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Frontiers of Chemical Science and Engineering 2017年第4期11卷 509-515页

作者： Zhou, Jie du, xuewen Wang, Jiaqing Yamagata, Natsuko Xu, Bing Brandeis Univ Dept Chem Waltham MA 02453 USA

Enzyme-instructed self-assembly （EISA） offers a facile approach to explore the supramolecular assemblies of small molecules in cellular milieu for a variety of biomedical applications. One of the commonly used enzymes is phosphatase, but the study of the substrates of phosphatases mainly focuses on the phos- photyrosine containing peptides. In this work, we examine the EISA of phosphoserine containing small peptides for the first time by designing and synthesizing a series of precursors containing only phosphoserine or both phos- phoserine and phosphotyrosine. Conjugating a phospho- serine to the C-terminal of a well-established self- assembling peptide backbone, （naphthalene-2-1y）-acetyl- diphenylalanine （NapFF）, affords a novel hydrogelation precursor for EISA. The incorporation ofphosphotyrosine, another substrate of phosphatase, into the resulting precursor, provides one more enzymatic trigger on a single molecule, and meanwhile increases the precursors＇ propensity to aggregate after being fully dephosphorylated. Exchanging the positions of phosphorylated serine and tyrosine in the peptide backbone provides insights on how the specific molecular structures influence self-assembling behaviors of small peptides and the subsequent cellular responses. Moreover, the utilization of D-amino acids largely enhances the biostability of the peptides, thus providing a unique soft material for potential biomedical applications.

关键词： enzyme-instructed self-assembly phosphoser-ine phosphatase supramolecular hydrogel

Supramolecular Nanofibers/Hydrogels of the Conjugates of Nucleobase,Saccharide,and Amino Acids

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Chinese Journal of Chemistry 2014年第4期32卷 313-318页

作者： Dongdong Wu xuewen du Junfeng Shi Jie Zhou Bing Xu Department of Chemistry Brandeis University415 South St.WalthamMA 02454USA

Three new hydrogelators based on the conjugates of three naturally occurring biological building blocks:nu-cleobase,saccharide,and amino acids,were *** synthesized via a facile solid phase peptide synthesis route,the hydrogelators self-assemble in water to afford supramolecular nanofibers and *** electron microscopy,oscillation rheometry,and circular dichroism reveal that the hydrogels consist of largely he-lix-based nanofibers of the widths of 5-12 nm and exhibit storage moduli up to 1 *** hydrogelators also exhibit excellent *** work illustrates a new platform for constructing molecular soft materials for nanobiotechnology.

关键词： hydrogelator nucleoside peptide nanofiber

SIMULATION AND EXPERIMENT OF BUBBLY FLOW INSIDE THROTTLING GROOVE

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Chinese Journal of Mechanical Engineering 2007年第5期20卷 37-41页

作者： FU Xin du xuewen ZOU Jun YANG Huayong JI Hong State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China School of Fluid Power and Control Engineering Lanzhou University of Technology Lanzhou 730050. China

The relationship between pressure distribution and cavitation （noise） inside throttling groove is investigated by numerical simulation and experimental method. A valve pocket with several transducers is performed to detect the pressure distributions inside the valve chamber, and the results fit quite well with the computational fluid dynamics（CFD） analysis. High-speed imaging techniques are employed to investigate the cavitation mechanisms, in particular bubble inception and cluster formation near the throttling groove. A spectrum analyzer is used to measure the sound pressure level of noise generated by the bubble flow. It is found that the pressure distributions inside the groove are sensitive to the valve port configuration and back pressure. The pressure distribution determines the bubble size and number passing through the valve grooves and the sound pressure level of noise induced by collapsing bubbles. The inlet pressure mainly affects the saturation degree of bubbly flow inside the groove and the intensity of sound nressure level accordingly.

关键词： Pressure distribution Throuling groove Valve Cavitation Noise

Enzymatic formation of curcumin in vitro and in vivo

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Nano Research 2018年第6期11卷 3453-3461页

作者： Jiaqing wang Taotao Xiong Jie Zhou Hongjian He Dongdong Wu xuewen du Xingyi Li Bing Xu Department of Chemistry Brandeis University 415 South Street Waltham MA 02454 USA Institute of Biomedical Engineering School of Ophthalmology & Optometry and Eye Hospital Wenzhou Medical University 270 Xueyuan Road Wenzhou 325027 China

The recent classification of curcumin （Cur） as a pan-assay interference compound （PAINS） and an invalid metabolic panaceas （IMPS） candidate demonstrated the controversial nature of Cur as a drug lead owing to its aggregation in aqueous phase and inherent instability in vivo. Here, we report a simple prodrug approach to generate nanoparticles of Cur in situ that allow it to function reproducibly as an anticancer and an anti-inflammatory agent. Diphosphorylated curcumin （Cur-2p）, a precursor of Cur and a substrate of alkaline phosphatase （ALP）, exhibited drastically improved chemical stability and low aggregation in water. After conversion to curcumin around or inside cancer cells by ALP, Cur-2p selectively inhibited cancer cells that overexpressed ALP, but did not affect normal cells. Moreover, the intravitreal injection of Cur-2p resulted in excellent intraocular biocompatibility with no apparent damage to the morphology and visual function of retina, as shown by fundus imaging, optical coherence tomography （OCT）, and histological observation. A rodent model of uveitis showed that Cur-2p significantly suppressed the inflammation response compared with Cur. As a rational approach to investigate and apply PAINS and IMPS candidates, this work presents a straightforward method to maximize the potential of drug leads and ultimately fulfil the promises and potential clinical benefits of PAINS and IMPS candidates.

关键词： enzymatic formation curcumin nanoparticles drug discovery anti-cancer anti-inflammatory

人文情怀与命运共同体——刘慈欣小说中的人类及其命运

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小说评论 2019年第3期 142-151页

作者：杜学文山西省作家协会

刘慈欣在其恢弘的《三体Ⅱ黑暗森林》的结尾,描写了一段地球人类--罗辑与三体人--两个半世纪前接收并隐藏了人类信号的1379号监听员的一段对话。这位长期处于脱水状态的三体人告诉在威慑打击中暂时拯救了人类的面壁者英雄罗辑,三体世界... 详细信息

刘慈欣在其恢弘的《三体Ⅱ黑暗森林》的结尾,描写了一段地球人类--罗辑与三体人--两个半世纪前接收并隐藏了人类信号的1379号监听员的一段对话。这位长期处于脱水状态的三体人告诉在威慑打击中暂时拯救了人类的面壁者英雄罗辑,三体世界也是有爱的。只是因为这种情感不利于三体文明的整体生存被压抑在萌芽状态。

关键词：刘慈欣人类人文情怀共同体小说状态英雄

京与都:时间维度中的空间意义--关于邱华栋的《北京传》

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扬子江文学评论 2022年第4期 91-96页

作者：杜学文山西省作家协会

近来,城市传的写作有若干作品出现,邱华栋的《北京传》应该是比较突出的一部。这主要是由于作者在结构作品时有自己独特的追求,形成了具有独创意义的文本。国外的城市传也多有影响较大者,如英国历史学家科林·琼斯的《巴黎传》。其视野... 详细信息

近来,城市传的写作有若干作品出现,邱华栋的《北京传》应该是比较突出的一部。这主要是由于作者在结构作品时有自己独特的追求,形成了具有独创意义的文本。国外的城市传也多有影响较大者,如英国历史学家科林·琼斯的《巴黎传》。其视野宏阔,涉及面广,突出了巴黎以及法国在不同历史时期的社会风貌。其中既关涉政治、军事、经济,也有文化、宗教与人们的日常生活。应该说,这是一部透过巴黎看法国的城市史。因为“作为‘法兰西的缩影’,巴黎长期处在法国政治、经济、文化活动的中心”。a不过,也存在一个问题,就是对于巴黎的城市形态是怎样的,科林·琼斯似乎语焉不详。

关键词：邱华栋英国历史学家空间意义社会风貌时间维度城市形态科林法兰西

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中国式现代化进程中文学艺术的历史性演变刍论

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中国文艺评论 2023年第6期 14-26,I0002页

作者：杜学文山西省文艺评论家协会

尽管现代化是一种全球性的历史潮流,但就具体国家而言,其发展态势却有很大的区别。向先发国家学习,汲取其经验教训是非常重要的,但这并不等于一切以其为标准。我们也不可能使现代化进程中的文学艺术演变成“唯一”的形态。随着生产力的... 详细信息

尽管现代化是一种全球性的历史潮流,但就具体国家而言,其发展态势却有很大的区别。向先发国家学习,汲取其经验教训是非常重要的,但这并不等于一切以其为标准。我们也不可能使现代化进程中的文学艺术演变成“唯一”的形态。随着生产力的发展,对文学艺术的外在形态产生了重要影响,也对其创作形态产生了重要影响。中国的文学艺术一直表现出最为敏感、最具主动性的状态,对中国实现现代化的历史进程有着极为自觉的表现,其表现手法亦与之前的“传统”不同,呈现出更加丰富生动的多样性。

关键词：中国式现代化现代化创作形态中国文学艺术多样性

Ghost Module Based Residual Mixture of Self-Attention and Convolution for Online Signature Verification

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Computers, Materials & Continua 2024年第4期79卷 695-712页

作者： Fangjun Luan xuewen Mu Shuai Yuan Department of Computer Technology School of Computer Science and EngineeringShenyang Jianzhu UniversityShenyang110168China Liaoning Province Big Data Management and Analysis Laboratory of Urban Construction Shenyang Jianzhu UniversityShenyang110168China Shenyang Branch of National Special Computer Engineering Technology Research Center Shenyang Jianzhu UniversityShenyang110168China

Online Signature Verification (OSV), as a personal identification technology, is widely used in various ***, it faces challenges, such as incomplete feature extraction, low accuracy, and computational heaviness. Toaddress these issues, we propose a novel approach for online signature verification, using a one-dimensionalGhost-ACmix Residual Network (1D-ACGRNet), which is a Ghost-ACmix Residual Network that combines convolutionwith a self-attention mechanism and performs improvement by using Ghost method. The Ghost-ACmix Residualstructure is introduced to leverage both self-attention and convolution mechanisms for capturing global featureinformation and extracting local information, effectively complementing whole and local signature features andmitigating the problem of insufficient feature extraction. Then, the Ghost-based Convolution and Self-Attention(ACG) block is proposed to simplify the common parts between convolution and self-attention using the Ghostmodule and employ feature transformation to obtain intermediate features, thus reducing computational ***, feature selection is performed using the random forestmethod, and the data is dimensionally reducedusing Principal Component Analysis (PCA). Finally, tests are implemented on the MCYT-100 datasets and theSVC-2004 Task2 datasets, and the equal error rates (EERs) for small-sample training using five genuine andforged signatures are 3.07% and 4.17%, respectively. The EERs for training with ten genuine and forged signaturesare 0.91% and 2.12% on the respective datasets. The experimental results illustrate that the proposed approacheffectively enhances the accuracy of online signature verification.

关键词： Online signature verification feature selection ACG block ghost-ACmix residual structure

Visual observation of photonic Floquet–Bloch oscillations

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Light(Science & Applications) 2024年第5期13卷 921-929页

作者： Zhen Zhang Yuan Li Xiankai Sun xuewen Shu Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhanHubei 430074China Department of Electronic Engineering The Chinese University of Hong KongShatinNew TerritoriesHong Kong SARChina

Bloch oscillations(BOs),an important transport phenomenon,have been studied extensively in static systems but remain mysterious in Floquet ***,by harnessing notions from photonic analogy,we propose a generalization of the existing BOs in photonic Floquet lattices,namely the“photonic Floquet–Bloch oscillations”,which refer to rescaled photonic Bloch oscillations with a period of extended least common multiple of the modulation period and the Bloch oscillation ***,we report the first visual observation of such photonic Floquet–Bloch oscillations(FBOs)by employing waveguide fluorescence *** significantly,the FBOs surpass the existing BOs in Floquet systems and exhibit exotic properties on their own,including fractal spectrum and fractional Floquet *** new transport mechanism offers an intriguing method of wave manipulation that may contribute to rapidly developing fields in photonics,condensed matter physics,and quantum physics.

关键词： Bloch analogy generalization

TIPE2 is Essential for Apocynin-mediated Protection against Intestinal Ischemia/Reperfusion-induced Acute Lung Injury

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Biomedical and Environmental Sciences 2024年第8期37卷 936-942页

作者： Huirong Jing Wenyan Jia xuewen Tang Affiliated Banan Hospital of Chongqing Medical University Chongqing 401320China Chongqing Traditional Chinese Medicine Hospital Chongqing 400021China Qingdao Municipal Hospital Qingdao 266000ShandongChina Healthy Management&Physical Examination Center The Affiliated Hospital of Qingdao UniversityQingdao 266000ShandongChina

Intestinal ischemia/reperfusion(II/R)is a severe clinical circumstance which is frequently apparent in situations including midgut volvulus,superior mesenteric vessels closure and hemorrhagic ***/R not only brings about severe intestinal local damage but also leads to remote organs injury including lung,liver etc[1].Lung injury is the most common and severe complications which manifested as pulmonary susceptibility,respiratory dysfunction,and even acute respiratory distress syndrome(ARDS)[2].

关键词： Lung respiratory organs