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基于文献检索的中国海堤监测研究进展

水运工程 2018年第3期 45-51页

作者：秦淑芳焦大容李硕苏俊玮河海大学海岸灾害及防护教育部重点实验室江苏南京210098 河海大学港口海岸与近海工程学院江苏南京210098 72695部队山东青岛266103

针对全球气候变化、海平面上升及大型围垦项目白热化推进背景下的海堤安全问题,开展中国海堤监测现状研究。采用大数据分析方法,依托中国期刊全文数据库CNKI,从海堤检测与监测理论、海堤状态安全检测、海堤安全长期监测以及经典海堤监... 详细信息

针对全球气候变化、海平面上升及大型围垦项目白热化推进背景下的海堤安全问题,开展中国海堤监测现状研究。采用大数据分析方法,依托中国期刊全文数据库CNKI,从海堤检测与监测理论、海堤状态安全检测、海堤安全长期监测以及经典海堤监测案例这4个全新的角度,分析我国海堤监测的现状。结论表明:现有海堤监测大多集中在施工期监测方面,对老海堤安全隐患的研究还不够全面和深入;指出海堤监测理论中渗压和沉降理论2个分支均未提及海浪本身对海堤的影响,建议将波浪资料纳入海堤渗压及沉降等影响因子中;建议提出一套规范化的海堤隐患检测综合方法,将海堤自身变形监测资料与海洋水文监测资料同步集成、综合分析进而实时预测海堤安全。

关键词：海堤监测防波堤监测海堤检测文献数据库

Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer

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Science China Chemistry 2025年第1期 35-45页

作者： Xinyu Peng Qian Ma da Han School of Life Science Shanghai University Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine State Key Laboratory of Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Department of Research and Development Intellinosis Biotechnologies Co.Ltd.

Gastric cancer(GC) is a prevalent and lethal malignancy worldwide, and the 5-year survival rate is less than 30%. The absence of distinctive symptoms often leads to late-stage diagnosis, contributing to a grim prognosis. Early detection is pivotal for improving the survival rates and outcomes of GC patients. Traditional diagnostic methods, including gastroscopy and histopathological examination, are restricted in the early diagnosis of GC. Conventional protein biomarkers, such as carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9), and carbohydrate antigen 72-4(CA72-4), exhibit insufficient sensitivity and specificity for GC screening, which diminishes their clinical value. Recently, novel circulating biomarkers, such as circulating tumor cells(CTCs), circulating tumor cell DNA(ct DNA), and circulating free RNA(cf RNA), have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and specificity. This review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.

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Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

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Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi Robert Chunhua Zhao jiao Wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

三维互穿结构SiC晶须骨架增强镁基复合材料制备及其力学性能

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金属学报 2022年第7期58卷 857-867页

作者：谷瑞成张健张明阳刘艳艳王绍钢焦大刘增乾张哲峰郑州大学河南先进技术研究院郑州450001 中国科学院金属研究所师昌绪先进材料创新中心沈阳110016 中国科学院金属研究所沈阳材料科学国家研究中心沈阳110016

选用SiC晶须骨架作为增强相,利用重力辅助沉降、压缩致密化、骨架烧结及无压熔渗的方法制备了具有微观三维互穿结构的SiC晶须骨架增强镁基复合材料,并对其微观组织结构与力学性能(特别是断裂韧性)进行了表征与分析。通过对SiC晶须骨架... 详细信息

选用SiC晶须骨架作为增强相,利用重力辅助沉降、压缩致密化、骨架烧结及无压熔渗的方法制备了具有微观三维互穿结构的SiC晶须骨架增强镁基复合材料,并对其微观组织结构与力学性能(特别是断裂韧性)进行了表征与分析。通过对SiC晶须骨架进行预氧化处理,提高了增强相与基体之间的润湿性,并通过调节预氧化温度控制析出相含量和孔洞等缺陷,优化了复合材料的弯曲强度与断裂韧性,获得了稳定的裂纹扩展行为(上升的R曲线)。相比于以纯Mg为基体的复合材料,以AZ91D镁合金为基体的复合材料中析出相含量高且发生粗化,使得材料强度提高的同时断裂韧性降低。

关键词：三维互穿结构镁基复合材料 SiC晶须断裂韧性增韧机制

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制备超薄多层膜的自动转速控厚法

中国激光 2001年第11期28卷 1027-1031页

作者：祝国龙冯仕猛邵建达汤兆胜易葵范正修中国科学院上海光机所上海201800

在转速控厚法的基础上 ,排除了射频溅射的电磁干扰 ,实现了自动转速控厚法。用这种方法镀制超薄多层膜时 ,可以实时记录下镀制每层膜的沉积时间、自动切换转速、完成设定周期后自动停止转动。自动转速控厚法与转速控厚法相比 ,明显降低... 详细信息

在转速控厚法的基础上 ,排除了射频溅射的电磁干扰 ,实现了自动转速控厚法。用这种方法镀制超薄多层膜时 ,可以实时记录下镀制每层膜的沉积时间、自动切换转速、完成设定周期后自动停止转动。自动转速控厚法与转速控厚法相比 ,明显降低了多层膜制备的劳动强度 ,提高了多层膜制备的成品率和监控精度。而且将在镀制复杂膜系多层膜时。

关键词：超薄多层膜膜厚精度小角X射线衍射自动转速控厚法

Imperative for long-term management and surveillance in Kawasaki disease

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World Journal of Clinical Cases 2025年第4期13卷 61-63页

作者： Yan Pan Fu-Yong jiao Department of Pediatrics The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Shaanxi Kawasaki Disease Diagnosis and Treatment Center Children’s HospitalShaanxi Provincial People’s Hospital of Xi’an Jiaotong UniversityXi’an 710000Shaanxi ProvinceChina

Kawasaki disease(KD)is a significant pediatric vasculitis known for its potential to cause severe coronary artery *** the effectiveness of initial treatments,such as intravenous immunoglobulin,KD patients can experience long-term cardiovascular issues,as evidenced by a recent case report of an adult who suffered a ST-segment elevation myocardial infarction due to previous KD in the World Journal of Clinical *** editorial emphasizes the critical need for long-term management and regular surveillance to prevent such *** drawing on recent research and case studies,we advocate for a structured approach to follow-up care that includes routine cardiac evaluations and preventive measures.

关键词： Kawasaki disease Long-term management Coronary artery aneurysm Surveillance Preventive care