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Correlation between the rock mass properties and maximum horizontal stress:A case study of overcoring stress measurements

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 39-48页

作者： Peng Li Meifeng Cai Shengjun Miao yuan Li Yu Wang Key Laboratory of Ministry of Education for Efficient Mining and Safety of Metal Mines University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and TechnologyXuzhou 221116China

Understanding the mechanical properties of the lithologies is crucial to accurately determine the horizontal stress *** investigate the correlation between the rock mass properties and maximum horizontal stress,the three-dimensional(3D)stress tensors at 89 measuring points determined using an improved overcoring technique in nine mines in China were adopted,a newly defined characteristic parameter C_(ERP)was proposed as an indicator for evaluating the structural properties of rock masses,and a fuzzy relation matrix was established using the information distribution *** results indicate that both the vertical stress and horizontal stress exhibit a good linear growth relationship with *** is no remarkable correlation between the elastic modulus,Poisson's ratio and depth,and the distribution of data points is scattered and ***,there is no obvious relationship between the rock quality designation(RQD)and *** maximum horizontal stress σ_(H) is a function of rock properties,showing a certain linear relationship with the C_(ERP)at the same *** addition,the overall change trend of σ_(H) determined by the established fuzzy identification method is to increase with the increase of C_(ERP).The fuzzy identification method also demonstrates a relatively detailed local relationship betweenσ_H and C_(ERP),and the predicted curve rises in a fluctuating way,which is in accord well with the measured stress data.

关键词： overcoring stress measurements elastic modulus Poisson's ratio rock quality designation maximum horizontal stress fuzzy identification

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FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui Kou Zongxue Jin Yusong yuan Bo Ma Wenyong Xie Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

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Molecular cloning and functional characterization of apple U-box E3 ubiquitin ligase gene MdPUB29 reveals its involvement in salt tolerance

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Journal of Integrative Agriculture 2019年第7期18卷 1604-1612页

作者： HAN Peng-liang DONG yuan-hua JIANG Han HU da-gang HAO Yu-jin State Key Laboratory of Crop Biology National Research Center for Apple Engineering and TechnologyShandong Agricultural University

An E3 ubiquitin ligase gene(Genbank accession no.:MD01 G1010900) was cloned from the Royal Gala apple genome(Malus×domestica Borkh.).Sequence analysis showed that the length of the MdPUB29 gene was 1 275 bp,encoding 424 amino *** tree analysis indicated that the apple E3 ubiquitin ligase exhibited the greatest sequence similarity to Pyrus×*** predicted protein structural domain of MdPUB29 showed that it contained a U-box ***-PCR analysis showed that Md PUB29 was expressed widely in different tissues of the Royal Gala apple species,and was highly expressed in the root,while the expression of MdPUB29 was significantly inhibited by exogenous *** assays revealed that MdPUB29 protein abundance in tissue cultures of the Royal Gala apple accumulated under NaC l stress ***-dimensional protein structure prediction indicated that MdPUB29 was highly homologous with *** growing potential of MdPUB29-expressing apple calli and Arabidopsis were much stronger than that of the control under salt stress conditions,suggesting that MdPUB29 may positively regulate salt tolerance.

关键词： apple E3 ubiquitin ligase MdPUB29 salt stress

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艾灸调节circ Pan3/mi R-667-5p/Ghrelin信号通路减轻膝骨关节炎大鼠的软骨病变

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中国组织工程研究 2025年第12期29卷 2475-2483页

作者：廖晴曾静陈峻袁立霞刘刚南方医科大学中医药学院广东省广州市510000 南方科技大学医院广东省深圳市518000 南方医科大学南方医院康复科广东省广州市510000

背景:既往研究表明艾灸能减轻膝骨关节炎软骨病变,延缓膝骨关节炎进展;课题组前期研究中发现调控circPan3/miR-667-5p/Ghrelin信号通路可增强软骨细胞自噬水平,从而在膝骨关节炎中发挥软骨保护作用。目的:基于circPan3/miR-667-5p/Ghre... 详细信息

背景:既往研究表明艾灸能减轻膝骨关节炎软骨病变,延缓膝骨关节炎进展;课题组前期研究中发现调控circPan3/miR-667-5p/Ghrelin信号通路可增强软骨细胞自噬水平,从而在膝骨关节炎中发挥软骨保护作用。目的:基于circPan3/miR-667-5p/Ghrelin信号通路探究艾灸对大鼠膝骨关节炎软骨的影响。方法:SD大鼠随机分为假手术组、模型组和艾灸组(n=10),对后2组大鼠行右后肢膝关节前交叉韧带横断和内侧半月板部分切除术建立膝骨关节炎大鼠模型;假手术组大鼠仅接受关节囊切开术。6周后,艾灸组大鼠每日艾灸“足三里”“肾俞”穴区20 min,持续4周,其余2组不予以特殊处理。4周后通过组织病理学染色观察膝关节滑膜病变和软骨损伤程度,通过酶联免疫吸附实验检测血清中炎症因子白细胞介素6和肿瘤坏死因子α的变化。此外,取上述3组大鼠右侧膝关节软骨细胞分为:正常对照组、模型组和艾灸组,通过Western blot和qRT-PCR检测各组细胞中软骨基质合成代谢分子(Ⅱ型胶原蛋白和Sox9)、基质降解分子(基质金属蛋白酶13和AdaMTS5)、自噬标志物(ATG5、Beclin-1、微管相关蛋白1轻链3)、Ghrelin、CircPan3以及miR-667-5P的表达水平。结果与结论:①治疗4周后,相对于假手术组,模型组大鼠滑膜显著增厚,炎症细胞浸润显著,关节间隙狭窄,软骨表面粗糙不平,变薄,软骨细胞数量减少,滑膜炎和OARSI评分显著升高,白细胞介素6和肿瘤坏死因子α水平明显上调(PdaMTS5和miR-667-5P表达增多,Ⅱ型胶原蛋白、Sox9、自噬标志物、Ghrelin和Circpan3表达减少(P<0.01);与模型组相比,艾灸可逆转上述指标改变(P<0.01)。③结果说明艾灸可能通过调节circPan3/miR-667-5p/Ghrelin信号通路增强软骨细胞自噬,抑制膝骨关节炎炎症和软骨破坏,对软骨发挥保护作用。

关键词：膝骨关节炎艾灸 ghrelin 软骨自噬大鼠信号通路

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Catechu Inhibiting Cathepsin B Activity and Motility of HT1080 Cells

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Chemical Research in Chinese Universities 2011年第2期27卷 269-272页

作者： yuan Hao YANG Jin-gang WANG Zhong-yuan ZHAO Shu-hua YU da-hai FANG Xue-xun Key Laboratory of Molecular Enzymology and Engineering Ministry of Education College of Life Science Jilin University Changchun 130012 P. R. China Department of Traditional Chinese Medicine China-Japan Union Hospital of Jilin University Changchun 130041 P R. China

We reported that Catechu extract has a significant inhibitory effect on cathepsin B activity. The IC50 value for the Catechu extract against cathepsin B was 7.6 μg/mL. In addition, we showed that HT1080 human fibrosarcoma cells express cathepsin B and Catechu modulate the invasion and motility of these cells. These data may provide molecular mechanisms for the therapeutic effects of Catechu.

关键词： Cathepsin B Traditional Chinese medicine Catechu Tumor Cell invasion Cell motility

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Smart crystalline frameworks constructed with bisquinoxaline-based component for multi-stimulus luminescent sensing materials

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Chinese Journal of Structural Chemistry 2023年第2期42卷 9-22页

作者： Peng-da Liu Ao-gang Liu Peng-Min Wang yuan Chen Bao Li Key Laboratory of Material Chemistry for Energy Conversion and Storage Semiconductor Chemistry CenterSchool of Chemistry and Chemical EngineeringHubei Key Laboratory of Bioinorganic Chemistry&Materia MedicaHuazhong University of Science and TechnologyWuhanHubei 430074People's Republic of China

Crystalline materials with well-defined structures and ordered molecular arrays can provide a new research platform to fabricate new smart materials with excellent stimulus response *** them,Luminescent Metal-Organic Frameworks(LMOFs)and Hydrogen-bonding Organic Frameworks(HOFs)show great promise for fluorescence detection to different *** order to further extend the smart sensing frameworks and enhance the relevant sensing performance,the present work specifically selects 4,4',4",4(")-([6,6'-biquinoxaline]-2,2',3,3'-tetrayl)tetrabenzoic acid(H4L)consisting of the bisquinoxaline functional group as an optical response group,and HOF(HUST-25,HUST=Huazhong University of Science and Technology),Zn-MOF(HUST-26),and Cd-MOF(HUST-27)were successfully *** could achieve the fluorescence recognition of Fe^(3+),MnO_(4)^(-),Cr_(2)O_(7)^(2-),p-nitrotoluene(4-NP),2,4,6-trinitrotoluene(TNP)and metronidazole(MDZ).The detection range of Zn-MOF constructed using Zn ions was similar to that of HOF,but the detection sensitivity of metal cations was significantly *** Cd-MOF formed a six-fold interpenetrating structure,it was still able to retain a large pore *** dense stacking structure increases the quinoxaline density,which effectively expanded the sensitivity and detection range of fluorescence ***,Cd-MOF showed better detection for nitro explosives,antibiotics,and organic small molecules with ketone *** example,compared to the previous literatures,Cd-MOF has a larger Ksv value for the nitro-explosive nitrobenzene(NB),indicating the very high detection *** series frameworks can present excellent sensing properties mainly because the func-tional primitives can be uniformly distributed in the skeleton of the crystalline materials,forming an ordered molecular array that enables the efficient energy transfer between the external stimulus signal and the response function *** related results indic

关键词： Metal-organic framework Hydrogen bonding organic framework Luminescent sening Bisquinoxaline group Sensor

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Authenticating GNSS civilian signals:a survey

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Satellite Navigation 2023年第1期4卷 196-213,I0006页

作者： Muzi yuan Xiaomei Tang gang Ou School of Electronic Science National University of Defense TechnologyChangshaChina

Civilian services of Global Navigation Satellite System are threatened by spoofng attacks since it is hard to determine the authenticity of a navigation signal with a detailed structure open to the *** authentication efectively protects the security of the signal by attaching unforgeable information to one or several elements of the *** can verify the authenticity of the signal by extracting and validating this *** good signal authentication schemes requires understanding possible spoofng modes,signal element specialty,and performance evaluation *** paper is an overview of navigation signal authentication,where the theories and reported approaches are described in detail.A design/performance matrix that demonstrates the advantages and defects of the signal element and its authentication design is *** are proposed to improve the robustness,security,efciency,and implementation hardness for future designs of navigation signal authentication.

关键词： GNSS spoofng Signal authentication Signal structure design Authentication scheme

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Empirical Study of Classification Process for Two-stage Turbo Air Classifier in Series

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Chinese Journal of Mechanical Engineering 2013年第3期26卷 526-531页

作者： YU yuan LIU Jiaxiang LI gang College of Mechanical and Electrical Engineering Beijing University of Chemical Technology College of Materials Science and Engineering Beijing University of Chemical Technology

The suitable process parameters for a two-stage turbo air classifier are important for obtaining the ultrafine powder that has a narrow particle-size distribution, however little has been published internationally on the classification process for the two-stage turbo air classifier in series. The influence of the process parameters of a two-stage turbo air classifier in series on classification performance is empirically studied by using aluminum oxide powders as the experimental material. The experimental results show the following: 1) When the rotor cage rotary speed of the first-stage classifier is increased from 2 300 r/min to 2 500 r/min with a constant rotor cage rotary speed of the second-stage classifier, classification precision is increased from 0.64 to 0.67. However, in this case, the final ultrafine powder yield is decreased from 79% to 74%, which means the classification precision and the final ultrafine powder yield can be regulated through adjusting the rotor cage rotary speed of the first-stage classifier. 2) When the rotor cage rotary speed of the second-stage classifier is increased from 2 500 r/min to 3 100 r/min with a constant rotor cage rotary speed of the first-stage classifier, the cut size is decreased from 13.16 μm to 8.76 μm, which means the cut size of the ultrafine powder can be regulated through adjusting the rotor cage rotary speed of the second-stage classifier. 3) When the feeding speed is increased from 35 kg/h to 50 kg/h, the 'fish-hook' effect is strengthened, which makes the ultrafine powder yield decrease. 4) To weaken the 'fish-hook' effect, the equalization of the two-stage wind speeds or the combination of a high first-stage wind speed with a low second-stage wind speed should be selected. This empirical study provides a criterion of process parameter configurations for a two-stage or multi-stage classifier in series, which offers a theoretical basis for practical production.

关键词： two-stage turbo air classifier in series aluminum oxide powders process parameters classification performance

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Numerical simulation of flow past a square cylinder with a circular bar upstream and a splitter plate downstream

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Journal of Hydrodynamics 2019年第5期31卷 949-964页

作者： yuan Ma MMRashidi Zhi-gang Yang Shanghai Automotive Wind Tunnel Center Tongji UniversityShanghai 201804China Shanghai Key Laboratory of Vehicle Aerodynamics and Vehicle Thermal Management Systems Shanghai 201804China Department o f Civil Engineering School of EngineeringUniversity of BirminghamBirminghamUK

A numerical investigation of flow past a square cylinder with a circular bar upstream and a splitter plate downstream is carried out in this paper by lattice Boltzmann method(LBM).The combination of the three obstacles and LBM is the main novelty of the present *** flow patterns are analyzed by a uniform flow of Reynolds number 100 based on the side length of the square cylinder,*** simulations are performed in the range of 1≤Ds/D≤5,0≤G/D≤7 and 1≤L/D≤6,where Ds,G and L are the center-to center distance,surface-to-surface distance and the splitter plate length,*** flow patterns are observed in the present *** maximum percentage reduction in mean drag coefficient is 68.76%at(ds,g,l)=(2.5,0,3)which is in pattern *** vortex shedding from the square cylinder and the circular bar can be completely suppressed in pattern *** small distance between the square cylinder and the splitter plate plays a more vital role in suppression of vortex shedding as compared with large distance and length.

关键词： Square cylinder lattice Boltzmann method(LBM) reduction of drag forces vortex shedding control circular bar splitter plate

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Recent advances in asymmetric synthesis with CO2

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Science China Chemistry 2020年第10期63卷 1336-1351页

作者： Chuan-Kun Ran Xiao-Wang Chen Yong-yuan Gui Jie Liu Lei Song Ke Ren da-gang Yu College of Chemistry and Materials Science Sichuan Normal UniversityChengdu 610068China Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China

Carbon dioxide(CO2)is an important and appealing C1 building block in chemical synthesis due to its nontoxicity,abundance,availability and *** progress has been achieved in the chemical transformation of CO2 into high valueadded organic ***,the asymmetric synthesis with CO2 to form enantioenriched molecules,especially the catalytic process,has lagged far *** enantioselective incorporation of CO2 into organic compounds is highly desirable,as the corresponding chiral products,such as carboxylic acids and amino acids,are common structural units in a vast array of natural products and biologically active ***,we discuss recent progress toward the enantioselective incorporation of CO2 into organic molecules,which mainly rely on three strategies:1)kinetic resolution or desymmetrization of epoxides with CO2 to form chiral cyclic carbonates and polycarbonates;2)nucleophilic attack of O-or N-nucleophiles to CO2 in tandem with asymmetric C–O bond formation to prepare chiral cyclic carbonates and carbamates;3)direct enantioselective nucleophilic attack of organometallic reagents to CO2 with asymmetric C–C bond ***,challenges and future outlook in this area are also presented.

关键词： carbon dioxide asymmetric catalysis carbonate carbamate carboxylic acid

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