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Upregulation of circ0000381 atienuates microglial/macrophage pyroptosis after spinal cord injury

Neural Regeneration Research 2024年第6期19卷 1360-1366页

作者： Yan Zhang Wenkai Zhang Tao Liu Ziqian Ma Wenxiu Zhang Yun Guan xueming Chen Central Laboratory Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Orthopedics Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Emergency Medicine Aerospace Center HospitalBeijingChina Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Neurological Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA

Neuroinflammation exacerbates secondary damage after spinal cord injury,while microglia/macrophage pyroptosis is important to *** RNAs(circRNAs)play a role in the central nervous ***,the functional role and mechanism of circRNAs in regulating microglia/macrophage pyroptosis after spinal cord injury are still poorly *** the present study,we detected microglia/macrophage pyroptosis in a female rat model of spinal cord injury,along with upregulated levels of circ0000381 in the spinal *** further experimental results suggest that circ0000381 may function as a sponge to sequester endogenous microRNA423-3p(miR-423-3p),which can increase the expression of NOD-like receptor 3(NLRP3),a pyroptosis ***,upregulation of circ0000381 may be a compensatory change after spinal cord injury to attenuate microglia/macrophage ***,knockdown of circ0000381 expression exacerbated microglia/macrophage ***,our findings provide novel evidence for the upregulation of circ0000381,which may serve as a neuroprotective mechanism to attenuate microglia/macrophage pyroptosis after spinal cord ***,circ0000381 may be a novel therapeutic target for the treatment of spinal cord injury.

关键词： circ0000381 inflammasome macrophage microglia miR-423-3p neuroinflammation neuroprotection NLRP3 pyroptosis RNA-Seq spinal cord injury

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An Ontology Reasoning Architecture for Data Mining Knowledge Management

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Wuhan University Journal of Natural Sciences 2008年第4期13卷 396-400页

作者： ZHENG Liang LI xueming College of Computer Science Chongqing UniversityChongqing 400044 China

In order to realize the intelligent management of data mining （DM） domain knowledge, this paper presents an architecture for DM knowledge management based on ontology. Using ontology database, this architecture can realize intelligent knowledge retrieval and automatic accomplishment of DM tasks by means of ontology services. Its key features include：①Describing DM ontology and meta-data using ontology based on Web ontology language （OWL）.② Ontology reasoning function. Based on the existing concepts and relations, the hidden knowledge in ontology can be obtained using the reasoning engine. This paper mainly focuses on the construction of DM ontology and the reasoning of DM ontology based on OWL DL（s）.

关键词： ontology data mining knowledge management ontology reasoning

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Variation of Antarctic marginal ice zone extent (1989-2019)

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Advances in Polar Science 2021年第4期32卷 341-355页

作者： WANG Miaojiang LIU Tingting YANG Zijian WU Bing ZHU xueming Changzhou Xinbei Natural Resources and Planning Technical Support Center Changzhou 213001China Chinese Antarctic Center of Surveying and Mapping Wuhan UniversityWuhan 430072China

The Antarctic marginal ice zone(MIZ)is the transition region between open water and consolidated pack ice,which is defined as an area with 15%-80%sea ice *** MIZ represents the outer circle of Antarctic sea ice and the biological activity circle of Antarctic organisms,which provides a direct indication of the extent of Antarctic sea *** this study,the joint total variation and nonnegative constrained least square algorithm are applied to retrieve the Antarctic MIZ extent based on passive microwave data sets from 1989 to *** spatial and temporal variations of the Antarctic MIZ extent and five regions are *** results show that the Antarctic MIZ extent follows a strong monthly variation pattern,decreasing from November to February and increasing from March to *** annual MIZ extent is largest in the Weddell Sea and smallest in the Western Pacific *** edge of the sea ice begins to form a closed ring in May,which eventually closes near the Antarctic *** ring width variation is large in summer,but generally stabilizes between 350 and 370 km in *** average latitude of the Antarctic MIZ is relatively stable in summer,but changes substantially in winter with a difference of approximately 3°.In October,the lowest mean latitude of the MIZ can reach 64.35°*** sea surface pressure,2-m temperature,and 10-m wind speed are negatively correlated with the MIZ extent variation,among which the second-order partial correlation coefficient of the sea surface pressure and MIZ extent is−0.8773 in the Western Pacific Ocean.

关键词： Antarctic marginal ice zone passive microwave data retrieval algorithm correlation analysis variation

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Identification and expression profiles of gustatory receptor genes in Bactrocera minax larvae(Diptera:Tephritidae):Role of BminGR59f in larval growth

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Insect Science 2022年第5期29卷 1240-1250页

作者： Guijian Zhang Shuai Cao Tong Guo Haoran Wang Xuewei Qi xueming Ren Changying Niu Hubei Key Laboratory of Insect Resource Application and Sustainable Pest Control College of Plant Science&TechnologyHuazhong Agricultural UniversityWuhanChina

Insects employ various types of gustatory receptors(GRs)to identify nutrient-rich food and avoid toxic *** larval gustatory system is the critical checkpoint for food acceptance or *** a specialist herbivore,the larvae of Bactrocera minax feed only on unripe citrus ***,how larvae use GRs to check and adapt to the secondary metabolites in unripe citrus fruits remains *** this study,we first performed developmental expression profiles showing that most BminGRs genes were highly expressed in 1st and 2nd instar larvae and that tissue-specific expression indicated high expression of most BminGRs genes in the mouthparts of 2nd instar ***,we found that silencing BminGR59f by RNA interference(RNAi)affected the growth of 2nd instar *** *** and naringin were screened as ligands of BminGR59f via RNAi and cell calcium imaging,and the combination of these two flavones increased the body weight of *** summary,we identified a novel gustatory perception pattern in *** for detecting hesperidin and naringin,which boosted the growth of *** *** results shed light on how specialist herbivores detect and adapt to host metbolites in adverse environments depending on larval GRs.

关键词： gustatory receptors secondary metabolites specialist herbivores tephritid unripe citrus fruits

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Recent improvements to the physical model of the Bohai Sea,the Yellow Sea and the East China Sea Operational Oceanography Forecasting System

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Acta Oceanologica Sinica 2021年第11期40卷 87-103页

作者： Ang Li xueming Zhu Yunfei Zhang Shihe Ren Miaoyin Zhang Ziqing Zu Hui Wang Key Laboratory of Marine Hazards Forecasting National Marine Environmental Forecasting CenterMinistry of Natural ResourcesBeijing 100081China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519000China

In order to satisfy the increasing demand for the marine forecasting capacity,the Bohai Sea,the Yellow Sea and the East China Sea Operational Oceanography Forecasting System(BYEOFS)has been upgraded and improved to Version *** on the Regional Ocean Modeling System(ROMS),a series of comparative experiments were conducted during the improvement process,including correcting topography,changing sea surface atmospheric forcing mode,adjusting open boundary conditions,and considering atmospheric pressure correction.(1)After the topography correction,the volume transport and meridional velocity maximum of Yellow Sea Warm Current increase obviously and the unreasonable bending of its axis around 36.1°N,123.5°E disappears.(2)After the change of sea surface forcing mode,an effective negative feedback mechanism is formed between predicted sea surface temperature(SST)by the ocean model and sea surface radiation fluxes *** simulation errors of SST decreased significantly,and the annual average of root-mean-square error(RMSE)decreased by about 18%.(3)The change of the eastern lateral boundary condition of baroclinic velocity from mixed Radiation-Nudging to Clamped makes the unreasonable westward current in Tsushima Strait disappear.(4)The adding of mean sea level pressure correction option which forms the mean sea level gradient from the Bohai Sea and the Yellow Sea to the western Pacific in winter and autumn is helpful to increasing the fluctuation of SLA and outflow of the Yellow Sea when the cold high air pressure system controls the Yellow Sea area.

关键词： Operational Oceanography Forecasting System East China Sea SST Yellow Sea Warm Current

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The 2012 Flash Drought Threatened US Midwest Agroecosystems

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Chinese Geographical Science 2019年第5期29卷 768-783页

作者： JIN Cui LUO Xue XIAO Xiangming DONG Jinwei LI xueming YANG Jun ZHAO Deyu College of Urban and Environment Liaoning Normal UniversityDalian116029China Department of Microbiology and PlantBiology Center for Spatial AnalysisUniversity of OklahomaNormanOK73019USA Ministry of Education Key Laboratory ofBiodiversity Science and Ecological Engineering Institute of Biodiversity ScienceFudan UniversityShanghai200433China KeyLaboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academyof SciencesBeijing100101China

In the summer of 2012, the US Midwest, the most productive agricultural region in the world, experienced the most intense and widespread drought on record for the past hundred years. The 2012 drought, characterized as ‘flash drought’, developed in May with a rapid intensification afterwards, and peaked in mid-July. ~76% of crop region and 60% of grassland and pasture regions have been under moderate to severe dry conditions. This study used multiple lines of evidences, i.e., in-situ AmeriFlux measurements, spatial satellite observations, and scaled ecosystem modeling, to provide independent and complementary analysis on the impact of 2012 flash drought on the US Midwest vegetation greenness and photosynthesis carbon uptake. Three datasets consistently showed that 1) phenological activities of all biomes advanced 1–2 weeks earlier in 2012 compared to the other years of 2010–2014;2) the drought had a more severe impact on agroecosystems(crop and grassland) than on forests;3) the growth of crop and grassland was suppressed from June with significant reduction of vegetation index, sun-induced fluorescence(SIF) and gross primary production(GPP), and did not recover until the end of growing season. The modeling results showed that regional total GPP in 2012 was the lowest(1.76 Pg C/yr) during 2010–2014, and decreased by 63 Tg C compared with the other-year mean. Agroecosystems, accounting for 84% of regional GPP assimilation, were the most impacted by 2012 drought with total GPP reduction of 9%, 7%, 6%, and 29% for maize, soybean, cropland, and grassland, respectively. The frequency and severity of droughts have been predicted to increase in future. The results imply the importance to investigate the influences of flash droughts on vegetation productivity and terrestrial carbon cycling.

关键词： food security terrestrial carbon cycling eddy covariance Vegetation Photosynthesis Model sun-induced fluorescence(SIF)

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Merkle Tree Digital Signature and Trusted Computing Platform

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Wuhan University Journal of Natural Sciences 2006年第6期11卷 1467-1472页

作者： WANG Xiaofei HONG Fan TANG xueming CUI Guohua College of Computer Science and Technology Huazhong University of Science and Technology Wuhan 430074 Hubei China

Lack of efficiency in the initial key generation process is a serious shortcoming of Merkle tree signature scheme with a large number of possible signatures. Based on two kinds of Merkle trees, a new tree type signature scheme is constructed, and it is provably existentially unforgeable under adaptive chosen message attack. By decentralizing the initial key generation process of the original scheme within the signature process, a large Merkle tree with 6.87×10^10 possible signatures can be initialized in 590 milliseconds. Storing some small Merkle trees in hard disk and memory can speed up Merkle tree signature scheme. Mekle tree signature schemes are fit for trusted computing platform in most scenarios.

关键词： digital signature one-time signature Merkle tree trusted computing platform

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Assimilating operational SST and sea ice analysis data into an operational circulation model for the coastal seas of China

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Acta Oceanologica Sinica 2015年第7期34卷 54-64页

作者： JI Qiyan ZHU xueming WANG Hui LIU Guimei GAO Shan JI Xuanliang XU Qing Key Laboratory of Ministry of Education for Coastal Disaster and Defence Hohai University Key Laboratory of Research on Marine Hazards Forecasting National Marine Environmental Forecasting CenterState Oceanic Administration

The prediction of sea surface temperature （SST） is an essential task for an operational ocean circulation model. A sea surface heat flux, an initial temperature field, and boundary conditions directly affect the accuracy of a SST simulation. Here two quick and convenient data assimilation methods are employed to improve the SST simulation in the domain of the Bohai Sea, the Yellow Sea and the East China Sea （BYECS）. One is based on a surface net heat flux correction, named as Qcorrection （QC）, which nudges the flux correction to the model equation; the other is ensemble optimal interpolation （EnOI）, which optimizes the model initial field. Based on such two methods, the SST data obtained from the operational SST and sea ice analysis （OSTIA） system are assimilated into an operational circulation model for the coastal seas of China. The results of the simulated SST based on four experiments, in 2011, have been analyzed. By comparing with the OSTIA SST, the domain averaged root mean square error （RMSE） of the four experiments is 1.74, 1.16, 1.30 and 0.91~C, respectively; the improvements of assimilation experiments Exps 2, 3 and 4 are about 33.3%, 25.3%, and 47.7%, respectively. Although both two methods are effective in assimilating the SST, the EnOI shows more advantages than the QC, and the best result is achieved when the two methods are combined. Comparing with the observational data from coastal buoy stations, show that assimilating the high-resolution satellite SST products can effectively improve the SST prediction skill in coastal regions.

关键词： sea surface temperature data assimilation ensemble optimal interpolation quick correction Bohai Sea Yellow Sea East China Sea

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Cryo-EM structure of R-loop monoclonal antibody S9.6 in recognizing RNA:DNA hybrids

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Journal of Genetics and Genomics 2022年第7期49卷 677-680页

作者： Qin Li Chao Lin Zhipu Luo Haitao Li xueming Li Qianwen Sun Center for Plant Biology School of Life SciencesTsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Structural Biology Tsinghua UniversityBeijing 100084China Institute of Molecular Enzymology School of Biology and Basic Medical SciencesSoochow UniversitySuzhouJiangsu 215123China University Beijing 100084China Tsinghua-Peking Center for Life Sciences Beijing 100084China

Three-stranded chromatin structure R-loops are thought to be formed co-transcriptionally with newly synthesized RNA behind RNA polymerases,and play essential biological roles(Costantino and Koshland,2015;Santos-Pereir... 详细信息

关键词： monoclonal structure

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Effect of weak magnetic field on the water-holding properties, texture, and volatile compounds of pork and beef during frozen storage

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FOOD BIOSCIENCE 2023年第3期53卷 2711-2720页

作者： Liu, Fan Yang, Na Zhang, Lingtao Jin, Yamei Jin, Zhengyu Xu, xueming Jiangnan Univ State Key Lab Food Sci & Resources Wuxi 214122 Peoples R China Jiangnan Univ Sch Food Sci & Technol Wuxi 214122 Peoples R China Jiangnan Univ Collaborat Innovat Ctr Food Safety & Qual Control Wuxi 214122 Peoples R China 1800 Lihu Ave Wuxi 214122 Peoples R China

The weak magnetic field has recently attracted much attention for improving the quality of frozen food due to its mild effectiveness and near-complete transmission through the food matrix. This study aimed to explore the effect of the magnetic field with 1 mT and 50 Hz on the freezing process and storage quality of pork and beef. The results showed that the freezing point of beef stored under the magnetic field was-1.7 & DEG;C, which was 0.5 & DEG;C lower than that of conventional frozen (CF) groups, and the phase transition times of pork and beef were reduced by 55.56% and 50.00%, respectively. The magnetic field maintained higher water-holding capacity and decreased drip loss and cooking loss for both types of meat. Coherently, the evaporation and redistribution of water was inhibited by MF, as indicated by the magnetic resonance imaging results. The magnetic field also effectively moderated the hardening in texture, odor deterioration and color change of frozen pork and beef. Less accumulation of free amino acids suggested the degradation of protein was suppressed under magnetic field . The present study would provide a scientific reference for the application of weak magnetic field in meat preservation.

关键词： Magnetic field Frozen prok Frozen beef Water-holding capacity Sensory qualities

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