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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li Peng Hao Hongmei duan Fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

Structural Properties of Ions and Polyelectrolytes in Aqueous Solutions under External Electric Fields:The Sign Effect

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Chinese Journal of Polymer Science 2024年第9期42卷 1341-1352,I0007页

作者： Cheng-Jiang Lin Jun-Jun Wang Yuan Jiang shu-Li Chen Hong-Fei Li Wen-Han Zhao Qing-rong Huang Chang-Ru rong Xiao-Zheng duan State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China National Key Laboratory of Advanced Vehicle Integration and Control China FAW Group Co.Ltd.Changchun130013China State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai200438China Department of Food Science Rutgers University65 Dudley RoadNew BrunswickNew Jersey08901USA

We utilize molecular dynamics simulations to investigate the microstructures of ions and polyelectrolytes in aqueous solutions under external electric *** focusing on the multi-body interactions between ionic components and H_(2)O molecules,as well as their responses to the external electric fields,we clarify several nontrivial molecular features of the ionic and polyelectrolyte solutions,such as the solvations of cations and anions,clustering of the ions,and dispersions/aggregations of polyelectrolyte chains,as well as the corresponding responses of H_(2)O molecules in these *** simulations illustrate the variations in structures of ionic solutions caused by reversing the charge sign of the ions,and elucidate the disparity in structures between anionic and cationic polyelectrolyte solutions in the presence of the external electric *** work clarifies the mechanism for the alternations in complex multi-body interactions in aqueous solutions caused by the application electric field,which can contribute to the fundamental understanding of the physical and chemical natures of ion-containing and charged polymeric systems.

关键词： Polyelectrolyte Ions Aqueous solutions External electric fields Asymmetric dipole

对比增强经颅多谱勒超声对心房右向左分流患者的诊断价值的分析

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现代生物医学进展 2019年第18期19卷 3594-3597页

作者：时美欣陈洪苹李国忠段淑荣刚宝芝李国霖哈尔滨医科大学附属第一医院神经内科

目的:比较对比增强经颅多普勒超声与经胸壁超声心动图、经食管超声心动图对心房右→左分流患者的鉴别诊断价值。方法:回顾性分析2014年9月至2018年11月哈尔滨医科大学附属第一医院经手术证实的41例心房右→左分流患者对比增强经颅多普... 详细信息

目的:比较对比增强经颅多普勒超声与经胸壁超声心动图、经食管超声心动图对心房右→左分流患者的鉴别诊断价值。方法:回顾性分析2014年9月至2018年11月哈尔滨医科大学附属第一医院经手术证实的41例心房右→左分流患者对比增强经颅多普勒超声及经胸壁超声心动图的检查所见及诊断结果,并回顾性分析其中29例患者对比增强经颅多普勒超声、经胸壁超声心动图及经食管超声心动图的检查所见及诊断结果。结果:在经手术证实的41例心房右→左分流患者中,对比增强经颅多普勒超声检查阳性结果 41例,阴性结果 0例,诊断准确性为100%;经胸壁超声心动图检查阳性结果 20例,阴性结果 21例,诊断准确性为48.8%。其中,同时进行对比增强经颅多普勒超声、经胸壁超声心动图及经食管超声心动图检查的29例患者中,经胸壁超声心动图阳性结果 12例,阴性结果 17例,诊断准确性为41.4%;经食管超声心动图检查阳性结果 24例,阴性结果 5例,诊断准确性为82.8%。结论:对比增强经颅多普勒超声可提高心房右→左分流的诊断准确率,其与经胸壁超声心动图及经食管超声心动图结合应用可提高心房右→左分流的鉴别诊断能力。

关键词：卵圆孔未闭右→左分流对比增强经颅多普勒超声与经胸壁超声心动图经胸壁超声心动图经食管超声心动图

CHARACTERISTICS OF THE INTERANNUAL AND INTERDECADAL TIMESCALES OF EVAPORATION IN NORTHERN CHINA IN THE RECENT 115 YEARS

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Journal of Hydrodynamics 2006年第5期18卷 593-596页

作者： rong Yan-shu TU Qi-pu duan Li-yao College of Water Resources and Environment Hohai University Nanjing 210098 China Tianjin Institute of Meteorological Science Tianjin 300074 China Tianjin Institute of Meteorological Science Tianjin 300074 China Nanjing University of Information Science and Technology Nanjing 210044 China Tianjin Climate Centre Tianjin 300074 China

Evaporation plays an important role in water balance on the land surface. In Northern China, the evaporation series of the recent 115 years was reconstructed on the basis of Yhornthwaite evaporation formula. The characteristics of the reconstructed series were analyzed using 10-year running mean filter, power spectrum method, and running t-text of abrupt changes on the paper. The results showed that there were remarkable interannual fluctuations with timescales of about quasi-8-year, 3-4-year, and quasi-2-year, and interdecadal oscillations with timescales of 57.5-year, quasi-23-year, and l l.5-year. Meanwhile, the abrupt changes of the evaporation series were also of interdecadal timescale. Either interannual fluctuations or interdecadal oscillations of evaporation were closely related to variations in air temperatures and precipitation.

关键词： reconstructed evaporation series interannual timescale interdecadal timescale Northern China

Cuproptosis: copper-induced regulated cell death

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Science China(Life Sciences) 2022年第8期65卷 1680-1682页

作者： Wen-Jun duan rong-rong He Guangdong Engineering Research Center of Chinese Medicine&Disease Susceptibility Jinan UniversityGuangzhou 510632China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education(MOE) Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research Jinan UniversityGuangzhou 510632China School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632China

“Life is pleasant. Death is peaceful. It's the transition that's troublesome.”——Isaac Asimov Copper is an essential trace element central to cardiovascular, neuronal, and immune functions. While copper deficiency ... 详细信息

关键词： functions copper peace

Microstructures and mechanical properties of a cast Al-Cu-Li alloy during heat treatment procedure

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Rare Metals 2021年第7期40卷 1897-1906页

作者： shu-Wei duan Kenji Matsuda Tao Wang Yong Zou MOE Key Laboratory for Liquid-Solid Structure Evolution and Materials Processing Institute of Materials JoiningShandong UniversityJinan 250061China Department of Materials Science and Technology Faculty of EngineeringUniversity of ToyamaToyama 930-8555Japan

Al-Cu-Li alloy is a huge potential alloy for aerospace industry due to its low density and excellent comprehensive *** this study,the microstructures and mechanical properties of a novel cast Al-Cu-Li alloy during the heat treatment were *** showed that most of the secondary phases along grain boundaries in as-cast state were dissolved into the Al matrix after homogenization and solution treatment,while the Cu-rich phases were slightly segregated once again on grain boundaries after aging.A relatively good combination of strength and ductility(average ultimate tensile strength of 430 MPa and elongation of 8.9%)was obtained after natural *** electron microscopy(TEM)results revealed that there was a complicated precipitate distribution in this cast alloy after natural *** with the similar alloys which introduced dislocations before aging,the density of T1(Al_(2)CuLi)phases was decreased but the size was *** low volume fraction of d0 phase,medium density of needle-shaped precipitates and relativity narrow precipitates-free zone with varying widths near grain boundary are the reasons accounting for the improvement of performances.

关键词： Al-Cu-Li alloy Heat treatment Microstructure Mechanical property Precipitate

On Blocks in Restricted Representations of Lie Superalgebras of Cartan Type

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Acta Mathematica Sinica,English Series 2020年第9期36卷 1061-1075页

作者： Fei Fei duan Bin shu Yu Feng YAO School of Mathematical Sciences Hebei Normal UniversityShijiazhuang 050024P.R.China School of Mathematical Sciences East China Normal UniversityShanghai 200241P.R.China Department of Mathematics Shanghai Maritime UniversityShanghai 201306P.R.China

Let g be a restricted Lie superalgebra of Cartan type W(n),S(n)or H(n)over an alge-braically closed field k of prime characteristic p>3,in the sense of modular version of Kac's definition in *** this note,we show that the restricted representation category over g has only one block(reckoning parities in).This phenomenon is very diff erent from the case of characteristic zero.

关键词： Lie superalgebra of Cartan type restricted representation block

Suppression of self-sustained oscillations of incompressible flow over aperture-cavities and its mechanisms

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Journal of Hydrodynamics 2022年第5期34卷 876-892页

作者： Wen-wen Zhang rong-wu Xu Lin He Jia duan Institute of Vibration and Sound Naval University of EngineeringWuhan430033China National Key Laboratory on Ship Vibration and Noise Naval University of EngineeringWuhan430033China

Experiments and large-eddy simulations(LESs)are conducted to study the effectiveness and the underlying physical mechanisms of a passive control technique for suppressing the self-sustained oscillations of incompressible flow over *** control technique is implemented by installing a wedge block above the chamfered *** experiments are carried out in a low-speed water tunnel with the freestream velocity ranging from 0.4 m/s to 4.4 m/s,while the large-eddy simulations are carried out corresponding to the experiment at a velocity of 4.0 m/*** wall pressure fluctuations measured along the cavity floor show that a significant suppression of the self-sustained oscillations of the shear layers can be achieved by the control ***,the suppression performance is improved as the freestream velocity increases,not limited to the design point of the control *** analysis of numerical simulation results focuses on three aspects,the vorticity fields,the velocity fields and the pressure fields,and the physical effects of the control device on the incompressible aperture-cavity flow are *** mechanisms of suppressing the cavity oscillations are identified from the numerical results,which are the destruction of the large vortex structures by the high frequency vortical excitations,the inhabitation of the intracavity recirculation feedback by introducing the lower shunt flow,and the attenuation of the trailing-edge impingement by thickening the shear layer.

关键词： Cavity oscillations flow control flow-induced noise numerical simulations hydrodynamic noise

Resist nanokirigami for multipurpose patterning

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National Science Review 2022年第11期9卷 68-78页

作者： Qing Liu Yiqin Chen Zhanyong Feng Zhiwen shu Huigao duan National Engineering Research Center for High Efficiency Grinding State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan University

Resist-based patterning solutions play essential roles in modern micro-and nanoscale science and technology. The commonly used 'resist' patterning strategy depends on selective-area scission or cross-linking of resist molecules under the action of an energy beam. In this work, we propose and demonstrate a different resist-patterning strategy, termed 'resist nanokirigami', in which the resist structures are defined by their outlines and revealed by selective mechanical peeling of the unwanted resist *** conventional resist-based patterning processes, the final resist-nanokirigami structures do not undergo exposure and the exposure area is dramatically reduced. With these two advantages, a variety of functional structures that are difficult or impossible to fabricate by conventional processes, such as inverse nanostructures and their oligomers, multi-scale electrodes and freestanding plasmonic nanogaps, can be easily achieved with much higher efficiency. Thus, with its unique and complementary capabilities, the resist-nanokirigami process provides a new patterning solution that expands the family of lithography techniques and will play a significant role in fabricating multi-scale functional structures.

关键词： nanokirigami multi-scale patterning multipurpose patterning electron-beam lithography inverse structure