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Research 2023年第2期2022卷 343-349页

作者： Jin-Meng Heng Hao-Lin Zhu Zhen-Hua Zhao da-shuai huang Jun-Yi Li Pei-Qin Liao Xiao-Ming Chen MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-Sen UniversityGuangzhou 510275China

Inorganic solids are a kind of important catalysts,and their activities usually come from sparse active sites,which are structurally different from inactive ***,the rational optimization of activity depends on studying these active *** is a widely used catalyst and is expected to be a promising catalyst for the electroreduction of CO_(2) to C_(2)H_(4).

关键词： Copper catalyst rational

Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： shuai Feng Juanji Li Tingting Liu Shiqi huang Xiangliang Chen Shen Liu Junshan Zhou Hongdong Zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin dai Lei Ye Tao Song shuai huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： shuai huang shuaige Bai Ting Luo Bin Feng Min Liu Fan Zheng Shuang huang Yanpeng Fang dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

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论灾害事故预防应对的调查评估问题

灾害学 2025年第1期40卷 1-7,85页

作者：刘传正米文忠黄帅应急管理部国家自然灾害防治研究院北京100085 清华大学合肥公共安全研究院灾害事故调查评估应急管理部重点实验室北京100084

为了推动我国灾害事故预防应对调查评估工作的科学化与规范化发展,该文通过界定灾害事故类型,探讨了灾害事故预防应对调查评估的目的任务、工作原则、工作方法、工作组织和成果应用方面的基本问题。灾害事故被划分为灾害、事故、灾害事... 详细信息

为了推动我国灾害事故预防应对调查评估工作的科学化与规范化发展,该文通过界定灾害事故类型,探讨了灾害事故预防应对调查评估的目的任务、工作原则、工作方法、工作组织和成果应用方面的基本问题。灾害事故被划分为灾害、事故、灾害事故(链)和事故灾害(链)四类。调查评估目的任务明确为认定事实、查找问题、分析原因并提出对策措施。在工作原则上,强调了6个方面:事实依据、法规准绳、认知判断、沟通协调、良知底线和素质保障。工作方法涵盖了现场勘查、档案查阅、访谈问询、检测试验、分析计算、模拟仿真、成因论证和性质界定等8个环节。工作组织或调查机构组成包括综合协调组、法规管理组、技术工作组和专家顾问组。成果应用范畴包括即时政策制定、法规标准制修订、管理体制改革以及工作机制完善等领域。

关键词：灾害事故预防应对调查评估工作原则工作方法

Intelligent Surfaces Thermally Switchable between the Highly Rough and Entirely Smooth States

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Chinese Journal of Polymer Science 2021年第12期39卷 1609-1616页

作者： Meng Wang da Chu Li Liu shuai huang Xu-Man Chen Zhi-Yang Liu Hong Yang Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research State Key Laboratory of BioelectronicsInstitute of Advanced MaterialsSchool of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China

Reversible switching from a highly rough surface to another entirely smooth surface under external stimuli is crucial for intelligent materials applied in the fields of an ti-foggi ng,self-clea ning,oil-water separati on and biotech no *** this work,a thermal-responsive liquid crystal elastomer(LCE)surface covered with oriented micropillars is prepared via a facile two-step crosslinking method coupled with an extrusion molding *** reversible change of topological structures of the LCE surface along with temperature is investigated by metallographic microscope,atomic force microscopy and optical con tact angle measuring *** room temperature,the LCE sample is filled with plenty of micropillars with an average len gth of 8.76 pm,resulting in a super-hydrophobic surface with a water con tact angle(WCA)of 135°.When the temperature is in creased to above the cleari ng point,all the micropillars disappear,the LCE surface becomes entirely flat and presents a hydrophilic state with a WCA of 64°.The roughness-related wetting property of this microstructured LCE surface possesses good recyclability in several heating/cooling *** work realizes a truly reversible transformation from a highly rough surface to an entirely smooth surface,and might promote the potential applications of this dynamic-responsive LCE surface in smart sensors and biomimetic control devices.

关键词： Intelligent surface Liquid crystal elastomer Switchable topological structure

Morphology-dependent interfacial interactions of Fe2O3 with Ag nanoparticles for determining the catalytic reduction of p-nitrophenol

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Journal of Environmental Sciences 2020年第6期32卷 1-10页

作者： Ningning Wang shuai Zeng Hong Yuan Jin huang Key Laboratory of Pesticide and Chemical Biology of Ministry of Education College of ChemistryCentral China Normal UniversityWuhan 430079China Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China

In this work,we fabricated three kinds of Ag/Fe2O3 model catalysts with different morphologies to study the interfacial interactions between Ag and Fe2O3,and how they affected the catalytic activity in hydrogenation of p-nitrophenol was *** hydrothermal method was used to synthesize the metal oxide supported silver catalyst,with various morphologies including nanoplates(NPs),nanospheres(NSs),and nanocubes(NCs).The crystal structure,morphology and surface elements of the composite were investigated by various measurements,such as X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM)and X-ray photoelectron spectroscopy(XPS).The catalytic activity was also evaluated by the reduction of p-nitrophenol to *** was found that the activities of the above catalysts varied with the morphology of the *** them,Ag/Fe2O3 NPs promoted the highest performance,Ag/Fe2O3 NSs were slightly inferior,and Ag/Fe2O3 NCs were the *** last,we ascribed the remarkable activity of Ag/Fe2O3 NPs to the strong metal-support interactions between Ag and Fe2O3.

关键词： Ag/Fe2O3 Interfacial interaction Catalytic activity p-Nitrophenol Morphology dependence

Role of oxysterol-binding protein-related proteins in malignant human tumours

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World Journal of Clinical Cases 2020年第1期8卷 1-10页

作者： Hao Liu shuai huang Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou University

The oxysterol-binding protein-related protein(ORP)family is a group of proteins that mediate oxysterol metabolism and bioactivity in *** constitute a large family of lipid transfer *** of the current evidence indicates that certain members of the family of oxysterol-binding proteins(OSBPs)can lead to *** studies have revealed the putative roles of OSBPs in various cancer ***,the exact effects and mechanisms of action of members of the OSBP/ORP family in cancer initiation and progression are currently *** review focuses on ORP family members that can accelerate human tumour cell proliferation,migration,and *** mechanisms and functions of various ORPs are introduced in *** also attempt to identify the roles of these proteins in malignant tumours with the ultimate aim of determining the exact role of the OSBP/ORP family in human tumour cells.

关键词： Oxysterol-binding protein family Oxysterol-binding protein-related protein Malignant tumour Role Human tumour Tumour proliferation,migration,and invasion

Aortic Dissection Research in China:Analysis of Studies Funded by the National Natural Science Foundation of China

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Current Medical Science 2023年第1期43卷 206-212页

作者： Zhang YUE da-shuai WANG Sheng LE Jia-hong XIA Ping YE Xiao-fan huang Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Cardiovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Department of Cardiology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430014China

Objective The National Natural Science Foundation of China(NSFC)has made great progress in promoting the development of aortic dissection research in recent *** study aimed to examine the development and research status of aortic dissection research in China so as to provide references for future *** The NSFC projects data from 2008 to 2019 were collected from the Internet-based Science Information System and other websites utilized as search *** publications and citations were retrieved by Google Scholar,and the impact factors were checked by the InCite Journal Citation Reports *** investigator’s degree and department were identified from the institutional faculty *** A total of 250 grant funds totaling 124.3 million Yuan and resulting in 747 publications were *** funds in economically developed and densely populated areas were more than those in underdeveloped and sparsely populated *** was no significant difference in the amount of funding per grant between different departments’***,the funding output ratios of the grants for cardiologists were higher than those for basic science *** amount of funding for clinical researchers and basic scientific researchers in aortic dissection was also *** researchers were better in terms of the funding output *** These results suggest that the medical and scientific research level of aortic dissection in China has been greatly ***,there are still some problems that urgently need to be solved,such as the unreasonable regional allocation of medical and scientific research resources,and the slow transition from basic science to clinical practice.

关键词： National Natural Science Foundation of China aortic dissection grant funding funding output ratio

Evaluation of the applicability of multiple drought indices in the core zone of “westerlies-dominated climatic regime”

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Science China Earth Sciences 2023年第7期66卷 1504-1520页

作者： Huiwen GUO Wei huang Tingting XIE shuai MA Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China

Drought indices are frequently used to measure the intensity,start and end of ***,the performances of these indices depend on regions and the type of ***,it is necessary to evaluate whether these indices are applicable for a given *** study evaluated the ability of the self-calibrating Palmer Drought Severity Index(sc PDSI),the Standardized Precipitation Evapotranspiration Index(SPEI),and the Standardized Moisture Anomaly Index(SZI) to describe the dry-wet conditions and drought events in the core zone of the “westerlies-dominated climatic regime”.The results showed that the 12-month SZI(SZI12) and SPEI(SPEI12) have good correlations with precipitation and PET respectively,while the sc PDSI can capture the changes in precipitation and soil *** Xinjiang region of China,the SZI12 and sc PDSI showed that this region gradually became wetter during 1961–2014,which was consistent with increased precipitation,decreased PET,and improved ***,the SPEI12 showed significant drying due to the strong influence of the PET,suggesting that this index exaggerated the drought conditions in this *** in Kazakhstan and the southern Central Asian regions has increased slightly over the past 50 years,but the PET has greatly increased,altogether,all three indices suggested a drying trend in Central *** evaluation of the ability of these drought indices to identify typical drought events in Xinjiang region of China suggested that the sc PDSI can better detect the typical drought events compared with the *** conclusion,the sc PDSI is the most suitable index for characterizing the long-term trend of hydroclimate conditions and drought events in the core zone of the “westerlies-dominated climatic regime”.This study provides a theoretical basis for the rational utilization and improvement of the drought index,which is critical for monitoring,attributing,and predicting of drought events in arid areas.

关键词： Drought index Applicability of the drought index Hydroclimate conditions Potential evapotranspiration Drought events