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Targeting the organelle for radiosensitization in cancer radiotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 52-71页

作者： Xiaoyan Sun Linjie Wu lina du Wenhong Xu Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Afliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China

Radiotherapy is a well-established cytotoxic therapy for local solid cancers, utilizing high-energy ionizing radiation to destroy cancer cells. However, this method has several limitations, including low radiation energy deposition, severe damage to surrounding normal cells, and high tumor resistance to radiation. Among various radiotherapy methods, boron neutron capture therapy (BNCT) has emerged as a principal approach to improve the therapeutic ratio of malignancies and reduce lethality to surrounding normal tissue, but it remains deficient in terms of insufficient boron accumulation as well as short retention time, which limits the curative effect. Recently, a series of radiosensitizers that can selectively accumulate in specific organelles of cancer cells have been developed to precisely target radiotherapy, thereby reducing side effects of normal tissue damage, overcoming radioresistance, and improving radiosensitivity. In this review, we mainly focus on the field of nanomedicine-based cancer radiotherapy and discuss the organelle-targeted radiosensitizers, specifically including nucleus, mitochondria, endoplasmic reticulum and lysosomes. Furthermore, the organelle-targeted boron carriers used in BNCT are particularly presented. Through demonstrating recent developments in organelle-targeted radiosensitization, we hope to provide insight into the design of organelle-targeted radiosensitizers for clinical cancer treatment.

关键词： Cancer radiotherapy Organelle-target Radiosensitization Boron neutron capture therapy Nanomedicines

Cancer cell membrane-coated bacterial ghosts for highly efficient paclitaxel delivery against metastatic lung cancer

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Acta Pharmaceutica Sinica B 2024年第1期14卷 365-377页

作者： Dandan Ling Xueli Jia Ke Wang Qiucheng Yan Bochuan Yuan lina du Miao Li Yiguang Jin Anhui Medical University Hefei 230032China Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China

Chemotherapy is one of the major approaches for the treatment of metastatic lung cancer,although it is limited by the low tumor delivery efficacy of anticancer *** therapy is emerging for cancer treatment due to its high immune stimulation effect;however,excessively generated immunogenicity will cause serious inflammatory response ***,we prepared cancer cell membrane-coated liposomal paclitaxel-loaded bacterial ghosts(LP@BG@CCM)by layer-by-layer encapsulation for the treatment of metastatic lung *** preparation processes were simple,only involving film formation,electroporation,and pore ***@BG@CCM owned much higher 4T1 cancer cell toxicity than LP@BG due to its faster fusion with cancer *** the 4T1 breast cancer metastatic lung cancer mouse models,the remarkably higher lung targeting of intravenously injected LP@BG@CCM was observed with the almost normalized lung appearance,the reduced lung weight,the clear lung tissue structure,and the enhanced cancer cell apoptosis compared to its ***,several major immune factors were improved after administration of LP@BG@CCM,including the CD4^(+)/CD8a^(+)T cells in the spleen and the TNF-α,IFN-γ,and IL-4 in the ***@BG@CCM exhibits the optimal synergistic chemo-immunotherapy,which is a promising medication for the treatment of metastatic lung cancer.

关键词： Apoptosis Bacterial ghost Cancer cell membrane Immune stimulation Liposome Lung targeting Metastatic lung cancer Paclitaxel

Ginger oil-loaded transdermal adhesive patch treats post-traumatic stress disorder

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 316-329页

作者： Xingshuang Song Yizhi Zhang Ziyan Tang Jing Dai Yanping Wu Guiyu Huang Hong Niu Yaxin Wang Xu Jin lina du School of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Information Department General Hospital of Western War ZoneChengdu 610083China Pharmaceutical College Henan UniversityKaifeng 475004China Beijing Tiantan Hospital Capital Medical UniversityBeijing 100070China Cancer Hospital Chinese Academy of Medical SciencesBeijing 100021China

Objective To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient *** In this study,we used ginger oil,a phytochemical with potential therapeutic properties,to prepare ginger oil ***-performance liquid chromatography(HPLC)was used to quantify the main active component of ginger oil,*** absorption experiments were conducted to optimize the various pressure-sensitive adhesives and permeation enhancers,including their type and ***,the ginger oil patches were optimized and subjected to content determination and property evaluations.A PTSD mouse model was established using the foot-shock *** therapeutic effect of ginger oil patches on PTSD was assessed through pathological sections,behavioral tests,and the evaluation of biomarkers such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),brain-derived neurotrophic factor(BDNF),and melatonin(MT).Results The results demonstrated that ginger oil patches exerted therapeutic effects against PTSD by inhibiting inflammatory responses and modulating MT and BDNF *** experiments revealed that ginger oil patches maintained a stable blood drug concentration for at least one day,addressing the rapid metabolism drawback of 6-gingerol and enhancing its therapeutic *** Ginger oil can be prepared as a transdermal drug patch that meets these requirements,and the bioavailability of the prepared patch is better than that of oral *** can improve PTSD with good patient compliance and ease of ***,it is a promising therapeutic formulation for the treatment of PTSD.

关键词： Post-traumatic stress disorder 6-Gingerol Pressure sensitive adhesive patch Transdermal delivery

基于ResNet-TSM和BiGRU网络的移动视频感知质量评价模型

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北京工业大学学报 2024年第1期50卷 18-26页

作者：杜丽娜杨硕卓力张菁李嘉锋北京工业大学信息学部北京100124 北京工业大学计算智能与智能系统北京市重点实验室北京100124

考虑到卡顿、质量切换、内容特征等因素对用户体验质量的影响都会直接体现在客户端的失真视频里,提出了一种客户端的移动视频感知质量评价模型。该模型无须对每种影响因素均进行表征和度量,而是基于深度特征提取+回归的思路,直接建立失... 详细信息

考虑到卡顿、质量切换、内容特征等因素对用户体验质量的影响都会直接体现在客户端的失真视频里,提出了一种客户端的移动视频感知质量评价模型。该模型无须对每种影响因素均进行表征和度量,而是基于深度特征提取+回归的思路,直接建立失真视频与平均意见分数之间的映射模型。首先,构建了ResNet-TSM网络结构,提取失真视频片段的深度时空特征;为了避免维度灾难,采用LargeVis算法对提取的深度特征进行降维,同时提升特征的表达与区分能力。然后,采用双向门控循环单元网络对视频的长时间依赖关系进行建模,得到各视频片段的打分,再利用时间平均池化方法将各片段分数进行聚合,得到整个视频的打分结果。在WaterlooSQoE-Ⅲ和LIVE-NFLX-Ⅱ数据集上的实验结果表明,提出的模型可以获得更高的预测精度。

关键词：视频感知质量评价平均意见分数卷积神经网络时间移位模块双向门控循环单元深度时空特征

顶端钠依赖性胆汁酸转运蛋白(ASBT)在肝胆疾病中的作用

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临床肝胆病杂志 2024年第1期40卷 199-203页

作者：谢晓暄杜丽娜郭紫云杨燕国家儿童医学中心首都医科大学附属北京儿童医院中医科北京100045

顶端钠依赖性胆汁酸转运蛋白(ASBT)是负责胆汁酸肠道重吸收的关键转运体,对维持胆汁酸和胆固醇稳态起重要作用,其表达受到转录因子、核受体和肠道微生物等多种因素的调控。ASBT的表达和功能异常会导致胆汁酸及胆固醇代谢紊乱,引起多种... 详细信息

顶端钠依赖性胆汁酸转运蛋白(ASBT)是负责胆汁酸肠道重吸收的关键转运体,对维持胆汁酸和胆固醇稳态起重要作用,其表达受到转录因子、核受体和肠道微生物等多种因素的调控。ASBT的表达和功能异常会导致胆汁酸及胆固醇代谢紊乱,引起多种肝胆相关疾病。目前,ASBT作为一种治疗靶点已受到广泛关注。本文阐述了ASBT的生物学特征及表达调控机制,并对ASBT在肝胆疾病中的作用进行了综述,为相关疾病的治疗提供新方向。

关键词：顶端钠依赖性胆汁酸转运蛋白胆汁酸类胆汁淤积

维普期刊数据库博看期刊

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杨燕教授从肺论治儿童功能性便秘的临床经验

中国医药导报 2024年第5期21卷 152-155页

作者：杜丽娜杨燕国家儿童医学中心、首都医科大学附属北京儿童医院中医科北京100045

儿童功能性便秘约占小儿便秘的95%以上,是小儿消化系统的常见病,病程迁延易对儿童的身心健康产生严重影响。文章总结杨燕教授治疗儿童功能性便秘的临床经验。杨燕教授认为便秘的病机主要是大肠的传导功能失常,但与肺脏密切相关。肺与大... 详细信息

儿童功能性便秘约占小儿便秘的95%以上,是小儿消化系统的常见病,病程迁延易对儿童的身心健康产生严重影响。文章总结杨燕教授治疗儿童功能性便秘的临床经验。杨燕教授认为便秘的病机主要是大肠的传导功能失常,但与肺脏密切相关。肺与大肠相表里,肺气亏虚或肺气郁闭,宣肃失职,气机不畅,津液疏布失常,肺热移于大肠,肠失濡润,均可导致便秘发生。从肺论治,临证采用塞因塞用之法补气启闭治虚秘,提壶揭盖之法理肺通腑治实秘,同时重视良好的饮食结构及日常护理,临床疗效显著。附验案1则以佐证。

关键词：功能性便秘肺与大肠相表里临床经验

清宣止咳颗粒治疗儿童感冒、支气管炎临床应用专家共识

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药物评价研究 2024年第1期47卷 153-159页

作者：杜丽娜林丽丽韩姗姗杨燕首都医科大学附属北京儿童医院北京100045 南京中医药大学江苏南京210029 河南中医药大学第一附属医院河南郑州450003

在系统回顾、梳理清宣止咳颗粒上市以来的临床及基础研究成果的基础上,采用国际临床医学专家共识研制方法,通过召开专家论证会及函审,结合现有循证证据制定本专家共识。共识对清宣止咳颗粒治疗儿童感冒、支气管炎的优势环节、给药方案... 详细信息

在系统回顾、梳理清宣止咳颗粒上市以来的临床及基础研究成果的基础上,采用国际临床医学专家共识研制方法,通过召开专家论证会及函审,结合现有循证证据制定本专家共识。共识对清宣止咳颗粒治疗儿童感冒、支气管炎的优势环节、给药方案与剂量疗程特点、安全性问题等进行了推荐或建议,并通过专家会议以及函审的方式,在全国范围内进行意见征求和同行评议,可为指导清宣止咳颗粒的临床合理用药提供参考。

关键词：清宣止咳颗粒儿童感冒儿童支气管炎临床应用合理用药

Humic acid transport in saturated porous media:Influence of flow velocity and influent concentration

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Journal of Environmental Sciences 2014年第12期26卷 2554-2561页

作者： Xiaorong Wei Mingan Shao lina du Robert Horton State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F University Institute of Geographical Sciences and Natural Resources Research Chinese Academy of Sciences Department of Agronomy Iowa State University Ames IA 50011 USA

Understanding the transport of humic acids（HAs） in porous media can provide important and practical evidence needed for accurate prediction of organic/inorganic contaminant transport in different environmental media and interfaces. A series of column transport experiments was conducted to evaluate the transport of HA in different porous media at different flow velocities and influent HA concentrations. Low flow velocity and influent concentration were found to favor the adsorption and deposition of HA onto sand grains packed into columns and to give higher equilibrium distribution coefficients and deposition rate coefficients, which resulted in an increased fraction of HA being retained in ***, retardation factors were increased and the transport of HA through the columns was delayed. These results suggest that the transport of HA in porous media is primarily controlled by the attachment of HA to the solid matrix. Accordingly, this attachment should be considered in studies of HA behavior in porous media.

关键词： Attachment Flow velocity Humic acid Initial concentration Porous media Transport

聚焦术语的专业话语分析——以“一带一路”话语为例

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中国科技术语 2024年第4期26卷 80-92页

作者：彭懿杜莉娜张雪莹湖南师范大学外国语学院湖南长沙410081

专业话语分析,作为术语认知话语分析理论的改进,由之前的术语视角明确拓展至专业学科视角,主要包括话语的专业辨识、话语的专业解读和话语的综合分析三个步骤,旨在聚焦于术语的专业视域鉴察和话语理解,促进大众对话语中专业内容及其使... 详细信息

专业话语分析,作为术语认知话语分析理论的改进,由之前的术语视角明确拓展至专业学科视角,主要包括话语的专业辨识、话语的专业解读和话语的综合分析三个步骤,旨在聚焦于术语的专业视域鉴察和话语理解,促进大众对话语中专业内容及其使用的理解等。文章以“一带一路”话语为例,开展专业话语分析,在建立相关话语语料库与术语表之后,分析其中代表性术语“一带一路”的认知语义与语法,综合术语和话语中的其他语言表征以及专业学科视角的三原则评估话语。研究发现:术语“一带一路”的核心认知机制为概念转喻,涉及结构省缩等构式化过程;与该术语相关的普通话语语境,基于概念隐喻和概念整合,构建起专业框架与普通框架之间的联系;话语真实性与积极性的提升方式包括引用权威专家言论,兼用高值与低值情态词,少用人称主语和模糊性词汇等。

关键词：专业话语术语话语分析术语认知话语分析 “一带一路”话语