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Intelligent Shape-Morphing Micromachines

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Research 2021年第1期2021卷 1018-1033页

作者： Qianying Chen Pengyu Lv Jianyong Huang Tian-yun Huang Huiling duan State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceBIC-ESATCollege of EngineeringPeking UniversityBeijing 100871China CAPT HEDPSPeking UniversityBeijing 100871China

Intelligent machines are capable of switching shape configurations to adapt to changes in dynamic environments and thus have offered the potentials in many applications such as precision medicine,lab on a chip,and *** though the developments of smart materials and advanced micro/nanomanufacturing are flouring,how to achieve intelligent shapemorphing machines at micro/nanoscales is still significantly challenging due to the lack of design methods and strategies especially for small-scale shape *** review is aimed at summarizing the principles and methods for the construction of intelligent shape-morphing micromachines by introducing the dimensions,modes,realization methods,and applications of shape-morphing ***,this review highlights the advantages and challenges in shape transformations by comparing micromachines with the macroscale counterparts and presents the future outlines for the next generation of intelligent shape-morphing micromachines.

关键词： machines realization dimensions

Antithetical impacts of deleterious LRP1B mutations in non-squamous and squamous NSCLCs on predicting benefits from immune checkpoint inhibitor alone or with chemotherapy over chemotherapy alone: retrospective analyses of the POPLAR/OAK and CHOICE-01 trial

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Science China Life Sciences 2025年第1期 249-262页

作者： Jinliang Wang Wenyong Zhou Yu Xu Jianchun duan Qiaoxia Zhou Guoqiang Wang Leo Li Chunwei Xu Wenxian Wang Shangli Cai Zhijie Wang Jie Wang Department of Oncology The Fifth Medical Center of Chinese PLA General Hospital Department of Thoracic Surgery Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong University Burning Rock Biotech CAMS Key Laboratory of Translational Research on Lung Cancer State Key Laboratory of Molecular OncologyDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for ancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)

In non-small cell lung cancers,the non-squamous and squamous subtypes（nsqNSCLC and sqNSCLC） exhibit disparities in pathophysiology,tumor immunology,and potential genomic correlates affecting responses to immune checkpoint inhibitor（ICI）-based *** our inhouse training cohort（n=85）,the presence of the LRP1B deleterious mutation（LRP1B-del） was associated with longer and shorter progression-free survival（PFS） on ICIs alone in nsqNSCLCs and sqNSCLCs,respectively(Pinteraction=0.008).These results were validated using a larger public ICI cohort(n=208,Pinteraction<0.001).Multiplex immunofluorescence staining revealed an association between LRP1B-del and increased and decreased numbers of tumor-infiltrating CD8+T cells in nsqNSCLCs（P=0.040） and sqNSCLCs（P=0.014）,*** the POPLAR/OAK cohort,nsqNSCLCs with LRP1B-del demonstrated improved PFS benefits from atezolizumab over docetaxel(hazard ratio（HR）=0.70,P=0.046),whereas this benefit was negligible in those without LRP1B-del（HR=1.05,P=0.64）.Conversely,sqNSCLCs without LRP1B-del benefited more from atezolizumab（HR=0.60,P=0.002） than those with LRP1B-del（HR=1.30,P=0.31）.Consistent results were observed in the in-house CHOICE-01 cohort,in which nsqNSCLCs with LRP1B-del and sqNSCLCs without LRP1B-del benefited more from toripalimab plus chemotherapy than from chemotherapy alone(Pinteraction=0.008).This multi-cohort study delineates the antithetical impacts of LRP1B-del in nsqNSCLCs and sqNSCLCs on predicting the benefits from ICI alone or with chemotherapy over chemotherapy *** findings highlight the distinct clinical utility of LRP1B-del in guiding treatment choices for nsqNSCLCs and sqNSCLCs,emphasizing the necessity for a detailed analysis based on pathological subtypes when investigating biomarkers for cancer therapeutics.

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三维阴道超声对育龄妇女子宫异常出血的诊断价值

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广东医学院学报 2007年第6期25卷 616-617,623页

作者：罗莉陈莞春贺芝英段学蕴张秀果吕晓亮韩淑珍吴宏广东省东莞市厚街医院妇产科广东东莞523945 广东省东莞市厚街医院超声科广东东莞523945 广东省东莞市厚街医院病理室广东东莞523945

目的探讨三维阴道超声(3D-TVS)对育龄妇女异常子宫出血患者的诊断价值。方法对我院收治的58例育龄妇女子宫异常出血患者进行3D-TVS检查,同时进行三维成像,并与病理检查结果及二维经阴道超声(2D-TVS)结果进行对比分析。结果58例中子宫内... 详细信息

目的探讨三维阴道超声(3D-TVS)对育龄妇女异常子宫出血患者的诊断价值。方法对我院收治的58例育龄妇女子宫异常出血患者进行3D-TVS检查,同时进行三维成像,并与病理检查结果及二维经阴道超声(2D-TVS)结果进行对比分析。结果58例中子宫内膜息肉29例,子宫黏膜下肌瘤11例,宫内节育器(IUD)异常9例,子宫内膜增生过长9例。以病理诊断结果为标准,2D-TVS的诊断符合率为72.4%,3D-TVS的诊断符合率为94.8%,两者差异有统计学意义(X^2=10.641,P<0.01)。结论3D-TVS能直接观察子宫及宫腔病灶的立体形态,能直观显示病灶与内膜、肌层的空间关系,大大提高了诊断的准确率,尤其对宫腔小型病变如黏膜下小肌瘤、内膜息肉的诊断准确率更高。

关键词：经阴道超声三维重建子宫异常出血

基于GC-MS及GC技术对片姜黄挥发油成分的定性定量分析

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中南药学 2019年第3期17卷 426-434页

作者：洪宗超吴和珍杨艳芳柳阳王秀兰段雪云陈树和湖北中医药大学武汉430065 湖北省中医院武汉430061 湖北省中医药研究院武汉430074

目的对片姜黄挥发油成分进行定性定量分析,明确片姜黄挥发油的主要成分及其中10种成分的含量,为进一步研究片姜黄,控制片姜黄质量提供科学依据。方法采用气相色谱-质谱联用、气相色谱法进行定性定量分析,使用Agilent 19091S-433(0.25μm... 详细信息

目的对片姜黄挥发油成分进行定性定量分析,明确片姜黄挥发油的主要成分及其中10种成分的含量,为进一步研究片姜黄,控制片姜黄质量提供科学依据。方法采用气相色谱-质谱联用、气相色谱法进行定性定量分析,使用Agilent 19091S-433(0.25μm×0.25 mm×30 m)及Elite-WAX ETR(0.25μm×0.25 mm×30 m)色谱柱;程序升温:初始温度70℃,保持2 min,以6℃·min^(-1)升至150℃,以8℃·min^(-1)升至230℃,保持15 min;载气流量2.0 mL·min^(-1);分流进样,进样口温度:250℃,进样量1.0μL。GC-MS用载气为高纯氦气(≥99.999%),质谱条件为EI源,轰击电压70 eV,正离子模式,质量扫描范围50～550 amu,离子源温度230℃;GC用载气为高纯氮气(≥99.999%),检测器为FID,检测器温度为280℃。结果分析12个批次的片姜黄挥发油样品后,鉴定了44种成分,并对其中的10种成分进行了GC定量分析,定量结果准确可靠。结论片姜黄挥发油成分复杂,其中主要组成成分为莪术二酮、樟脑、β-榄香烯、异龙脑等物质。气相色谱定量法简单可靠,可用于片姜黄挥发油的质量控制。

关键词：片姜黄挥发油气相色谱-质谱联用气相色谱定性定量分析

New diterpenoid glucosides from Siegesbeckia pubescens

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Chinese Chemical Letters 2001年第1期12卷 51-54页

作者： Jiang XIONG Qi duan JIN yun Long XU Kunming Institute of Botany The Chinese Academy of SciencesKunming 650204

Five new diterpenoids isolated from Siegesbeckia pubescens, pubesides A similar toE, were established as ent-2 alpha ,15,16-trihydroxypimar-8(14)-en-2-O-beta -D-glucopyranoside (1), ent-15,16,19-trihydroxypimar-8(14)-en-19-O-beta -D-glucopyranoside (2), beta -D-glucopyranosyl-ent-15,16-dihydroxypimar-8(14)-en-19-oiclate (3), ent-2-oxo-15,16,19-trihydroxypimar-8(14)-en-19-O-beta -D-gluco-pyranoside (4), ent-2-oxo-15,16,19-trihydroxypimar-8(14)-en-19-O-beta -D-glucopyranoside-15,16-acetonide (5) by 1D and 2D NMR techniques.

关键词： Siegesbeckia pubescens new diterpenoid glucosides pubesides A~E

Hybrid response surface method for system reliability analysis of pilereinforced slopes

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3395-3406页

作者： Xiangrui duan Jie Zhang Leilei Liu Jinzheng Hu Yadong xue Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education and Department of Geotechnical Engineering Tongji UniversityShanghai200092China Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of EducationSchool of Geosciences and Info-PhysicsCentral South UniversityChangsha410083China

To consider the complex soil-structure interaction in a pile-slope system,it is necessary to analyze the performance of pile-slope systems based on a three-dimensional(3D)numerical *** analysis of a pile-slope system based on 3D numerical modeling is very challenging because it is computationally expensive and the performance function of the pile failure mode is only defined in the safe domain of soil *** this paper,an efficient hybrid response surface method is suggested to study the system reliability of pile-reinforced slopes,where the support vector machine and the Kriging model are used to approximate performance functions of soil failure and pile failure,*** versatility of the suggested method is illustrated in detail with an *** the example examined in this paper,it is found that the pile failure can significantly contribute to system failure,and the reinforcement ratio can effectively reduce the probability of pile *** exists a critical reinforcement ratio beyond which the system failure probability is not sensitive to the reinforcement *** pile spacing affects both the probabilities of soil failure and pile failure of the pile-reinforced *** exists an optimal location and an optimal length for the stabilizing piles.

关键词： Slope Piles System reliability Support vector machine Ordinary kriging

A general Boolean semantic modelling approach for complex and intelligent industrial systems in the framework of DES

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Journal of Systems Engineering and Electronics 2024年第5期35卷 1219-1230页

作者： XU Changyi WANG yun duan Yiman ZHANG Chao Key Laboratory of Intelligent Control and Optimization for Industrial Equipment of Ministry of Education School of Control Science and EngineeringDalian University of TechnologyDalian 116024China State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China

Discrete event system(DES)models promote system engineering,including system design,verification,and *** advancement in manufacturing technology has endowed us to fabricate complex industrial ***,the adoption of advanced modeling methodologies adept at handling complexity and scalability is ***,industrial systems are no longer quiescent,thus the intelligent operations of the systems should be dynamically specified in the *** this paper,the composition of the subsystem behaviors is studied to generate the complexity and scalability of the global system model,and a Boolean semantic specifying algorithm is proposed for generating dynamic intelligent operations in the *** traditional modeling approaches,the change or addition of specifications always necessitates the complete resubmission of the system model,a resource-consuming and error-prone *** with traditional approaches,our approach has three remarkable advantages:(i)an established Boolean semantic can be fitful for all kinds of systems;(ii)there is no need to resubmit the system model whenever there is a change or addition of the operations;(iii)multiple specifying tasks can be easily achieved by continuously adding a new ***,this general modeling approach has wide potential for future complex and intelligent industrial systems.

关键词： industrial complex system operation specifying Boolean semantic discrete event system(DES)theory intelligent operation

Effect of electrode change on solidification of slag and metal pool profile in electroslag remelting process

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Journal of Iron and Steel Research International 2021年第12期28卷 1582-1590页

作者： Yi-ru duan Bao-kuan Li xue-chi Huang Zhong-qiu Liu School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina

A two-dimensional axisymmetric model is established to study the effect of electrode change on the solidification of slag and metal pool profile during electroslag remelting *** basic considerations of flow and heat transfer are included in the model,and the growth of ingot is described by the dynamic mesh *** electrode melting rate is predicted based on the transient thermal conductivity model between slag and *** results indicate that in the electrode change stage,the slag temperature drops from 1847 to 1763 K gradually and the“hot heart”phenomenon is *** the metal pool profile is slightly changed with a depth decrease from 0.3984 to 0.3688 *** the heating and melting stage of new electrode,the maximum slag temperature firstly increases from 1763 to 1892 K,then decreases to 1845 K,and finally at 3558 s,the maximum slag temperature is stable at 1884 *** slag shell with a maximum volume of 7.31×10^(-3) m^(3) is formed at the electrode tip,and then,the solidified slag melts *** depth of metal pool firstly rises to 0.3700 m and then drops to 0.3565 *** the preheating temperature of the new electrode increases from 473 to 973 K,the maximum volume of solidified slag decreases from 0.00748 to 0.00592 m^(3),and the time from heating to melting of the new electrode decreases from 996 to 887 s.

关键词： Electroslag remelting Electrode change Metal pool profile Solidified slag Numerical simulation

An asymmetrically substituted dithieno[3,2-b:2',3'-d]pyrrole organic small-molecule hole-transporting material for high-performance perovskite solar cells

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Chinese Journal of Chemical Engineering 2022年第5期35卷 51-57页

作者： Jingwen Jia Yue Zhang Liangsheng duan Quanping Wu Yu Chen Song xue Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control School of Mechanical EngineeringTianjin University of TechnologyTianjin 300384China Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion Department of Applied ChemistryTianjin University of TechnologyTianjin 300384China

Hole-transporting materials play a vital role in terms of the performance of perovskite solar cells(PSCs).The dithieno[3,2-b:2’,3’-d]pyrrole(DTP),an S,N-heterocyclic building block,has been proved to be desirable for molecular design of hole-transporting materials in *** developed an asymmetrically substituted DTP small-molecule(JW12)and a reference compound(JW11).The asymmetrical structure of JW12 leads to different absorption properties and electron *** device in a planar n-i-p architecture using JW12 shows a much higher PCE(18.07%)than that based on JW11(15.46%),which is also better than the device based on spiro-OMe TAD(17.47%).We hope our research can provide a new perspective in molecular design of organic HTMs for perovskite solar cells.

关键词： Hole-transporting materials DTP Perovskite Photovoltaic performance