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Chinese Physics B 2024年第6期33卷 125-140页

作者：黄习习肖敏 Leszek Rutkowski 包海波黄霞曹进德 College of Automation&College of Artificial Intelligence Nanjing University of Posts and TelecommunicationsNanjing 210023China Systems Research Institute of the Polish Academy of Sciences 01-447 WarsawPoland College of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdao 266590China School of Mathematics Southeast UniversityNanjing 210096China

A dynamical model is constructed to depict the spatial-temporal evolution of malware in mobile wireless sensor networks(MWSNs). Based on such a model, we design a hybrid control scheme combining parameter perturbation and state feedback to effectively manipulate the spatiotemporal dynamics of malware propagation. The hybrid control can not only suppress the Turing instability caused by diffusion factor but can also adjust the occurrence of Hopf bifurcation induced by time delay. Numerical simulation results show that the hybrid control strategy can efficiently manipulate the transmission dynamics to achieve our expected desired properties, thus reducing the harm of malware propagation to MWSNs.

关键词： mobile wireless sensor networks reaction-diffusion Hopf bifurcation hybrid control

Iodine Nutrition, Thyroid-stimulating Hormone, and Related Factors of Postpartum Women from three Different Areas in China: A Cross-sectional Survey

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Biomedical and Environmental Sciences 2024年第3期37卷 254-265页

作者： SHAN xiao Yun ZOU Yan HUANG Li Chun JIANG Shan ZHOU Wei Wen QIN Qiu Lan LIU Chang Qing LUO xiao Yan LU Jia xi MAO De Qian LI Min YANG Zhen Yu YANG Li Chen Key Laboratory of Trace Element Nutrition of National Health Committee National Institute for Nutrition and HealthChinese Center for Disease Control and PreventionBeijing 100050China Hunan Key Laboratory of Typical Environmental Pollution and Health Hazards School of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 241001HunanChina Zhejiang Provincial Center for Disease Prevention and Control Hangzhou 310051ZhejiangChina Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning 530028GuangxiChina Hebei Provincial Center for Disease Control and Prevention Shijiazhuang 050021HebeiChina

Objective Studies on the relationship between iodine,vitamin A(VA),and vitamin D(VD)and thyroid function are *** study aimed to analyze iodine and thyroid-stimulating hormone(TSH)status and their possible relationships with VA,VD,and other factors in postpartum *** A total of 1,311 mothers(896 lactating and 415 non-lactating)from Hebei,Zhejiang,and Guangxi provinces were included in this *** urinary iodine concentration(UIC),TSH,VA,and VD were *** The median UIC of total and lactating participants were 142.00µg/L and 139.95µg/L,*** median TSH,VA,and VD levels in all the participants were 1.89 mIU/L,0.44μg/mL,and 24.04 ng/mL,*** differences in the UIC were found between lactating and non-lactating *** and TSH levels were significantly different among the three *** rural UIC was higher than the urban *** mothers had a higher UIC and a higher prevalence of excessive *** UICs and TSHs levels were observed in both the VD deficiency and insufficiency groups than in the VD-sufficient *** adjustment,no linear correlation was observed between UIC and VA/*** interaction was found between vitamins A/D and UIC on TSH *** The mothers in the present study had no iodine ***,area type,BMI,and VD may be related to the iodine status or TSH levels.

关键词： Median urinary iodine concentration Thyroid-stimulating hormone Vitamin A Vitamin D Postpartum women

Artificial intelligence-based pathological analysis of liver cancer:Current advancements and interpretative strategies

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iLIVER 2024年第1期3卷 82-89页

作者： Guang-Yu Ding Jie-Yi Shi xiao-Dong Wang Bo Yan xi-Yang Liu Qiang Gao Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalShanghai 200032China Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Fudan UniversityShanghai 200032China School of Computer Science and Technology Xidian UniversityXi'an 710126China School of Computer Science Shanghai Key Laboratory of Intelligent Information ProcessingFudan UniversityShanghai 200433China Institute of Biomedical Sciences Fudan UniversityShanghai 200030China State Key Laboratory of Genetic Engineering Fudan UniversityShanghai 200433China

In recent years,significant advances have been achieved in liver cancer management with the development of artificial intelligence(AI).AI-based pathological analysis can extract crucial information from whole slide images to assist clinicians in all aspects from diagnosis to prognosis and molecular ***,AI techniques have a“black box”nature,which means that interpretability is of utmost importance because it is key to ensuring the reliability of the methods and building trust among clinicians for actual clinical *** this paper,we provide an overview of current technical advancements in the AI-based pathological analysis of liver cancer,and delve into the strategies used in recent studies to unravel the“black box”of AI's decision-making process.

关键词： Liver cancer Artificial intelligence Pathology Interpretative model

Cognitive dysfunction in schizophrenia patients caused by downregulation of γ-aminobutyric acid receptor subunits

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World Journal of Psychiatry 2024年第6期14卷 784-793页

作者： xi Chen Ya-Nan Zhou xiao-Zi Lu Ren-Jiao Li Yi-Fan xiong xia Sheng Wei-Wei Zhu Department of Child and Adolescent Psychiatric Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Psychiatry Qingdao Mental Health CenterQingdao 266034Shandong ProvinceChina Department of Psychiatry Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina Department of Sleep Disorders and Neurosis Brain Hospital of Hunan ProvinceThe Second People’s Hospital of Hunan ProvinceChangsha 410007Hunan ProvinceChina

BACKGROUND The expression pattern of gamma aminobutyric acid(GABA)receptor subunits are commonly altered in patients with schizophrenia,which may lead to nerve excitation/inhibition problems,affecting cognition,emotion,and *** To explore GABA receptor expression and its relationship with schizophrenia and to provide insights into more effective *** This case-control study enrolled 126 patients with schizophrenia treated at our hospital and 126 healthy volunteers who underwent physical examinations at our hospital during the same *** expression levels of the GABA receptor subunits were detected using 1H-magnetic resonance *** recognized cognitive battery tool,the MATRICS Consensus Cognitive Battery,was used to evaluate the scores for various dimensions of cognitive *** correlation between GABA receptor subunit downregulation and schizophrenia was also *** Significant differences in GABA receptor subunit levels were found between the case and control groups(Pdually,indicating a positive correlation between the downregulation of these 4 receptor subunits and schizophrenia(P0.05).CONCLUSION Downregulation of the GABA receptor subunits is positively correlated with *** other words,when GABA receptor subunits are downregulated in patients,cognitive impairment becomes more severe.

关键词： Cognitive function Schizophrenia Downregulation Gamma-aminobutyric acid receptor subunits Correlation

Highly-chlorinated inert and robust interphase without mineralization of oxide enhancing high-rate Li metal batteries

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Chinese Chemical Letters 2024年第6期35卷 239-243页

作者： Long Li Kang Yang Chenpeng xi Mengchao Li Borong Li Gui Xu Yuanbin xiao xiancai Cui Zhiliang Liu Lingyun Li Yan Yu Chengkai Yang Key Laboratory of Advanced Materials Technologies International(HongKong Macao and Taiwan)Joint Laboratory on Advanced Materials TechnologiesSchool of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China College of Material Sciences and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

Side reactions and dendrite growth triggered by the unstable interface and inhomogeneous deposition have become the biggest obstacle to the commercialization for lithium metal *** this study,a highly-chlorinated organic-inorganic hybrid interfacial protective layer is developed by rationally tuning the interfacial passivation and robustness to achieve the convenient and efficient Li metal *** polyvinyl chloride(PVC)can effectively resist water and oxygen,which is confirmed by density functional *** organic-dominant solid electrolyte interphases(SEI)with lithium chloride are investigated by the X-ray photoelectron spectroscopy(XPS)with little mineralization of oxide,such as Li_(2)O and Li_(2)CO_(3).With such artificial SEI,a uniform and dense lithium deposition morphology are formed and an ultra-long stable cycle of over 500 h are achieved even at an ultra-high current density of 10 m A/cm^(2).Moreover,the simple and convenient protected anode also exhibits excellent battery stability when paired with the LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)and LiFePO_(4)(LFP)cathode,showing great potential for the commercial application of lithium metal batteries.

关键词： Highly-chlorinated Water/oxygen resistance Stable interphase Dendrite-free lithium metal batteries High-rate

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一种电机直驱操动机构行程曲线规划方法

电机与控制学报 2024年第5期28卷 9-16页

作者：王潇吴旭升肖曦海军工程大学电气工程学院湖北武汉430034 清华大学电机工程与应用电子技术系北京100084

电机直驱操动机构过控制电机按照行程曲线运行,直接驱动高压开关实现分合闸动作。针对电机直驱操动机构行程曲线缺乏系统性规划方法,无法与机构运行特性相匹配,规划、验证及优化周期长,可移植性差等问题,结合多项式模型与负载特性模型... 详细信息

电机直驱操动机构过控制电机按照行程曲线运行,直接驱动高压开关实现分合闸动作。针对电机直驱操动机构行程曲线缺乏系统性规划方法,无法与机构运行特性相匹配,规划、验证及优化周期长,可移植性差等问题,结合多项式模型与负载特性模型提出一种电机直驱操动机构行程曲线规划方法。根据运动学和动力学分析,建立电机直驱操动机构负载特性数学模型。利用多项式模型生成行程曲线簇,并结合电机直驱操动机构及高压开关特性建立多目标优化算法,筛选出最佳行程曲线。仿真和实验结果表明,所提方案可以实现电机直驱操动机构及高压开关的稳定、可靠运行,与传统的行程曲线规划方法相比,可以实现10.3%的能耗优化,能够进一步提升控制系统整体功率密度。

关键词：高压开关操动机构电机行程曲线曲线规划多项式模型

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中药上市后评价的机遇与挑战

中国中药杂志 2014年第18期39卷 3427-3429页

作者：杜晓曦宋海波任经天杨乐郭晓昕逄瑜国家食品药品监督管理总局药品评价中心北京100045

上市后评价是对药品临床应用的风险、效益等进行全面、系统评估的过程,科学系统的上市后评价结果,既可为中药临床安全用药提供数据支持,也是监管部门制订风险管理措施的可靠依据。随着人民群众治疗及预防疾病的需求不断增加,中药的应用... 详细信息

上市后评价是对药品临床应用的风险、效益等进行全面、系统评估的过程,科学系统的上市后评价结果,既可为中药临床安全用药提供数据支持,也是监管部门制订风险管理措施的可靠依据。随着人民群众治疗及预防疾病的需求不断增加,中药的应用更加广泛,安全性问题也日益凸显。如何早期发现中药安全风险信号,有针对性的开展中药上市后评价研究,及时控制风险,已成为中医药产业发展中的挑战性问题。

关键词：中药上市后评价不良反应监测

ROS Balance Autoregulating Core-Shell CeO_(2)@ZIF-8/Au Nanoplatform for Wound Repair

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Nano-Micro Letters 2024年第8期16卷 341-361页

作者： xi Zhou Quan Zhou Zhaozhi He Yi xiao Yan Liu Zhuohang Huang Yaoji Sun Jiawei Wang Zhengdong Zhao xiaozhou Liu Bin Zhou Lei Ren Yu Sun Zhiwei Chen xingcai Zhang The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Research Center of Biomedical Engineering of XiamenDepartment of BiomaterialsCollege of MaterialsXiamen UniversityXiamen 361005People’s Republic of China Department of Electronic Science Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance ResearchSchool of Electronic Science and EngineeringXiamen UniversityXiamen 361005People’s Republic of China John A Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA Department of Otorhinolaryngology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China NO.1 Middle School Affiliated to Central China Normal University Wuhan 430223People’s Republic of China

Reactive oxygen species(ROS)plays important roles in living *** ROS is a double-edged sword,which can eliminate drug-resistant bacteria,but excessive levels can cause oxidative damage to cells.A core–shell nanozyme,Ce O_(2)@ZIF-8/Au,has been crafted,spontaneously activating both ROS generating and scavenging functions,achieving the multifaceted functions of eliminating bacteria,reducing inflammation,and promoting wound *** Au Nanoparticles(NPs)on the shell exhibit high-efficiency peroxidase-like activity,producing ROS to kill ***,the encapsulation of Ce O_(2) core within ZIF-8 provides a seal for temporarily limiting the superoxide dismutase and catalase-like activities of Ce O_(2) ***,as the ZIF-8 structure decomposes in the acidic microenvironment,the Ce O_(2) core is gradually released,exerting its ROS scavenging activity to eliminate excess ROS produced by the Au *** two functions automatically and continuously regulate the balance of ROS levels,ultimately achieving the function of killing bacteria,reducing inflammation,and promoting wound *** innovative ROS spontaneous regulators hold immense potential for revolutionizing the field of antibacterial agents and therapies.

关键词： Metal-organic framework(MOF) Reactive oxygen species(ROS) Cerium dioxide Au nanoparticles Wound healing

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不良反应监测对中药安全性评价的启示

中国中药杂志 2015年第8期40卷 1620-1623页

作者：宋海波杜晓曦任经天杨乐郭晓昕逄瑜国家食品药品监督管理总局药品评价中心北京100045

不良反应监测在早期预警中药风险、发现质量隐患、保障临床用药安全方面有重要作用。研究符合中药特点的风险信号挖掘技术,充分考虑中药成分、炮制、配伍、制备及临床用药的复杂性特点,早期发现中药风险信号,探索建立以不良反应风险信... 详细信息

不良反应监测在早期预警中药风险、发现质量隐患、保障临床用药安全方面有重要作用。研究符合中药特点的风险信号挖掘技术,充分考虑中药成分、炮制、配伍、制备及临床用药的复杂性特点,早期发现中药风险信号,探索建立以不良反应风险信号为先导的中药安全性评价体系,提高中药安全性研究的靶向性,及时有效控制风险,有助于改变目前中药"安全性问题"频发的局面。

关键词：中药不良反应监测安全性评价

基于中医药古籍的何首乌安全性及风险因素分析

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中国中药杂志 2015年第5期40卷 985-988页

作者：宋海波杜晓曦郭晓昕任经天杨乐逄瑜国家食品药品监督管理总局药品评价中心北京100045

中药何首乌Polygoni Multiflori Radix为蓼科植物何首乌Polygortum multiflorum Thunb.的干燥块根,临床应用记载首见于唐代,历代本草文献对何首乌的基原、功效、毒性、炮制、使用禁忌等多有论述。近年来,随着公众健康意识的增强,何首乌... 详细信息

中药何首乌Polygoni Multiflori Radix为蓼科植物何首乌Polygortum multiflorum Thunb.的干燥块根,临床应用记载首见于唐代,历代本草文献对何首乌的基原、功效、毒性、炮制、使用禁忌等多有论述。近年来,随着公众健康意识的增强,何首乌及其成方制剂在治疗和预防疾病中的使用更为广泛,涉及何首乌肝损伤的文献报道也逐渐增加,何首乌的安全性问题日益引起社会的关注。该文对历代本草中记载的何首乌毒性及用药风险因素进行了归纳分析,提出在安全性研究中应重点关注种植、炮制方法等对何首乌的成分和毒性的影响,为进一步的研究提供了线索。

关键词：何首乌安全性文献研究