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PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α

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Genes & Diseases 2024年第4期11卷 353-367页

作者： Yu wei Dian Zhang He Shi Husun Qian Hongling Chen Qian Zeng Fangfang Jin Yan Ye Zuli Ou Minkang Guo Bianqin Guo Tingmei Chen Key Laboratory of Clinical Laboratory Diagnostics(Ministry of Education) College of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China

Pyruvate dehydrogenase kinase 1(PDK1)phosphorylates the pyruvate dehydroge-nase complex,which inhibits its *** pyruvate dehydrogenase complex inhibits the tricarboxylic acid cycle and the reprogramming of tumor cell metabolism to glycolysis,which plays an important role in tumor *** study aims to elucidate how PDK1 pro-motes breast cancer *** found that PDK1 was highly expressed in breast cancer tissues,and PDK1 knockdown reduced the proliferation,migration,and tumorigenicity of breast cancer cells and inhibited the HIF-1α(hypoxia-inducible factor 1α)*** investigation showed that PDK1 promoted the protein stability of HIF-1αby reducing the level of ubiquitination of HIF-1α.The HIF-1αprotein levels were dependent on PDK1 kinase ***,HIF-1αphosphorylation at serine 451 was detected in wild-type breast cancer cells but not in PDK1 knockout breast cancer *** phosphorylation of HIF-1αat Ser 451 stabilized its protein levels by inhibiting the interaction of HIF-1αwith von Hippel-Lindau and prolyl hydroxylase *** also found that PDK1 enhanced HIF-1αtranscriptional *** summary,PDK1 enhances HIF-1αprotein stability by phosphorylating HIF-1αat Ser451 and promotes HIF-1αtranscriptional activity by enhancing the binding of HIF-1αto ***1 and HIF-1αform a positive feedback loop to promote breast cancer progression.

关键词： Breast cancer HIF-1α PDK1 Protein phosphorylation Transcriptional activity

数字贸易促进数字经济发展:机理、事实与建议

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国际贸易 2024年第7期 33-45,68页

作者：李俊付鑫商务部国际贸易经济合作研究院国际服务贸易研究所

数字贸易逐渐成为国际贸易加速升级和演变的新趋势,数字贸易通过在全球范围内配置数字经济资源来重塑全球数字经济产业链供应链,数字经济的发展升级亦有助于培育数字贸易的国际竞争力。文章基于跨境电商及数字服务贸易视角,在深入分析... 详细信息

数字贸易逐渐成为国际贸易加速升级和演变的新趋势,数字贸易通过在全球范围内配置数字经济资源来重塑全球数字经济产业链供应链,数字经济的发展升级亦有助于培育数字贸易的国际竞争力。文章基于跨境电商及数字服务贸易视角,在深入分析数字贸易促进数字经济发展的机理与典型事实的基础上,从加快体制机制创新、促进跨境电商高质量发展及数字服务贸易创新发展、加强数字贸易平台载体建设、拓展数字贸易发展朋友圈等方面提出了中国以数字贸易促进数字经济发展的建议。

关键词：数字贸易数字经济跨境电商促进机制

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The association between folic acid supplementation,maternal folate during pregnancy and intelligence development in infants:a prospective cohort study

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Food Science and Human Wellness 2021年第2期10卷 197-204页

作者： Shaokang Wang Jie wei Di Wang Li Hua da Pan Lingmeng fu Jin Yang Guiju Sun Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food Hygieneschool of Public HealthSoutheast UniversityNanjingChina Jurong Maternity and Child Health Care Hospital ZhenjiangChina

Objective The study aimed to explore the association between folic acid supplementation,maternal nutritional levels during pregnancy and intelligence development of *** This was a prospective cohort study,mothers and their offspring in Jurong Maternal and Child Health Hospital were followed up through pregnancy up to 1 *** basic information of pregnant women was obtained through questionnaire survey,including pregnancy lifestyle,marital status,vitamin and mineral supplements during *** samples of pregnant women were collected on admission,serum folate,vitamin B12 and homocysteine concentrations were *** postpartum colostrum was collected and the concentrations of folate and vitamin B12 in colostrum were *** women(n=478)and their corresponding infants were followed up and the Developmental Screen Test scores were recorded at 1,3,6,8 and 12 months of *** Compared with the normal group,infants in the low serum folate group had a score of 0.12 points lower in the intellectual energy zone(95%CI:-0.23–-0.01,P=0.04),and infants with the high homocysteine level scored 1.30 points lower than the lower-level group(95%CI:-2.52–-0.08,P=0.04).In the colostrum low-vitamin B12 level group,infants scored 0.10 points lower(95%CI:-1.84–-0.02,P=0.02)in the social adaptation zone compared to the normal *** In conclusion,folic acid supplementation in the pre-pregnancy supplementation group and the post-pregnancy supplementation group may be not associated with infant mental *** addition,maternal folate and homocysteine may be related to the intellectual development of *** level of vitamin B_(12)in colostrum may be associated with infants’social adaptive *** result may be caused by individual differences in folate and homocysteine metabolism in pregnant women.

关键词： Folic acid Vitamin B_(12) Homocysteine Intelligent development

2-O-β-D-Glucopyranosyl-L-ascorbic acid,an ascorbic acid derivative isolated from the fruits of Lycium barbarum L.,ameliorates high fructose-induced neuroinflammation in mice:involvement of gut microbiota and leaky gut

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Food Science and Human Wellness 2024年第1期13卷 241-253页

作者： wei Dong Yujia Peng Guijie Chen Zhiyong Xie weiqi Xu Wangting Zhou Jia Mi Lu Lu Yi Sun Xiaoxiong Zeng Youlong Cao Yamei Yan College of Food Science and Technology Nanjing Agricultural UniversityNanjing 210095China Institute of Wolfberry Engineering Technology National Wolfberry Engineering Research CenterNingxia Academy of Agriculture and Forestry SciencesYinchuan 750002China

Western diet(rich in highly refined sugar and fat)can induce a range of metabolic dysfunctions in animals and humans,including neuroinflammation and cognitive function *** and cognitive impairment,two critical pathological characteristics of Alzheimer’s disease,have been closely associated with microbial alteration via the gut-brain ***,the present study aimed to investigate the influence of 2-O-β-D-glucopyranosyl-L-ascorbic acid(AA-2βG)isolated from the fruits of Lycium barbarum on preventing the high-fructose diet(HFrD)induced neuroinflammation in *** was found that AA-2βG prevented HFr D-induced cognitive ***-2βG also predominantly enhanced the gut barrier integrity,decreased lipopolysaccharide entry into the circulation,which subsequently countered the activation of glial cells and neuroinflammatory *** beneficial effects were transmissible by horizontal fecal microbiome transplantation,transferring from AA-2βG fed mice to HFr D fed ***,AA-2βG exerted neuroprotective effects involving the enrichment of Lactobacillus and Akkermansia,potentially beneficial intestinal *** present study provided the evidence that AA-2βG could improve indices of cognition and neuroinflammmation via modulating gut dybiosis and preventing leaky *** a potential functional food ingredient,AA-2βG may be applied to attenuate neuroinflammation associated with Western-style diets.

关键词： Neuroinfl ammation Gut microbiota Leaky gut Lipopolysaccharide Fecal microbiome transplantation 2-O-β-D-Glucopyranosyl-L-ascorbic acid

Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets

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Journal of Animal Science and Biotechnology 2024年第2期15卷 878-897页

作者： Chang Cui Yulong wei Yibo Wang Wen Ma Xiaoyu Zheng Jun Wang Ziwei Ma Caichi Wu Licui Chu Shihai Zhang Wutai Guan Fang Chen Guangdong Provincial Key Laboratory of Animal Nutrition Control College of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642China College of Animal Science and National Engineering Research Center for Breeding Swine Industry South China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture South China Agricultural UniversityGuangzhou 510642China

Background The benefits of combining benzoic acid and essential oils(BAO)to mitigate intestinal impairment during the weaning process have been well established,while the detailed underlying mechanism has not been fully *** research has primarily focused on the reparative effects of BAO on intestinal injury,while neglecting its potential in enhancing intestinal stress *** In this study,we investigated the pre-protective effect of BAO against LPS-induced stress using a modified experimental *** were pre-supplemented with BAO for 14 d,followed by a challenge with LPS or saline to collect blood and intestinal *** Our findings demonstrated that BAO supplementation led to significant improvements in piglets’final weight,average daily gain,and feed intake/body gain ***,BAO supplementation positively influenced the composition of intestinal microbiota,increasing beneficial Actinobacteriota and Alloprevotella while reducing harmful Desulfobacterota,Prevotella and ***,BAO supplementation effectively mitigated oxidative disturbances and inflammatory responses induced by acute LPS *** was evidenced by elevated levels of T-AOC,SOD,and GSH,as well as decreased levels of Mda,TNF-α,and IL-6 in the ***,piglets subjected to LPS challenge and pre-supplemented with BAO exhibited significant improvements in intestinal morphological structure and enhanced integrity,as indicated by restored expression levels of Occludin and Claudin-1 compared to the non-supplemented *** analysis revealed that BAO supplementation enhanced the jejunal antioxidative capacity by increasing GSH-Px levels and decreasing Mda levels under the LPS challenge and stimulated the activation of the Nrf2 signaling ***,the reduction of TLR4/NF-κB/MAPK signaling pathways activation and proinflammatory factor were also observed in the jejunal of those piglets fed with ***

关键词： Anti-stress Benzoic acid Essential oils Intestine LPS Weaned piglets

Cu nanowire array with designed interphases enabling high performance Si anode toward flexible lithium-ion battery

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Nano Research 2024年第3期17卷 1516-1524页

作者： Pengfei Su Ziqi Zhang Linshan Luo Zhiyong Zhang Chaofei Lan Yahui Li Shaowen Xu Shanpeng Pei Guangyang Lin Cheng Li Xiang Han wei Huang Songyan Chen fujian Provincial Key Laboratory of Semiconductors and Applications Collaborative Innovation Center for Optoelectronic Semiconductors and Efficient DevicesDepartment of PhysicsXiamen UniversityXiamen 361005China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China Science and Technology on Analog Integrated Circuit Laboratory Chongqing 400060China Shandong Electric Power Engineering Consulting Institute Co. Ltd.Jinan 250013China

To meet the growing demand for wearable smart electronic devices,the development of flexible lithium-ion batteries(LIBs)is *** is an ideal candidate for the anode material of flexible lithium-ion batteries due to its high specific capacity,low working potential,and earth *** largest challenge in developing a flexible silicon anode is how to maintain structural integrity and ensure stable electrochemical reactions during external *** this work,we propose a novel design for fabricating core–shell electrodes based on a copper nanowire(CuNW)array core and magnetron sputtered Si/C *** nanowire array structure has characteristics of bending under longitudinal stress and twisting under transverse stress,which helps to maintain the mechanical stability of the structure during electrode bending and *** low-temperature annealing generates a small amount of Cu3Si alloy,which enhances the connection strength between Si and the conductive network and solves the poor conductivity problem of Si,which is known as a semiconductor *** unique configuration design of CuNW@Si@C-400℃ leads to stable long cycle performance of 1109 mAh∙g^(-1) after 1000 cycles and excellent rate performance of 500 mAh∙g^(-1) at a current density of 10 A∙g^(-1).furthermore,the CuNW@Si@C-400℃||LiFePO_(4)(LFP)full battery demonstrates excellent flexibility,with a capacity retention of more than 96%after 100 *** study provides a promising strategy for the development of flexible lithium-ion batteries.

关键词： flexible lithium-ion battery silicon anode magnetron sputtering core–shell electrode Cu nanowire array

Phase engineering of Ni-Mn binary layered oxide cathodes for sodiumion batteries

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Journal of Energy Chemistry 2024年第4期91卷 501-511页

作者： Feifei Hong Xin Zhou Xiaohong Liu Guilin Feng Heng Zhang weifeng Fan Bin Zhang Meihua Zuo Wangyan Xing Ping Zhang Hua Yan wei Xiang College of Materials and Chemistry&Chemical Engineering Chengdu University of TechnologyChengdu 610059SichuanChina College of Chemical Engineering Sichuan UniversityChengdu 610065SichuanChina Research Institute for Electronic Science(RIES)and Division of Information Science and Technology Graduate School of Information Science and TechnologyHokkaido UniversityN20W10SapporoHokkaido 001-0020Japan School of Materials Science and Engineering Suzhou University of Science and TechnologySuzhou 215009JiangsuChina Yibin Libode New Materials Co. Ltd.Yibin 644200SichuanChina Engineering Research Center of the Ministry of Education for Advanced Battery Materials School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083HunanChina

Nickel-manganese binary layered oxides with high working potential and low cost are potential candidates for sodium-ion batteries,but their electrochemical properties are highly related to compositional *** composite materials with various phase structures of P3,P2/P3,P2,P2/O3,and P2/P3/O3 were synthesized by manipulating the sodium content and calcination conditions,leading to the construction of a synthetic phase diagram for Na_(x)Ni_(0.25)Mn_(0.75)O_(2)(0.45≤x≤1.1).Then,we compared the electrochemical characteristics and structural evolution during the desodiation/sodiation process of P2,P2/P3,P2/03,and P2/P3/O3-Na_(x)Ni_(0.25)Mn_(0.75)O_(2).Among them,P2/P3-Na0.75Ni0.25Mn0.75O2exhibits the best rate capability of 90.9 mA h g^(-1)at 5 C,with an initial discharge capacity of 142.62 mA h g^(-1)at 0.1 C and a capacity retention rate of 78.25%after 100 cycles at 1 C in the voltage range of 2-4.3 *** observed superior sodium storage performance of P2/P3 hybrids compared to other composite phases can be attributed to the enhanced Na^(+)transfer dynamic,reduction of the Jahn-teller effect,and improved reaction reversibility induced by the synergistic effect of P2 and P3 *** systematic research and exploration of phases in Na_(x)Ni_(0.25)Mn_(0.75)O_(2)provide new sights into high-performance nickel-manganese binary layered oxide for sodium-ion batteries.

关键词： Phase engineering Ni-Mn layered oxide Cathode Sodium-ion batteries

英烈无名:现代中国的地下革命、女性与文艺政治

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厦门大学学报（哲学社会科学版） 2024年第5期74卷 149-159页

作者：符杰祥上海交通大学人文学院上海200240

中国革命由弱到强,经历了一个从地下到地上、从隐蔽到公开的过程。在看不见的地下革命中,女性与革命如何暗自纠缠,她们如何利用自己的文艺才华与性别身份承担特殊使命,又会遭遇怎样的困境,折射的是怎样的问题20世纪革命中国的广阔视域,... 详细信息

中国革命由弱到强,经历了一个从地下到地上、从隐蔽到公开的过程。在看不见的地下革命中,女性与革命如何暗自纠缠,她们如何利用自己的文艺才华与性别身份承担特殊使命,又会遭遇怎样的困境,折射的是怎样的问题20世纪革命中国的广阔视域,涵盖了一个从秋瑾到赵一曼、江姐、丁玲、关露等漫长而复杂的地下人物谱系。女地下革命者及其文学形象有两类,一类形象鲜明,一类暧昧不明。在地下革命的舞台上,形塑革命女性的,既有作为思潮和行动的政治,也有作为阅读和写作的文艺。女地下革命者以及为其发声的文学创作在历史中的复杂遭遇,提出了一个特殊而又普遍性的问题:爱国主义是否可以覆盖或克服性别难题?比“漫长的革命”更漫长的,恐怕还有“漫长的启蒙”。

关键词：地下革命文艺政治英烈无名女性

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孟戏的“腔”与“调”

中国音乐 2024年第5期 5-14,F0002页

作者：傅利民中国音乐学院江西科技师范大学音乐学院

孟戏是指江西广昌甘竹地区于每年正月演出《孟姜女》故事用于本宗酬神祭祖的一种活动。孟戏有两种,一种是曾姓演出的“曾家孟戏”,一种为刘姓演出的“刘家孟戏”。本文在对孟戏的唱腔、剧目及相关曲牌进行考察分析与研究的基础上认为:... 详细信息

孟戏是指江西广昌甘竹地区于每年正月演出《孟姜女》故事用于本宗酬神祭祖的一种活动。孟戏有两种,一种是曾姓演出的“曾家孟戏”,一种为刘姓演出的“刘家孟戏”。本文在对孟戏的唱腔、剧目及相关曲牌进行考察分析与研究的基础上认为:孟戏为高腔,孟戏唱腔中存在海盐性的孟戏高腔曲牌。对于孟戏的调,艺人们在实践中有“不寻宫数调”的做法,具有较大的灵活性特点。因此,对于孟戏“调”和“腔”内涵的深入探究具有重要的乐学价值和实践意义。

关键词：孟戏声腔宫调