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Building the toolbox for in vivo glia-to-neuron reprogramming

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Neural Regeneration Research 2024年第6期19卷 1171-1172页

作者： Ye xie Bo Chen Departments of Ophthalmology and Neuroscience Icahn School of Medicine at Mount Sinai

Unlike regenerative-competent species that possess a remarkable intrinsic capacity to replenish lost neurons and restore neurocircuits spontaneously, the central nervous system in adult mammals lacks the ability to compensate for the neuronal loss caused by neurodegenerative diseases or traumatic injuries resulting in permanent loss of functionality. Inspired by earlier discoveries that radial glia or astrocytes isolated from the postnatal cortex can generate neurons,

关键词： CONVERSION DISEASE

Phonon-blockade-based multiple-photon bundle emission in a quadratically coupled optomechanical system

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Frontiers of physics 2024年第3期19卷 207-215页

作者： Ye-Jun Xu Hong xie Interdisciplinary Research Center of Quantum and Photoelectric Information Chizhou UniversityChizhou 247000China Department of Mathematics and Physics Fujian Jiangxia UniversityFuzhou 350108China

We propose a scheme to realize antibunched multiple-photon bundles based on phonon blockade in a quadratically coupled optomechanical *** adjusting the detunings to match the conditions of phonon blockade in the photon sidebands,we establish super-Rabi oscillation between zero-photon state and multiple-photon states with adjustable super-Rabi frequencies under appropriate single-phonon resonant *** the system dissipation into account,we numerically calculate the standard and generalized second-order functions of the cavity mode as well as the quantum trajectories of the state populations with Monte Carlo simulation to confirm that the emitted photons form antibunched multiple-photon ***,the desirable n-photon states are reconstructed after a direct phonon emission based on phonon blockade,and thus the single-phonon emission heralds the cascade emission of n-photon *** proposal shows that the optomechanical system can simultaneously behave as antibunched multiple-photon emitter and single-phonon *** a nonclassical source could have potential applications in quantum information science.

关键词： multiple-photon bundle emission phonon blockade optomechanical system

Progress and prospect of Pt-based catalysts for electrocatalytic hydrogen oxidation reactions

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Nano Research 2024年第3期17卷 960-981页

作者： Xu Zhang Ying xie Lei Wang Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080China

To achieve the goals of the peak carbon dioxide emissions and carbon neutral,the development and utilization of sustainable clean energy are extremely *** fuel cells are an important system for converting hydrogen energy into electrical ***,the slow hydrogen oxidation reaction(HOR)kinetics under alkaline conditions has limited its ***,elucidating the catalytic mechanism of HOR in acidic and alkaline media is of great significance for the construction of highly active and stable *** terms of practicality,Pt is still the primary choice for commercialization of fuel *** the above basis,we first introduced the hydrogen binding energy theory and bifunctional theory used to describe the HOR activity,as well as the pH *** that,the rational design strategies of Pt-based HOR catalysts were systematically classified and summarized from the perspective of activity *** addition,we further emphasized the importance of theoretical simulations and in situ characterization in revealing the HOR mechanism,which is crucial for the rational design of ***,the practical application of Pt-based HOR catalysts in fuel cells was also *** closing,the current challenges and future development directions of HOR catalysts were *** review will provide a deep understanding for exploring the mechanism of highly efficient HOR catalysts and the development of fuel cells.

关键词： Pt-based catalysts hydrogen oxidation reaction(HOR) electrocatalytic mechanism hydrogen binding energy theory bifunctional theory

When debugging encounters artificial intelligence: state of the art and open challenges

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Science China(Information Sciences) 2024年第4期67卷 42-84页

作者： Yi SONG Xiaoyuan xie Baowen XU School of Computer Science Wuhan University State Key Laboratory of Novel Software Technology Nanjing University

Both software debugging and artificial intelligence techniques are hot topics in the current field of software engineering. Debugging techniques, which comprise fault localization and program repair, are an important part of the software development lifecycle for ensuring the quality of software systems. As the scale and complexity of software systems grow, developers intend to improve the effectiveness and efficiency of software debugging via artificial intelligence(artificial intelligence for software debugging, AI4SD). On the other hand, many artificial intelligence models are being integrated into safety-critical areas such as autonomous driving, image recognition, and audio processing, where software debugging is highly necessary and urgent(software debugging for artificial intelligence, SD4AI). An AI-enhanced debugging technique could assist in debugging AI systems more effectively, and a more robust and reliable AI approach could further guarantee and support debugging techniques. Therefore, it is important to take AI4SD and SD4AI into consideration comprehensively. In this paper, we want to show readers the path, the trend, and the potential that these two directions interact with each other. We select and review a total of 165 papers in AI4SD and SD4AI for answering three research questions, and further analyze opportunities and challenges as well as suggest future directions of this cross-cutting area.

关键词： software debugging fault localization program repair artificial intelligence machine learning

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决奈达隆在心房颤动导管消融空白期应用的安全性和有效性

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中国新药与临床杂志 2024年第4期43卷 268-272页

作者：方任远杜先锋何斌丰明俊边昶冷冰王彬浩卓伟东周忠李恒栋孙汉泽沈文均赵乾磊谢达奇吴斌储慧民宁波大学附属第一医院浙江宁波315000 浙江大学医学院附属第二医院浙江杭州310003 浙江大学明州医院浙江宁波315800 中国科学院大学宁波华美医院浙江宁波315099 慈溪市人民医院浙江宁波315399 宁波市医疗中心李惠利医院浙江宁波315040 宁波大学附属人民医院浙江宁波315020 宁波市第九医院浙江宁波315032 宁波市海曙区第二医院浙江宁波315099

目的评估决奈达隆在心房颤动导管消融空白期应用的真实世界安全性和有效性。方法纳入2021年5月1日至2021年12月31日间在各合作中心接受导管消融治疗的心房颤动患者150例,空白期予口服决奈达隆片,每次400 mg,早晚各1次,持续3个月。术后3... 详细信息

目的评估决奈达隆在心房颤动导管消融空白期应用的真实世界安全性和有效性。方法纳入2021年5月1日至2021年12月31日间在各合作中心接受导管消融治疗的心房颤动患者150例,空白期予口服决奈达隆片,每次400 mg,早晚各1次,持续3个月。术后3个月±14 d至门诊随访,复查24 h动态心电图、经胸心脏彩超、肝功能、肾功能等,记录随访期间发生的不良事件。结果与手术前相比,术后用药3个月时患者的心率、PR间期及左室射血分数无显著变化,QTc间期延长[(434.0±29.2)ms vs.(443.5±31.8)ms,P=0.017],左房内径[(40.6±6.5)mm vs.(38.4±6.0)mm,P=0.007]及左室舒张末内径[(47.9±4.3)mm vs.(46.4±5.1)mm,P=0.012]减小。6例患者空白期内停药,包括高度房室传导阻滞1例、显著心动过缓2例、QTc间期显著延长1例及消化系统症状2例。未出现与抗心律失常药物相关的心血管死亡、心力衰竭、再住院的复合终点。术后随访3个月时,患者窦性心律维持率85.3%(128/150)。结论决奈达隆在心房颤动导管消融空白期应用安全、有效,依从性好。

关键词：决奈达隆心房颤动射频消融术抗心律失常药空白期

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Visible-Light-Promoted Palladium-Catalyzed Cross-Coupling of lodocarboranes with Disulfides and Phenylselenyl Chloride

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Chinese Journal of Chemistry 2024年第2期42卷 129-134页

作者： Shimeng Li Yizhen Liu Zuowei xie Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and TechnologyShenzhenGuangdong 518055China

This work describes a general method for the synthesis of a series of sulfenylated and selenylated carboranes at room temperature using readily available iodocarboranes as starting materials via boron-centered carboranyl *** hypervalent boron radicals are generated by a visible-light-promoted Pd(O)/Pd(I)*** are useful intermediates and can be trapped by disulfides and phenylselenyl chloride for the convenient construction of B-S/Sebonds.

关键词： Carborane Sulfenylation Selenylation B-I activation Radical Photocatalysis Boron Selectivity

Optimizing urban block morphologies for net-zero energy cities:Exploring photovoltaic potential and urban design prototype

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Building Simulation 2024年第4期17卷 607-624页

作者： Xiaotian Geng Dong xie Zhonghua Gou School of Urban Design Wuhan UniversityWuhanChina

The morphology of urban areas plays a crucial role in determining solar potential,which directly affects photovoltaic capacity and the achievement of net-zero *** study focuses on the City of Melbourne to investigate the utilization of solar energy across different urban densities and proposes optimized *** analysis encompasses blocks with diverse population densities,examining medium and high-density *** utilizing a multi-objective genetic optimization approach,the urban morphology of these blocks is *** findings indicate that low-density blocks exhibit photovoltaic potential ranging from 1 to 6.6 times their total energy *** and high-density blocks achieve photovoltaic potential levels approximately equivalent to 40%-85%of their overall energy ***,significant variations in photovoltaic potential are observed among different urban forms within medium and high-density ***“elevated corners with central valley”prototype is proposed as an effective approach,enhancing the overall photovoltaic potential by approximately 14%.This study introduces novel analytical concepts,shedding light on the intricate relationship between urban morphologies and photovoltaic potential.

关键词： net-zero energy solar energy urban density urban morphology multi-objective optimization photovoltaic potential

Spatio-temporal variability of surface chlorophyll a in the Yellow Sea and the East China Sea based on reconstructions of satellite data of 2001-2020

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Journal of Oceanology and Limnology 2024年第2期42卷 390-407页

作者： Weichen xie Tao WANG Wensheng JIANG Key Laboratory of Marine Environment and Ecology Ocean University of ChinaQingdao 266100China College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao 266100China

Chlorophyll-a(Chl-a)concentration is a primary indicator for marine environmental *** spatio-temporal variations of sea surface Chl-a concentration in the Yellow Sea(YS)and the East China Sea(ECS)in 2001-2020 were investigated by reconstructing the MODIS Level 3 products with the data interpolation empirical orthogonal function(DINEOF)*** reconstructed results by interpolating the combined MODIS daily+8-day datasets were found better than those merely by interpolating daily or 8-day ***-a concentration in the YS and the ECS reached its maximum in spring,with blooms occurring,decreased in summer and autumn,and increased in late autumn and early *** performing empirical orthogonal function(EOF)decomposition of the reconstructed data fields and correlation analysis with several potential environmental factors,we found that the sea surface temperature(SST)plays a significant role in the seasonal variation of Chl a,especially during spring and *** increase of SST in spring and the upper-layer nutrients mixed up during the last winter might favor the occurrence of spring *** high sea surface temperature(SST)throughout the summer would strengthen the vertical stratification and prevent nutrients supply from deep water,resulting in low surface Chl-a *** sea surface Chl-a concentration in the YS was found decreased significantly from 2012 to 2020,which was possibly related to the Pacific Decadal Oscillation(PDO).

关键词： chlorophyll a(Chl a) data interpolation empirical orthogonal function(DINEOF) empirical orthogonal function(EOF)analysis Yellow Sea East China Sea

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Observer design and interval estimation of time-delay discrete-time linear systems with external disturbance and measurement noise

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Control Theory and Technology 2024年第1期22卷 69-80页

作者： Junqi Yang Jianhao xie Feiyang Liu School of Electrical Engineering and Automation Henan Key Laboratory of Intelligent Detection and Control of Coal Mine EquipmentHenan Polytechnic UniversityJiaozuo454003HenanChina

For a class of time-delay discrete-time linear systems with external disturbance and measurement noise, the interval estimation problems of state and measurement noise are investigated in this paper. First, the system state together with the time-delay term and measurement noise is augmented as a new state, and a singular system is then constructed. Subsequently, a kind of decoupling technique is employed to eliminate the effect of external disturbance, and an observer is designed to simultaneously estimate the system state and measurement noise. Based on the estimated state and measurement noise, the interval estimations of system state and measurement noise are obtained by reachability analysis technique. Finally, the effectiveness of the proposed method is verified by a four-tank liquid level system.

关键词： Interval estimation Time-delay system Observer design Reachability analysis