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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na Li Yue-Yue Ren Ying Tang Qi Yang tian-tian Meng Song Li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

Supramolecular adhesive materials from small‐molecule self‐assembly

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SmartMat 2020年第1期1卷 85-103页

作者： chen‐Yu Shi Qi Zhang He tian da‐Hui Qu Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistrySchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghaiChina

Developing high‐performance adhesive materials not only aims at industrial and social requirements but also bears the fundamental importance of understanding the chemical factors of biological adhesion to develop biomimetic adhesive *** to the wide development of supramolecular chemistry,numerous supramolecular tools are exploited and proved to be reliable in the replacement of traditional covalent materials by reversible noncovalent or dynamic covalent *** advantage of these readyto‐use supramolecular toolboxes,supramolecular adhesive materials are rising and promising toward“smart”adhesives,that is,enabling responsiveness,reversibility,and *** with polymeric adhesive materials,low‐molecular‐weight adhesives feature chemically precise structure,easier engineering by molecular design,and hence higher ***,it remains highly challenging to make high‐performance adhesive materials by low‐molecular‐weight *** review will focus on the recent advancement in the construction of supramolecular adhesive materials by smallmolecule self‐*** design guidelines and consideration on the molecular scale will be discussed and summarized on how to enhance the strength of ***,owing to the dynamic nature of supramolecular self‐assembly,several“smart”functions of such materials will be presented,such as stimuli–responsiveness and ***,current challenges and future perspectives of this emerging field will be proposed.

关键词： adaptiveness responsiveness small‐molecule self‐assembly supramolecular adhesive materials

A New Method for Searching Cubes and Its Application to 815-Round Trivium

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Journal of Systems Science & Complexity 2023年第5期36卷 2234-2254页

作者： LIU chen tian tian QI Wenfeng PLA Strategic Support Force Information Engineering University Zhengzhou 450001China

The cube attack proposed by Dinur and Shamir is one of the most important key-recovery attacks against *** division property based cube attacks have been extensively studied and significantly *** particular,the MILP modeling technique for the three-subset division property without unknown subset proposed by Hao,et *** EUROCRYPT 2020 and the new technique with nested monomial predictions proposed by Hu,et *** ASIACRYPT 2021 are best techniques to recover exact superpolies in division property based cube ***,at this state of the art,whether a superpoly can be recovered in division property based cube attacks is mainly decided by the scale of the superpoly,that is,the number of *** the choice for proper cubes corresponding to low-complexity superpolies is more critical *** effective cube construction methods were proposed for experimental cube attacks,but not applicable to division property based cube *** this paper,the authors propose a heuristic cube criterion and a cube sieve algorithm,which can be combined with the three-subset division property to recover a number of *** to815-round Trivium,the authors recovered 417 superpolies from 441 cubes obtained by our algorithm of sizes between 41 and *** success rate is 94.56%.There are 165 non-constant superpolies with degree less than *** order to demonstrate the significance of the new algorithm,the authors tested the best superpoly recovery technique at EUROCRYPT 2020 using random cubes of similar sizes on 815-round *** experimental result shows that no cube could be completely recovered within a given period of time because the superpolies for random cubes are too complex.

关键词： Cube attacks division property key-recovery attacks trivium

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肿瘤标志物在肠黏液腺癌中的表达及临床意义

中国肿瘤临床与康复 2017年第8期24卷 901-905页

作者：陈达天黄洁何小芳刘宝瑞钱晓萍南京医科大学鼓楼临床医学院南京210008 南京大学附属鼓楼医院肿瘤中心南京210008

目的探讨血清肿瘤标志物在肠黏液腺癌中的表达及临床意义。方法选取2011年6月至2016年1月间南京鼓楼医院收治的155例肠黏液腺癌患者,经手术治疗和病理学确诊,采用化学发光法检测各血清肿瘤标志物水平。结果肿瘤标志物在大多数患者血清... 详细信息

目的探讨血清肿瘤标志物在肠黏液腺癌中的表达及临床意义。方法选取2011年6月至2016年1月间南京鼓楼医院收治的155例肠黏液腺癌患者,经手术治疗和病理学确诊,采用化学发光法检测各血清肿瘤标志物水平。结果肿瘤标志物在大多数患者血清中均有不同程度的升高。患者癌胚抗原(CEA),糖类抗原(CA)199、125、153、724、242,甲胎蛋白(AFP)和联检血清肿瘤标志物的阳性率分别为23.2%、27.5%、15.7%、5.3%、44.1%、38.5%、0.7%和62.4%。联合检测肿瘤标志物的阳性率与患者TNM分期不相关(P>0.05),与脉管侵犯和神经侵犯相关(P0.05);CA724阳性率与脉管侵犯和神经侵犯相关(P0.05)。结论联检血清肿瘤标志物升高,可能是肠黏液腺癌神经、脉管侵犯及侵袭转移的重要标志,CA724和CA125可能是有效的生物标记。

关键词：肿瘤标志物黏液腺肿瘤脉管侵犯神经侵犯

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong Hu Yong Cao chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

Stabilization of Continuous-Time Systems Against Stochastic Network Uncertainties:Fundamental Variance Bounds

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Journal of Systems Science & Complexity 2021年第5期34卷 1858-1878页

作者： QI tian chen Jie School of Automation Science and Engineering Key Laboratory of Autonomous Systems and Networked ControlSouth China University of TechnologyGuangzhou 510640China Department of Electrical Engineering City University of Hong KongHong KongChina

This paper studies the stabilizability and stabilization of continuous-time systems in the presence of stochastic multiplicative *** authors consider multi-input,multi-output(MIMO)linear time-invariant systems subject to multiple static,structured stochastic uncertainties,and seek to derive fundamental conditions to ensure that a system can be stabilized under a mean-square *** the stochastic control framework,this problem can be considered as one of optimal control under state-or input-dependent random noises,while in the networked control setting,a problem of networked feedback stabilization over lossy communication *** authors adopt a mean-square small gain analysis approach,and obtain necessary and sufficient conditions for a system to be meansquare stabilizable via output *** single-input,single-output(SISO)systems,the condition provides an analytical bound,demonstrating explicitly how plant unstable poles,nonminimum phase zeros,and time delay may impose a limit on the uncertainty variance required for mean-square *** MIMO minimum phase systems with possible delays,the condition amounts to solving a generalized eigenvalue problem,readily solvable using linear matrix inequality optimization techniques.

关键词： Mean-square small gain theorem multiplicative stochastic uncertainty networked control

Innate lymphocytes:pathogenesis and therapeutic targets of liver diseases and cancer

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Cellular & Molecular Immunology 2021年第1期18卷 57-72页

作者： Yongyan chen Zhigang tian Hefei National Laboratory for Physical Sciences at Microscale the CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Institute of Immunology University of Science and Technology of ChinaHefeiChina

The liver is a lymphoid organ with unique immunological properties,particularly,its predominant innate immune *** balance between immune tolerance and immune activity is critical to liver physiological functions and is responsible for the sensitivity of this organ to numerous diseases,including hepatotropic virus infection,alcoholic liver disease,nonalcoholic fatty liver disease,autoimmune liver disease,and liver cancer,which are major health problems *** the past decade,with the discovery of liver-resident natural killer cells,the importance of innate lymphocytes with tissue residency has gradually become the focus of *** this review,we address the current knowledge regarding hepatic innate lymphocytes with unique characteristics,including NK cells,ILC1/2/3s,NKT cells,γδ T cells,and MAIT cells,and their potential roles in liver homeostasis maintenance and the progression of liver diseases and cancer.A better understanding of the immunopathogenesis of hepatic innate lymphocytes will be helpful for proposing effective treatments for liver diseases and cancer.

关键词： Innate lymphocyte Liver disease Liver cancer Innate lymphoid cell Innate-like T lymphocyte

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美国公法域外适用机制及中国因应研究

海南大学学报（人文社会科学版） 2025年第1期43卷 195-206页

作者：田静南开大学法学院天津300071

公法域外适用衍生于国际体系的结构性演变,有着经济全球化下独特的政治、经济与意识形态背景。其在公法域外适用需求的显现、国家主权观念的转换、公法禁忌原则的突破以及法律形式的嬗变上,具备了一定的存在基础。但是近年来,囿于美国... 详细信息

公法域外适用衍生于国际体系的结构性演变,有着经济全球化下独特的政治、经济与意识形态背景。其在公法域外适用需求的显现、国家主权观念的转换、公法禁忌原则的突破以及法律形式的嬗变上,具备了一定的存在基础。但是近年来,囿于美国国际法理念的转变,其由原先对严格属地主义的固守转为对国家利益至上的推崇,因而在公法域外适用上愈发地恣意与专断,使公法域外适用存在严重的法律、外交和道德张力。为应对美国公法域外适用,中国须秉承防御与建设共进的思路。一方面,加强国际合作共同抗衡美国公法域外适用制度的滥用,同时健全中国的反制法律体系;另一方面,梳理总结美国多年来在公法域外适用过程中形成的丰富经验,在此基础上构建完善符合国际法基本原则的中国法域外适用制度。

关键词：域外适用管辖权效果原则公法禁忌

Cauchy matrix structure of the Mel’nikov model of long-short wave interaction

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Communications in Theoretical Physics 2020年第12期72卷 83-93页

作者： Hong-Juan tian da-Jun Zhang Department of Mathematics Shanghai UniversityShanghai 200444China

We propose a systematic method to construct the Mel’nikov model of long–short wave interactions,which is a special case of the Kadomtsev–Petviashvili(KP)equation with self-consistent sources(KPSCS).We show details how the Cauchy matrix approach applies to Mel’nikov’s model which is derived as a complex reduction of the *** a new result wefind that in the dispersion relation of a 1-soliton there is an arbitrary time-dependent function that has previously not reported in the literature about the Mel’nikov *** function brings time variant velocity for the long wave and also governs the short-wave *** variety of interactions of waves resulting from the time-freedom in the dispersion relation is illustrated.

关键词： Mel’nikov model of long–short wave interaction Cauchy matrix approach self-consistent sources KP equation

Regulating ion transport behaviors toward dendrite-free potassium metal batteries:recent advances and perspectives

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Rare Metals 2024年第4期43卷 1435-1460页

作者： Lu-Kang Zhao Xuan-Wen Gao tian-Zhen Ren da Wang da-Wei Wang Zhao-Meng Liu Hong chen Wen-Bin Luo School of Metallurgy Northeastern UniversityShenyang110819China School of Chemical Engineering The University of New South WalesSydneyNSW2052Australia

With abundant potassium resources and high capacity,potassium metal batteries(PMBs)present a compelling option for the next generation of energy storage ***,PMBs suffer from an unstable anode interface caused by uncontrolled dendrite growth,which results in unsatisfactory cyclability and safety *** investigations suggest that significant progress has been made in enhancing the interfacial stability of *** various effective strategies for stabilizing interfaces can ultimately be attributed to the regulation of the sluggish ion transfer kinetics and irregular deposition,i.e.,the arrangement of ion transport behaviors at the *** modulation of ions transport rate and ions deposition directions makes it possible to obtain a dendrite-free and smooth deposition ***,the influencing factors and action mechanism of K^(+)interface transport behaviors are discussed to understand the nature of material design for constructing stable anode interfaces,including regulating the solvation and desolvation structures,accelerating K^(+)transport kinetics and controlling K^(+)deposition *** addition,the deficiencies and prospects of the research on electrolyte,separators and designed electrode involved in the manufacturing and testing and ion transport process of PMBs are *** review is expected to provide some possible directions for constructing dendrite-free interfaces in advanced PMBs-related research and offer significant insights for prospective experimental research and commercial applications.

关键词： Ion transport rate Ion transport direction Interface Potassium metal batteries Dendrites growth