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Deposition of Small Clusters on Surface: a Molecular Dynamics Simulation

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Chinese Physics Letters 2000年第6期17卷 416-418页

作者： duan Xiang-Mei GONG Xin-Gao zheng Qing-Qi Institute of Solid State Physics Chinese Academy of SciencesHefei 230031

By using the molecular dynamics simulation,we have studied the dynamic behaviors of small energetic clusters deposited on the *** find that,at incident energy as low as 1.0eV/atom,the structure of the cluster is destroyed and cluster atoms form an epitaxial layer above the *** high energy incidence,the site exchange between cluster atom and surface atom is *** effects of the cluster size and orientation are discussed.

关键词： surface. cluster destroyed

Personalized treatment based on mini patient-derived xenografts and WES/RNA sequencing in a patient with metastatic duodenal adenocarcinoma

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Cancer Communications 2018年第1期38卷 586-592页

作者： Peng Zhao Hui Chen Danyi Wen Shuo mou Feifei Zhang Shusen zheng Cancer Biotherapy Center The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003P.R.China Department of General Surgery Zhejiang HospitalHangzhou 310013P.R.China LIDE Biotech Co. LtdShanghaiP.R.China OrigiMed Co. LtdShanghaiP.R.China Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003P.R.China Key Lab of Combined Multi-Organ Transplantation Ministry of Public HealthHangzhouChina

Background:Treatment guidelines for a variety of cancers have been increasingly used in clinical practice,and have resulted in major improvement in patient ***,recommended regimens(even first-line treat-ments)are clearly not ideal for every *** the present study,we used mini patient-derived xenograft(mini-PDX)and next-generation sequencing to develop personalized treatment in a patient with metastatic duodenal ***:Resected metachronous metastatic tumor tissues were implanted into SCID mice to determine the sensitivity to a variety of drug *** profiles were assessed using both DNA whole-exome sequencing(DNA-WES)and RNA *** results of the analyses were used to select optimal treatment for the patient with metastatic duodenal ***:Assessment with mini-PDX models took only 7 *** results showed high sensitivity to S-1 plus cis-platin,gemcitabine plus cisplatin and everolimus *** patient received gemcitabine plus cisplatin initially,but the treatment was terminated due to *** patient was then switched to treatment with S-1 *** overall disease-free survival was 34 ***-WES and RNA sequencing identified KRAS mutation(A146T),TP53(C229Yfs*10)and RICTOR amplification in the metastatic duodenal *** findings provided further support to the results of the mini-PDX,and suggest mTOR inhibitors should be used if and when relapse eventually occurs in this ***:Mini-PDX model combined with WES/RNA sequencing can rapidly assess drug sensitivity in cancer patients and reveal key genetic *** research on this technology for personalized therapy in patients with refractory malignant tumors is warranted.

关键词： Duodenal adenocarcinoma Mini patient-derived xenograft Whole-exome sequencing RNA sequencing Somatic mutation Personalized therapy

Unleash electron transfer in C–H functionalization by mesoporous carbon-supported palladium interstitial catalysts

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National Science Review 2021年第4期8卷 154-166页

作者： Xiaorui Zhao Yueqiang Cao Linlin duan Ruoou Yang zheng Jiang Chao Tian Shangjun Chen Xuezhi duan De Chen Ying Wan Key Laboratory of Resource Chemistry of Ministry of Education Shanghai Key Laboratory of Rare Earth Functional MaterialsDepartment of Chemistry Shanghai Normal University State Key Laboratory of Chemical Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Zhangjiang National Lab Shanghai Advanced Research Institute Chinese Academy of Sciences Department of Chemical Engineering Norwegian University of Science and Technology

The functionalization of otherwise unreactive C–H bonds adds a new dimension to synthetic chemistry,yielding useful molecules for a range of applications. Arylation has emerged as an increasingly viable strategy for functionalization of heteroarenes which constitute an important class of structural moieties for organic materials. However, direct bisarylation of heteroarenes to enable aryl-heteroaryl-aryl bond formation remains a formidable challenge, due to the strong coordination between heteroatom of N or S and transitional metals. Here we report Pd interstitial nanocatalysts supported on ordered mesoporous carbon as catalysts for a direct and highly efficient bisarylation method for five-membered heteroarenes that allows for green and mild reaction conditions. Notably, in the absence of any base, ligands and phase transfer agents, high activity(turn-over frequency, TOF, up to 107 h-1) and selectivity(>99%) for the2,5-bisarylation of five-membered heteroarenes are achieved in water. A combination of characterization reveals that the remarkable catalytic reactivity here is attributable to the parallel adsorption of heteroarene over Pd clusters, which breaks the barrier to electron transfer in traditional homogenous catalysis and creates dual electrophilic sites for aryl radicals and adsorbate at C2 and C5 positions. The d-band filling at Pd sites shows a linear relationship with activation entropy and catalytic activity. The ordered mesopores facilitate the absence of a mass transfer effect. These findings suggest alternative synthesis pathways for the design, synthesis and understanding of a large number of organic chemicals by ordered mesoporous carbon supported palladium catalysts.

关键词： palladium interstitial catalyst ordered mesoporous carbon direct bisarylation multi-site electron transfer d-charge gain

Damage-ignition mechanism studies on modified propellant with different crosslinking density under dynamic loading

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Defence Technology（防务技术） 2023年第10期28卷 155-164页

作者： Hong-zheng duan Yan-qing Wu Xiao Hou Kun Yang Feng-lei Huang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081PR China School of Aerospace Engineering Beijing Institute of TechnologyBeijing100081PR China The Fourth Institute of China Aerospace Science and Technology Corporation Xi'an710025PR China

The study of high-energy and low-vulnerability propellants is important for the power performance and safety of solid propellant rocket *** modified split Hopkinson pressure bar(SHPB)tests are performed on two kinds of propellant with different crosslinking density to study the dynamic mechanical responses and damage-ignition *** apparatus is equipped with a highperformance infrared camera and high-speed camera to capture the deformation,damage-ignition feature and temperature evolution images in the impact *** results suggested that the mechanical responses and damage-ignition mechanism of the propellants were affected by the strain rates and crosslinking *** damage-ignition degree is more intense and the reaction occurs earlier with the increase of strain *** propellant 1 with higher crosslinking density,the critical ignition strain rate is 4500 s^(-1).Two kinds of propellants show different ignition mechanism,*** generation,propagation and final fracture for propellant 1 while viscous shear flow for propellant ***,the SEM images also reveal the difference of damage-ignition mechanism of the two kinds of ***,the ignition mechanism under different strain rates and critical ignition strain rate of propellants are further explained by the theoretical calculation of temperature variations.

关键词： The modified propellants Dynamic loading Mechanical property Damage-ignition mechanism Experimental and theoretical calculation

Event-Triggered-Backstepping-Based Parallel Approaching Guidance Method for Maneuvering Target Interception

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Guidance, Navigation and Control 2022年第1期2卷 77-100页

作者： Yaohua Shen mou Chen Zixuan zheng Hongzhen Guo College of Automation Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China School of Astronautics National Key Laboratory of Aerospace Flight DynamicsNorthwestern Polytechnical UniversityXian 710072P.R.China

In order to achieve a straight ballistic trajectory of missile and reduce the update frequency of the missile normal acceleration for the interception of maneuvering target,a backstepping-based parallel approaching guidance method is designed with nonlinear disturbance observer(NDO)technique and event-triggered(ET)mechanism in this *** order to suppress the adverse e®ect of target maneuver,the NDO is designed to estimate the target maneuvering ***,the NDO-based backstepping method is used to obtain the normal acceleration of missile and realize the parallel approaching *** order to reduce the update frequency of missile normal acceleration,the ET mechanism is employed in the parallel approaching guidance *** the missile trajectory is relatively straight,the normal acceleration of missile remains *** the contrary,if the missile trajectory is not straight,the normal acceleration of missile is updated to make the missile trajectory *** this way,the ET-based parallel approaching guidance can be ***,a determined method for the initial missile°ight-path angle is proposed to keep the normal acceleration of missile at zero in the initial stage of ***,Lyapunov stability analysis method is used to prove that all signals in the closed-loop guidance system are uniformly ultimately ***,simulation results show the e®ectiveness of the proposed guidance method.

关键词： Parallel approaching guidance maneuvering target nonlinear disturbance observer event-triggered mechanism backstepping method

副热带高压控制下一次极端暴雨成因分析及成功预警

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灾害学 2025年第1期40卷 92-101页

作者：郭萍段绍玲郑建萌张万诚陈静杨宏庆中国气象局横断山区(低纬高原)灾害性天气研究中心云南昆明650034 中国气象局大理山地气象野外科学试验基地云南大理671003 云南省气候中心云南昆明650034 云南省气象科学研究所云南昆明650034 云南省临沧市气象局云南临沧677099 中国气象局大理国家气候观象台云南大理671003

2022年10月8日,临沧市双江县忙懦乡遭遇历史性极端暴雨,最大小时雨量达到57.2 mm。该文通过高空、区域自动站雨量、ERA5再分析、FY-2G、多普勒天气雷达等资料综合分析,揭示此次暴雨的成因:①此过程的大尺度环流背景是在强盛的副高控制下... 详细信息

2022年10月8日,临沧市双江县忙懦乡遭遇历史性极端暴雨,最大小时雨量达到57.2 mm。该文通过高空、区域自动站雨量、ERA5再分析、FY-2G、多普勒天气雷达等资料综合分析,揭示此次暴雨的成因:①此过程的大尺度环流背景是在强盛的副高控制下,由中尺度系统触发产生的强降雨。②强降雨期间大气层结不稳定,存在暖湿底层与干冷高层,低抬升凝结高度和自由对流高度;强降雨发生与水汽输送和水汽辐合大值区相对应,低层辐合中高层辐散且与强垂直上升运动区配合。③两个强降雨时段对应不同的雷达回波特征,初时段无大范围的降雨回波,局地出现中-γ尺度对流回波;次时段降雨回波范围扩大,形成列车效应。④忙懦乡的地形和低层东偏南气流对中尺度对流系统的触发与维持起到关键作用。⑤“1262”服务模式提前发出警报,夜间强降雨得以有效预警,避免了人员伤亡,成为预警联动的成功案例。

关键词：极端暴雨副热带高压中尺度系统临沧市递进式气象服务

Nonlocal Imaging by Conditional Averaging of Random Reference Measurements

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Chinese Physics Letters 2012年第7期29卷 152-156页

作者： LUO Kai-Hong HUANG Bo-Qiang zheng Wei-mou WU Ling-An Laboratory of Optical Physics Institute of Physics and Beijing National Laboratory for Condensed Matter PhysicsChinese Academy of SciencesBeijing 100190 Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190

We report the nonlocal imaging of an object by conditional averaging of the random exposure frames of a reference detector,which only sees the freely propagating field from a thermal light source.A bucket detector,synchronized with the reference detector,records the intensity fluctuations of an identical beam passing through the object *** fluctuations are sorted according to their values relative to the mean,then the reference data in the corresponding time-bins for a given fluctuation range are averaged,to produce either positive or negative *** no correlation calculations are involved,this correspondence imaging technique challenges our former interpretations of “ghost” *** with conventional correlation imaging or compressed sensing schemes,both the number of exposures and computation time are greatly reduced,while the visibility is much improved.A simple statistical model is presented to explain the phenomenon.

关键词： identical correspondence frames

Experimental study of drag reduction characteristics related to the multifactor coupling of a bionic jet surface

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Journal of Hydrodynamics 2019年第1期31卷 186-194页

作者： Yun-qing Gu Song-wei Yu Jie-gang mou Tian-xing Fan Shui-hua zheng Gang Zhao College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310014China College of Mechanical and Electrical Engineering Harbin Engineering UniversityHarbin 150001China

To study the drag reduction of a jet surface,an experiment is conducted with a gyrorotor *** aim of this study is to analyze the influence of the jet aperture,the jet angle and the rotational velocity coupled with the jet velocity on the friction torque acting on a jet surface model by using a jet surface drag reduction testing experimental *** drag reduction characteristics of the jet surface are also *** results show that the maximum drag reduction rate is attained when the jet diameter is 5 mm and the jet velocity is 1.2 m/*** influence of the jet velocity on the drag reduction rate decreases as the diameter ***,the maximum drag reduction rate can be attained when the angle of the jet is 30° and the velocity of the jet is 1.0 m/*** the jet diameter is small,the influence of the jet velocity on the drag reduction rate is small,whereas the maximum drag reduction rate is attained when the jet angle is 30° and the jet velocity is 1.0 m/*** the jet angle is 15°,the drag reduction rate fluctuation is *** maximum drag reduction rate is attained when the rotational velocity is 2 100 r/min and the jet velocity is 1.0 m/*** results show that the best scheme is A2B2D3 A maximum drag reduction rate of 8.57% can be *** effective control of the jet effect on the separation of the boundary layer demonstrates the drag reduction principle of a bionic jet surface.

关键词： Drag reduction bionic jet surface friction torque coupling experiment

A Transformer-Based Ensemble Framework for the Prediction of Protein-Protein Interaction Sites

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Research 2024年第2期2023卷 703-718页

作者： Minjie mou Ziqi Pan Zhimeng Zhou Lingyan zheng Hanyu Zhang Shuiyang Shi Fengcheng Li Xiuna Sun Feng Zhu College of Pharmaceutical Sciences The Second Affliated HospitalZhejiang University School of MedicineNational Key Laboratory of Advanced Drug Delivery and Release SystemsZhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University Alibaba-Zhejiang University Joint Research Center of Future Digital HealthcareHangzhou 330110China

The identification of protein-protein interaction (PPI) sites is essential in the research of protein function and the discovery of new drugs. So far, a variety of computational tools based on machine learning have been developed to accelerate the identification of PPI sites. However, existing methods suffer from the low predictive accuracy or the limited scope of application. Specifically, some methods learned only global or local sequential features, leading to low predictive accuracy, while others achieved improved performance by extracting residue interactions from structures but were limited in their application scope for the serious dependence on precise structure information. There is an urgent need to develop a method that integrates comprehensive information to realize proteome-wide accurate profiling of PPI sites. Herein, a novel ensemble framework for PPI sites prediction, EnsemPPIS, was therefore proposed based on transformer and gated convolutional networks. EnsemPPIS can effectively capture not only global and local patterns but also residue interactions. Specifically, EnsemPPIS was unique in (a) extracting residue interactions from protein sequences with transformer and (b) further integrating global and local sequential features with the ensemble learning strategy. Compared with various existing methods, EnsemPPIS exhibited either superior performance or broader applicability on multiple PPI sites prediction tasks. Moreover, pattern analysis based on the interpretability of EnsemPPIS demonstrated that EnsemPPIS was fully capable of learning residue interactions within the local structure of PPI sites using only sequence information. The web server of EnsemPPIS is freely available at http://***/ensemppis.

关键词： residue extracting ensemble