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当代医学科学（英文） 2024年第4期44卷 726-734页

作者： Liang wang ping wang Bing LIU Hui ZHANG Cheng-cheng WEI Ming XIONG Gang LUO Miao wang Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Urology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China

Objective:This study aimed to investigate the role of the long noncoding RNA(lncRNA)maternally expressed gene 3(MEG3)in the epithelial-mesenchymal transition(EMT)of bladder cancer cells and the potential ***:Cell invasion,migration,and wound healing assays were conducted to assess the effects of MEG3 on the invasive and migratory capabilities of bladder cancer *** expression levels of E-cadherin were measured using Western blotting,RT-qPCR,and dual luciferase reporter *** immunoprecipitation and pull-down assays were performed to investigate the interactions between MEG3 and its downstream ***:MEG3 suppressed the invasion and migration of bladder cancer cells and modulated the transcription of *** binding of MEG3 to the zinc finger region of the transcription factor Snail prevented its ability to transcriptionally repress ***,MEG3 suppressed the phosphorylation of extracellular regulated protein kinase(ERK),c-Jun N-terminal kinase(JNK),and P38,thereby decreasing the expression of Snail and stimulating the expression of ***:MEG3 plays a vital role in suppressing the EMT in bladder cancer cells,indicating its potential as a promising therapeutic target for the treatment of bladder cancer.

关键词： Snail bladder cancer epithelial-mesenchymal transition long noncoding RNA maternally expressed gene 3

Graphdiyne oxide substrate-enhanced peroxidase-mimicking performance of Ru nanoparticles with physiological pH preference

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Nano Research 2024年第3期17卷 1123-1131页

作者： Cong Xu Wenjie Ma Haozhi wang Leihou Shao Weiqi Li ping Yu Lanqun Mao Beijing National Laboratory for Molecular Science Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan UniversityHaikou 570228China College of Chemistry Beijing Normal UniversityBeijing 100875China

Modulating electronic structure of metal nanoparticles via metal–support interaction has attracted intense interest in the field of catalytic ***,the roles of supporting substrates in regulating catalytic properties of nanozymes remain *** this study,we find that the use of graphdiyne oxide(GDYO)as the substrate for self-terminating growth of Ru nanoparticles(Ru@GDYO)endows the peroxidase-like activity of Ru nanoparticles with intrinsic physiological pH preference and natural horseradish peroxidase(HRP)comparable *** nanoparticles electrolessly deposited onto GDYO possess a partially oxidized electronic structure owing to limited charge transfer between Ru and GDYO,contributing to the intrinsic physiological pH preference of the peroxidase-mimicking *** importantly,the substrate GDYO plays an influential factor in enhancing catalytic activity,that is,the activity of Ru@GDYO is much higher than that of Ru nanoparticles deposited on other carbon substrates including graphene oxides and *** demonstrate the application of Ru@GDYO nanozyme in neutral solutions,we employ Ru@GDYO with nicotinamide adenine dinucleotide(NAD+)-dependent dehydrogenases in physiological conditions to realize a sustainable cascade reaction by means of forming continuous NAD^(+)/dihydronicotiamide adenine dinucleotide(NADH)*** finding represents a promising perspective on designing high-performance peroxidase-mimicking nanozymes with broader applicability,raising fundamental understanding of structure–activity relationship,and investigating new applications of nanozymes in biological systems.

关键词： nanozyme graphdiyne reactive oxygen species electroless deposition metal–support interaction

Forecast of cosmological constraints with superluminous supernovae from the Chinese Space Station Telescope

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 128-138页

作者： Xuan-Dong Jia Jian-ping Hu Fa-Yin wang Zi-Gao dai School of Astronomy and Space Science Nanjing UniversityNanjing 210093China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of EducationNanjing 210093China Department of Astronomy University of Science and Technology of ChinaHefei 230026China

Superluminous supernovae(SLSNe)are a class of intense celestial events that can be standardized for measuring cosmological parameters,bridging the gap between type Ia supernovae and the cosmic microwave *** this work,we discuss the cosmological applications of SLSNe from the Chinese Space Station Telescope(CSST).Our estimation suggests that SLSNe rate is biased tracing the cosmic star formation rate,exhibiting a factor of(1+z)^(1.2).We futher predict that CSST is poised to observe~360 SLSNe in the 10 square degrees ultra-deep field survey within a span of 2.5 years.A stringent constraint on cosmological parameters can be derived from their peak-color *** is anticipated to uncover a substantial number of SLSNe,contributing to a deeper understanding of their central engines and shedding light on the nature of dark energy at high redshifts.

关键词： supernovae cosmology cosmological constant

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Placenta-derived mesenchymal stem cells attenuate secondary brain injury after controlled cortical impact in rats by inhibiting matrix metalloproteinases

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BIOCELL 2024年第1期48卷 149-162页

作者： ping YANG YUANXIANG LAN ZHONG ZENG YAN wang HECHUN XIA Department of Neurosurgery School of Clinical MedicineNingxia Medical UniversityYinchuanChina Key Laboratory of Ningxia Stem Cell and Regenerative Medicine General Hospital of Ningxia Medical UniversityYinchuanChina Department of Neurosurgery Xi’an International Medical Center HospitalXi’anChina

Background:As a form of biological therapy,placenta-derived mesenchymal stem cells(PDMSCs)exhibit considerable promise in addressing the complex pathological processes of traumaticbrain injury(TBI)due to their multi-target and multi-pathway mode of ***&Methods:This study investigates the protective mechanisms and benefits of PDMSCs in mitigating the effects of controlled cortical impact(CCI)in rats and glutamate-induced oxidative stress injury in HT22 cells in *** primary objective is to provide evidence supporting the clinical application of ***:In the in vivo arm of our investigation,we observed a swift elevation of matrix metalloproteinase-9(MMP-9)in the proximal cortex of injured brain tissues after ***,distinguished by their heightened expression of metalloproteinase tissue inhibitors-1 and-2(TIMP-1 and TIMP-2):were intravenously administered via the caudal *** intervention yielded significant reductions in the permeability of the blood-brain barrier(BBB):the extent of brain edema,the levels of inflammatory cytokines IL-1βand TNF-αin damaged brain tissue,and the activation status of microglia in CCI-afflicted *** the realm of in vitro experiments,PDMSC-conditioned media demonstrated substantial reductions in mortality rates and cleaved caspase-3 levels in glutamate-induced HT22 cells compared with conventional ***,this advantage was negated upon the introduction of neutralizing antibodies targeting TIMP-1 and ***:Collectively,our findings underscore the potential of PDMSCs in alleviating oxidative stress injury and secondary brain injury in the pathological process of TBI.

关键词： Traumatic brain injury Mesenchymal stem cells Oxidative stress Matrix metalloproteinases

Study of inter-well interference in shale gas reservoirs by a robust production data analysis method based on deconvolution

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Petroleum Science 2024年第4期21卷 2502-2519页

作者： Wen-Chao Liu Cheng-Cheng Qiao ping wang Wen-Song Huang Xiang-Wen Kong Yu-ping Sun He-Dong Sun Yue-Peng Jia School of Civil and Resource Engineering University of Science and Technology Beijing PetroChina Research Institute of Petroleum Exploration and Development

In order to overcome the defects that the analysis of multi-well typical curves of shale gas reservoirs is rarely applied to engineering, this study proposes a robust production data analysis method based on deconvolution, which is used for multi-well inter-well interference research. In this study, a multi-well conceptual trilinear seepage model for multi-stage fractured horizontal wells was established, and its Laplace solutions under two different outer boundary conditions were obtained. Then, an improved pressure deconvolution algorithm was used to normalize the scattered production data. Furthermore, the typical curve fitting was carried out using the production data and the seepage model solution. Finally,some reservoir parameters and fracturing parameters were interpreted, and the intensity of inter-well interference was compared. The effectiveness of the method was verified by analyzing the production dynamic data of six shale gas wells in Duvernay area. The results showed that the fitting effect of typical curves was greatly improved due to the mutual restriction between deconvolution calculation parameter debugging and seepage model parameter debugging. Besides, by using the morphological characteristics of the log-log typical curves and the time corresponding to the intersection point of the log-log typical curves of two models under different outer boundary conditions, the strength of the interference between wells on the same well platform was well judged. This work can provide a reference for the optimization of well spacing and hydraulic fracturing measures for shale gas wells.

关键词： Shale gas Inter-well interference Deconvolution Production data analysis Typical curves Multi-stage fractured horizontal well

Multi-gait snake robot for inspecting inner wall of a pipeline

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Biomimetic Intelligence & Robotics 2024年第2期4卷 32-41页

作者： Jingwei Liu Man Li Yahui wang da Zhao Rui Deng School of Electrical and Information Engineering Beijing University of Civil Engineering and ArchitectureBeijing 100044China Bejing Key Laboratory of Robot Bionics and Function Research Bejing 100044China

In the field of pipeline inner wall inspection,the snake robot demonstrates significant advantages over other inspection *** a simple traveling wave or meandering motion will suffice for inspecting the inner wall of small-diameter pipes,comprehensively and meticulously inspecting the inner wall of large-diameter pipes requires the snake robot to adopt a helical gait that closely adheres to the inner *** review of existing literature indicates that most research and development on the helical gait of snake robots has focused on the outer surface of cylinders,with very few studies dedicated to developing a helical gait specifically for the inspection of the inner wall of ***,in this study,we propose a helical gait that is suitable for the inner wall of pipes and meets the requirements of gas pipeline *** helical gait is designed using the backbone curve ***,we create a mathematical model for a circular helix curve with constant curvature and torsion,ensuring it is applicable to a snake robot prototype in a laboratory *** calculate the joint angles required for two conical spiral curves with variable curvature and torsion,establish a new model,and define the physical significance of the specific *** ensure the feasibility of the proposed gait,we conduct experiments involving meandering and traveling wave motions to verify the communication and control between the host computer and the snake *** upon this foundation,we further validate the mathematical model of the complex helical motion gait through simulation *** findings provide a theoretical basis for realizing helical movement with a real snake robot.

关键词： Pipeline inner wall detection Snake robot Spiral motion Backbone curve Modeling and simulation

Simulation Analysis of Deformation Control for Magnetic Soft Medical Robots

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 794-796页

作者： Jingxi wang Baoyu Liu Edmond Q.Wu Jin Ma ping Li Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of Education Beijing Advanced Innovation Center for Biomedical Engineeringthe School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China IEEE the Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China the Department of Aerospace Medicine Air Force Medical UniversityXi’an 710032China

Dear Editor,This letter presents a biocompatible cross-shaped magnetic soft robot and investigates its deformation mode control strategy through COMSOL modeling and *** soft robots offer novel avenues for precise trea... 详细信息

关键词： robot simulation COMSOL

Recent advances in visible light-mediated chemical transformations of enaminones

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Chinese Chemical Letters 2024年第2期35卷 4-15页

作者： Yu Han Liyun Zhou Chengyu wang Shangti Feng Rong Ma Jie-ping Wan College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China School of Chemistry and Chemical Engineering Linyi UniversityLinyi 276000China Linyi Sanfeng Chemical Co. Ltd.Linyi 276000China

Enaminones,which possesses both the nucleophilic enamine as well as electrophilic enone structures,are well known versatile building blocks in organic ***,visible light-mediated reactions have emerged as useful synthetic strategy with enhanced *** the last decade,various photochemical transformations of enaminones have been developed to construct cyclic or acyclic *** this review,we describe the recent advances in visible light-mediated chemical transformations of *** discussion on the reaction mechanism of the related reactions is given to provide guide to the ***,a summary on the existing challenges and the future outlook towards the development of practical photocatalytic reactions of enaminones is also presented.

关键词： Enaminone Visible light C-H functionalization C=C bond cleavage Cyclization Multicomponent reactions

Improving Thermal-oxidative Aging Resistance of Styrene-butadiene Rubber by Antioxidant Loaded Silica Aerogel

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Chinese Journal of Polymer Science 2024年第8期42卷 1198-1209页

作者： Xue-Fei ping Yu wang Lu Liu Fu-Yong Liu Hong-Wei He Pi wang Wen-Wen Yu Qiang Zheng College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058China

The antioxidant N-isopropyl-N'-phenyl-p-phenylenediamine(4010NA)was dissolved in ethanol and impregnated into silica aerogel(SAG)via vacuum-pressure cycles,yielding composite particles(A-N)with enhanced sustained-release and reinforcing *** effect of A-N on the mechanical properties and thermal-oxidative aging resistance of styrene-butadiene rubber(SBR)vulcanizates was *** and BET assessments indicated that the loading efficiency of 4010NA in SAG reached 14.26%within ethanol's solu bility *** A-N into SBR vulcanizates significantly elevated tensile strength by 17.5%and elongation at break by 41.9%over those with fumed silica and ***,A-N notably enhanced the thermal-oxidative aging resistance of *** aging for 96 h at 100℃,the tensile strength and elongation at break of SBR with A-N sustained 70.09%and 58.61%of their initial values,respectively,with the retention rate of elongation at break being 62.8%higher than that of SBR with fumed silica and free *** study revealed that A-N composite particles significantly inhibited the crosslinking in SBR's molecular chains,reducing hardening and embrittlement during later thermal-oxidative aging stages.

关键词： Styrene-butadiene rubber Silica aerogel Loading modification Thermal-oxidative aging

Identifying the effective combination of acupuncture and traditional Chinese medicinal herbs for postmenopausal osteoporosis therapy through studies of their molecular regulation of bone homeostasis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 212-219页

作者： REN ping wang Quanwu BAI Wei SUN Miao LIU Zheling GAO Ming wang Liang PENG Bo XU Liguang Department of Health Management the Third Affiliated Clinical Hospital of Changchun University of Chinese MedicineChangchun 130117China Department of Dirty Tuina the affiliated Hospital to Changchun University of Chinese MedicineChangchun 130117China Department of Acupuncture the affiliated Hospital to Changchun University of Chinese MedicineChangchun 130117China Department of Rehabilitation Medicine the 924th Hospital of the PLA Joint Logistic Support ForceFoshan 528226China Department of College of Acupuncture and Massage Changchun University of Chinese MedicineChangchun 130117China

Worldwide,as the population age,osteoporosis is becoming increasingly common,and osteoporotic fractures have a significant economic *** women are the most susceptible to developing osteoporosis and the most critical time to prevent it is during the perimenopausal and early menopausal *** this regard,we hypothesize rational combination of acupuncture and Traditional Chinese Medicine(TCM)in the form of herbal extract could prevent osteoporosis in *** deficiency during menopause causes low-level inflammation that stimulates the formation of osteoclasts,the boneresorbing cells,and simultaneously inhibits the viability and function of osteoblasts,the bone-forming *** most potent inflammatory cytokine in skeletal homeostasis is the receptor activator of nuclear factor kappa B ligand(RANKL)that stimulates osteoclast ***,the canonical Wnt pathway is essential for osteoblastogenesis and bone formation,and estrogen deficiency leads to diminished functioning of this *** and acupuncture could target the RANKL and the Wnt pathway in favorable ways to prevent the accelerated bone loss experienced during the early menopausal stage and promote the gain in bone mass in postmenopausal *** this review,we propose a rational combination of specific TCM and acupuncture targeting those signaling molecules/pathways by the drugs that are in clinical use for the treatment of postmenopausal *** rational approach revealed that danshen(Radix Salviae Miltiorrhizae)could exert a synergistic effect with *** then propose a translational path for developing the putative combination in women with postmenopausal osteoporosis to curtail the risk of osteoporotic fractures.

关键词： medicine traditional osteogenic anti-resorptive review