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Two novel 2,5-diphenyl oxazole derivatives from Gymnotheca chinensis

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Chinese Chemical letters 2016年第7期27卷 1064-1066页

作者： Shi-Ji Xiao da-le guo Mao-Sheng Zhang Shu-Ling Peng Fang Chen Yan Zhou Li-Sheng Ding School of Pharmacy Zunyi Medical University Chengdu Institute of Biology Chinese Academy of Sciences College of Life Science Sichuan University

Two novel 2,5-diphenyl oxazole derivatives,named gymnothecaoxazoles A（1） and B（2）,were isolated from the whole parts of endemic medicinal plant of Gymnotheca chinensis（Saururaceae）.The structures of the new compounds were elucidated by extensive NMR and MS data,and the structure of compound 1was further confirmed by X-ray crystal diffraction analysis.

关键词： Gymnotheca chinensis Saururaceae 2,5-Diphenyl oxazole Alkaloid Gymnothecaoxazole

Disturbance Observer-Based Predictive Tracking Control of Uncertain HOFA Cyber-Physical Systems

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1711-1713页

作者： da-Wei Zhang guo-Ping Liu IEEE the Center for Control Theory and Guidance Technology Harbin Institute of TechnologyHarbin 150001China the Center for Control Science and Technology Southern University of Science and TechnologyShenzhen 518055China

Dear Editor,In this letter,an output tracking control problem of uncertain cyber-physical systems(CPSs)is considered in the perspective of high-order fully actuated(HOFA)system theory,where a lumped disturbance is use... 详细信息

关键词： Observer Uncertain letter

Theoretical study of the nonlinear force-loading control in single-molecule stretching experiments

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Communications in Theoretical Physics 2024年第4期76卷 167-175页

作者： Xingyu Qi Zilong guo Shimin le Hu Chen Research Institute for Biomimetics and Soft Matter Fujian Provincial Key Lab for Soft Functional Materials ResearchDepartment of PhysicsXiamen UniversityXiamen 361005China Center of Biomedical Physics Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325000China

Force spectrum measurements with constant loading rates are widely used in single-molecule manipulation experiments to study the mechanical stability and force response of ***-dependent transition rates can be obtained from the transition force distribution,but it is limited to the force range with non-zero force *** constant loading rate control can be realized with magnetic tweezers,the loading rate range is limited due to the slow movement of permanent ***-linear exponential and exponential squared force loading functions are more feasible in magnetic tweezers,while there is no theoretical result available for these two kinds of non-linear force loading *** this study,we solved the unfolding process of a protein following Bell's model under nonlinear exponential and exponential squared force loading functions,which offer a broader range of unfolding force distribution compared to the traditional constant loading rate ***,we derived two force loading functions,which can produce uniform unfolding force *** research contributes fundamental equations for the analysis of experimental data obtained through single-molecule manipulation under nonlinear force loading controls,paving the way for the use of nonlinear force control in magnetic tweezer experiments.

关键词： single-molecule manipulation magnetic tweezers force loading transition rates force distribution

Ferrite features in simulated transition zone of EH36 shipbuilding steel submerged arc welded by CaF_(2)-SiO_(2)-MnO fluxes

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Journal of Iron and Steel Research International 2024年第4期31卷 790-796页

作者： Ming Zhong Dong Hu da-ming guo Somnath Basu Cong Wang Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Department of Metallurgical Engineering and Materials Science Indian Institute of Technology BombayMumbai 400076MaharashtraIndia

Ferrite features in the simulated transition zone welded with CaF_(2)-SiO_(2)-MnO fluxes containing various MnO contents have been *** laser scanning microscopy has been applied to simulate the thermal cycling of the transition zone and the phase transformations during cooling have been in-situ *** has been found that the appearance temperature for ferrite side plate decreases with increasing Mn content in the weld metals caused by MnO content ***,growth rates for both ferrite side plate and acicular ferrite are significantly enhanced with a higher Mn content of weld ***,from the statistical fractions of salient microstructures,for all samples,the acicular ferrite,grain boundary ferrite,and polygonal ferrite take over more than 90%.It has also been demonstrated that with the increase in Mn content,the ferrite side plate fraction increases slightly from 5%to 10%and the acicular ferrite fraction shows a tendency of first increasing and then decreasing,which experiences the maximum with the flux containing 30 wt.%*** phenomenon is believed to be controlled by the O and Mn contents in weld metals synergistically.

关键词： Submerged arc welding Transition zone Phase transformation Microstructure

Neg-Entropy Mechanism as a Target for Natural Medicines

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Engineering 2024年第7期38卷 11-12页

作者： Tian-le Gao Hui-Hui guo Jian-Dong Jiang Institute of Materia Medica Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Current strategies for drug discovery research mainly focus on molecular targets,in which structure biology plays a central role,such as the detailed mechanism of a drug-target *** principle of this approach is the presumed molecular mechanism or genetic background of the disease being *** this approach has brought progress in understanding the mode of action for some drugs,most prevalent illnesses-especially chronic diseases-are multifactorial and present with a group of symptoms,as is often the case in cardiovascular diseases,metabolic disorders,cancers,and so *** newly emerging term“multi-morbidity”(i.e.,multiple co-occurring diseases)describes a grand challenge for this strategy,and successful drug intervention for multimorbidity should be multifaceted[1].So,our research team has shifted its attention to a new direction that views the disease as a whole instead of a single-molecule abnormality,and focusing on drugs with multiple targets.

关键词： drugs diseases cardiovascular

Vulnerability assessment of UAV engine to laser based on improved shotline method

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Defence Technology（防务技术） 2024年第3期33卷 588-600页

作者： le Liu Chengyang Xu Changbin Zheng Sheng Cai Chunrui Wang Jin guo Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China University of Chinese Academy of Sciences Beijing 100049China

Laser anti-drone technology is entering the sequence of actual combat,and it is necessary to consider the vulnerability of typical functional parts of *** the concept of"vulnerability"was proposed,a variety of analysis programs for battlefield targets to traditional weapons have been developed,but a comprehensive assessment methodology for targets'vulnerability to laser is still *** on the shotline method,this paper proposes a method that equates laser beam to shotline array,an efficient vulnerability analysis program of target to laser is established by this method,and the program includes the circuit board and the wire into the vulnerability analysis category,which improves the precision of the vulnerability *** the UAV engine part as the target of vulnerability analysis,combine with the"life-death unit method"to calculate the laser penetration rate of various materials of the UAV,and the influence of laser weapon system parameters and striking orientation on the killing probability is quantified after introducing the penetration rate into the vulnerability analysis *** quantitative analysis method proposed in this paper has certain general expansibility,which can provide a fresh idea for the vulnerability analysis of other targets to laser.

关键词： Laser weapon Laser damage Vulnerability UAV Engine Killing probability

Artemisia argyi extract subfraction exerts an antifungal effect against dermatophytes by disrupting mitochondrial morphology and function

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Chinese Journal of Natural Medicines 2024年第1期22卷 47-61页

作者： CHEN le ZHU Yunyun guo Chaowei guo Yujie ZHAO Lu MIAO Yuhuan DU Hongzhi LIU dahui College of Pharmacy Hubei University of Chinese MedicineWuhan 430065China National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China College of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China

Artemisia argyi(***),a plant with a longstanding history as a raw material for traditional medicine and functional diets in Asia,has been used traditionally to bathe and soak feet for its disinfectant and itch-relieving *** its widespread use,scientific evidence validating the antifungal efficacy of *** water extract(AAWE)against dermatophytes,particularly Trichophyton rubrum,Trichophyton mentagrophytes,and Microsporum gypseum,remains *** study aimed to substantiate the scientific basis of the folkloric use of *** by evaluating the antifungal effects and the underlying molecular mechanisms of its active subfraction against *** results indicated that AAWE exhibited excellent antifungal effects against the three aforementioned dermatophyte *** subfraction AAWE6,isolated using D101 macroporous resin,emerged as the most potent *** minimum inhibitory concentrations(MICs)of AAWE6 against ***,***,and *** were 312.5,312.5,and 625μg·mL−1,*** electron microscopy(TEM)results and assays of enzymes linked to cell wall integrity and cell membrane function indicated that AAWE6 could penetrate the external protective barrier of ***,creating breaches(“small holes”),and disrupt the internal mitochondrial structure(“granary”).Furthermore,transcriptome data,quantitative real-time PCR(RT-qPCR),and biochemical assays corroborated the severe disruption of mitochondrial function,evidenced by inhibited tricarboxylic acid(TCA)cycle and energy ***,chemical characterization and molecular docking analyses identified flavonoids,primarily eupatilin(131.16±4.52 mg·g^(−1))and jaceosidin(4.17±0.18 mg·g^(−1)),as the active components of *** conclusion,the subfraction AAWE6 from *** exerts antifungal effects against dermatophytes by disrupting mitochondrial morphology and *** research validates the traditional use of *** and provides scient

关键词： Artemisia argyi Dermatophyte Antifungal activity Mitochondrial structure Mitochondrial function Transcriptome analysis

Attaining synergetic equilibrium of electrical conductivity and tensile strength in GQDs@GN/Cu composites through multi-scale intragranular and intergranular reinforcements

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Rare Metals 2024年第1期43卷 366-379页

作者： Shuang-Yin Zhang Liang Liu Rui Bao Jian-Hong Yi Sheng-da guo Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China Key Laboratory of Advanced Materials of Yunnan Province Kunming University of Science and TechnologyKunming 650093China Faculty of Materials Metallurgy and Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China

The configuration and quality of reinforcements, as well as the robustness of interfacial bonding,holding a critical significance in determining the concurrence between electrical conductivity and mechanical strength in metal matrix composites. In this study, citric acid was employed as the precursor for synthesizing multiscale carbon nanomaterials(graphene quantum dots and graphene, abbreviated as GQDs and GN). The GQDs@GN/Cu composites were fabricated through a segmented ball milling process in conjunction with subsequent spark plasma sintering(SPS). The intragranular GQDs and intergranular GQDs@GN had synergistically reinforced Cu composites through Orowan strengthening, load transfer strengthening and refinement strengthening. Furthermore,the robust interface bonding between GQDs@GN and Cu effectively mitigated interfacial impedance stemming from electron-boundary scattering. The yield strength and ultimate tensile strength of the GQDs@GN/Cu composites were recorded as 270 and 314 MPa, respectively, representing an improvement of 92 and 28% over pure Cu, while maintaining electrical conductivity at a level comparable to that of pure Cu. This study advances the understanding of the possibility of realizing a synergistic compatibility between electrical conductivity and mechanical strength in Cu composites.

关键词： Cu matrix composites Interface bonding Mechanical property Graphene quantum dots(GQDs) Electrical conductivity

Innovations in metallurgical and materials processes:advancing liquid theory and honoring ***-jie guo's contributions to physical chemistry in metallurgy

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Journal of Iron and Steel Research International 2024年第1期31卷 1-2页

作者： Shuai Liu Jing guo Han-jie guo School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China

Spanning three decades,***-jie guo's research group has dedicated itself to exploring the fundamental theories and practical applications of physical chemistry within the realm of *** under the assumption that molecul... 详细信息

关键词： chemistry liquid complexes