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Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3651-3671页

作者： Yan Li Li-Na Jiang bo-Kang Zhao Mei-Ling Li Yi-yun Jiang Yi-Si Liu Shu-Hong Liu Li Zhu Xin Ye Jing-Min Zhao Department of Pathology and Hepatology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Department of Hepatology Center of Infectious Diseases and Pathogen BiologyThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina First Department of Liver Disease Center Beijing Youan HospitalCapital Medical UniversityBeijing 100069China Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Savaid Medical School University of Chinese Academy of SciencesBeijing 100190China Department of Pathology The Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

BACKGROUND Hepatocellular carcinoma(HCC)is a major cause of cancer mortality worldwide,and metastasis is the main cause of early recurrence and poor ***,the mechanism of metastasis remains poorly *** To determine the possible mechanism affecting HCC metastasis and provide a possible theoretical basis for HCC *** The candidate molecule lecithin-cholesterol acyltransferase(LCAT)was screened by gene microarray and bioinformatics *** expression levels of LCAT in clinical cohort samples was detected by quantitative realtime polymerase chain reaction and western *** proliferation,migration,invasion and tumor-forming ability were measured by Cell Counting Kit-8,Transwell cell migration,invasion,and clonal formation assays,*** formation was detected in nude mice after LCAT gene knockdown or *** immunohistochemistry for Ki67,E-cadherin,N-cadherin,matrix metalloproteinase 9 and vascular endothelial growth factor were performed in liver tissues to assess the effect of LCAT on *** set enrichment analysis(GSEA)on various gene signatures were analyzed with GSEA version *** machine-learning algorithms(random forest,support vector machine,and logistic regression)were applied to predict HCC metastasis in The Cancer Genome Atlas and GEO *** LCAT was identified as a novel gene relating to HCC metastasis by using gene microarray in HCC *** was significantly downregulated in HCC tissues,which is correlated with recurrence,metastasis and poor outcome of HCC *** analysis indicated that LCAT inhibited HCC cell proliferation,migration and invasion both in vitro and in *** data showed that LCAT was negatively associated with HCC size and metastasis(HCC size≤3 cm vs 3-9 cm,P9 cm,P<0.01;metastatic-free HCC vs extrahepatic metastatic HCC,P<0.05).LCAT suppressed the growth,migration and invasion of HCC cell lines via PI3K/A

关键词： Lecithin-cholesterol acyltransferase Tumor suppressor gene Hepatocellular carcinoma PI3K/AKT/mTOR Predicting model

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MAPK9 as a therapeutic target:unveiling ferroptosis in localized prostate cancer progression

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BIOCELL 2024年第5期48卷 771-792页

作者： CHENG-GONG LUO JIAO ZHANG yun-ZHAO AN XUAN LIU SHUAI-JIE LI WEI ZHANG KAI LI XU ZHAO DONG-bo YUAN LING-YUE AN WEI CHEN YE TIAN BIN XU Department of Urology Guizhou Provincial People’s HospitalGuiyangChina Department of Urology First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Background:Ferroptosis,a lipid peroxidation-mediated programmed cell death,is closely linked to tumor development,including prostate cancer(PCa).Despite established connections between ferroptosis and PCa,a comprehensive investigation is essential for understanding its impact on patient ***:A risk model incorporating four ferroptosis-related genes was developed and *** risk scores correlated with an increased likelihood of biochemical recurrence(BCR),diminished immune infiltration,and adverse clinicopathological *** corroborate these results,we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort(TCGA)and the Gene Expression Synthesis Cohort(GEO).Moreover,we conducted further investigations into the pivotal gene identified in our model to explore its impact on tumor characteristics through cell proliferation and invasion assays,as well as animal studies conducted in ***,we conducted further experiments involving ferroptosis-related analysis to validate its association with ***:The risk model demonstrated exceptional predictive capabilities for prognosis and therapeutic outcomes in PCa ***-activated protein kinase 9(MAPK9)emerged as a crucial gene within the *** vivo and in vitro experiments explored MAPK9’s role in ferroptosis and its influence on tumor migration and ***:The findings provide a novel perspective for advancing ferroptosis exploration in PCa,bridging basic research and clinical applications.

关键词： Ferroptosis Biochemical recurrence Prostate cancer TCGA GEO MAPK9

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IF钢连铸头坯质量的研究

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包钢科技 2022年第2期48卷 12-18页

作者：李彬马鑫段云波宿成内蒙古包钢稀土钢板材有限责任公司内蒙古包头014010

针对某钢厂生产的IF钢,对头坯的表面质量、皮下气泡、中心疏松、中心偏析、氧氮含量和夹杂物进行研究,并对头坯轧制缺陷进行跟踪和采用火焰扒皮处理。研究结果表明:头坯表面质量和皮下气泡均随着铸坯长度的增加而逐步改善;内部质量中心... 详细信息

针对某钢厂生产的IF钢,对头坯的表面质量、皮下气泡、中心疏松、中心偏析、氧氮含量和夹杂物进行研究,并对头坯轧制缺陷进行跟踪和采用火焰扒皮处理。研究结果表明:头坯表面质量和皮下气泡均随着铸坯长度的增加而逐步改善;内部质量中心疏松级别在铸坯长度1 m处存在超标现象,而中心偏析未见异常;氧和氮含量均沿铸坯长度的增加呈降低趋势;夹杂物主要为Al_(2)O_(3)、TiN和Al_(2)O_(3)-TiN复合夹杂物,其数量随着铸坯长度的增加而逐渐减少;在头坯1 m处存在Al_(2)O_(3)-MgO-CaO大型复合夹杂物;头坯轧制缺陷主要为脱氧产物Al_(2)O_(3)类和结晶器液位波动卷渣类的皮下夹杂缺陷;火焰扒皮处理可以有效提高头坯质量。

关键词：超低碳钢连铸头坯夹杂物手工清理洁净度

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Interaction between catechol-O-methyltransferase Val/Met polymorphism and cognitive reserve for negative symptoms in schizophrenia

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World Journal of Psychiatry 2024年第5期14卷 695-703页

作者： Wen-Peng Hou Xiang-Qin Qin Wei-Wei Hou yun-Yi Han Qi-Jing bo Fang Dong Fu-Chun Zhou Xian-Bin Li Chuan-Yue Wang Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders&National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 100088China Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China

BACKGROUND Cognitive reserve(CR)and the catechol-O-methyltransferase(COMT)Val/Met polymorphism are reportedly linked to negative symptoms in ***,the regulatory effect of the COMT genotype on the relationship between CR and negative symptoms is still *** To investigate whether the relationship between CR and negative symptoms could be regulated by the COMT Val/Met *** In a cross-sectional study,54 clinically stable patients with schizophrenia underwent assessments for the COMT genotype,CR,and negative *** was estimated using scores in the information and similarities subtests of a short form of the Chinese version of the Wechsler Adult Intelligence *** COMT Met-carriers exhibited fewer negative symptoms than Val *** the total sample,significant negative correlations were found between negative symptoms and information,*** between information,similarities and negative symptoms were observed in Val homozygotes only,with information and similarities showing interaction effects with the COMT genotype in relation to negative symptoms(information,β=-0.282,95%CI:-0.552 to-0.011,P=0.042;similarities,β=-0.250,95%CI:-0.495 to-0.004,P=0.046).CONCLUSION This study provides initial evidence that the association between negative symptoms and CR is under the regulation of the COMT genotype in schizophrenia.

关键词： Catechol-O-methyltransferase Val/Met polymorphism Cognitive reserve Crystallized intelligence Negative symptoms Schizophrenia

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连铸坯角裂缺陷产生原因及解决对策

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包钢科技 2019年第3期45卷 22-24页

作者：张立通李强段云波内蒙古包钢钢联股份有限公司技术中心内蒙古包头041010 内蒙古包钢钢联股份有限稀土钢板材厂内蒙古包头014010

文章对铸坯角裂缺陷进行了研究,分析了铸坯产生角裂缺陷的工艺、操作因素和设备原因,通过提高钢水质量、调整结晶器冷却水量和二冷水量以及提高在线设备性能、倒角结晶器等一系列改进措施,改善了作用于凝固坯壳上的热应力和机械应力不... 详细信息

文章对铸坯角裂缺陷进行了研究,分析了铸坯产生角裂缺陷的工艺、操作因素和设备原因,通过提高钢水质量、调整结晶器冷却水量和二冷水量以及提高在线设备性能、倒角结晶器等一系列改进措施,改善了作用于凝固坯壳上的热应力和机械应力不均现象,减少了铸坯角部裂纹发生率,提高了连铸板坯质量。

关键词：连铸角部裂纹结晶器二冷

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Correction of microwave pulse reflection by digital filters in superconducting quantum circuits

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Chinese Physics B 2024年第9期33卷 117-123页

作者： Liang-Liang Guo Peng duan Lei Du Hai-Feng Zhang Hao-Ran Tao Yong Chen Xiao-Yan Yang Chi Zhang Zhi-Long Jia Wei-Cheng Kong Zhao-yun Chen Guo-Ping Guo CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Origin Quantum Computing Company Limited Hefei 230088China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China

Reducing the control error is vital for high-fidelity digital and analog quantum *** superconducting circuits,one disagreeable error arises from the reflection of microwave signals due to impedance mismatch in the control ***,we demonstrate a reflection cancelation method when considering that there are two reflection nodes on the control *** propose to generate the pre-distortion pulse by passing the envelopes of the microwave signal through digital filters,which enables real-time reflection correction when integrated into the field-programmable gate array(FPGA).We achieve a reduction of single-qubit gate infidelity from 0.67%to 0.11%after eliminating microwave ***-time correction of microwave reflection paves the way for precise control and manipulation of the qubit state and would ultimately enhance the performance of algorithms and simulations executed on quantum processors.

关键词： reflection cancelation digital filter single-qubit gate superconducting circuit

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Tandem asymmetric dearomatized functionalization reaction of phenols with Evans-ynamides enabled by divergent electrophiles

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Science China Chemistry 2024年

作者： Ying-Qi Zhang Gan-Lu Qian yun Liu Jia-Hui Li Xin Hong Zhou Xu bo Zhou Long-Wu Ye State Key Laboratory of Physical Chemistry of Solid Surfaces Key Laboratory of Chemical Biology of Fujian Province and College of Chemistry and Chemical Engineering Xiamen University Center of Chemistry for Frontier Technologies Department of Chemistry State Key Laboratory of Clean Energy Utilization Zhejiang University Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy School of Pharmacy Xuzhou Medical University State Key Laboratory of Elemento-Organic Chemistry Nankai University State Key Laboratory of Organometallic Chemistry Chinese Academy of Sciences

Herein, we disclose a highly regio-/chemoselective tandem asymmetric dearomatized halofunctionalization reaction of phenoltethered ynamides with diverse electrophilic halogenation sources in a catalyst-free manner for the practical and rapid assembly of a series of halogenated spirocyclic enones. Besides, the related dearomatized selenation and protonation are also achieved,affording the corresponding selenated and protonated spirocycles in high efficiency. Moreover, the enantioselectivities of these products can be perfectly induced by Evans auxiliaries (99%ees). Significantly, this protocol not only represents the first tandem asymmetric halofunctionalization reaction of phenol derivatives, but also constitutes the first asymmetric halogenation/selenation of ynamides. Theoretical calculations indicate a remote induction model of Evans chiral auxiliary-attached keteniminium.

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Human immunodeficiency virus-associated dementia complex with positive 14-3-3 protein in cerebrospinal fluid:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2065-2073页

作者： yun-Sen He Xiao-Hong Qin Min Feng Qin-Jiang Huang Meng-Jun Zhang Li-Li Guo Ming-Bin Bao Ye Tao Hong-Yuan Dai bo Wu Department of Neurosurgery Sichuan Lansheng Brain Hospital&Shanghai Lansheng Brain Hospital Investment Co.Ltd.Chengdu 610036Sichuan ProvinceChina Department of Psychiatry Sichuan Provincial Center for Mental HealthChengdu 610072Sichuan ProvinceChina Department of Geriatrics Municipal People’s Hospital in LuzhouLuzhou 646000Sichuan ProvinceChina Department of Neurosurgery Wenjiang District People’s Hospital of ChengduChengdu 611100Sichuan ProvinceChina Department of Neurosurgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of China ChengduChengdu 610072Sichuan ProvinceChina Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina

BACKGROUND Human immunodeficiency virus(HIV)-associated dementia(HAD)is a subcortical form of dementia characterized by memory deficits and psychomotor ***,HAD often presents with symptoms similar to those of Creutzfeldt-Jakob disease(CJD),particularly in patients with acquired immune deficiency syndrome(AIDS).CASE SUMMARY We report the case of a 54-year-old male who exhibited cognitive dysfunction and secondary behavioral changes following HIV infection and suspected prion *** patient was diagnosed with HIV during hospitalization and his cerebrospinal fluid tested positive for 14-3-3 *** electroencephalogram showed a borderline-abnormal periodic triphasic wave ***-enhanced magnetic resonance imaging revealed moderate encephalatrophy and ***,symptomatic treatment and administration of amantadine were pursued for presumed CJD,but the patient’s condition continued to *** contrast,the patient’s condition improved following anti-HIV *** individual is also the only patient with this prognosis to have survived over 4 ***,the diagnosis was revised to *** In the diagnostic process of rapidly progressive dementia,it is crucial to rule out as many potential causes as possible and to consider an autopsy to diminish diagnostic *** 14-3-3 protein should not be regarded as the definitive marker for *** laboratory screening for infectious diseases is essential to enhance diagnostic precision,especially in AIDS patients with potential ***,a trial of diagnostic treatment may be considered when additional testing is not feasible.

关键词： HIV-associated dementia Cognitive dysfunction Creutzfeld-Jakob disease Rapidly progressive dementia Case report

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Non-flammable long chain phosphate ester based electrolyte via competitive solventized structures for high-performance lithium metal batteries

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Journal of Energy Chemistry 2024年第10期97卷 156-165页

作者： Li Liao Zhiqiang Han Xuanjie Feng Pan Luo Jialin Song Yin Shen Xiaoshuang Luo Xinpeng Li Xuanzhong Wen bo Yu Junchen Chen Bingshu Guo Mingshan Wang yun Huang Hongmei Zhang Mengmeng Yin Jiangtao Liu Yuanhua Lin Xing Li School of New Energy and Materials Southwest Petroleum University Beijing Advanced Innovation Center for Materials Genome Engineering Center for Green Innovation School of Mathematics and Physics University of Science and Technology Beijing State Key Laboratory of Advanced Chemical Power Sources Guizhou Meiling Power Sources Co.Ltd

Safety remains a persistent challenge for high-energy-density lithium metal batteries（LMBs）.The development of safe and non-flammable electrolytes is especially important in harsh conditions such as high ***,a flame-retardant,low-cost and thermally stable long chain phosphate ester based（tributyl phosphate,TBP） electrolyte is reported,which can effectively enhance the cycling stability of highly loaded high-nickel LMBs with high safety through co-solvation *** interfacial compatibility between TBP and electrode is effectively improved using a short-chain ether（glycol dimethyl ether,DME）,and a specially competitive solvation structure is further constructed using lithium borate difluorooxalate（LiDFOB） to form the stable and inorganic-rich electrode *** from the presence of the cathode electrolyte interphase（CEI） and solid electrolyte interphase（SEI） enriched with LiF and LixPOyFz,the electrolyte demonstrates excellent cycling stability assembled using a 50 μm lithium foil anode in combination with a high loading NMC811(15.4 mg cm-2) cathode,with 88% capacity retention after 120 ***,the electrolyte exhibits excellent high-temperature characteristics when used in a 1-Ah pouch cell（N/P=0.26）,and higher thermal runaway temperature（238℃） in the ARC（accelerating rate calorimeter） demonstrating high *** novel electrolyte adopts long-chain phosphate as the main solvent for the first time,and would provide a new idea for the development of extremely high safety and high-temperature electrolytes.

关键词： Battery safety Lithium metal batteries Long chain phosphate ester Non-flammable electrolyte Solvation structure

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基于G-W理论的轮轨三维粗糙表面摩擦生热

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科学技术与工程 2024年第11期24卷 4722-4729页

作者：赵博段志东兰州交通大学土木工程学院兰州730000

为了研究粗糙表面形貌特征对轮轨摩擦副滑动过程中产生的热、温度场和应力场的分布规律及其相互影响,基于G-W模型,将轮轨摩擦副简化为一不同形貌的微凸体粗糙表面与一理想平面,通过数值模拟方法研究了粗糙表面轮轨摩擦过程中热的大小及... 详细信息

为了研究粗糙表面形貌特征对轮轨摩擦副滑动过程中产生的热、温度场和应力场的分布规律及其相互影响,基于G-W模型,将轮轨摩擦副简化为一不同形貌的微凸体粗糙表面与一理想平面,通过数值模拟方法研究了粗糙表面轮轨摩擦过程中热的大小及温度场和应力场的分布规律。结果表明:微凸体之间的相互作用对摩擦生热有影响,随着球冠状微凸体堆叠度的增大,热区分布面积增加,热源减小;微凸体的数量和排布规律对摩擦生热有影响,微凸体横向排布时,摩擦温升随微凸体数量的增加而减小,微凸体纵向排布时,摩擦温升随微凸体数量增加而增大,热区分布向滑动方向后方集中;不同形貌微凸体对对摩擦温升结果也会产生影响,球冠状微凸体粗糙表面摩擦温升总体高于长方体状微凸体摩擦温升。可见,微观层面粗糙表面形貌特征对轮轨摩擦副热源、热区分布、温度场和应力场分布等都会产生影响,为进一步研究轮轨相互作用,保障列车安全运行提供理论依据。

关键词：摩擦接触粗糙表面数值模拟热机耦合轮轨

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