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Shape optimisation of basin insulator for DC gas insulated switchgear/gas insulated transmission lines based on artificial bee colony algorithm

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High Voltage 2024年第2期9卷 275-286页

作者： Yi Luo Shiyi Mao Ju Tang Zijun pan Cheng pan State Key Laboratory of Power Grid Environmental Protection School of Electrical Engineering and AutomationWuhan UniversityWuhanChina

The surface charge accumulation on the basin insulator is a particular problem in high-voltage direct current(HVDC)gas insulated switchgears(GIS)and gas insulated trans-mission lines(GIL),which restricts the development and application of extra/ultra high-voltage(EHV/UHV)*** surface charge distribution and anti-flashover performance are closely related to the insulator *** obtain the optimal basin insulator,a shape optimisation model based on artificial bee colony algorithm was established,and the minimisation objective functions based on capacitive(initial)electric field distribution and resistive(steady-state)electric field distribution were respectively *** optimisation results of the two objective functions were calculated,and the electric field and charge distribution on the surface of the insulator before and after optimisation were evaluated and compared using the simulation *** results indicated that the optimisation based on the capacitive electric field can significantly inhibit the surface charge accumulation,and the optimised insulator can significantly reduce the surface normal electric field and make the distribution of the tangential electric field more uniform,and the maximum tangential electric field can be reduced by 10%;the optimisation based on resistive electric field can achieve similar results,but requires more computational *** on the results,the‘anti-charge’basin insulator structure suitable for the DC field was given.

关键词： insulator artificial charge

Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

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World Journal of Diabetes 2024年第5期15卷 898-913页

作者： Su-Su Feng Si-Jing Wang Lin Guo pan-pan Ma Xiao-Long Ye Ming-Lin pan Bo Hang Jian-Hua Mao Antoine M Snijders Yi-Bing Lu da-Fa Ding Department of Endocrinology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Biological Systems and Engineering Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720United States

BACKGROUND The understanding of bile acid(BA)and unsaturated fatty acid(UFA)profiles,as well as their dysregulation,remains elusive in individuals with type 2 diabetes mellitus(T2DM)coexisting with non-alcoholic fatty liver disease(NAFLD).Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in *** To identify potential metabolite biomarkers capable of distinguishing between NAFLD and *** A training model was developed involving 399 participants,comprising 113 healthy controls(HCs),134 individuals with T2DM without NAFLD,and 152 individuals with T2DM and *** validation encompassed 172 *** patients were divided based on liver fibrosis *** analytical approach employed univariate testing,orthogonal partial least squares-discriminant analysis,logistic regression,receiver operating characteristic curve analysis,and decision curve analysis to pinpoint and assess the diagnostic value of serum *** Compared to HCs,both T2DM and NAFLD groups exhibited diminished levels of specific *** UFAs,particular acids exhibited a positive correlation with NAFLD risk in T2DM,while theω-6:ω-3 UFA ratio demonstrated a negative *** ofα-linolenic acid andγ-linolenic acid were linked to significant liver fibrosis in *** validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM *** This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM,proposing their potential as biomarkers in the pathogenesis of NAFLD.

关键词： Bile acid Non-alcoholic fatty liver disease Type 2 diabetes mellitus Unsaturated fatty acid

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中医“方证对应”数学模型研究的思路与方法

北京中医药大学学报 2010年第10期33卷 659-663页

作者：潘大为广东暨南大学中医系广东510632

建立"方证对应"数学模型是探讨方证对应证治规律的较好途径。方证对应是一个复杂系统问题,建立方证对应数学模型,必须与研究对象的特点和复杂程度匹配,并在模型的保真性和建模成本间取得平衡。选择具有适当规模和复杂程度、又有足够代... 详细信息

建立"方证对应"数学模型是探讨方证对应证治规律的较好途径。方证对应是一个复杂系统问题,建立方证对应数学模型,必须与研究对象的特点和复杂程度匹配,并在模型的保真性和建模成本间取得平衡。选择具有适当规模和复杂程度、又有足够代表性的建模对象,实现符合临床实际要求的"证-方"定量关联的算法,这是目前方证对应模型研究要解决的2个关键问题。围绕这2个问题,选取《伤寒论》方证对应具体用例作为建模基础;选用一种分析复杂系统的有效数学工具层次分析法(AHP)作为建模工具,建立《伤寒论》方证耦合模型,可为系统探讨方证对应规律提供科学依据。

关键词：方证对应数学模型伤寒论层次分析法

MicroRNA changes of bone marrow-derived mesenchymal stem cells differentiated into neuronal-like cells by Schwann cell-conditioned medium

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Neural Regeneration Research 2019年第8期14卷 1462-1469页

作者： Zhi-Jian Wei Bao-You Fan Yang Liu Han Ding Hao-Shuai Tang da-Yu pan Jia-Xiao Shi Peng-Yuan Zheng Hong-Yu Shi Heng Wu Ang Li Shi-Qing Feng Department of Orthopedics Tianjin Medical University General Hospital Tianjin China Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Tianjin Lung Cancer Inst让ute Tianjin Medical University General Hospital Tianjin China Department of Orthopedics Henan Provincial People's Hospital Zhengzhou Henan Province China

Bone marrow-derived mesenchymal stem cells differentiate into neurons under the induction of Schwann cells. However, key microRNAs and related pathways for differentiation remain unclear. This study screened and identified differentially expressed microRNAs in bone marrow- derived mesenchymal stem cells induced by Schwann cell-conditioned medium, and explored targets and related pathways involved in their differentiation into neuronal-like cells. Primary bone marrow-derived mesenchymal stem cells were isolated from femoral and tibial bones, while primary Schwann cells were isolated from bilateral saphenous nerves. Bone marrow-derived mesenchymal stem cells were cultured in unconditioned (control group) and Schwann cell-conditioned medium (bone marrow-derived mesenchymal stem cell + Schwann cell group). Neuronal differentiation of bone marrow-derived mesenchymal stem cells induced by Schwann cell-conditioned medium was observed by time-lapse imaging. Upon induction, the morphology of bone marrow-derived mesencaymal stem cells changed into a neural shape with neurites. Results of quantitative reverse transcription-polymerase chain reaction revealed that nestin mRNA expression was upregulated from 1 to 3 days and downregulated from 3 to 7 days in the bone marrow-derived mesenchymal stem cell + Schwann cell group. Compared with the control group, microtubule-associated protein 2 mRNA expression gradually increased from 1 to 7 days in the bone marrow-derived mesenchymal stem cell + Schwann cell group. After 7 days of induction, microRNA analysis iden:ified 83 significantly differentially expressed microRNAs between the two groups. Gene Ontology analysis indicated enrichment of microRNA target genes for neuronal projection development, regulation of axonogenesis, and positive regulation of cell proliferation. Kyoto Encyclopedia of Genes and Genomes pathway analysis demonstrated that Hippo, Wnt, transforming growth factor-beta, and Hedgehog signaling pathv/ays were potenti

关键词： nerve regeneration microRNA analysis bone marrow-derived mesenchymal stem cells: Schwann cells neuronal-like cells neuronal differentiation Gene Ontology analysis Hippo signaling pathway Wnt signaling pathway transforming growth factor-beta signaling pathway Hedgehog signaling pathway neural regeneration

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城市公安指挥中心的设计研制

四川大学学报（自然科学版） 1999年第2期36卷 262-266页

作者：潘大任四川大学分析测试中心

介绍了一个城市公安指挥中心的设计方案，分析了该系统的特点。

关键词：公安指挥中心 C^3I GIS GPS CSCW 城市

New opportunities for ferroelectric deep-UV nonlinear optical crystals

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Science China Materials 2024年第3期67卷 1004-1005页

作者： Miriding Mutailipu Shilie pan Research Center for Crystal Materials Xinjiang Technical Institute of Physics and ChemistryChinese Academy of SciencesUrumqi 830011China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Deep-ultraviolet(deep-UV)light with the wavelength below200 nm is one of the most crucial elements of both laser-driven industrial and scientific applications in recent years[1].DeepUV light has been produced using a variety of techniques,such as gas discharge lamps,synchrotron radiation,excimer lasers,free electron lasers,and nonlinear frequency conversion.

关键词： nonlinear optical ferroelectric

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40Cr钢磨削淬硬层组织形成机理的研究

材料热处理学报 2007年第B8期28卷 41-45页

作者：刘菊东侯达盘王大镇集美大学机械工程学院福建厦门361021

以单程切入式平面磨削淬硬加工试验为基础,利用X射线衍射仪和透射电镜对40Cr钢磨削淬硬层组织的形成及其变化进行了研究,进而阐明了磨削淬硬层组织的形成机理。结果表明,40Cr钢磨削淬硬层由板条马氏体和少量微细孪晶组成;在磨削温度场... 详细信息

以单程切入式平面磨削淬硬加工试验为基础,利用X射线衍射仪和透射电镜对40Cr钢磨削淬硬层组织的形成及其变化进行了研究,进而阐明了磨削淬硬层组织的形成机理。结果表明,40Cr钢磨削淬硬层由板条马氏体和少量微细孪晶组成;在磨削温度场和应力-应变场的耦合作用下,磨削淬硬层中的马氏体含量以及板条马氏体特征尺寸沿层深呈现不同的变化趋势,马氏体内部的位错密度及孪晶数则随层深的增加而逐渐降低。

关键词：磨削表面淬火显微组织温度场应力-应变场

Time-domain Differential Protection Based on Operating and Restraining Trajectory Indices for Lines Connecting Battery Storage Energy Stations

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1074-1086页

作者： Yingyu Liang Cunyue pan School of Mechanical and Electrical Engineering China University of Mining and Technology(Beijing)BeijingChina

Battery energy storage stations(BESSs)pose sever-al challenges for both phasor-based differential protection and the newly-proposed time-domain differential *** challenges include low sensitivity and even ***,the negative impact of various nonideal conditions,including current transformer(CT)saturation,errors,and outliers,on the security of differential protection remains an important *** by the aforementioned issues,this study ac-counts for the trajectory distribution discrepancy on Cartesian plane under various conditions and proposes a time-domain dif-ferential protection *** this paper,the trajectory formed by operating and restraining current samples is ***,after considering different operating states,the fault severity levels,and nonideal conditions,the variances in trajectory distribution between internal and external faults are extensively *** this basis,the Cartesian plane is divided into operating,uncertainty,and restraining ***-ther,the operating and restraining trajectory indices are meticu-lously designed and a protection criterion based on these indi-ces is formed to accurately separate internal faults from other events,unaffected by CT saturation,errors,and *** exceptional performance of the proposed protection method is extensively validated through PSCAD simulations and a hard-ware-in-the-loop testing *** the dependability,sensitivity,and security,the proposed protection method outper-forms three state-of-the-art differential protection methods.

关键词： Battery energy storage station time-domain differential protection operating trajectory index(OTI) restraining trajectory index(RTI)

Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma:a multi-center integrated analysis of microbiome,metabolome,and transcriptome data

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Frontiers of Medicine 2024年第2期18卷 399-402页

作者： Wenjin Chen Xiuwu pan Wang Zhou da Xu Jiaxin Chen Keqin Dong Weijie Chen Brian Rini Xingang Cui Department of Urology Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai200092China Department of Urology Third Affiliated Hospital of the Second Military Medical UniversityShanghai201805China Division of Hematology Oncology Vanderbilt University Medical CenterNashvilleTN37232USA

Dear editor,Patients with clear-cell renal cell carcinoma(ccRCC)potentially have a high recurrence rate of more than 40%[1].Patients receive radical or partial nephrectomy,sometimes assisted by targeted therapies or/and immune checkpoint inhibitors(ICIs),to improve overall survival(OS)[2].Large-cohort studies and large-scale human tissue sequencing have provided a series of molecular subtyping methods for precision medicine-based ccRCC risk stratification and therapeutic regimens,such as ClearCode34,the prognostic risk predictor[3],and seven subsets for ICI and angiogenesis blockade outcomes[4].However,these subtyping results are all based on human genomes without including the host microbiota,which may be non-negligible genome components.

关键词： editor negligible characteristics