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Zhuangyao Jianshen pill(壮腰健肾丸) ameliorates testosterone-induced benign postatic hyperplasia in rats

Journal of Traditional Chinese Medicine 2024年第4期44卷 694-702页

作者： ZHENG Jingrui CHEN Weijian YE Binbin MO Ziyao du qunqun QIN Renan NIE Ke School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China Modern Chinese Medicine Research Institute Guangzhou Baiyunshan Chenliji Pharmaceutical Factory Co.Ltd.Guangzhou 510228China

OBJECTIVE:To determine the therapeutic effects of the Zhuangyao Jianshen pill(壮腰健肾丸,ZYJSP)against benign prostatic hyperplasia(BPH)and investigate the underlying ***:Forty-eight male Sprague-Dawley rats were randomly divided into six groups:Control group,BPH model group,finasteride-treated group,ZYJSP low,medium and high dose *** for the control group,40 rats were castrated and injected with testosterone propionate(TP)for 28 consecutive day to induce ***,the corresponding drugs were administered by *** prostate wet weight,prostate index(PI),and the histopathological changes in the prostate were measured as the basis for examining the efficacy of ZYJSP against *** of the serum sex hormones,oxidative stress markers,inflammatory markers,renal function markers,growth factors,and Cyclin D1 expression in prostate were measured to characterize the therapeutic mechanism of ZYJSP against ***:ZYJSP administration significantly reduced prostate wet weight and PI and ameliorated histological changes of the prostate in TP-treated castrated *** markedly increased the levels of creatinine,blood urea nitrogen and growth factors in the serum as well as the expression of the Cyclin D1 in the *** of these markers were significantly decreased by *** significantly restored the dysregulation of testosterone,estradiol,and dihydrotestosterone caused by ***,ZYJSP relieved TP-induced prostate injury and exhibited both anti-inflammatory and anti-oxidant activity by decreasing interleukin-6,interleukin-8,and malondialdehyde levels and increasing the activity of superoxide dismutase in the ***:These findings indicate that ZYJSP can effectively ameliorate BPH induced by TP in castrated rats,and the underlying mechanism might be related to regulating sex hormone balance,reducing oxidative stress,and inhibiting the inflammatory response.

关键词： testosterone ameliorate hyperplasia

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规范反常及其上同调分析

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华东师范大学学报(自然科学版) 1988年第4期 25-30页

作者：杜群群郭汉英胡瑶光华东师大物理系中国科学院理论物理研究所

本文利用推广的Chern-Simons型示性类,从导出的descent方程出发,对规范反常进行上同调分析,讨论了Wess-Zumino反常有效作用量作为一上闭链即作为上时群H_△~-的群元与反常相消条件、有限规范反常和Gross-Jakiw反常的关系.

关键词：规范反常上同调分析上同群 Gross-Jakiw反常

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一种改善睡眠胶囊的制备及其质量标准研究

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山东化工 2020年第11期49卷 26-28页

作者：翁立冬吴文峰王显杜群群陈婷婷刘强南方医科大学中医药学院广东广州510515 南方医科大学南方医院广东广州510515

确定改善睡眠胶囊主要的提取工艺并对其质量标准进行研究。通过正交试验,以五味子醇甲含量为评价指标,优化最佳提取工艺条件,确立提取工艺;研究处方中五味子的定性鉴别及五味子醇甲的含量测定。提取工艺为提取2次,每次加水4倍量,提取2次... 详细信息

确定改善睡眠胶囊主要的提取工艺并对其质量标准进行研究。通过正交试验,以五味子醇甲含量为评价指标,优化最佳提取工艺条件,确立提取工艺;研究处方中五味子的定性鉴别及五味子醇甲的含量测定。提取工艺为提取2次,每次加水4倍量,提取2次;供试品薄层色谱中,在与五味子对照药材和五味子醇甲对照品色谱相应位置上,显相同颜色的斑点;供试品高效液相色谱图中,在与五味子醇甲对照品色谱相应位置上色谱峰保留时间基本一致。该制备工艺合理、简便,建立的质量标准能准确地进行定性、定量检测,可作为改善睡眠胶囊的质量控制。

关键词：改善睡眠胶囊制备五味子醇甲薄层鉴别含量测定

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Cloning of sft-4 and its influence on vitality and virulence of pine wood nematode,Bursaphelenchus xylophilus

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Journal of Forestry Research 2024年第5期35卷 191-200页

作者： Shuisong Liu Linsong Wang Ronggui Li Mengyu Chen Wenjun Deng Chao Wang Guicai du qunqun Guo College of Life Sciences Qingdao UniversityQingdao 266071People’s Republic of China

In our previous screening of the transcriptome of the causal agent of the devastating pine wilt disease,pine wood nematode(PWN,Bursaphelenchus xylophilus),after treatment with the nematicide fomepizole,Surfeit locus gene sft-4,which encodes a regulatory factor,was found to be *** situ hybridization results showed that the sft-4 was continuously expressed from egg to adult and was especially high in the reproductive *** in a study of the effect of RNA interference(RNAi)of sft-4 and recombinant SFT-4 on PWN activity,treatment with sft-4 dsRNA inhibited feeding,reproduction,oviposition and egg hatching of PWN with the greatest inhibition on reproduction and oviposition,whereas recombinant SFT-4 had the opposite *** addition,RNAi of sft-4 changed the female–male ratio and lifespan of *** bioassays of PWNs,with RNAi of sft-4 on seedlings and 2-year-old Pinus thunbergii trees,none of the treated plants developed symp-toms during the monitoring period,indicating that virulence of PWNs was either significantly *** results indicate that the influence of sft-4 on PWN pathogenicity may be mainly through regulating reproductive function of PWN and its lifespan.

关键词： Black pine Pinaceae Bursaphelenchus xylophilus Sft-4 In situ hybridization RNAi Pathogenicity

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Growth inhibition and oxidative stress in two species of marine diatoms exposed to 1-phenylethanol

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Journal of Oceanology and Limnology 2019年第4期37卷 1342-1352页

作者： DOU Xiang MENG Fanping duAN Weiyan LIU qunqun LI Hao du Shuhao PENG Xiaoling Key Laboratory of Marine Environment and Ecology Ministry of Education Qingdao 266000 China College of Environmental Science and Engineering Ocean University of China Qingdao 266000 China

1-phenylethanol (1-PEA) is a flavor extensively used in the production of cosmetics, beverages, and food. The release of 1-PEA into coastal environments has aroused great concern. However, its potential effects on marine organisms are still unknown. In order to provide a better understanding of the ecological risks of 1-PEA in marine environments, this study determined the toxic effects of 1-PEA on two marine diatoms (Phaeodactylum tricornutum and Skeletonema costatum). The diatoms were grown in culture medium containing different concentrations of 1-PEA for 96 h. The contents of chlorophyll a, chlorophyll c, glutathione (GSH), malondialdehyde (MDA), and the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), were measured at the end of the exposure period. 1-PEA was shown to significantly inhibit the growth of diatoms, with 96-h EC50 values of 257.14 mg/Land 126.46 mg/L in P. tricornutum and S. costatum, respectively. In P. tricornutum, the levels of SOD, CAT, GPx, GSH, and MDA were stimulated only when 1-PEA concentrations were close to or greater than the 96-h EC50 value. However, in S. costatum, the activities of SOD and CAT, and the syntheses of two chlorophylls were inhibited even at an exposure concentration below the 96-h EC50 value. Taken together, these findings indicate a potential ecological risk by discharging 1-PEA into coastal areas and its species-specific toxic effects on marine organisms.

关键词： Phaeodactylum tricornutum Skeletonema costatum 1-phenylethanol (1-PEA) growth inhibition oxidative stress

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A Fluorescent Zirconium-Based Metal-Organic Framework for Selective Detection of Nitro Explosives and Metal Ions

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Chinese Journal of Chemistry 2017年第7期35卷 1091-1097页

作者： YuanzheTang Hongliang Huang Yaguang Peng qunqun Ruan KekeWang Pengda Yi Dahuan Liu Chongli Zhong Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Beo'ing 100029 China

In this work, a new porous Zrobased metal-organic framework （MOF） with a large Brunner-Emmet-Teller （BET） surface area was prepared by the solvothermal method using 4,4＇-（naphthalene-1,4-diyl）dibenzoic acid （NDDA） as the organic ligand, and the luminescent detection performance was studied systematically. The experiments comb- ing with computations indicate that the as-synthesized material can sensitively and selectively detect nitro explo- sives and metal ions, especially for 2,4,6-trinitrophenol （TNP） and Fe3＋, due to the possible electron transfer from inorganic moieties to organic moieties with naphthalene part. Interestingly, owing to its high porosity and large sur- face area, this Zr-MOF showed quick luminescent response time （in 1 min） for TNP and Fe3＋. The results obtained may provide useful information for the design of MOFs with the large permanent porosity in sensing applications for large molecules in the future.

关键词： metal-organic framework detection capacity Fe3+ ion nitro explosives

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Deterioration of Antioxidant Competence in Barley Lesion Mimic Mutant 194

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Phyton-International Journal of Experimental Botany 2019年第2期88卷 109-117页

作者： qunqun Hao Bo Lyu Yuhan Tang Deya Wang Yuanyuan Li Qingliang Li Yuhai Wang Wenqiang Wang College of Life Sciences Zaozhuang UniversityZaozhuang277000China State Key Laboratory of Crop Biology College of AgronomyShandong Agricultural UniversityTai’an271018China.

A barley mutant,194,was observed to exhibit a leaf spot phenotype over the whole course of its growing *** this study,the phenotype and antioxidant competence were studied in the lesion mimic mutant *** height was slightly higher in mutant 194 than in the wild type(WT).In addition,leaf spot per plant in mutant 194 was significantly higher than in *** competence,as indicated by reactive oxygen species(ROS)accumulation,antioxidant enzyme activity,and the expression of antioxidant enzyme-encoding genes was also assessed in mutant *** to the WT,mutant 194 displayed a relatively higher accumulation of ROS,accompanied by lower activities of some antioxidant enzymes and downregulation of antioxidant enzyme-encoding *** demonstrated reduced antioxidant competence in mutant *** results suggested that this lower antioxidant competence of mutant 194 could lead to the accumulation of excessive *** excess of ROS could induce programmed cell death and has the potential to promote disease resistance in mutant 194.

关键词： Lesion mimic mutant ROS accumulation antioxidant enzymes barley

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Creating large EMS populations for functional genomics and breeding in wheat

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Journal of Integrative Agriculture 2024年第2期23卷 484-493页

作者： Wenqiang Wang Xizhen Guan Yong Gan Guojun Liu Chunhao Zou Weikang Wang Jifa Zhang Huifei Zhang qunqun Hao Fei Ni Jiajie Wu Lynn Epstein Daolin Fu Spring Valley Agriscience Co. Ltd.Jinan 250300China College of Life Sciences Zaozhuang UniversityZaozhuang 277160China National Key Laboratory of Wheat Improvement College of AgronomyShandong Agricultural UniversityTai’an 271018China Department of Plant Pathology University of CaliforniaDavisCA 95616USA

Wheat germplasm is a fundamental resource for basic research,applied studies,and wheat breeding,which can be enriched normally by several paths,such as collecting natural lines,accumulating breeding lines,and introducing mutagenesis *** methane sulfonate(EMS)is an alkylating agent that can effectively introduce genetic variations in a wide variety of plant *** this study,we created a million-scale EMS population(MEP)that started with the Chinese wheat cultivars‘Luyan 128’,‘Jimai 38’,‘Jimai 44’,and‘Shannong 30’.In the M1 generation,the MEP had numerous phenotypical variations,such as>3,000 chlorophyll-deficient mutants,2,519 compact spikes,and 1,692 male sterile *** were also rare mutations,including 30 independent tillers each with double *** M1 variations of chlorophyll-deficiency and compact spikes were inheritable,appearing in the M2 or M3 *** advance the entire MEP to higher generations,we adopted a single-seed descendent(SSD)*** other seed composites of M2 were used to screen other agronomically important traits,such as the tolerance to herbicide *** MEP is available for collaborative projects,and provides a valuable toolbox for wheat genetics and breeding for sustainable agriculture.

关键词： wheat germplasm ethyl methane sulfonate genetics and breeding

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The “1-3-7” Approach to Malaria Surveillance and Response--Henan Province, China, 2012−2018

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China CDC weekly 2020年第17期2卷 289-292页

作者： qunqun Zhang Ying Liu Yabo Hu Yuling Zhao Chengyun Yang Dan Qian Ruimin Zhou Suhua Li Zhou Guan Deling Lu Hongwei Zhang Wanshen Guo Henan Center for Disease Prevention and Control ZhengzhouChina College of Public Health Zhengzhou UniversityZhengzhouChina.

What is already known about this topic?The“1-3-7”approach to malaria surveillance and response was a key measure for malaria elimination in China and was first introduced into the World Health Organization(WHO)as an international guideline for malaria surveillance and response in *** is added by this report?The“1-3-7”approach was well implemented in Henan Province from 2012−*** this study period,a total of 1,294 malaria cases were detected and reported,and all cases were diagnosed and reported within 1 day with 99.23%(1,284/1,294)of cases were investigated within 3 *** addition,93.7%(1,212/1,294)of foci were investigated and vector control was implemented within 7 days at all residual non-active foci to prevent further *** are the implications for public health practice?The“1-3-7”controlling pattern would be an effective and approachable method for implementation especially in malaria-eliminating countries and regions,but the interval from symptom onset to diagnosis cannot be ***,the roles and responsibilities that all actors involved in the health sector must be specified too.

关键词： Henan specified eliminating

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交易费用、经济组织与治理机制——诺贝尔经济学奖得主奥利弗·威廉姆森的学术贡献和借鉴意义

引用

财贸经济 2010年第3期31卷 99-105页

作者：张群群中国社会科学院财政与贸易经济研究所

奥利弗·威廉姆森教授是2009年度诺贝尔经济学奖得主之一,其学术贡献不只是对纵向一体化或企业边界问题的开创性研究,纵向一体化只是经济组织问题的一个特例。以制度、组织和治理为主线,对威廉姆森的学术生涯、知识谱系、代表性著作的回... 详细信息

奥利弗·威廉姆森教授是2009年度诺贝尔经济学奖得主之一,其学术贡献不只是对纵向一体化或企业边界问题的开创性研究,纵向一体化只是经济组织问题的一个特例。以制度、组织和治理为主线,对威廉姆森的学术生涯、知识谱系、代表性著作的回顾,揭示了他所提出的交易费用经济学的分析方法,特别是匹配交易活动与治理形式的契约关系有效治理的分析框架,具有更大的理论价值和广泛的适用性。此外,他把产业组织理论与交易费用分析融合在一起,对反垄断和规制等问题的研究成果也独具特色。其理论成果在经验检验、应用经济学和公共政策研究领域具有广阔的应用前景,跨学科研究方法具有借鉴意义。

关键词：交易费用契约组织治理产业组织

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