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Compound extreme inundation risk of coastal wetlands caused by climate change and anthropogenic activities in the Yellow River Delta,China

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Advances in Climate Change Research 2024年第1期15卷 134-147页

作者： Xiao-li WANG Ai-Qing FENG Xi-Yong HOU Qing-Chen CHAO Bai-Yuan SONG Yu-Bin liU Qi-Guang WANG He XU Yu-Xin ZHANG Dong li li-Jie DONG Yu GUO CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003China Shandong Key Laboratory of Coastal Environmental Processes Yantai 264003China China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Tongji Urban Planning Design Research Institute Shanghai 200092China School of Geography and Tourism Qilu Normal UniversityJinan 250200China China Meteorological Administration Training Centre China Meteorological AdministrationBeijing 10008China University of Chinese Academy of Sciences Beijing 100049China Marine Science and Technology College Zhejiang Ocean UniversityZhoushan 316022China

The coastal wetlands of the Yellow River Delta(YRD)in China are crucial for their valuable resources,environmental significance,and economic ***,these wetlands are also vulnerable to the dual threats of climate change and human *** substantial attention to the historical shifts in YRD's coastal wetlands,uncertainties remain regarding their future trajectory in the face of compound risks from climate change and anthropogenic *** on a range of remote sensing data sources,this study undertakes a comprehensive investigation into the evolution of YRD's coastal wetlands between 2000 and ***,the potential fate of coastal wetlands is thoroughly analyzed through the Land Use/Cover Change(LUCC)simulation using System Dynamic-Future Land Use Simulation(SD-FLUS)model and the extreme water levels projection integrated future sea-level rise,storm surge,and astronomical high tide in 2030,2050,and 2100 under scenarios of SSP1-2.6,SSP2-4.5,and *** revealed that YRD's coastal wetlands underwent a marked reduction,shrinking by 1688.72 km²from 2000 to *** decline was mostly attributed to the substantial expansion in the areas of artificial wetlands(increasing by 823.78 km2),construction land(increasing by 767.71 km²),and shallow water(increasing by 274.58 km²).Looking ahead to 2030-2100,the fate of coastal wetlands appears to diverge based on different *** the SSP1-2.6 scenario,the area of coastal wetland is projected to experience considerable *** contrast,the SSP5-8.5 scenario anticipates a notable decrease in coastal *** to the inundated area suffered from the current extreme water levels,the study projects a decrease of 6.8%-10.6%in submerged coastal wetlands by 2030 and 9.4%-18.2%by 2050 across all *** 2100,these percentages are projected to decrease by 0.4%(SSP2-4.5)and 27.1%(SSP5-8.5),but increase by 35.7%(SSP1-2.6).Results suggest that coastal wetlands in th

关键词： Climate change Anthropogenic activities Compound extreme risk Coastal wetlands Yellow River Delta

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Modelling Anti-Corrosion Coating Performance of Metallic Bipolar Plates for PEM Fuel Cells:A Machine Learning Approach

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Energy and AI 2024年第3期17卷 495-512页

作者： Pramoth Varsan Madhavan Samaneh Shahgaldi Xianguo li Mechanical and Mechatronics Engineering University of WaterlooOntarioCanada Hydrogen Research Institute Universitédu QuébecàTrois-RivièresQuebecCanada

Proton exchange membrane(PEM)fuel cells have significant potential for clean power generation,yet challenges remain in enhancing their performance,durability,and cost-effectiveness,particularly concerning metallic bipolar plates,which are pivotal for lightweight compact fuel cell *** coatings are commonly employed to combat metallic bipolar plate corrosion and enhance water management within *** methods for predicting coating performance in terms of corrosion resistance involve complex physical-electrochemical modelling and extensive experimentation,with significant time and *** this study machine learning techniques are employed to model metallic bipolar plate coating performance,diamond-like-carbon coatings of varying thicknesses deposited on SS316L are considered,and coating performance is evaluated using potentiodynamic polarization and electrochemical impedance *** obtained experimental data is split into two datasets for machine learning modelling:one predicting corrosion current density and another predicting impedance *** learning models,including extreme gradient boosting(XGB)and artificial neural networks(ANN),are developed,and optimized to predict coating performance *** preprocessing and hyperparameter tuning are carried out to enhance model *** show that ANN outperforms XGB in predicting corrosion current density,achieving an R2>0.98,and accurately predicting impedance parameters with an R2>0.99,indicating that the models developed are very promising for accurate prediction of the corrosion performance of coated metallic bipolar plates for PEM fuel cells.

关键词： Fuel cell Metallic bipolar plate Coating performance Machine learning Extreme gradient boosting Artificial neural networks

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家庭教育的价值回归与困境化解——朝向个体成人的教育

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教育研究 2024年第8期45卷 59-69页

作者：杜薇教育部人文社会科学重点研究基地湖南师范大学中华伦理文明研究中心长沙410081

家庭教育不仅是促使子代“成人”的有效途径,也是通过代际“筹划”实现亲代生命延续的重要方式。然而,家庭教育过程中仍存在忽视“个体成人”价值本身的问题,从而影响了子代健全人格的培养和人类代际更好的继替,为此,须回归家庭教育价... 详细信息

家庭教育不仅是促使子代“成人”的有效途径,也是通过代际“筹划”实现亲代生命延续的重要方式。然而,家庭教育过程中仍存在忽视“个体成人”价值本身的问题,从而影响了子代健全人格的培养和人类代际更好的继替,为此,须回归家庭教育价值及实践本身。不同的时空场域和文化环境,家庭教育展开的逻辑起点和实践理路不同,现代家庭教育正处于古今交融的时间场域、中西互嵌的空间场域、家庭变迁的社会场域。在如此复杂的处境中,要切实开展并发挥家庭教育的现实功用,应该树立“在世代之中存在”的家庭发展观、“亲亲为大”的家庭亲子观、“成人先于成才”的家庭成才观。在此基础上,通过政府层面“再家庭化”的政策支持、社会层面拟“亲缘共育”机制的再造、家-校合作层面“主体权责”边界的明晰、家庭本身层面的“自觉自为”等实践措施,共同培育内心丰盈、人格健全的子代。

关键词：家庭教育亲子关系价值取向子代培养个体成人

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论双层次刑事证明模式

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国家检察官学院学报 2024年第5期32卷 41-59页

作者：杜邈北京市人民检察院第四检察部

我国刑事证据法关于证明力审查的规定零乱繁杂,缺乏系统化的理论框架作为支撑,可能出现案件事实认定的偏差。考虑到我国的刑事诉讼制度、证据法规定和法律文化传统,有必要引入“以印证判断为基础,以情理判断为检验”的双层次刑事证明模... 详细信息

我国刑事证据法关于证明力审查的规定零乱繁杂,缺乏系统化的理论框架作为支撑,可能出现案件事实认定的偏差。考虑到我国的刑事诉讼制度、证据法规定和法律文化传统,有必要引入“以印证判断为基础,以情理判断为检验”的双层次刑事证明模式,并在《刑事诉讼法》中予以明确,推动构建以证据为中心的刑事指控体系。在双层次模式下,印证判断和情理判断围绕证据证明力展开,两者均属于案件事实认定的基本方式,但判断顺序具有先后位次性,在不同案件中介入比重不同。司法人员应当准确把握证据“关联性”要求,通过分析印证证据之间的先后关系、追溯关键证据的形成过程、最大限度挖掘个体证据蕴含的细节信息、全流程审查证据链条、在连续犯案件中引入相似事实证据等方法,为情理判断提供充分信息支撑,提升案件事实认定的准确性。

关键词：双层次刑事证明情理关联性印证

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Cancer profiles in China and comparisons with the USA:a comprehensive analysis in the incidence,mortality,survival,staging,and attribution to risk factors

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Science China(life Sciences) 2024年第1期67卷 122-131页

作者： Siyi He Changfa Xia He li Maomao Cao Fan Yang Xinxin Yan Shaoli Zhang Yi Teng Qianru li Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

China faces a disproportionate cancer burden to the population size and is undergoing a transition in the cancer *** extracted data in five aspects of cancer incidence,mortality,survival,staging distributions,and attribution to risk factors in China,the USA and worldwide from open-source *** conducted a comprehensive secondary analysis of cancer profiles in China in the above aspects,and compared cancer statistics between China and the USA.A total of 4,546,400 new cancer cases and 2,992,600 deaths occurred in China in 2020,accounting for 25.1%and 30.2%of global cases,***-related cancers including lung cancer,colorectal cancer,and breast cancer showed an upward trend and have been the leading cancer types in China.41.6%of new cancer cases and 49.3%of cancer deaths occurred in digestive-system cancers in China,and the cancers of esophagus,nasopharynx,liver,and stomach in China accounted for over 40%of global ***-related cancers showed the highest population-attributable fractions among Chinese adults,and most cancers could be attributed to behavioral and metabolic *** proportions of stage I for most cancer types were much higher in the USA than in China,except for esophageal cancer(78.2%vs.41.1%).The 5-year relative survival rates in China have improved substantially during 2000–2014,whereas survival for most cancer types in the USA was significantly higher than in China,except for upper gastrointestinal *** findings suggest that although substantial progress has been made in cancer control,especially in digestive system cancers in China,there was still a considerable disparity in cancer burden between China and the *** robust policies on risk factors and standardized screening practices are urgently warranted to curb the cancer growth and improve the prognosis for cancer patients.

关键词： cancer burden survival rate neoplasm staging risk factors China

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Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application

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Acta Pharmaceutica Sinica B 2024年第2期14卷 623-634页

作者： Jiacheng Xiong Rongrong Cui Zhaojun li Wei Zhang Runze Zhang Zunyun Fu Xiaohong liu Zhenghao li Kaixian Chen Mingyue Zheng Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China College of Computer and Information Engineering Dezhou UniversityDezhou 253023China AI Department Suzhou Alphama Biotechnology Co.Ltd.Suzhou 215000China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and TechnologyShanghaiTech UniversityShanghai 200031China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Aldehyde oxidase(AOX)is a molybdoenzyme that is primarily expressed in the liver and is involved in the metabolism of drugs and other ***-mediated metabolism can result in unexpected outcomes,such as the production of toxic metabolites and high metabolic clearance,which can lead to the clinical failure of novel therapeutic *** models can assist medicinal chemists in rapidly evaluating the AOX metabolic risk of compounds during the early phases of drug discovery and provide valuable clues for manipulating AOX-mediated metabolism *** this study,we developed a novel graph neural network called AOMP for predicting AOX-mediated *** integrated the tasks of metabolic substrate/non-substrate classification and metabolic site prediction,while utilizing transfer learning from 13C nuclear magnetic resonance data to enhance its performance on both *** significantly outperformed the benchmark methods in both cross-validation and external *** AOMP,we systematically assessed the AOX-mediated metabolism of common fragments in kinase inhibitors and successfully identified four new scaffolds with AOX metabolism liability,which were validated through in vitro ***,for the convenience of the community,we established the first online service for AOX metabolism prediction based on AOMP,which is freely available at https://***.

关键词： Drugmetabolism Aldehyde oxidase Transferlearning Graph neural network Kinase inhibitor

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在高应变率拉伸/压缩-扭转载荷下TC17钛合金的屈服和塑性流动行为

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Acta Mechanica Sinica 2024年第4期40卷 185-198页

作者：杨学赵敬凡杜冰郭亚洲李玉龙 School of Aeronautics Northwestern Polytechnical University(NPU)Xi’an710072China Yangtze River Delta Research Institute of NPU Taicang215400China Shaanxi Key Laboratory of Impact Dynamics and Engineering Application(IDEA) Northwestern Polytechnical UniversityXi’an710072China

金属材料经常暴露在高应变率和复杂的应力条件下.研究这些材料的动态力学行为对工程设计和工业应用至关重要.本文研究了TC17钛合金在压缩/拉伸-扭转作用下的动态塑性流动行为.研究了TC17钛合金在准静态和动态载荷下的初始屈服行为,并采... 详细信息

金属材料经常暴露在高应变率和复杂的应力条件下.研究这些材料的动态力学行为对工程设计和工业应用至关重要.本文研究了TC17钛合金在压缩/拉伸-扭转作用下的动态塑性流动行为.研究了TC17钛合金在准静态和动态载荷下的初始屈服行为,并采用杨、郭和李提出的动态不对称屈服准则(DAYC)来表征动态初始屈服行为.根据不同应力状态下的硬化特性,提出了一种修正的动态硬化规律(MDHL)来拟合加载面.研究了TC17钛合金在准静态和动态载荷作用下的塑性流动方向.结果表明,塑性势函数基本符合相关联流动法则.总之,本文系统性的研究了TC17钛合金的屈服性能,应变硬化规律和塑性流动规律,并利用DAYC和MDHL对其进行了表征.

关键词： TC17钛合金金属材料塑性流动高应变率扭转载荷动态力学行为应变硬化屈服准则

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基于双衍生-串联质谱技术检测类固醇激素研究

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药物分析杂志 2024年第9期44卷 1513-1523页

作者：吴巧莉童霄毅化强江巧玲沈媛赵淑霞李伟曾添福浙江中医药大学杭州310053 兰溪市人民医院金华321102 上海万子健医学检验实验室有限公司上海200000

目的:建立一种双衍生法-结合串联质谱技术同时检测人血清中18种类固醇激素的方法。方法:血清样本采用羟胺和1,2-二甲基咪唑-5-磺酰氯对进行衍生处理,采用液相色谱-串联质谱法正离子选择离子监测模式(SRM)下检测,色谱柱为Kinetex■C_(8)(... 详细信息

目的:建立一种双衍生法-结合串联质谱技术同时检测人血清中18种类固醇激素的方法。方法:血清样本采用羟胺和1,2-二甲基咪唑-5-磺酰氯对进行衍生处理,采用液相色谱-串联质谱法正离子选择离子监测模式(SRM)下检测,色谱柱为Kinetex■C_(8)(100 mm×2.1 mm,2.6μm),以0.1%甲酸水溶液为流动相A,0.1%甲酸甲醇溶液为流动相B,梯度洗脱(0~0.5 min,35%B;0.5~5 min,35%B→100%B;5.0~5.1 min,100%B→35%B;5.1~7 min,35%B),柱温40℃,流速0.4 mL·min^(-1),进样量20μL,采集时间为6 min。结果:18种类固醇激素的线性相关系数均>0.99,回收率均在85%~115%,精密度RSD均<15%。用该方法成功地检测了156份健康人群受试者血清样本(男性75例,女性61例)并制定了参考区间。结论:该方法可用非固相萃取法同时检测孕烯醇酮、17-羟孕烯醇酮、孕酮、17-羟孕酮、皮质酮、皮质醇、11-脱氧皮质醇、21-脱氧皮质醇、醛固酮、睾酮、雄烯二酮、脱氢表雄酮、硫酸脱氢表雄酮、皮质素、18-羟皮质酮、雌酮、雌二醇、雌三醇等18种类固醇激素。

关键词：类固醇激素液相色谱-串联质谱法羟胺双衍生内分泌疾病高通量

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Neuroprotective Effect and Mechanism of Tanreqing Injection on Ischemic Stroke:Insights from Network Pharmacology and in vivo Experiments

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Chinese Journal of Integrative Medicine 2024年第8期30卷 713-720页

作者： li Zhong-hao PU Xiao-qi li Sha-sha DONG Xiao-ke ZHANG Guo-qiang WANG Yu liU Jin-min Department of Emergency China-Japan Friendship HospitalBeijing100029China Department of Neurology Beijing University of Chinese Medicine Dongfang HospitalBeijing100078China Department of Radiology China-Japan Friendship HospitalBeijing100029China Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To explore the neuroprotective effects and mechanism of Tanreqing Injection(TRQ)on treating ischemic stroke based on network pharmacology and in vivo experimental *** The chemical compounds of TRQ were retrieved based on published data,with targets retrieved from PubChem,Therapeutic Target Database and *** visualization and analysis were performed using Cytoscape,with protein-protein interaction networks derived from the STRING *** analysis was performed using Kyoto Encyclopedia of Genes Genomes pathway and Gene Ontology *** in vivo experiments,the middle cerebral artery occlusion(MCAO)model was *** volume was determined by 2,3,5-triphenyltetrazolium hydrochloride staining and protein expressions were analyzed by Western *** docking was performed to predict ligand-receptor *** We screened 81 chemical compounds in TRQ and retrieved their therapeutic *** the targets,116 were therapeutic targets for *** enrichment analysis showed that the apelin signaling pathway was a key pathway for ischemic ***,in in vivo experiment we found that administering with intraperitoneal injection of 2.5 mL/kg TRQ every 6 h could significantly reduce the infarct volume of MCAO rats(Plin receptor(APJ)/phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)pathway were increased by TRQ(Pling ***,further studies are needed to confirm the findings.

关键词： Tanreqing Injection Chinese medicine ischemic stroke middle cerebral artery occlusion quantitative estimate of drug-likeness

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3种啮齿动物抗生素抗性基因多样性比较

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应用生态学报 2024年第1期35卷 229-236页

作者：初鹏飞邢洁王声泽李婷乔征磊原宝东牡丹江师范学院生命科学与技术学院黑龙江牡丹江157011 聊城大学生命科学学院山东聊城252000

抗生素抗性基因(ARGs)作为全球新型污染物受到广泛关注,其产生的原因主要是抗生素的滥用。为探究大林姬鼠、棕背鼠平和黑线姬鼠的抗生素抗性基因多样性,采用宏基因组测序分析来自黑龙江牡丹峰的17只大林姬鼠、17只棕背鼠平和三道关的9... 详细信息

抗生素抗性基因(ARGs)作为全球新型污染物受到广泛关注,其产生的原因主要是抗生素的滥用。为探究大林姬鼠、棕背鼠平和黑线姬鼠的抗生素抗性基因多样性,采用宏基因组测序分析来自黑龙江牡丹峰的17只大林姬鼠、17只棕背鼠平和三道关的9只黑线姬鼠的抗生素抗性基因多样性。从3种啮齿动物中共检测到19种类型及248个亚类的ARGs。棕背鼠平和黑线姬鼠差异显著的ARGs有7个,差异极显著的有5个;大林姬鼠和黑线姬鼠差异显著的ARGs有7个,差异极显著的有4个;棕背鼠平和大林姬鼠差异显著的ARGs有4个,差异极显著的有5个。3种啮齿动物丰度较高的抗生素抗性基因大类为大环内酯类、林可酰胺类、四环素类、β-内酰胺类。ARGs已广泛存在于3种啮齿动物体内,不同物种之间抗生素抗性基因的多样性存在显著差异,产生差异的原因可能是由于3种啮齿动物的分布区不同并存在食性分化。本研究可以为啮齿动物抗生素抗性基因的后续研究提供依据,并加深对ARGs传播危害的认识。

关键词：棕背鼠平大林姬鼠黑线姬鼠抗生素抗性基因宏基因组测序

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