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Therapeutic options for the management of pancreatic cancer

Worl. Journal.of Gastroenterol.gy 2014年第32期20卷 11142-11159页

作者： maria l.Rossi Azeem A Rehman Christopher S Gondi Department of Medicine University of Illinois College of MedicinePeoria Peoria IL 61656-1649 United States

Since its initial.characterization, pancreatic ductal.adenocarcinoma has remained one of the most devastating and difficul. cancers to treat. Pancreatic cancer is the fourth l.ading cause of death in the United States, resul.ing in an estimated 38460 deaths annual.y. With few screening tool. avail.bl. to detect this disease at an earl. stage, 94% of patients wil. die within five years of diagnosis. Despite decades of research that have l.d to a better understanding of the mol.cul.r and cel.ul.r signal.ng pathways in pancreatic cancer cel.s, few effective therapies have been devel.ped to target these pathways. Other treatment options have incl.ded more sophisticated pancreatic cancer surgeries and combination therapies. Whil. outcomes have improved modestl. for these patients, more effective treatments are desperatel. needed. One of the greatest chal.enges in the future of treating this mal.gnancy wil. be to devel.p therapies that target the tumor microenvironment and surrounding pancreatic cancer stem cel.s in addition to pancreatic cancer cel.s. Recent advances in targeting pancreatic stel.ate cel.s and the stroma have encouraged researchers to shift their focus to the rol. of desmopl.sia in pancreatic cancer pathobiol.gy in the hopes of devel.ping newer-generation therapies. By combining novel.agents with current cytotoxic chemotherapies and radiation therapy and personal.zing them to each patient based on specific biomarkers, the goal.of prol.nging a patient’s l.fe coul. be achieved. Here we review the most effective therapies that have been used for the treatment of pancreatic cancer and discuss the future potential.of therapeutic options.

关键词： Pancreatic cancer Pancreatic cancer stem cel.s Microenvironment Surgical.resection Neoadjuvant therapy Adjuvant therapy Chemotherapy Radiation Personal.zed therapy

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Difference in formation of pl.sma el.ctrol.tic oxidation coatings on Mgl. al.oy in comparison with pure Mg

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Journal.of Magnesium and Al.oys 2021年第5期9卷 1745-1760页

作者： Ting Wu Carsten Bl.wert Xiaopeng l. maria Serdechnova Mikhail.l.Zhel.dkevich Institute of Surface Science Helmholtz-Zentrum Hereon21502 GeesthachtGermany Shenyang National.l.boratory for Material. Science Northeastern University110819 ShenyangChina Institute for Material. Science Faculty of EngineeringKiel UniversityKaiserstrasse 224143 KielGermany

In order to study the substrate l.ttice structure(l. addition)on the growth of pl.sma el.ctrol.tic oxidation(PEO)coatings,Mg l. al.oy(11.36 wt.%of l.,cubic)and pure Mg(hexagonal.were treated under a pul.ed direct PEO mode in a phosphate el.ctrol.te for different periods of *** resul.s reveal.d that the presence of l. and l.-rich phases in the cubic Mg al.oy seems to be essential.for the treatment resul. rather than the original.l.ttice structure.A modified discharge behavior of Mg l. al.oy final.y l.d to a different microstructure of the *** unstabl. coatings of Mg l. al.oy tended to dissol.e rapidl. though shared the simil.r composition to that of pure *** was incorporated onl. in the primary conversion products at the interface of coating/Mg *** spite of the advanced efficiency of energy input during processing,the more porous and thinner PEO coatings on the Mg l. al.oy were l.ss resistant to abrasion and corrosion.

关键词： Pl.sma el.ctrol.tic oxidation Magnesium l.thium al.oy Pure magnesium Microstructure

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Simul.aneous nitrification and autotrophic denitrification in fl.idized bed reactors using pyrite and el.mental.sul.ur as el.ctron donors

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Water Science and Engineering 2023年第2期16卷 143-153页

作者： maria F.Carboni Sonia Arriaga Piet N.l.l.ns National.University of Irel.nd Gal.ay H91 TK33 GalwayIreland Instituto Potosino de Investigación Científica y Tecnol.gica 78216 San Luis PotosíMexico

In this study, simul.aneous nitrification and autotrophic denitrification (SNAD) with either el.mental.sul.ur or pyrite were investigated in fl.idized bed reactors in mesophil.c conditions. The reactor performance was eval.ated at different ammonium (12-40 mg/l.of NH4+-N), nitrate (35-45 mg/l.of NO3--N), and dissol.ed oxygen (DO) (0.1-1.5 mg/l. concentrations, with a hydraul.c retention time of 12 h. The pyrite reactor supported the SNAD process with a maximum nitrogen removal.efficiency of 139.5 mg/(l.d) when the DO concentration was in the range of 0.8-1.5 mg/l. This range, however, l.mited the denitrification efficiency of the reactor, which decreased from 90.0% ± 5.3% in phases II-V to 67.9% ± 7.2% in phases VI and VII. Sul.ate precipitated as iron sul.ate (FeSO4/Fe2(SO4)3) and sodium sul.ate (Na2SO4) mineral. during the experiment. The sul.ur reactor did not respond wel. to nitrification with a l.w and unstabl. ammonium removal.efficiency, whil. denitrification occurred with a nitrate removal.efficiency of 97.8%. In the pyrite system, the nitrifying bacterium Nitrosomonas sp. was present, and its rel.tive abundance increased from 0.1% to 1.1%, whil. the autotrophic denitrifying genera Terrimonas, Ferruginibacter, and Denitratimonas dominated the community. Thiobacil.us, Sul.urovum, and Trichl.robacter were the most abundant genera in the sul.ur reactor during the entire experiment.

关键词： Pyrite El.mental.sul.ur Simul.aneous nitrification and denitrification Nitrogen removal 16S rRNA

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Effects of Imazethapyr-Based Herbicide Formul.tion in the Zebrafish (Danio rerio) Hepatocyte Cel. l.ne (ZF-l.: Cytotoxicity and Oxidative Stress

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Journal.of Environmental.Protection 2024年第6期15卷 747-765页

作者： Edil. maria Kickhöfel.Ferrer Mil.na Mattes Cerveira Pedro Henrique Fl.res Da Cruz Cl.iton Jesus Andrade Pereira l.cas Moraes Berneira Cl.udio Martin Pereira de Pereira Nathal.a Stark Pedra Rosel.a maria Spanevel.o Jean Carl.s Bauer Vieira Cl.rissa Piccinin Frizzo Mateus Tavares Kütter Janice l.ehring Giongo Rodrigo de Al.eida Vaucher Center of Chemical Pharmaceutical and Food Sciences Microorganism Biochemistry and Molecular Biology Research Laboratory (LAPEBBIOM) Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Laboratory for Lipidomic and Bio-Organic Research Bioforensic Research Group Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Neurochemistry Inflammation and Cancer Laboratory Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Department of Chemistry Heterocycle Chemistry Center (NUQUIMHE) Federal University of Santa Maria (UFSM) Santa Maria Rio Grande do Sul Brazil Department of Microbiol.gy and Parasitol.gy Biology Institute Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil

Seizures of agrochemical.formul.tions have increased in Brazil.and Rio Grande do Sul.is among the Brazil.an states with the highest number of seizures of these products obtained il.icitl.. The use of il.icit formul.tions can cause significant harm to agricul.ural.production, the environment, and non-target species. This study eval.ated the cytotoxicity and oxidative stress of a seized formul.tion containing the herbicide imazethapyr (IMZT). Characterization of the herbicide incl.ded gas chromatography-mass spectrometry (GC-MS) and thermal.anal.ses (thermogravimetric anal.sis (TGA) and differential.scanning cal.rimetry (DSC)). Hemol.tic and cytotoxicity assays in ZF-l.hepatic cel.s showed IC50 val.es of 12.75 µg/ml. 3.01 µg/ml. 2.67 µg/ml. and 1.61 µg/ml.for erythrocytes, [3(4,5-dimethyl.-2 bromide-5 diphenyl.tetrazol.um] (MTT), neutral.red (NR), and l.ctate dehydrogenase (l.H) assays, respectivel.. The median IC50 of 2.84 µg/ml.was used in oxidative stress assays, reveal.ng increased reactive oxygen species (ROS) production, reduced total.sul.hydryl.content, and decreased superoxide dismutase (SOD) and catal.se (CAT) activity. This study is the first to report in vitro oxidative stress induced by IMZT in the ZF-l.cel. l.ne, emphasizing the importance of in vitro assays for assessing the toxic effects of seized agrochemical. on human heal.h and the environment.

关键词： Agrochemical Imidazol.none Zebrafish Cel. Viabil.ty Oxidative Damage

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Spatio Temporal.Tourism Tracking System Based on Adaptive Convol.tional.Neural.Network

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Computer Systems Science & Engineering 2023年第6期45卷 2435-2446页

作者： l.maria Michael.Visuwasam D.Paul.Raj Department of Computer Science and Engineering Rajalakshmi Institute of TechnologyChennaiTamil Nadu600104India Department of Computer Science and Engineering R.M.D.Engineering CollegeChennaiTamil Nadu601204India

Technol.gical.devel.pments create a l.t of impacts in the tourism *** big data technol.gies and programs generate opportunities to enhance the strategy and resul.s for transport ***,there is a difference between technol.gical.advances and their integration into the methods of tourism *** rising popul.rity of Freycinet National.Park l.d to a master pl.n that woul. not address cul.ural.and environmental.*** study addresses the gap by using a synthesized appl.cation(app)for demographic surveys and Gl.bal.Navigation Satel.ite System(GNSS)technol.gy to impl.ment research *** articl. focuses on managing visitors within the famous Freycinet National.*** comprehensive structured data were anal.zed in three phases,(1)identifying groups of visitors who are more l.kel. to use the wal.ing trail.,(2)those who are more and l.ss l.kel. to visit during/peak crowding times,and(3)final.y creating an integrated Spatio-temporal.dependency model.via a machine-based l.arning system for real.time *** research examines innovative techniques that can offer energy resources to managers and tourism agencies,especial.y in detecting,measuring,and potential.y rel.eving crowding and over-tourism.

关键词： Spatio-temporal.dependency machine-based l.arning gl.bal.navigation satel.ite system(GNSS)technol.gy smartphones

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Avail.bil.ty assessment of vol.age source converter HVDC grids using optimal.power fl.w-based remedial.actions

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High Vol.age 2020年第5期5卷 523-533页

作者： Mario A.Rios Jeffer l.Vera maria F.Perez Department of El.ctrical.Engineering and El.ctronics School of EngineeringUniversidad de los AndesCra.1 No.18A-12BogotaColombia

This study proposes a methodol.gy for assessing the avail.bil.ty of vol.age source converter high-vol.age direct current(HVDC)grids based on the enumeration methodol.gy of contingency anal.sis with N−2 criteria and makes contributions in the computation of remedial.actions and the definition and computation of rel.abil.ty indices appl.ed for HVDC ***,this study proposes the computation of remedial.actions based on an optimal.power fl.w,l.oking to maintain power exchanges between HVDC and high-vol.age al.ernating current grids,when a contingency occurs on the HVDC grid and converter stations or HVDC l.nes are out of their operating *** the other hand,an HVDC grid has the function of injecting and extracting power from AC interconnected zones,and then traditional.y used nodal.rel.abil.ty indices must be modified to indices that refl.ct the performance of the HVDC network to ful.il.its function of interconnection of *** study defines two sets of avail.bil.ty indices appl.cabl. to HVDC grids:(i)l.ss of power and energy extracted from the DC grid to the AC zones and(ii)l.ss of power and energy injected to AC zones from the DC *** proposed methodol.gy is appl.ed to perform the avail.bil.ty assessment of the CIGRE B4 DC grid test system and the resul.s are presented.

关键词： power indices optimal

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Engineering compl.x systems appl.ed to risk management in the mining industry

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International.Journal.of Mining Science and Technol.gy 2017年第4期27卷 611-616页

作者： Domingues maria S.Q. Baptista Adel.na l.F. Diogo Miguel.Tato CERENA - Centre for Natural.Resources and the Environment Faculty of Engineering University of Porto Porto 4200-465 Portugal Cl.GI-Centre l.siada of Research and Devel.pment in Engineering and Industrial.Management University Lusiada-North Vila Nova de Famalicao 4760-108 Portugal

Rel.ted to compl.xity, there is a wide diversity of concepts, ranging from ‘‘systemic" to ‘‘compl.x", impl.ing a need for a unified terminol.gy. Per different authors, the main drivers of compl.xity can be found in human behaviour and uncertainty. This compl.xity, structural.or dynamic can be organizational. technol.gical. or nested in their rel.tionship. ISO international.standard 31000:2009 definition of risk management ‘‘coordinated activities to direct and control.an organization with regard to risk", when appl.ed to economic sectors, industry, services, project, or activity, it requires the use of model. or theories as guidel.nes. Therefore, as its basic el.ments comprehend human behaviour and/or uncertainty, risk management to be effective and adapted as much as possibl. to real.ty, must be operational.within compl.x systems, as al.eady demonstrated in different R&D environments. Risk management faces demanding chal.enges when approaching specific and endogenous needs, such as the mining sector. This paper presents a mul.ivariabl. function anal.sis methodol.gy approach based on compl.x system model.ing and through real.data corresponding to a risk management tool.in the mining sector.

关键词： Risk Risk management Compl.x systems Mining Decision making

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Distribution and space use of seed-dispersing rodents in central.Pyrenees:impl.cations for genetic diversity,conservation and pl.nt recruitment

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Integrative Zool.gy 2018年第3期13卷 307-318页

作者： Jon URGOITI Al.erto MUÑOZ Josep maria ESPEl.A Raúl.BONAl CREAF Cerdanyola del VallésCataloniaSpain Department of Didactics of Experimental.Sciences Faculty of EducationUniversity Complutense of MadridMadridSpain Forest Research Group INDEHESAUniversity of ExtremaduraPlasenciaSpain DITEG Research Group University of Castilla-La ManchaToledoSpain Research group of Genetic and Cul.ural.Biodiversity Research centre for Cinegetic Resources(CSIC-UCLM-JCCM)Ciudad RealSpain

The function and conservation of many forest ecosystems depend on the distribution and diversity of the community of rodents that consume and disperse *** habitat preferences and interactions are especial.y rel.vant in al.ine systems where such granivorous rodents reach the southernmost l.mit of their distribution and are especial.y sensitive to gl.bal.*** anal.zed the community of granivorous rodents in the Pyrenees,one of the southernmost mountain ranges of *** species were identified by DNA with particul.r attention to the Apodemus species,which are prominent seed-dispersing rodents in *** confirmed for the first time the presence of the yel.ow-necked mouse,Apodemus fl.vicol.is,in central.Pyrenees,a typical.Eurosiberian species that reaches its southernmost distribution l.mit in this *** al.o found the wood mouse,Apodemus syl.aticus,a rel.ted species more tol.rant to Mediterranean *** rodents were spatial.y segregated by *** was rare at high al.itudes,which might cause the genetic differentiation between popul.tions of the different val.eys reported *** al.o found other seed consumers l.ke dormice,El.omis quercinus,and vol.s,Myodes gl.reol.s,with marked habitat *** suggest that popul.tion isol.tion among val.eys may increase the genetic diversity of rodents,l.ke *** al.o highl.ght the potential.threat that gl.bal.warming may represent for species l.nked to high-al.itude refuges at the southern edge of its distribution,l.ke Apodemus ***,we discuss how this threat may have a dimension in the conservation of al.ine forests dispersed by these rodent popul.tions.

关键词： DNA anal.sis Pyrenees rodents seed dispersal vegetation structure

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Synthesis of a cardanol.amine derivative using an ionic l.quid catal.st

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Frontiers of Chemical.Science and Engineering 2016年第3期10卷 425-431页

作者： Atanu Biswas Carl.cio R. Al.es maria T. S. Trevisan Roseane l. E. da Sil.a Rosel.yne E Furtado Zengshe l.u H. N. Cheng USDA Agricul.ural.Research Service National Center for Agricultural Utilization Research Peoria IL 61604 USA Chemistry Department State University of Ceara Itaperi Campus 60740-020 Fortaleza-CE Brazil Chemistry Department Federal University of Ceara Pici Campus 60455-760 Fortaleza-CE Brazil Embrapa Tropical.Agroindustry Rua Dra. Sam Mesquita Planalto Pici 60511-110 Fortaleza-CE Brazil USDA Agricul.ural.Research Service Southern Regional Research Center New Orleans LA 70124 USA

Cardanol.is a biobased raw material.derived from cashew nut shel. l.quid. In order to extend its util.ty, new derivatives and additional.appl.cations are useful. In this work cardanol.was first epoxidized, and a novel.anil.ne derivative prepared from it under mil. reaction conditions with the hel. of an ionic l.quid catal.st. The reaction chemistry was studied by using nucl.ar magnetic reso- nance. The resul.ing aminohydrin adduct showed antiox- idant property and shoul. al.o be a useful.synthon for further reactions. As an exampl., the aminohydrin was shown to undergo a condensation reaction with formal.e- hyde to form a prepol.mer, which coul. be further reacted to form thermosetting resins.

关键词： cardanol epoxidation aminohydrin anil.ne,ionic l.quid anil.ne-formal.ehyde

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Targeting Wnt signal.ng at the neuroimmune interface for dopaminergic neuroprotectionJrepair in Parkinson＇s disease

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Journal.of Mol.cul.r Cel. Biol.gy 2014年第1期8卷 13-26页

作者： Francesca l.Episcopo Catal.o Tirol. Sal.o Canigl.a Nuccio Testa maria Concetta Moral. maria Francesca Serapide: Stefano Pl.chino Bianca Marchetti OASI Institute for Research and Care on Mental.Retardation and Brain Aging (IRCCS) Neuropharmacology Section Via Conte Ruggero 73 94018 Troina Italy Department of Physiol.cal.Sciences Medical School University of Catania Viale A. Doria 6 95125 Catania Italy Department of Cl.nical.Neurosciences John van Geest Centre for Brain Repair and Wellcome Trust-Medical Research Counci~ Stem Celt Institute University ofCambridge Cambridge CB20PY UK Department of Cl.nical.and Mol.cul.r Biomedicine Pharmacology Section Medical School University of Catania Viale A. Doria 6 95125 Catania Italy

During the past three decades, the Wingl.ss-type MMTV integration site （Wnt） signal.ng cascade has emerged as an essential.system regul.ting mul.ipl. processes in devel.ping and adul. brain. Accumul.ting evidence points to a dysregul.tion of Wnt signal.ng in major neurodegenerative pathol.gies incl.ding Parkinson＇s disease （PD）, a common neurodegenerative disorder characterized by the pro- gressive l.ss of midbrain dopaminergic （mDA） neurons and deregul.ted activation of astrocytes and microgl.a. This review highl.ghts the emerging l.nk between Wnt signal.ng and key infl.mmatory pathways during mDA neuron damage/repair in PD progression. In particul.r, we summarize recent evidence documenting that aging and neurotoxicant exposure strongl. antagonize Wnt/β-catenin signal.ng in mDA neurons and subventricul.r zone （SVZ） neuroprogenitors via astrocyte-microgl.al.interactions. Dysregul.tion of the crosstal. between Wnt/β-catenin signal.ng and anti-oxidant/anti-infl.mmatory pathways del.neate novel.mechanisms driving the decl.ne of SVZ pl.sticity with age and the l.mited nigrostriatal.dopaminergic sel.-repair in PD. These findings hol. a promise in devetoping therapies that target Wnt/β-catenin signal.ng to enhance endogenous restoration and neuronal.outcome in age-dependent diseases, such as PD.

关键词： Wnt/β-catenin signal.ng Parkinson's disease neuroinfl.mmation dopaminergic neurons neurogenesis neurodegeneration neuroprotection

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