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Biomedical and Environmental Sciences 2022年第5期35卷 448-452页

作者： FAN Ya Hui LI Xin Ling LIU xiao Hua GUO Zhi Feng YAN Meng Qing duan xiao ran MIAO Wen Bin WANG Wei Department of Occupational Health and Occupational Diseases College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Biotherapy Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhou 450052HenanChina Director of Efficacy and Safety Evaluation Laboratory Pony Testing Group Shanghai Co.Ltd.Shanghai 201600China

Organophosphorus pesticides(OPs)are extensively used for their high efficiency,broad spectrum,and low ***,the health hazards caused by long-term,low-dose exposure to OPs are easily *** is a large class of OPs that is widely used in *** inhibition of the cholinesterase(ChE)activity is the main toxicity mechanism of OPs,and such an activity is used as a biomarker of exposure to OPs.

关键词： pesticides China. residue

Relationship between TERT Polymorphism and Telomere Length in Workers Exposed to Omethoate

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Biomedical and Environmental Sciences 2021年第10期34卷 838-841页

作者： CHENG Shuai LIU Bin GUO Zhi Feng duan xiao ran LIU Su Xiang LI Lei YAO Wu YANG Yong Li WANG Wei Department of Occupational Health and Occupational Diseases College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Department of Zhengzhou Institute of Occupational Health Zhengzhou 450053HenanChina Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina The Key Laboratory of Nano medicine and Health Inspection of Zhengzhou Zhengzhou 450001HenanChina

Omethoate is a highly toxic organophosphorus pesticide that is widely used in agricultural production because of its high efficiency,broad spectrum,and low *** phorus pesticides,such as omethoate,can inhibit acetylcho... 详细信息

关键词： residue pesticides spectrum

Benchmark Dose Assessment for Coke Oven Emissions-Induced Mitochondrial DNA Copy Number Damage Effects

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Biomedical and Environmental Sciences 2023年第6期36卷 490-500页

作者： YAN Zhao Fan GU Zhi Guang FAN Ya Hui LI Xin Ling NIU Ze Ming duan xiao ran Mallah Ali Manthar ZHANG Qiao YANG Yong Li YAO Wu WANG Wei Department of Occupational Health and Occupational Diseases College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Department of Toxicology College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina

Objective The study aimed to estimate the benchmark dose(BMD)of coke oven emissions(COEs)exposure based on mitochondrial damage with the mitochondrial DNA copy number(mtDNAcn)as a *** A total of 782 subjects were recruited,including 238 controls and 544 exposed *** mtDNAcn of peripheral leukocytes was detected through the real-time fluorescence-based quantitative polymerase chain *** BMD approaches were used to calculate the BMD of COEs exposure based on the mitochondrial damage and its 95%confidence lower limit(BMDL).Results The mtDNAcn of the exposure group was lower than that of the control group(0.60±0.29 vs.1.03±0.31;P<0.001).A dose-response relationship was shown between the mtDNAcn damage and *** the Benchmark Dose Software,the occupational exposure limits(OELs)for COEs exposure in males was 0.00190 mg/m^(3).The OELs for COEs exposure using the BBMD were 0.00170 mg/m^(3)for the total population,0.00158 mg/m^(3)for males,and 0.00174 mg/m^(3)for *** possible risk obtained from animal studies(PROAST),the OELs of the total population,males,and females were 0.00184,0.00178,and 0.00192 mg/m^(3),*** Based on our conservative estimate,the BMDL of mitochondrial damage caused by COEs is0.002 mg/m^(3).This value will provide a benchmark for determining possible OELs.

关键词： Coke oven emissions Mitochondrial DNA copy number Benchmark dose Occupational exposure limits

《南方车站的聚会》:悲剧人物个体生命价值的自由表达

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电影文学 2020年第19期 24-28页

作者：段晓冉四川电影电视学院电视学院党总支四川电影电视学院编导系

《南方车站的聚会》作为近年中国艺术电影的佳片之一,虽在类型上延续着导演一贯的创作偏好,继续以黑色电影为类型基调,关注社会底层人物的生存意识和生命状态,聚焦他们游走在犯罪边缘或犯罪逃逸时的精神世界;但相较以往,该片最突出的艺... 详细信息

《南方车站的聚会》作为近年中国艺术电影的佳片之一,虽在类型上延续着导演一贯的创作偏好,继续以黑色电影为类型基调,关注社会底层人物的生存意识和生命状态,聚焦他们游走在犯罪边缘或犯罪逃逸时的精神世界;但相较以往,该片最突出的艺术气质呈现在对人的主体性的表达开始由个体深入到对集体的思考,对人的精神世界的展示也表现出从“求生”到“向死”的深层跨越。此外,它也通过营造物质空间的丰富性和仪式感,凸显出电影空间表达的更多可能性。

关键词：《南方车站的聚会》存在主义死本能空间仪式

Preparation and applications of calcium ferrite as a functional material:A review

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 292-310页

作者： Xiuli Han Bowen duan Lei Liu Shilong Fang Weiwei Wang College of Mining Engineering North China University of Science and TechnologyTangshan 063210China Collaborative Innovation Center of Green Development and Ecological Restoration of Mineral Resources of Hebei Province Tangshan 063210China Key Laboratory of Mining Development and Security Technology of Hebei Province Tangshan 063210China

Calcium ferrite(CF)is recognized as a potential green and efficient functional material because of its advantages of magnetism,electrochemistry,catalysis,and biocompatibility in the fields of materials chemistry,environmental engineering,and ***-fore,the obtained research results need to be systematically summarized,and new perspectives on CF and its composite materials need to be *** on the presented studies of CF and its composite materials,the types and structures of the crystal are *** addition,the current application technologies and theoretical mechanisms with various properties in different fields are ***,the various preparation methods of CF and its composite materials are elaborated in *** importantly,the advantages and disadvantages of the synthesis methods of CF and its composite materials are discussed,and the existing problems and emerging challenges in practical production are ***,the key future research directions of CF and its composite materials have been prospected from the potential application technologies to provide references for its synthesis and efficient utilization.

关键词： calcium ferrite mineral functional materials preparation application perspectives

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin duan Feiyang Xing Jun Wu Minmin xiao Fangqing Zhao Jing-Dong J.Han Qi Liu xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

A novel insight into enhanced propane combustion performance on PtUSY catalyst

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Rare Metals 2017年第1期36卷 1-9页

作者： Hui Luo xiao-Dong Wu duan Weng Shuang Liu Rui ran State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Beijing 100084 China The Key Laboratory of Advanced Materials of Ministry of Education School of Materials Science and EngineeringTsinghua University Beijing 100084 China

Platinum was supported on c-AlOand ultrastable Y zeolite(USY) by an incipient wetness impregnation method. The catalysts were characterized by nitrogen physisorption, transmission electron microscopy(TEM),CO/CHisothermal oxidations, NHtemperature-programmed desorption(NH–TPD) and infrared(IR) spectroscopy of adsorbed probe molecules(CO, CHand CH+ O). Compared with Pt/AlO, Pt USY catalyst shows obviously higher activity for the combustion of propane. After estimating the size effect of Pt particles and propane adsorption capacity of USY, the excellent activity of Pt USY is also attributed to the strong interactions between the precious metal and the acidic zeolite. It inhibits the oxidation of Pt in an oxygen-rich atmosphere at high temperatures, which facilitate the initial oxidation step involving the C–H bond activation on metallic Pt as reflected by in situ diffuse reflectance infrared Fouriertransformed(DRIFT) spectra.

关键词： Platinum Zeolite Propane combustion Adsorption Metallic state Acidity

Mechanical properties and microstructure of 3D-printed high Co–Ni secondary hardening steel fabricated by laser melting deposition

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International Journal of Minerals,Metallurgy and Materials 2017年第9期24卷 1027-1033页

作者： Hui-ping duan xiao Liu Xian-zhe ran Jia Li Dong Liu School of Materials Science and Engineering Beihang UniversityBeijing 100191China National Engineering Laboratory of Additive Manufacturing for Large Metallic Components Beijing 100191China Engineering Research Center of Ministry of Education on Laser Direct Manufacturing for Large Metallic Component Beijing 100191China

The mechanical properties and microstructure of the 3D-printed high Co–Ni secondary hardening steel fabricated by the laser melting deposition technique was investigated using a material testing machine and electron microscopy. A microstructure investigation revealed that the samples consist of martensite laths, fine dispersed precipitates, and reverted austenite films at the martensite lath boundaries. The precipitates are enriched with Co and Mo. Because the sample tempered at 486°C has smaller precipitates and a higher number of precipitates per unit area, it exhibits better mechanical properties than the sample tempered at 498°C. Although the 3D-printed samples have the same phase constituents as Aer Met 100 steel, the mechanical properties are slightly worse than those of the commercial wrought Aer Met 100 steel because of the presence of voids.

关键词： laser deposition high strength steel mechanical properties microstructure

Controlled pore size of Pt/KIT-6 used for propane total oxidation

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Rare Metals 2018年第2期37卷 123-128页

作者： Yu-Sheng Chen Yi-Dan Cao Rui ran xiao-Dong Wu duan Weng Key Laboratory of Advanced Materials of Ministry of Education School of Materials Science and EngineeringTsinghua University State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University

Mesoporous silica KIT-6 with different pore sizes was controllably synthesized by hydrothermal meth- ods. The same contents of Pt were loaded on KIT-6 sup- ports to apply for propane total oxidation. Low-angle X-ray diffraction （XRD）, nitrogen adsorption-desorption, CO chemisorption and transmission electron microscopy （TEM） were carried out to investigate the physicochemical properties of the catalysts. The results reveal that different pore sizes of KIT-6 supports could affect the Pt particle sizes on KIT-6. The mesopores on KIT-6-80 and KIT-6- 130 effectively confine the size of the inside Pt nanopar- ticles during calcining. Pt/KIT-6-80 with the appropriate pore size as well as the Pt particle size exhibits the best catalytic performance with T50 （the temperature at which hydrocarbon （HC） conversion reaches 50%） of only 237 ℃. However, Pt particles prefer dispersing on the external surface of KIT-6-40 due to those too small pores.

关键词： Mesoporous silica KIT-6 Pore size Propanetotal oxidation

Regeneration of sintered Rh/ZrO2 catalysts via Rh re-dispersion and Rh–ZrO2 interaction

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Science China(Technological Sciences) 2016年第7期59卷 1023-1028页

作者： WAN Jie CAO YiDan ran Rui LI Min xiao Yi WU xiaoDong WENG duan Key Laboratory of Advanced Materials of Ministry of Education School of Materials Science and Engineering Tsinghua University Beijing 100084 China Haier Group Technique R&D Center Qingdao 266101 China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University Beijing 100084 China

Rh/ZrO2 catalyst was prepared by the impregnation method and then aged in N2 atmosphere with 10% steam at 1050℃ for 12 h. The regeneration of the aged catalyst was examined by slow cooling the catalyst in O2 following preheating at 950℃. The as-prepared, aged, and regenerated catalysts were characterized by X-ray diffraction, Brunauer–Emmett–Teller specific surface area analysis, and（CO＋NO） reaction activity tests, CO chemisorption, and transmission electron microscopy. The results revealed that the Rh species on ZrO2 that underwent severe sintering during the high-temperature aging process could be regenerated by the slow re-oxidation process employed herein. Owing to the remarkable increase in the degree of Rh dispersion after the regeneration process, the activity could be markedly recovered. Further investigations revealed that such a regeneration phenomenon, involving the re-dispersion of the Rh species during the slow cooling process in O2, was strongly related to the phase transformation of the ZrO2 support and the interaction between the Rh and tetragonal ZrO2 species.

关键词： Rhodium zirconia sintering regeneration re-dispersion Rh–Zr interaction