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Matrix metalloproteinases(MMPs)and trophoblast invasion

Chinese Science Bulletin 2005年第12期50卷 1169-1173页

作者： LIJing ZHAOTianfu duanenkui StateKeyLaboratoryofReproductiveBiology InstituteofZoologyChineseAcademyofSciencesBeijing100080China//GraduateSchooloftheChineseAcademyofSciencesBeijing100039China DepartmentofBiology BaodingTeacher'sCollegeBaoding071000China StateKeyLaboratoryofReproductiveBiology InstituteofZoologyChineseAcademyofSciencesBeijing100080China

MMPs and their natural tissue inhibitors TIMPs are crucial in coordinated breakdown and remodel- ing of the extracellular matrix (ECM) in physiological and pathological situations. Placentation is a key event of pregnancy in which MMPs/TIMPs system plays important roles in regulating the extravillus cytotrophoblast (EVTs) invasion. This paper focuses on expression patterns and regulatory mechanisms of MMPs/TIMPs family members during the process of placentation. Their implications in curing pregnancy-related diseases are also discussed.

关键词： MMPs 细胞外矩阵组织抑制剂胚胎入侵胎盘

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Regulation of mouse blastocyst adhesion, outgrowth and secretion of matrix metalloproteinase-2 by cGMP and nitric oxide in vitro

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Chinese Science Bulletin 2004年第11期49卷 1142-1145页

作者： SHENZheng ZHAOxingxu CAOYujing BUShumin LIUWeimin duanenkui CollegeofVeterinaryMedicine GansuAgriculturalUniversityLanzhou730070China StateKeyLaboratoryofReproductiveBiology InstituteofZoologyChineseAcademyofSciencesBeijing100080China

Nitric oxide (NO) is a multifunctional messen-ger molecule produced through oxidation of L-arginine to L-citrulline by enzyme NO synthase (NOS). In the current study, mouse blastocysts were cultured in the different media, and the implantation capacity of blastocyst was evaluated by evaluating the percentage of embryos adhesion and out-growth after culture for 12, 24 or 48 h. Matrix metallopro-teinase-2 (MMP-2) mRNA was detected by RT-PCR, and MMP-2 protein was detected by gelatin zymography. Inhibi-tion of blastocyst adhesion and outgrowth was observed in embryo cultured with 500 mmol/L NOS inhibitor NG-mono- methyl-L-arginine (L-NMMA) alone; however, 100 mmol/L S-nitroso-Nacetylpenicillamine (SNAP), a NO donor, and 20 mmol/L cGMP analogue, 8-Br-cGMP could block this inhibi-tion. The expression and production of MMP-2 in the blas-tocysts were suppressed by L-NMMA, and SNAP or 8-br-cGMP could reverse this suppression. These results suggest that NO induces embryo implantation by cGMP sig-naling pathway.

关键词：基体金属蛋白酶一氧化氮循环鸟苷一磷酸盐粘附生长物植入胚胎

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