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Establishing and clinically validating a machine learning model for predicting unplanned reoperation risk in colorectal cancer

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World Journal of Gastroenterology 2024年第23期30卷 2991-3004页

作者： Li-Qun Cai da-qing yang Rong-Jian Wang He Huang Yi-Xiong Shi Department of Colorectal and Anal Surgery Whenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina Department of Colorectal and Anorectal Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Colorectal cancer significantly impacts global health,with unplanned reoperations post-surgery being key determinants of patient *** predictive models for these reoperations lack precision in integrating complex clinical *** To develop and validate a machine learning model for predicting unplanned reoperation risk in colorectal cancer *** data of patients treated for colorectal cancer(n=2044)at the First Affiliated Hospital of Wenzhou Medical University and Wenzhou Central Hospital from March 2020 to March 2022 were retrospectively *** were divided into an experimental group(n=60)and a control group(n=1984)according to unplanned reoperation *** were also divided into a training group and a validation group(7:3 ratio).We used three different machine learning methods to screen characteristic variables.A nomogram was created based on multifactor logistic regression,and the model performance was assessed using receiver operating characteristic curve,calibration curve,Hosmer-Lemeshow test,and decision curve *** risk scores of the two groups were calculated and compared to validate the *** More patients in the experimental group were≥60 years old,male,and had a history of hypertension,laparotomy,and hypoproteinemia,compared to the control *** logistic regression analysis confirmed the following as independent risk factors for unplanned reoperation(P<0.05):Prognostic Nutritional Index value,history of laparotomy,hypertension,or stroke,hypoproteinemia,age,tumor-node-metastasis staging,surgical time,gender,and American Society of Anesthesiologists *** operating characteristic curve analysis showed that the model had good discrimination and clinical *** This study used a machine learning approach to build a model that accurately predicts the risk of postoperative unplanned reoperation in patients with colorectal cancer,which can improve tr

关键词： Colorectal cancer Postoperative unplanned reoperation Unplanned reoperation Clinical validation Nomogram Machine learning models

ZnGa_(2)S_(4):an infrared nonlinear optical material with large second-harmonic generation response and wide band gap

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Rare Metals 2024年第1期43卷 395-401页

作者： Chen-yang Zhang Xiao-Nan Niu Yan-Feng Wei Shu-Xing Zhou da-qing yang Ying Wang Jian Wang Bing-Bing Zhang College of Chemistry and Materials Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of EducationState Key Laboratory of New Pharmaceutical Preparations and ExcipientsHebei UniversityBaoding 071002China Hubei Key Laboratory of Low Dimensional Optoelectronic Materials and Devices Hubei University of Arts and ScienceXiangyang 441053China Hubei Longzhong Laboratory Xiangyang 441000China Department of Chemistry and Biochemistry Wichita State UniversityKansas 67260USA

High-performance nonlinear optical(NLO)crystals are crucial devices to convert wavelength of solid-state *** play an indispensable role in the research of infrared NLO *** this work,ternary chalcogenide ZnGa_(2)S_(4) ... 详细信息

关键词： optical nonlinear harmonic

Functional switching of ATM:sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells

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Chinese Journal of Cancer 2012年第8期31卷 364-372页

作者： Yan Li Hua Xiong da-qing yang The Hormel Institute University of MinnesotaAustinMN 55912USA

Ataxia-telangiectasia(A-T) is an autosomal recessive disorder characterized by cerebellar ataxia and oculocutaneous *** gene mutated in this disease,ATM(A-T,mutated),encodes a 370-kda Ser/Thr protein *** not only mediates cellular response to DNA damage but also acts as an activator of Akt in response to ***,despite intensive studies,the mechanism underlying the neuronal degeneration symptoms of human A-T is still poorly *** found that the topoisomerase inhibitors etoposide and camptothecin readily induced apoptosis in undifferentiated proliferating SH-SY5Y cells but could not induce apoptosis in neuronally differentiated SH-SY5Y *** addition,etoposide induced p53 phosphorylation and H2AX foci formation in proliferating SH-SY5Y cells but failed to do so in differentiated SH-SY5Y ***,while inhibition of ATM in undifferentiated SH-SY5Y cells partially protected them from etoposide-induced apoptosis,the same treatment had no effect on cell viability in differentiated SH-SY5Y *** results suggest that DNA damage or defective response to DNA damage is not the cause of neuronal cell death in human *** contrast,we discovered that Akt phosphorylation was inhibited when ATM activity was suppressed in differentiated SH-SY5Y ***,inhibition of ATM induced apoptosis following serum starvation in neuronally differentiated SH-SY5Y cells but could not trigger apoptosis under the same conditions in undifferentiated proliferating SH-SY5Y *** results demonstrate that ATM mediates the Akt signaling and promotes cell survival in neuron-like human SH-SY5Y cells,suggesting that impaired activation of Akt is the reason for neuronal degeneration in human A-T.

关键词：神经元样细胞 DNA损伤细胞增殖 ATM Akt SH-SY5Y细胞人类有丝分裂

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： qing Qiu Mengting yang danfeng Gong Haiying Liang Tingting Chen Department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina Department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

Ideal Bi-Based Hybrid Anode Material for Ultrafast Charging of Sodium-Ion Batteries at Extremely Low Temperatures

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NANO-MICRO LETTERS 2025年第1期17卷 1-16页

作者： Bai, Jie Jia, Jian Hui Wang, Yu yang, Chun Cheng Jiang, qing Jilin Univ Key Lab Automobile Mat Sch Mat Sci & Engn Minist Educ Changchun 130022 Peoples R China

Metallic nanoparticles with excellent size controllability and high loading rate are obtained via ultrafast high temperature shock *** Bi/CNRs-15 electrode exhibits an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, while the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C.A novel strategy of high-rate activation is proposed to obtain high capacity and superior stability at low temperature by creating new active sites for interfacial reaction. Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at - 20 degrees C or lower. However, the key capability of ultrafast charging at ultralow temperature for SIBs is rarely reported. Herein, a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue, which is synthesized via a high temperature shock method. Such a hybrid shows an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, outperforming all reported SIB anode materials. Coupled with a Na3V2(PO4)3 cathode, the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C. Based on this work, a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway:a potential therapeutic approach for neurodegenerative diseases

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Neural Regeneration Research 2025年第11期20卷 3095-3112页

作者： Fengcheng Deng dan yang Lingxi qing Yifei Chen Jilian Zou Meiling Jia Qian Wang Runda Jiang Lihua Huang College of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina

The interaction between the gut microbiota and cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)signaling pathway in the host's central nervous system plays a crucial role in neurological diseases and enhances communication along the gut–brain *** gut microbiota influences the cAMP-PKA signaling pathway through its metabolites,which activates the vagus nerve and modulates the immune and neuroendocrine ***,alterations in the cAMP-PKA signaling pathway can affect the composition of the gut microbiota,creating a dynamic network of microbial-host *** reciprocal regulation affects neurodevelopment,neurotransmitter control,and behavioral traits,thus playing a role in the modulation of neurological *** coordinated activity of the gut microbiota and the cAMP-PKA signaling pathway regulates processes such as amyloid-β protein aggregation,mitochondrial dysfunction,abnormal energy metabolism,microglial activation,oxidative stress,and neurotransmitter release,which collectively influence the onset and progression of neurological *** study explores the complex interplay between the gut microbiota and cAMP-PKA signaling pathway,along with its implications for potential therapeutic interventions in neurological *** pharmacological research has shown that restoring the balance between gut flora and cAMP-PKA signaling pathway may improve outcomes in neurodegenerative diseases and emotional *** can be achieved through various methods such as dietary modifications,probiotic supplements,Chinese herbal extracts,combinations of Chinese herbs,and innovative dosage *** findings suggest that regulating the gut microbiota and cAMP-PKA signaling pathway may provide valuable evidence for developing novel therapeutic approaches for neurodegenerative diseases.

关键词： cyclic adenosine monophosphate emotional disorders gut microbiota neurodegenerative diseases neurological diseases protein kinase A reciprocal regulation signaling pathway strategy therapies

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论艺术设计基础素描新方法

山东农业大学学报（自然科学版） 2004年第2期35卷 284-289页

作者：李强鞠达青郑阳山东农业大学水利土木工程学院山东泰安271018 山东农业大学林学院山东泰安271018

在中国艺术设计中传统素描训练偏重于绘画技法的传授 ,技法的明暗写实素描为主 ,方法较单一 ,已不能适应当今艺术设计对人材个性的培养要求 ,应积极改革借鉴当今国际先进的素描方法及经验 ,运用现代绘画手段 ,构建起适应现代艺术特别是... 详细信息

在中国艺术设计中传统素描训练偏重于绘画技法的传授 ,技法的明暗写实素描为主 ,方法较单一 ,已不能适应当今艺术设计对人材个性的培养要求 ,应积极改革借鉴当今国际先进的素描方法及经验 ,运用现代绘画手段 ,构建起适应现代艺术特别是艺术设计的现代素描理论体系 ,本文以全新的视角论述了 ,素描形象思维的丰富性及素描技法的多元性。文中基于世界范围内艺术与设计的历史演变 ,基于对视觉思维的整体观照和科学研究 ,就素描与构成、画法系统等视知觉研究主要问题进行了深入的比较研究 ,如传统素描与新素描的比较 ,通过一系列专题及相关练习整合视觉训练课程 ,为设计基础素描改革提供了新方法、新思路。

关键词：艺术设计素描基础多元思维现代艺术现代建筑视觉思维

Penetration Resistance of Skirt-Tip with Rough Base for Suction Caissons in Clay

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China Ocean Engineering 2020年第6期34卷 784-794页

作者： WU Yu-qi LI da-yong yang qing State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China College of Civil Engineering Fuzhou UniversityFuzhou 350108China College of Civil Engineering and Architecture Shandong University of Science and TechnologyQingdao 266590China

Suction caissons can readily penetrate into the seabed under the combination of the self-weight and suction resulted from the encased water being increasingly pumped out. During suction-assisted penetration, the equivalent overburden at the skirt-tip level outside the caisson is generally higher than that inside because the vertical stress within the soil plug is reduced by the exerted suction. This may result in a uniform shear stress developing over the base of the skirt-tip as the soil below the skirt-tip tends to move into the caisson, which leads to an asymmetric failure wedge existing below the base of the skirt-tip. Besides, different adhesion factors along the inside(αi) and outside(αo) of the skirt wall will cause asymmetric plastic zones inside and outside the caisson. Accordingly, an asymmetric failure mechanism is therefore proposed to calculate the penetration resistance of the skirt-tip. The proposed failure mechanism is the first to consider the effect of different adhesion factors(αi) and(αo) on the failure mechanism at the skirt-tip, and involves the contribution from the weighted average of equivalent overburdens inside and outside caisson at the skirt-tip level. The required suction pressure can be obtained in terms of force equilibrium of the caisson in a vertical direction. Finally, the asymmetric failure mechanism at the skirt-tip is validated with the FE calculations. By comparing with the measured data, the predictions of the required suction pressure are found to be in good agreement with the experimental results.

关键词： suction caisson required suction pressure penetration resistance skirt-tip rough base clay

Ancient Art Retains Splendor in New Era

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China Today 2025年第1期74卷 74-75页

作者： GUO qing 不详

With government support,more young people are studying Thangka art,securing its innovative *** 1,300-year-old Thangka art,religious painting on woven material,has been lauded as an illustrated encyclopedia of Tibetan *** unique artistic and cultural value earned it a place on China’s intangible cultural heritage list in *** institution tasked with preserving and developing this ancient art is the Tibet Academy of Thangka(TAT)in *** focuses on the Mansar School of Thangka *** can observe the whole process of creating a Mansar Thangka piece,from sketching to adding the final touch.

关键词： religious earned sketch