检索结果-南通市图书馆

Transforming growth factor-beta 1 enhances discharge activity of cortical neurons

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 548-556页

作者： Zhihui Ren Tian Li Xueer Liu Zelin Zhang Xiaoxuan chen Weiqiang chen Kangsheng Li Jiangtao Sheng Department of Microbiology and Immunology Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular ImmunopathologyShantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Shantou University Medical CollegeShantouGuangdong ProvinceChina

Transforming growth factor-beta 1(TGF-β1)has been extensively studied for its pleiotropic effects on central nervous system *** neuroprotective or neurotoxic effects of TGF-β1 in specific brain areas may depend on the pathological process and cell types ***-gated sodium channels(VGSCs)are essential ion channels for the generation of action potentials in neurons,and are involved in various neuroexcitation-related ***,the effects of TGF-β1 on the functional properties of VGSCs and firing properties in cortical neurons remain *** this study,we investigated the effects of TGF-β1 on VGSC function and firing properties in primary cortical neurons from *** found that TGF-β1 increased VGSC current density in a dose-and time-dependent manner,which was attributable to the upregulation of Nav1.3 *** VGSC current density and Nav1.3 expression were significantly abolished by preincubation with inhibitors of mitogen-activated protein kinase kinase(PD98059),p38 mitogen-activated protein kinase(SB203580),and Jun NH2-terminal kinase 1/2 inhibitor(SP600125).Interestingly,TGF-β1 significantly increased the firing threshold of action potentials but did not change their firing rate in cortical *** findings suggest that TGF-β1 can increase Nav1.3 expression through activation of the ERK1/2-JNK-MAPK pathway,which leads to a decrease in the firing threshold of action potentials in cortical neurons under pathological ***,this contributes to the occurrence and progression of neuroexcitatory-related diseases of the central nervous system.

关键词： central nervous system cortical neurons ERK firing properties JNK Nav1.3 p38 transforming growth factor-beta 1 traumatic brain injury voltage-gated sodium currents

Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3273-3286页

作者： Shiming Li Jianfeng Li Guoliang chen Tao Lin Penghui Zhang Kuileung Tong Ningning chen Shaoyu Liu Shenzhen Key Laboratory of Bone Tissue Repair and Translational Research Department of Orthopedic SurgeryThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedics and Traumatology Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Orthopedic Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

We previously demonstrated that inhibiting neural stem cells necroptosis enhances functional recovery after spinal cord *** exosomes are recognized as playing a pivotal role in neural stem cells exocrine function,their precise function in spinal cord injury remains *** investigate the role of exosomes generated following neural stem cells necroptosis after spinal cord injury,we conducted singlecell RNA sequencing and validated that neural stem cells originate from ependymal cells and undergo necroptosis in response to spinal cord ***,we established an in vitro necroptosis model using neural stem cells isolated from embryonic mice aged 16-17 days and extracted *** results showed that necroptosis did not significantly impact the fundamental characteristics or number of *** sequencing of exosomes in necroptosis group identified 108 differentially expressed messenger RNAs,104 long non-coding RNAs,720 circular RNAs,and 14 microRNAs compared with the control *** of a competing endogenous RNA network identified the following hub genes:tuberous sclerosis 2(Tsc2),solute carrier family 16 member 3(Slc16a3),and forkhead box protein P1(Foxp1).Notably,a significant elevation in TSC2 expression was observed in spinal cord tissues following spinal cord ***2-positive cells were localized around SRY-box transcription factor 2-positive cells within the injury ***,in vitro analysis revealed increased TSC2 expression in exosomal receptor cells compared with other *** assessment of cellular communication following spinal cord injury showed that Tsc2 was involved in ependymal cellular communication at 1 and 3 days post-injury through the epidermal growth factor and midkine signaling *** addition,Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling

关键词： cellular communication competing endogenous RNA exosomes Foxp1 necroptosis neural stem cells Slc16a3 spinal cord injury transcriptome sequencing Tsc2

Torsion Fields Generated by the Quantum Effects of Macro-bodies

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2022年第12期22卷 335-343页

作者： da-Ming chen National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China

We generalize Einstein's General Relativity(GR)by assuming that all matter(including macro-objects)has quantum *** appropriate theory to fulfill this task is Gauge Theory Gravity(GTG)developed by the Cambridge *** is a“spin-torsion”theory,according to which,gravitational effects are described by a pair of gauge fields defined over a flat Minkowski background *** matter content is completely described by the Dirac spinor field,and the quantum effects of matter are identified as the spin tensor derived from the spinor *** existence of the spin of matter results in the torsion field defined over *** field plays the role of Bohmian quantum potential which turns out to be a kind of repulsive force as opposed to the gravitational potential which is *** equivalence principle remains and essential in this theory so that GR is relegated to a locally approximate theory wherein the quantum effects(torsion)are *** a toy model,we assume that the macro matter content can be described by the covariant Dirac equation and apply this theory to the simplest radially symmetric and static gravitational ***,by virtue of the cosmological principle,we are led to a static universe model in which the Hubble redshifts arise from the torsion fields.

关键词： cosmology:theory (cosmology:)dark matter (cosmology:)dark energy

Enhancement of motor functional recovery in thoracic spinal cord injury: voluntary wheel running versus forced treadmill exercise

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 836-844页

作者： Do-Hun Lee dan Cao Younghye Moon chen chen Nai-Kui Liu Xiao-Ming Xu Wei Wu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteIndiana University School of MedicineIndianapolisINUSA Department of Neurological Surgery Indiana University School of MedicineIndianapolisINUSA Department of Neuroscience Baylor College of MedicineHoustonTXUSA

Spinal cord injury necessitates effective rehabilitation strategies, with exercise therapies showing promise in promoting recovery. This study investigated the impact of rehabilitation exercise on functional recovery and morphological changes following thoracic contusive spinal cord injury. After a 7-day recovery period after spinal cord injury, mice were assigned to either a trained group(10 weeks of voluntary running wheel or forced treadmill exercise) or an untrained group. Bi-weekly assessments revealed that the exercise-trained group, particularly the voluntary wheel exercise subgroup, displayed significantly improved locomotor recovery, more plasticity of dopaminergic and serotonin modulation compared with the untrained group. Additionally, exercise interventions led to gait pattern restoration and enhanced transcranial magnetic motor-evoked potentials. Despite consistent injury areas across groups, exercise training promoted terminal innervation of descending axons. In summary, voluntary wheel exercise shows promise for enhancing outcomes after thoracic contusive spinal cord injury, emphasizing the role of exercise modality in promoting recovery and morphological changes in spinal cord injuries. Our findings will influence future strategies for rehabilitation exercises, restoring functional movement after spinal cord injury.

关键词： behavioral assessment motor function neural plasticity running wheel exercise spinal cord injury treadmill exercise voluntary exercise

Recombinant anti-HBsAg Fab blocks hepatitis B virus infection after orthotopic liver transplantation

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2007年第4期6卷 370-375页

作者： Pan, Tao Tang, Li Yuan, Jin Gong, nian-Qiao Wang, da-Wei chen, Dun-Xiu Guo, Hui chen, Zhi-Shui Huazhong Univ Sci & Technol Tongji Med Coll Inst Organ Transplantat Minist Educ Minist Publ HlthKey Lab Organ Transp Wuhan 430030 Peoples R China

BACKGROUND: Recurrence of hepatitis B virus (HBV) after orthotopic liver transplantation is very common in the absence of adequate prophylaxis and is often associated with poor prognosis because of the development of cirrhosis, fibrosing cholestatic hepatitis, or fulminant hepatitis. Therefore it is important to study the prevention of HBV reinfection after liver transplantation. METHODS: Recombinant Fab (rFab) was constructed to evaluate gene therapy for post-transplantation HBV reinfection. Hepatocytes were divided into three groups: HBV-infection, rFab-blocked HBV-infection, and control. The inhibition of HBsAg adsorption test, the micro-cytotoxicity assay, and the blockade test of HBV infection were carried out. The HBsAg adsorption rate, the hepatocyte death rate and the HBV infection rate were statistically analyzed. RESULTS: The HBsAg adsorption rate blocked by rFab in the HBsAg adsorption test was 0.3%. The hepatocyte death rate was 98.8% induced by rFab in the micro-cytotoxicity assay, 1.3% in the rFab-blocked HBV-infected group and 77% in the HBV-infected group in the blockade test of HBV. CONCLUSIONS: We found that rFab effectively blocked HBV infection in human hepatocytes. This provides an attractive alternative for hepatitis B prophylaxis.

关键词： monoclonal antibodies hepatitis B virus liver transplantation

Correlation between anxiety, depression, and social stress in young patients with thoracolumbar spine fractures

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2025年第1期15卷 83-92页

作者： Bo Wang da Shi Yin-Di Sun Bo Dong Joint Ward of Orthopedics Department of TCM Honghui HospitalXi'an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina Pain Ward of Orthopedics Department of TCM Honghui HospitalXi'an Jiaotong UniversityXi’an 710054Shaanxi ProvinceChina

BACKGROUND Traumatic injuries,such as falling,car accidents,and crushing mostly cause spinal fractures in young and middle-aged people,and>50%of them are thoracolumbar *** kind of fracture is easily combined with serious injuries to peripheral nerves and soft tissues,which causes paralysis of the lower limbs if there is no timely rehabilitation *** patients with thoracolumbar fractures find it difficult to recover after the operation,and they are prone to depression,low self-esteem,and other negative *** To investigate the association between anxiety,depression,and social stress in young patients with thoracolumbar spine fractures and the effect on rehabilitation *** This study retrospectively analyzed 100 patients admitted to the orthopedic department of Honghui Hospital,Xi’an Jiaotong University who underwent thoracolumbar spine fracture surgery from January 2022 to June *** general data of the patients were assessed with the Hamilton anxiety scale(HAMA),Hamilton depression scale(HAMD),life events scale,and social support rating scale(SSRS)to identify the correlation between anxiety,depression scores,and social stress and social *** Japanese Orthopedic Association(JOA)was utilized to evaluate the rehabilitation outcomes of the patients and to analyze the effects of anxiety and depression scores on *** According to the scores of HAMD and HAMA in all patients,the prevalence of depression in patients was 39%(39/100),and the prevalence of anxiety was 49%(49/100).Patients were categorized into non-depression(n=61)and depression(n=39),non-anxiety(n=51),and anxiety(n=49)*** significant differences in gender,occupation,Pittsburgh Sleep Quality Index(PSQI)score,and monthly family income were observed between the non-depression and depression groups(P<0.05).A significant difference in occupation and PSQI score was found between the non-anxiety and anxiety *** depression(r=0

关键词： Patients with thoracolumbar fractures Anxiety Depression Social pressure Social support

Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie Wang Wei Wang Xuheng chen Junfang Bao Qiuyue Hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

Self-assembly of nanoparticles at solid-liquid interface for electrochemical capacitors

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2022年第11期41卷 3591-3611页

作者： Xue Li chen chen Qian Niu nian-Wu Li Le Yu Bao Wang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China StateKey Lab of Organic-Inorganic Composites Beijing UniversityofChemicalTechnologyBeijing100029China

Self-assembly of nanoparticles at solid-liquid interface could be promising to realize the assembled functions for various applications,such as rechargeable batteries,supercapacitors,and *** review summarizes the self-assembly of the nanoparticles at solid-liquid interface according to the different driving forces of assembly,including hydrophilic-hydrophobic interactions,solvophobic and electrostatic *** be specific,the self-assembly can be divided into the following two types:surfactant-assisted self-assembly and direct self-assembly of Janus particles(inorganic and amphiphilic copolymer-inorganic Janus nanoparticles).Using the emulsion stabilized by nanoparticles as the template,the self-assembly constructed by the interaction of the nanostructure unit(including metal,metal oxide,and semiconductor,etc.)not only possesses the characteristic of nanostructure unit,but also exhibits the excellent assembly performance in electrochemistry *** application of these assemblies in the area of electrochemical capacitors is ***,the current research progress and perspectives toward the self-assembly of nanoparticles at stabilized solid-liquid interface are proposed.

关键词： Self-assembly Solid-liquid interface Driving force Electrochemical capacitors

Effects of Roughness Elements Distribution on Overland Flow Resistance

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2015年第5期12卷 1145-1156页

作者： YE chen LIU Xing-nian WANG Xie-kang State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University

Roughness elements are various in a mountain area; they include gravel and ground surface vegetation that often result in surface friction drag to resist overland flows. The variation and characteristics of flow resistance strongly impact the overland flow process and watershed floods. In view of the universal existence of natural vegetation, such as Chlorophytum malayense(CM) or Ophiopogon bodinieri(OB), and the sand-gravel bed of the river channel, it is important to understand the role of different types of roughness elements in flow resistance. This study was performed to investigate and compare through flume experiments the behaviors of overland flow resistance by the reaction of multi-scale configuration of different roughness elements. The result showed that the resistance coefficient gradually reduced versus the increase of flow rate in unit width and tended to be a constant when q = 3.0 l/s.m, Fr = 1.0, and Re = 4000 for slopes of 6 to 10 degrees. The gap of the vegetated rough bed and the gravel rough bed is limited to the same as the gap of the two types of vegetation, CM and OB. It was noted that the vegetation contributed to the increase in form resistance negatively and may lead to the mean resistance on decrease. To classify the flow pattern, the laminar flows were described by darcyWeisbach's equation. In the study the f-Re equation of vegetated bed was developed with f ?5000 *** friction coefficient for laminar flows can be regarded as the critical value for identifying the transformation point of the flow pattern.

关键词： Overland flow Roughness element Flowresistance Reynolds number Chlorophytummalayense Ophiopogon bodinieri