_(2) transformation to high‐value ethylene(C_(2)H_(4))at high currents and efficiencies is desired and yet remains a grand *** show for the first time that coupling single Sb atoms and oxygen vacancies of CuO enable synergistic electrocatalytic reduction of CO_(2) to C_(2)H_(4) at low *** dispersed Sb atoms occupying metal substitutional sites of CuO are synthesized under mild *** overall CO_(2) reduction faradaic efficiency(FE)reaches 89.3±1.1%with an FE toward C_(2)H_(4) exceeding 58.4%at a high‐current density of 500 mA/cm^(2).Addition of the p‐block metal is found to induce transformation of CuO from flakes to nanoribbons rich in nanoholes and oxygen vacancies,greatly enhancing CO_(2) adsorption and activation while suppressing hydrogen *** density functional theory calculations with in situ X‐ray diffraction reveal that combining Sb sites and oxygen vacancies prominently lessen the dimerization energy of adsorbed CO intermediate,thus boosting the conversion of CO_(2) to produce C_(2)H_(4).This study provides a new perspective for promoting selective C-C coupling for electrochemical CO_(2) reduction.

关键词： CO_(2)reduction copper oxide electrocatalysis ethylene single sites