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IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity

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Cellular & Molecular Immunology 2018年第5期15卷 493-505页

作者： Juan Feng lingyi li Zhiying Ou Qiao li Baoyong Gong Zhenxian Zhao Weiwei Qi Ti Zhou Jun zhong weibin Cai Xia Yang Aiping Zhao Guoquan Gao zhonghan Yang Program of Molecular Medicine Affiliated Guangzhou Women and Children’s HospitalZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Institute of Pediatrics Affiliated Guangzhou Women and Children's Medical CenterSun Yat-sen UniversityGuangzhou 510623China Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring InstituteGuangzhou 510063China PancreatoBiliary Surgery First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Engineering and Technology Research Center for Disease-Model Animals SUN Yat-sen UniversityGuangzhou 510006China Department of Radiation Oncology Department of MedicineUniversity of Maryland School of MedicineBaltimoreMD 21201USA

Obesity and associated metabolic diseases are characterized by a chronic low-grade inflammatory state with the infiltration of many inflammatory cells,especially *** molecules,including some cytokines,have a close relationship with ***(IL)-25 is a member of the IL-17 cytokine family that can regulate macrophages and alleviate some metabolic dysfunction;however,its role and mechanisms in lipid metabolism remain to be extensively *** serum and liver biopsy specimens,high-fat diet-induced obesity mice and DB/DB(Lepr−/−)animal models were used to examine IL-25 expression in obesity and nonalcoholic fatty liver diseases(NAFLD).To observe the role of IL-25 in lipid metabolism,model mice were administered with IL-25 or adoptively transferred with IL-25-educated macrophages in vivo,whereas bone marrow-derived macrophages,the macrophage cell line RAW264.7 and adipocytes differentiated from 3T3-L1 were used in ***-25 was decreased in NAFLD patients and obese *** addition,IL-25 reduced body weight gain and lipid accumulation,enhanced lipid uptake by macrophages and increased the expression of lipolysis andβ-oxidation enzymes via alternatively activating ***-25 also promoted lipolysis and suppressed lipogenesis in adipocytes co-cultured with the IL-25-educated ***,IL-25 improved the mitochondrial respiratory capacity and oxygen consumption rate of macrophages and produced more NAD+/NADH and *** conclusion,IL-25 can stimulate M2 macrophage polarization and thereby promote lipolysis and mitochondrial respiratory capacity,highlighting the potential for IL-25 to be used as a therapeutic agent against obesity and associated metabolic syndromes.

关键词： adipocyte immunometabolism IL-25 macrophage obesity

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Mechanoluminescent hybrids from a natural resource for energy-related applications

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InfoMat 2021年第11期3卷 1272-1284页

作者： Chunfeng Wang Ronghua Ma Dengfeng Peng Xianhu liu Jing li Boru Jin Aixian Shan Yu Fu lin Dong wenchao Gao zhong lin Wang Caofeng Pan Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenChina CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijingChina Key Laboratory of Materials Processing and Mold(Ministry of Education) Henan Key Laboratory of Diamond Optoelectronic Materials and DevicesKey Laboratory of Material PhysicsMinistry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhouChina Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Magneto-Photoelectrical Composite and Interface ScienceSchool of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijingChina Department of Civil Engineering Monash UniversityClaytonAustralia

Mechanoluminescent(ML)materials that directly convert mechanical energy into photon emission have emerged as promising candidates for various *** the recent advances in the development of both novel and conventional ML materials,the limited access to ML materials that simultaneously have the attributes of high brightness,low cost,self-recovery,and stability,and the lack of appropriate designs for constructing ML devices represent significant challenges that remain to be addressed to boost the practical application of ML ***,ML hybrids derived from a natural source,waste eggshell,with the aforementioned attributes are *** introduction of the eggshell not only enables the preparation of the hybrid in a simple and cost-effective manner but also contributes to the homochromatism(red,green,or blue emission),high brightness,and robustness of the resultant ML *** significant properties of the ML hybrids,together with the proposed structural design,such as porosity or core–shell structure,could expedite a series of mechanic-optical applications,including the self-luminous shoes for the conversion of human motions into light and light generators that efficiently harvest water wave *** fascinating properties,versatile designs,and the efficient protocol of“turning waste into treasure”of the ML hybrids represent significant advances in ML materials,promising a leap to the practical applications of this flouring material family.

关键词： blue energy harvesting eggshell waste mechanoluminescent hybrids smart sensing

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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A 4-bp Insertion at ZmPLA 1 Encoding a Putative Phospholipase A Generates Haploid Induction in Maize

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Molecular Plant 2017年第3期10卷 520-522页

作者： Chenxu liu Xiang li Dexuan Meng Yu zhong Chen Chen Xin Dong Xiaowei Xu Baojian Chen Wei li liang li Xiaolong Tian Haiming Zhao weibin Song Haishan Luo Qinghua Zhang Jinsheng Lai Weiwei Jin Jianbing Yan Shaojiang Chen National Maize Improvement Center of China Key Laboratory of Crop Heterosis and Utilization (MOE) China Agricultural University No. 2 Yuan Ming Yuan West Road Haidian District Beijing 100193 China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China Maize Research Institute Chongqing Academy of Agricultural Sciences Baishiyi Town Jiulongpo District Chongqing 401329 China These aut-hors contributed equally to this article.

Maize is one of the most important crops in the world and is also an essential raw material for the food, fuel, and fodder industries. Maize hybrids are widely used today, and gain of elite inbred lines is a crucial s... 详细信息

关键词： A 4-bp Insertion ZmPLA1 Encoding Putative Phospholipase

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Distributed Asymptotic Consensus Control of linearly Parameterized Multiagent Systems With Unknown Control Gain

Distributed Asymptotic Consensus Control of Linearly Paramet...

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第36届中国控制会议

作者： Jinglan li wenchao Meng Zhiguang zhong Qinmin Yang The State Key Laboratory of Industrial Control Technology and the College of Control Science and EngineeringZhejiang University Department of Electronics Carleton University College of Science and Technology Ningbo University

ISBN: (纸本)9781538629185

A class of inearly parameterized multiagent systems with unknown parameters and unknown control gain are investigated in this *** adaptive algorithm is implemented for such multiagent systems to obtain *** most previous cases,consensus approaches usually induce uniformly ultimately bounded consensus error because of the uncertainties existing in the system *** contrast,this paper introduces a novel robust consensus algorithm which can ensure that the consensus error converges to zero *** specifically,an adaptive controller will be designed for on-line unknown parameter identification,and a robust continuous term will be applied to ease the effects of the external ***,the control signal is insured continuously to neglect actuator bandwidth requirement and avoid the caused chattering *** that,for multiagent systems studied in this paper,each agent only needs to exchange information with its neighbor agents,i.e.,the proposed consensus algorithm is *** theoretical verification of asymptotic consensus result is given through Lyapunov synthesis and several simulation tests on a linearly parameterized multiagent system are conducted to demonstrate the performance of the algorithm.

关键词： adaptive control consensus distributed control linearly parameterized uncertainty

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践行“两山论”永葆漓江水绿山青

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旅游学刊 2020年第10期35卷 3-4页

作者：林业江钟泓粟维斌桂林旅游学院广西桂林541006

“绿水青山就是金山银山”(简称“两山论”)作为新时代习近平生态哲学思想的核心理念,是我国生态文明建设长期坚持的根本遵循,是对迄今人类与自然关系认识与实践经验教训的总结,是对生态文明时代生产力构成变化趋势的把握,以及在此基础... 详细信息

“绿水青山就是金山银山”(简称“两山论”)作为新时代习近平生态哲学思想的核心理念,是我国生态文明建设长期坚持的根本遵循,是对迄今人类与自然关系认识与实践经验教训的总结,是对生态文明时代生产力构成变化趋势的把握,以及在此基础上对生产力理论的创新与发展,是指导我国生态文明建设的科学的世界观和方法论。“两山论”高度概括了生态环境健康和经济发展繁荣之间的关系,指明了生态文明建设与经济、政治、文化和社会建设的关系,成为指导中国推进生态文明建设的指导思想和生态文明体制改革的重要理念。多年来,广西壮族自治区和桂林市对漓江的保护正是遵循和践行了这一发展理念,使得如今的漓江青山常在、绿水长流。

关键词：生态文明建设生态环境健康水绿山青漓江生态哲学思想指导思想生态文明时代经验教训

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大管径TiO_2纳米管的制备及其光解水性能研究

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功能材料 2015年第18期46卷 18129-18133页

作者：李温超仲小敏杨春艳马卫华南京理工大学化工学院南京210094

采用阳极氧化法制备小管径（20-300nm）的TiO2纳米管已经有很多报道,但大管径的TiO2纳米管的制备还是一个挑战.为制备大管径的TiO2纳米管,研究了高水含量的电解液对纳米管管径的影响.结果表明,纳米管的管径随水含量的增加而增加（8%-12... 详细信息

采用阳极氧化法制备小管径（20-300nm）的TiO2纳米管已经有很多报道,但大管径的TiO2纳米管的制备还是一个挑战.为制备大管径的TiO2纳米管,研究了高水含量的电解液对纳米管管径的影响.结果表明,纳米管的管径随水含量的增加而增加（8%-12%（体积分数））,而水含量增加到13%（体积分数）时,无法得到规则的纳米管,进一步增加水含量到20%（体积分数）,只能得到致密的TiO2 薄膜. 此外,在含有0.3%（质量分数）NH4F 和12%（体积分数）H2O 的乙二醇电解液中,研究了不同氧化电压对纳米管管径的影响.结果表明,在170V 氧化电压下制备的TiO2纳米管的管径可达到600nm.纳米管的光解水性能测试结果表明,管径的增大有利于提高TiO2纳米管的光解水性能.

关键词： TiO2纳米管阳极氧化水含量高电压光解水

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基于ABAQUS的超高层建筑逆作法施工控制研究

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施工技术 2014年第19期43卷 9-12,16页

作者：张忠李维滨沈炜东南大学土木工程学院江苏南京210096

以某高层建筑逆作法项目为研究背景,采用ABAQUS有限元软件对逆作过程进行施工过程的数值模拟分析。对支护结构与主体地下结构相结合的深基坑建立了考虑土、支护结构、水平支撑体系和竖向支承系统共同作用的二维平面有限元模型,采用弹塑... 详细信息

以某高层建筑逆作法项目为研究背景,采用ABAQUS有限元软件对逆作过程进行施工过程的数值模拟分析。对支护结构与主体地下结构相结合的深基坑建立了考虑土、支护结构、水平支撑体系和竖向支承系统共同作用的二维平面有限元模型,采用弹塑性的修正剑桥本构模型模拟基坑开挖过程中土体的非线性特性,分析了地下连续墙水平位移与墙身弯矩随施工过程的变化以及地下连续墙与立柱桩的沉降及其差异沉降。

关键词：高层建筑地下工程逆作法有限元分析施工控制

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静拉爆管施工中的拉力估算

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应用力学学报 2020年第6期37卷 2370-2376,I0005页

作者：钟海晨黄雷马孝春李子明钟伟斌黄峰中国地质大学(北京)工程技术学院北京100083 中国电建集团华东勘测设计研究院有限公司杭州311122

静拉爆管法是非开挖管道更换中的重要方法,其拉力估算对于设备选型和施工成败具有决定性意义。而现有计算理论相对较少,对实际工程参考有限。针对已有公式的不足,结合相关理论,推导并提出了新的静拉爆管施工拉力估算模型,依据受力情况不... 详细信息

静拉爆管法是非开挖管道更换中的重要方法,其拉力估算对于设备选型和施工成败具有决定性意义。而现有计算理论相对较少,对实际工程参考有限。针对已有公式的不足,结合相关理论,推导并提出了新的静拉爆管施工拉力估算模型,依据受力情况不同,将爆管所需的总拉力分为四部分,包括更换管外表面所受摩擦力、爆管头等径部分所受摩擦力、土体对爆管头锥体部分的阻力和原管道对爆管头锥体部分的阻力。为增强适用性,明确了模型中涉及系数的意义并给出了建议值。将模型代入工程实例进行验证对比,发现所提出模型的计算结果介于Ariaratnam-Hahn模型计算结果与实测值之间,与实际情况更为符合。针对更换管超径和管道埋深两主要变量,计算分析拉力值在不同工况下的变化,得到了斜率均匀的线性规律,其中更换管超径大小对拉力值的影响更为显著,是保障安全施工需考虑的关键性因素。

关键词：静拉爆管法拉力估算受力分析管道更换非开挖

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Dicalcium silicate-induced mitochondrial dysfunction and autophagy-mediated macrophagic inflammation promotes osteogenic differentiation of BMSCs

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Regenerative Biomaterials 2022年第1期9卷 93-106页

作者： Qianting Luo Xingyang li wenchao zhong Wei Cao Mingjing Zhu Antong Wu Wanyi Chen Zhitong Ye Qiao Han duraipandy Natarajan Janak L.Pathak Qingbin Zhang Department of Temporomandibular Joint Affiliated Stomatology Hospital of Guangzhou Medical UniversityGuangdong Engineering Research Center of Oral Restoration and ReconstructionGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative MedicineGuangzhou 510182China Jiangmen Central Hospital Affiliated Jiangmen Hospital of Sun Yat-sen UniversityJiangmen 529030China Department of Oral Cell Biology Academic Centre of Dentistry Amsterdam(ACTA)Vrije Universiteit Amsterdam and University of AmsterdamAmsterdam 1081LAThe Netherlands Affiliated Stomatology Hospital of Guangzhou Medical University Guangdong Engineering Research Center of Oral Restoration and ReconstructionGuangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative MedicineGuangzhou 510182China

Dicalcium silicate(Ca_(2)SiO_(4),C_(2)S)has osteogenic potential but induces macrophagic *** function plays a vital role in macrophage polarization and macrophagic *** mitochondrial function of C_(2)S-treated macrophages is still *** study hypothesized:(i)the C_(2)S modulates mitochondrial function and autophagy in macrophages to regulate macro-phagic inflammation,and(ii)C_(2)S-induced macrophagic inflammation regulates *** used RAW264.7 cells as a model of *** C_(2)S(75–150μg/ml)extract was used to analyze the macrophagic mitochondrial function and macrophagemediated effect on osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells(BMSCs).The results showed that C_(2)S extract(150μg/ml)induced TNF-α,IL-1βand IL-6 production in macrophages.C_(2)S extract(150μg/ml)enhanced reactive oxygen species level and intracellular calcium level but reduced mitochondrial membrane potential and ATP *** images showed reduced mitochondrial abundance and altered the mitochondrial morphology in C_(2)S(150μg/ml)-treated *** level expression of PINK1,Parkin,Beclin1 and LC3 was upregulated but TOMM20 was *** sequencing and KEGG analysis showed that C_(2)S-induced differentially expressed mRNAs in macrophages were mainly distributed in the essential signaling pathways involved in mitochondrial function and *** conditioned medium from C_(2)S-treated macrophage robustly promoted osteogenic differentiation in *** conclusion,our results indicate mitochondrial dysfunction and autophagy as the possible mechanism of C_(2)S-induced macrophagic *** promotion of osteogenic differentiation of BMSCs by the C_(2)S-induced macrophagic inflammation suggests the potential application of C_(2)S in developing immunomodulatory bone grafts.

关键词： dicalcium silicate macrophagic inflammation mitochondrial function autophagy osteogenesis

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