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Chapter 3 Extra-galactic gamma-ray sources

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Chinese Physics C 2022年第3期46卷 63-84页

作者： Xiang-Yu Wang Xiao-Jun Bi Zhen Cao Piero Vallania Han-Rong Wu da-Hai yan Qiang Yuan School of Astronomy and Space Sciences Nanjing UniversityNanjing 210093China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China INAF-Osservatorio Astrofisico di Torino Strada Osservatorio 2010025 Pino Torinese(TO)Italy and INFN Sezione di TorinoVia P.Giuria 110125 TorinoItaly Key Laboratory for the Structure and Evolution of Celestial Objects Yunnan ObservatoriesChinese Academy of SciencesKunming 650011China Key Laboratory of dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China

Extra-galactic gammaray sources,such as gamma-ray bursts,active galactic nuclei,starburst galaxies,are interesting and important targets for LHAASO *** this chapter,the prospects of detecting these sources with LHAASO and their physical implications are *** upgrade plan for the Water Cherenkov Detector Array(WCda),which aims to enhance the detectability of relatively lower energy photons,is also *** addition,a study on constraining the extragalactic background light with LHAASO observation of blazars is presented.

关键词： AGN Gamma-rays GRBs

High sensitive detection of presenilin-1 point mutation based on electrochemilumi-nescence

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Chinese Science Bulletin 2003年第16期48卷 1741-1744页

作者： ZHU Debin, XING da, SHEN Xingyan & yan Guihong Institute of Laser Life Science, South China Normal University, Guang-zhou 510631, China Correspondence should be addressed to Xing da (e-mail: xingda@ ***) Institute of Laser Life Sciences South China Normal University Guangzhou 510631 China

Electrochemiluminescence (ECL) is a high- sensitive detection method with broad biological applications. Ruthenium (Ⅱ) tris (bipyridyl) 2+3(Ru(bpy)) and tripro-pylamine (TPA) are most commomly used combination of the reactive species in ECL. The redox of 2+3Ru(bpy) with excess TPA at the surface of an electrode produces a highly efficient and stable light emission due to a rapid cycle of the reactions. This rapid, highly sensitive and accurate method has been applied to gene quantification. In this work, an ECL detection system is designed and applied in detection of presenilin-1 (PS-1) gene mutation. The results show that given the same polymerase chain reaction (PCR) cycle num-ber, the ECL intensities from the digested and the undigested wild-type samples are nearly identical, but the difference in ECL intensities between the digested and the undigested mutant samples is distinctive. This detection technology connects PCR with ECL and allows a reliable discrimination between the wild-type and the mutant genes.

关键词：电化学发光 ECL 高灵敏探测方法钌三丙基胺反应剂氧化还原作用电极

Detection of reassortant avian influenza A (H11N9) virus in environmental samples from live poultry markets in China

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Infectious Diseases of Poverty 2016年第1期5卷 499-504页

作者： Ye Zhang Shu-Mei Zou Xiao-dan Li Li-Bo Dong Hong Bo Rong-Bao Gao da-yan Wang Yue-Long Shu National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Key Laboratory for Medical Virology National Health and Family Planning CommissionBeijing 102206China

Background:Avian influenza viruses have caused human infection and posed the pandemic *** poultry markets are considered as a source of human infection with avian influenza *** influenza routine surveillance of live poultry markets is taken annually in *** isolated the 2 H11N9 influenza virus from the surveillance *** better understand the risk caused by these new viruses,we characterize the genetic and pathogenicity of the two ***:Viral isolation was conducted with specific pathogen-free(SPF)embryonated chicken *** genome was sequenced,and phylogenetic analysis was ***:Two H11N9 viruses were identified,with all 8 segments belonging to the Eurasian *** HA,NA,M,NS and PA genes were similar to virus isolates from ducks,and the NP,PB2 and PB1 gene segments were most similar to those viruses from wild birds,indicating that the H11N9 viruses might represent reassortant viruses from poultry and wild *** HA receptor binding preference was avian-like,and the cleavage site sequence of HA showed low *** NA gene showed 94.6%identity with the novel H7N9 virus that emerged in *** was no drug resistance mutation in the M2 *** Asn30Asp and Thr215Ala substitutions in the M1 protein implied a potentially increased pathogenicity in *** viruses were low-pathogenic strains,as assessed by the standards of intravenous pathogenicity index(IVPI)***:Two reassortant H11N9 avian influenza viruses were *** viruses showed low pathogenicity to chickens in the IVPI *** health concern caused by the reassortant H11N9 viruses should be emphasized during the future surveillance.

关键词： Avian influenza H11N9 Genetic characterization Reassortant

Correlation between ultrasonic tumor volume doubling time (TVDT) and malignant molecule expression in breast cancer

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Journal of Hainan Medical University 2018年第8期24卷 73-77页

作者： Gen-Jin Wang da-Xue yan Department of Thyroid and Breast Surgery Xiangyang No.1 People's HospitalHubei University of MedicineXiangyangHubei Province441000

Objective:To investigate the correlation between ultrasonic tumor volume doubling time (TVDT) and malignant molecule expression in breast ***: A total of 118 patients with breast cancer undergoing surgical treatment in this hospital between August 2016 and August 2017 were selected as breast cancer group and 100 patients with breast adenoma undergoing adenoma resection in this hospital during the same period were selected as breast adenoma group. The differences in TVDT levels as well as proliferation-related gene and invasion-related gene mRNA expression in lesion tissue were compared between the two groups of patients. Pearson test was used to assess the intrinsic relationship between ultrasonic TVDT level in patients with breast cancer and malignant molecule expression in tumor. Results: The tumor TVDT level of breast cancer group was lower than that of breast adenoma group;pro-proliferation genes PKM2, Notch1 and FSCN1 mRNA expression in tumor tissue of breast cancer group were higher than those of breast adenoma group whereas anti-proliferation genes FBXW7, HSG and EBP50 mRNA expression were lower than those of breast adenoma group;pro-invasion genes Gab2 and VEGF mRNA expression in tumor tissue of breast cancer group were higher than those of breast adenoma group whereas anti-invasion genes NDRG1, DKK-1 and NUAK1 mRNA expression were lower than those of breast adenoma group. The Pearson test showed that the TVDT level of breast cancer was directly correlated with the expression of proliferation-related genes and invasion-related ***: Ultrasonic TVDT level of breast cancer decreases abnormally, and the specific TVDT level is directly correlated with tumor cell proliferation and invasion activity.

关键词： Breast cancer Ultrasonic tumor volume doubling time Proliferation Invasion

Non-asymptotic state estimation method using auxiliary time-varying modulating dynamical systems

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Non-asymptotic state estimation method using auxiliary time-...

A SSR Marker for Leaf Rust Resistance Gene Lr19 in Wheat

第43届中国控制会议

作者： Li-Fei Wang da-yan Liu yan-Qiao Wei School of Science Yanshan University INSA Centre Val de Loire Université d'Orléans School of Electrical Engineering Yanshan University

The classical modulating functions method has undergone significant generalization over the past decade,extending its applicability to state estimation for both linear and nonlinear systems. This advancement involves employing generalized modulating functions,which can be viewed as solutions to a series of auxiliary dynamical systems with zero initial *** paper aims to provide auxiliary time-varying modulating dynamical systems for non-asymptotic and robust state estimation for a class of linear time-varying systems. First,to better introduce the proposed method,a recent modulating functions method applied to the observable canonical form is recalled to deduce algebraic integral formulas for the state variables. Then,the idea of the proposed method is presented to obtain similar state's formulas. Finally,by comparing these two methods,numerical results are given to demonstrate their accuracy and robustness against corrupting noises.

关键词： Non-asymptotic estimation Robust estimation Auxiliary time-varying modulating dynamical systems Linear time-varying systems

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Agricultural Sciences in China 2006年第2期5卷 111-115页

作者： LI Xing yanG Wen-xiang LI Ya-ning LIU da-qun yan Hong-fei MENG Qing-fang ZHANG Ting Department of Plant Pathology College of Plant Protection Hebei Agricultural University/Biological Control Center of Plant Diseasesand Plant Pests of Hebei Province Baoding 071001 P.R.China

Microsatellite was carded out in Thatcher, six near-isogenic lines and F2 progeny of TcLr19xThatcher to develop molecular markers for leaf rust resistance gene Lr19. Thirteen primer pairs were screened, of which one primer pair Xgwm44 displayed polymorphsim in the population of TcLr 19, Thatcher, and their F2 generations. One marker closed linked to Lr19 resistance trait was obtained, and was named Xgwm44139bp with the genetic distance 0.9 cM. The research shows that Lr19 has more potential in marker-assisted breeding programs in wheat and provides a step stone for mapping genetic map, physical map and the eventual cloning.

关键词： wheat leaf rust Lr19 microsatellite

Identification of AFLP Markers Linked to Lr19 Resistance to Wheat Leaf Rust

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Agricultural Sciences in China 2007年第3期6卷 311-315页

作者： LI Xing yanG Wen-xiang LI Ya-ning LIU da-qun yan Hong-fei MENG Qing-fang ZHANG Ting Department of Plant Pathology/Biological Control Center of Plant Diseases and Plant Pests of Hebei Province Agricultural University ofHebei Baoding 071001 P.R.China

AFLP analyses were carried out on Thatcher, 23 near-isogenic lines and F2 generation of TcLr19 × Thatcher, to develop molecular markers for gene Lr19 resistance to wheat leaf rust. Seven markers linked to Lr19 resistance trait were obtained, which were P-AGT/M-GAG289 bp （3.3 cM）, P-ACA/M-GGT102 bp （4.1 cM）, P-ACA/M-GGT106 bp （4.1 cM）, P-AAC/M-CAG123 bp （4.9 cM）, P-AAC/M-GGT203bp （5.0 cM）, P-ACA/M-GGT290bp （5.7 cM）, and P-ATC/M-GAG293bp （9.6 cM）. All of these specific fragments were isolated from the polyacrylamide gels, reamplified, cloned, and sequenced. The research may facilitate genetic mapping, physical mapping, and the eventual cloning of Lr19.

关键词： wheat Lr19 molecular marker AFLP

新兴市场国家市场经济环境与跨国并购相关性研究

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中南财经政法大学学报 2007年第5期 125-130页

作者：阎大颖南开大学国际经济研究所天津市300071

新兴市场的市场潜力(包括市场规模、市场增长率、市场强度、市场消费能力、商业基础设施、经济自由度、市场对外接受度和国家风险)越大,对跨国并购的吸引力越强,其中经济自由度、市场强度、商业基础设施的发展水平对跨国并购的吸引能力... 详细信息

新兴市场的市场潜力(包括市场规模、市场增长率、市场强度、市场消费能力、商业基础设施、经济自由度、市场对外接受度和国家风险)越大,对跨国并购的吸引力越强,其中经济自由度、市场强度、商业基础设施的发展水平对跨国并购的吸引能力更强。新兴市场内部市场经济制度的完善及与发达国家的接轨是提高吸引外资竞争力的重要条件。

关键词：新兴市场跨国并购市场潜力指数

我国各省区吸引外资规模及模式的影响因素分析

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中国软科学 2008年第3期 36-43页

作者：阎大颖南开大学经济学院国际经济研究所天津市300071

近年来,中国沿海地区吸收外商直接投资的独资化倾向普遍高于中部和内陆地区。本文综合国际投资学、新制度经济学和企业能力等理论多角度诠释了外资独资倾向与地区市场化发育程度的相关关系,并应用实证分析证明,政府对经济运行和价格机... 详细信息

近年来,中国沿海地区吸收外商直接投资的独资化倾向普遍高于中部和内陆地区。本文综合国际投资学、新制度经济学和企业能力等理论多角度诠释了外资独资倾向与地区市场化发育程度的相关关系,并应用实证分析证明,政府对经济运行和价格机制的行政干预越少、市场机制与发达国家越接近,跨国企业对投资环境的适应能力越强,外资企业独资化经营倾向性越高。

关键词：外国直接投资独资倾向市场自由化区域差异