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A method for expanding the screening space for protein crystallization

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A method for expanding the screening space for protein cryst...

第五届中国结构生物学学术讨论会

作者： da-chuan yin Chen-Yan Zhang Rui-Qing Chen Chen Dong Qin-Qin Lu Hai Hou School of Life Sciences Northwestern Polytechnical University

Protein crystals are very useful in a number of fields like structural biology, pharmacy, protein purification, and materials sciences. In the field of structural biology, they are used for structural determination of protein molecules via X-ray, electron, or neutron diffraction. The first step to obtain protein crystals is to find out the crystallization agents that can help to crystalize the target proteins. This step is often challenging. Methods to tackle this challenge are therefore necessary. In this report, we will present a new crystallization plate design which can be used to expand the screening space for protein crystallization based on cross-diffusion microbatch（CDM） method[1]. The new plate consists of 96 units corresponding to the conditions of the commercial screening kits, and each unit contains four wells for holding the crystallization droplets. By dispensing crystallization droplets to the four wells at different volume ratios of protein to precipitant solutions, we can obtain four different initial concentrations for each unit, thus a wider concentration range can be screened. The comparison between the screening performance of the new plates and the traditional sitting-drop vapor diffusion plate showed that the new design of the plates exhibited significantly improved results in obtaining more crystallization conditions[2]. Similar concept can be utilized in expanding the p H screening space by adding extra buffer solutions to different wells, so as to realize screens with four different initial p H values simultaneously. The new crystallization plate can be made compatible with the SBS standard so that automation can be carried out easily. Apparently, the method is applicable in routine crystallization screening experiment, and hopefully it can be of use in the process of obtaining crystallization conditions.

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Containerless Protein Crystallization in Microgravity Generated by a Superconducting Magnet

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Containerless Protein Crystallization in Microgravity Genera...

中国晶体学会第五届全国会员代表大会暨学术大会（大分子分会场）

作者： Hui-Ling Cao da-chuan yin Yun-Zhu Guo Yong-ming Liu Hui-Meng Lu Wei-Hong Guo Peng Shang School of Life Sciences Northwestern Polytechnical University

It was reported that protein crystals of larger size and higher quality can be obtainedinspace environment.A superconducting magnet is thought one of the best ground-based simulation techniques at *** the first time,crystals of lysozyme were obtained successfully from levitated containerless droplets in microgravity condition generated by the superconducting

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Utilization of adsorption and desorption for improving crystallization success rate and protein crystal quality

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Utilization of adsorption and desorption for improving cryst...

中国晶体学会第五届全国会员代表大会暨学术大会（晶体生长分会场）

作者： Yun-Zhu Guo da-chuan yin Hui-Ling Cao Jin He Chen-Yan Zhang Yong-Ming Liu Huan-Huan Huang School of Life Sciences Northwestern Polytechnical University

Three-dimensional structural information of proteins is very important in the study of the function of the macromolecules.X-ray diffraction technique is the most widely used method for determining protein *** major problem to be solved is how to obtain high quality protein crystals suitable for X-ray *** the crystallization experiments,high degree of supersaturation is needed for spontaneous nucleation,however,protein

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Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： Li-Rong Xiao Chen Chen Shuo Wang Zi-yin dai Hideo Kimura Cui Ni chuan-Xin Hou Xue-Qin Sun Si-Jie Guo Wei Du Xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

Erratum to“The Possibility of Changing the Wettability of Material Surface by Adjusting Gravity”

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Research 2020年第1期2020卷 1354-1356页

作者： Yong-Ming Liu Zi-Qing Wu Sheng Bao Wei-Hong Guo da-Wei Li Jin He Xiang-Bin Zeng Lin-Jun Huang Qin-Qin Lu Yun-Zhu Guo Rui-Qing Chen Ya-Jing Ye Chen-Yan Zhang Xu-Dong Deng da-chuan yin Key Lab of Space Bioscience&Biotechnology School of Life SciencesNorthwestern Polytechnical UniversityXi’an710072 ShaanxiChina School of Bioengineering Sichuan University of Science and EngineeringZigong643000 SichuanChina Shenzhen Research Institute of Northwestern Polytechnical University Shenzhen518057 GuangdongChina

In the article titled“The Possibility of Changing the Wettability of Material Surface by Adjusting Gravity”[1],there were errors in Figure 2 which occurred during *** errors are listed below,and the corrected versio... 详细信息

关键词： Figure Surface listed

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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi Dennis Yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

DKP-SLAM:A Visual SLAM for Dynamic Indoor Scenes Based on Object Detection and Region Probability

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Computers, Materials & Continua 2025年第1期82卷 1329-1347页

作者： Menglin yin Yong Qin Jiansheng Peng College of Automation Guangxi University of Science and TechnologyLiuzhou545000China Department of Artificial Intelligence and Manufacturing Hechi UniversityHechi546300China Key Laboratory of AI and Information Processing Education Department of Guangxi Zhuang Autonomous RegionHechi546300China Guangxi Key Laboratory of Sericulture Ecology and Applied Intelligent Technology School of Chemistry and BioengineeringHechi UniversityHechi546300China

In dynamic scenarios,visual simultaneous localization and mapping(SLAM)algorithms often incorrectly incorporate dynamic points during camera pose computation,leading to reduced accuracy and *** paper presents a dynamic SLAM algorithm that leverages object detection and regional dynamic ***,a parallel thread employs the YOLOX object detectionmodel to gather 2D semantic information and compensate for missed ***,an improved K-means++clustering algorithm clusters bounding box regions,adaptively determining the threshold for extracting dynamic object contours as dynamic points *** process divides the image into low dynamic,suspicious dynamic,and high dynamic *** the tracking thread,the dynamic point removal module assigns dynamic probability weights to the feature points in these *** with geometric methods,it detects and removes the dynamic *** final evaluation on the public TUM RGB-D dataset shows that the proposed dynamic SLAM algorithm surpasses most existing SLAM algorithms,providing better pose estimation accuracy and robustness in dynamic environments.

关键词： Visual SLAM dynamic scene YOLOX K-means++clustering dynamic probability

Research on Stock Price Prediction Method Based on the GAN-LSTM-Attention Model

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Computers, Materials & Continua 2025年第1期82卷 609-625页

作者： Peng Li Yanrui Wei Lili yin College of Computer Science and Technology Harbin University of Science and TechnologyHarbin150006China

Stock price prediction is a typical complex time series prediction problem characterized by dynamics,nonlinearity,and *** paper introduces a generative adversarial network model that incorporates an attention mechanism(GAN-LSTM-Attention)to improve the accuracy of stock price ***,the generator of this model combines the Long and Short-Term Memory Network(LSTM),the Attention Mechanism and,the Fully-Connected Layer,focusing on generating the predicted stock *** discriminator combines the Convolutional Neural Network(CNN)and the Fully-Connected Layer to discriminate between real stock prices and generated stock ***,to evaluate the practical application ability and generalization ability of the GAN-LSTM-Attention model,four representative stocks in the United States of America(USA)stock market,namely,Standard&Poor’s 500 Index stock,Apple Incorporatedstock,AdvancedMicroDevices Incorporatedstock,and Google Incorporated stock were selected for prediction experiments,and the prediction performance was comprehensively evaluated by using the three evaluation metrics,namely,mean absolute error(MAE),root mean square error(RMSE),and coefficient of determination(R2).Finally,the specific effects of the attention mechanism,convolutional layer,and fully-connected layer on the prediction performance of the model are systematically analyzed through ablation *** results of experiment show that the GAN-LSTM-Attention model exhibits excellent performance and robustness in stock price prediction.

关键词： Stock price prediction generative adversarial network attention mechanism time-series prediction

Flexible Strain Sensors with Ultra‑High Sensitivity and Wide Range Enabled by Crack‑Modulated Electrical Pathways

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Nano-Micro Letters 2025年第3期17卷 246-264页

作者： Yunzhao Bai Yunlei Zhou Xuanyu Wu Mengfei yin Liting yin Shiyuan Qu Fan Zhang Kan Li YongAn Huang State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Flexible Electronics Research Center Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200People’s Republic of China School of Mechano‑Electronic Engineering Xidian UniversityXi’an 710071People’s Republic of China Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultrahigh sensitivity and wide-range sensor,addressing the critical challenge of reconciling sensitivity with measurement *** by the structure of bamboo slips,we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric *** resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%.The integration of patterned liquid metal enables customisable tuning of the sensor’s response,while the porous fabric structure ensures superior comfort and air permeability for the *** design not only optimises the sensor’s performance but also enhances the electrical stability that is essential for practical *** systematic investigation,we reveal the intrinsic mechanisms governing the sensor’s response,offering valuable insights for the design of wearable strain *** sensor’s exceptional performance across a spectrum of applications,from micro-strain to large-strain detection,highlights its potential for a wide range of real-world uses,demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device