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Acta Pharmaceutica Sinica B 2024年第9期14卷 4073-4086页

作者： Mengru Cai Tingting Fu Rongyue Zhu Panxiang hu Jiahui Kong Shilang Liao Yuji du Yongqiang Zhang Changhai Qu Xiaoxv Dong Xingbin Yin Jian Ni School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China

Ferroptosis is a recently discovered pathway for regulated cell death ***,its efficacy is affected by limited iron content and intracellular ion ***,we designed a metalorganic framework(MOF)-based nanoplatform that incorporates calcium peroxide(CaO2)and oridonin(ORI).This platform can improve the tumor microenvironment and disrupt intracellular iron homeostasis,thereby enhancing ferroptosis *** cell membranes(FM)were used to modify nanoparticles(ORI@CaO2@Fe-TCPP,NPs)to produce FM@ORI@CaO2@Fe-TCPP(FM@NPs).The encapsulated ORI inhibited the HSPB1/PCBP1/IREB2 and FSP1/COQ10 pathways simultaneously,working in tandem with Fe3t to induce *** therapy(PDT)guided by porphyrin(TCPP)significantly enhanced ferroptosis through excessive accumulation of reactive oxygen species(ROS).This selfamplifying strategy promoted robust ferroptosis,which could work synergistically with FM-mediated *** vivo experiments showed that FM@NPs inhibited 91.57%of melanoma cells within six days,a rate 5.6 times higher than chemotherapy ***@NPs were biodegraded and directly eliminated in the urine or faeces without substantial ***,this study demonstrated that combining immunotherapy with efficient ferroptosis induction through nanotechnology is a feasible and promising strategy for melanoma treatment.

关键词： Metal-organic frameworks Immunotherapy Self-amplifying ferroptosis Photodynamic therapy Chemodynamic therapy Oridonin Fused cell membrane coating Metabolization

Promoting interactions between cognitive science and large language models

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The Innovation 2024年第2期5卷 9-10页

作者： Youzhi Qu Penghui du Wenxin Che Chen Wei Chi Zhang Wanli Ouyang Yatao Bian Feiyang Xu Bin hu Kai du Haiyan Wu Jia Liu Quanying Liu Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 518055China Shanghai AI Laboratory Shanghai 200232China Tencent AI Lab Shenzhen 518057China iFLYTEK AI Research Hefei 230088China School of Medical Technology Beijing Institute of TechnologyBeijing 100081China Institute for Artificial Intelligence Peking UniversityBeijing 100871China Centre for Cognitive and Brain Sciences and Department of Psychology University of MacaoMacao 999078China Department of Psychology Tsinghua UniversityBeijing 100084China

Large language models(LLMs)have made unprecedented progress,demonstrating human-like language proficiency and an extraordinary ability to encode complex *** emergence of high-level cognitive capabilities in LLMs,such as in-context learning and complex reasoning,suggests a path toward the realization of artificial general intelligence(AGI).However,we lack scientific theories and tools to assess and interpret such an emergence of the advanced intelligence of *** intelligence(AI)has been extensively applied in various areas of fundamental science to accelerate scientific research.

关键词： cognitive such language

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社会学方法论在我国艺术设计批评中的应用

安徽师范大学学报（社会科学版） 2010年第1期38卷 121-124页

作者：杜军虎江南大学设计学院江苏无锡214122

对社会学方法论在我国艺术设计批评中的应用进行探讨,指出社会学方法论评判艺术设计的价值取向,分析了社会学方法论在艺术设计批评中的主要应用方式,以期为我国艺术设计批评的规范化和促进艺术设计的社会性功能的有效发挥作出努力。

关键词：社会学方法论艺术设计批评

Effect of CO_(2) Opposing Multiple Jets on Thermoacoustic Instability and NO_(x) Emissions in a Lean-Premixed Model Combustor

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Journal of Thermal Science 2024年第1期33卷 207-221页

作者： ZHOU Hao hu Liubin Institute for Thermal Power Engineering State Key Laboratory of Clean Energy UtilizationZhejiang UniversityHangzhou 310027China

This paper experimentally studied the effect of CO_(2) opposing multiple jets on the thermoacoustic instability and NO_(x) emissions in a lean-premixed model *** feasibility was verified from three variables:the CO_(2) jet flow rate,hole numbers,and hole diameters of the *** indicate that the control effect of thermoacoustic instability and NO_x emissions show a reverse trend with the increase of open area ratio on the whole,and the optimal jet flow rate range is 1-4 L/min with CO_(2) opposing multiple *** this flow rate range,the amplitude and frequency of the dynamic pressure and heat release signals CH~* basically decrease as the CO_(2) flow rate increases,which avoids high-frequency and high-amplitude thermoacoustic *** amplitude-damped ratio of dynamic pressure and CH*can reach as high as 98.75% and 93.64% with an optimal open area ratio of 3.72%.NO_(x) emissions also decrease as the jet flow rate increases,and the maximum suppression ratio can reach 68.14%.Besides,the flame shape changes from a steep inverted "V" to a more flat "M",and the flame length will become shorter with CO_(2) opposing multiple *** research achieved the synchronous control of thermoacoustic instability and NO_(x) emissions,which could be a design reference for constructing a safer and cleaner combustor.

关键词： thermoacoustic instability lean-premixed model combustor CO_(2)opposing multiple jets open area ratio NO_(x)emissions

Multi-Axis Attention With Convolution Parallel Block for Organoid Segmentation

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1295-1297页

作者： Pengwei hu Xun Deng Feng Tan Lun hu Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of SciencesUrumqi 830011 University of Chinese Academy of Sciences Beijing 100049 Xinjiang Laboratory of Minority Speech and Language Information Processing Urumqi 830011China Merck KGaA Darmstadt 64293Germany

Dear Editor,This letter presents an organoid segmentation model based on multi-axis attention with convolution parallel *** adeptly captures dynamic dependencies within bright-field microscopy images,improving global ... 详细信息

关键词： letter convolution organo

A vertical track nonlinear energy sink

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 931-946页

作者： Meng LI hu DING Shanghai Key Laboratory of Mechanics in Energy Engineering School of Mechanics and Engineering ScienceShanghai Frontier Science Center of MechanoinformaticsShanghai UniversityShanghai 200444China

Eliminating the effects of gravity and designing nonlinear energy sinks(NESs)that suppress vibration in the vertical direction is a challenging task with numerous damping *** this paper,the dynamic design of a vertical track nonlinear energy sink(VTNES)with zero linear stiffness in the vertical direction is proposed and realized for the first *** motion differential equations of the VTNES coupled with a linear oscillator(LO)are *** the strong nonlinearity considered of the VTNES,the steady-state response of the system is analyzed with the harmonic balance method(HBM),and the accuracy of the HBM is verified *** this basis,the VTNES prototype is manufactured,and its nonlinear stiffness is *** damping effect and dynamic characteristics of the VTNES are studied theoretically and *** results show that the VTNES has better damping effects when strong modulation responses(SMRs)***,even for small-amplitude vibration,the VTNES also has a good vibration suppression *** sum up,in order to suppress the vertical vibration,an NES is designed and developed,which can suppress the vertical vibration within certain ranges of the resonance frequency and the vibration intensity.

关键词： track nonlinear energy sink(TNES) vertical direction gravity nonlinear stiffness harmonic balance method(HBM) vibration control

Distributed Fault-Tolerant Control of Uncertain Multi-Agent Systems with Connectivity Maintenance

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Journal of Systems Science & Complexity 2024年第1期37卷 40-62页

作者： XING Xueyan hu Guoqiang Continental-NTU Corporate Lab Nanyang Technological UniversitySingapore 639798Singapore Continental-NTU Corporate Lab and the School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

In this paper,a distributed cooperative control protocol is presented to deal with actuator failures of multi-agent systems in the presence of connectivity *** the developed strategy,each agent can track the reference trajectory of the leader in the presence of actuator failures,disturbances and *** connectivity of the multi-agent system can always be ensured during the control *** achieve the aforementioned control objectives,a potential function is introduced to the distributed adaptive fault-tolerant control algorithm to preserve the initial connected network among the *** uncertainty of the multi-agent system,which is allowed to be described by discontinuous functions,is approximated and compensated using the fuzzy logic *** asymptotic stability of the closed-loop system is demonstrated through the use of Cellina’s approximate selection theorem of nonsmooth *** to the developed adaptive laws,the upper bound of the disturbance is allowed to be uncertain,which facilitates the implementation of the control ***,simulation results are provided to verify the effectiveness of the proposed control scheme.

关键词： Actuator failure connectivity maintenance coordination control uncertainties

Near-Field Heat Transfer Enhancement of SiC-hBN-InSb Thermophotovoltaic System by Graphene Strong Coupling Effects

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Journal of Thermal Science 2024年第4期33卷 1409-1420页

作者： XU Zhiguo hu Zhifang School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai200240China

Near-field thermophotovoltaic(NTPV)devices comprising a SiC-hBN-graphene emitter and a graphene-InSb cell with gratings are designed to enhance the performance of the NTPV *** electrodynamics and rigorous coupled-wave analysis are employed to calculate radiative heat transfer *** is found that the NTPV systems with two graphene ribbons perform better due to the graphene strong coupling *** effects of graphene chemical potential are *** is demonstrated that near-field radiative heat transfer of thermophotovoltaic devices is enhanced by the coupling of surface plasmon polaritons,surface phonon polaritons,hyperbolic phonon polaritons,and magnetic polaritons caused by the graphene strong coupling *** splitting frequency of different polaritons is calculated to quantify the mutual interaction of graphene strong coupling ***,the effects of cell grating filling ratio are *** excitation of magnetic polaritons is affected by the graphene ribbon and the cell filling *** investigation provides a new explanation of the enhancement mechanism of graphene-assisted thermophotovoltaic systems and a novel approach for improving the output power of the near-field thermophotovoltaic system.

关键词： near-field radiative heat transfer thermophotovoltaics strong coupling effect multiple magnetic polaritons graphene-hbn heterostructures

Enhancing adhesive bond strength of CFRP/titanium joints through NaOH anodising and resin pre-coating treatments with optimised anodising conditions

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Chinese Journal of Aeronautics 2024年第2期37卷 511-523页

作者： Yunsen hu Jingheng ZHANG Lin WANG Fei CHENG Xiaozhi hu School of Materials and Chemistry Southwest University of Science and TechnologyMianyang 621000China School of Mechanical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Engineering Research Center of Biomass Materials Ministry of EducationSouthwest University of Science and TechnologyMianyang 621010China Department of Mechanical Engineering University of Western AustraliaPerthWA 6009Australia

Adhesively Bonded Carbon Fibre Reinforced Plastic(CFRP)and titanium alloy have been extensively used as a hybrid structure in modern aircrafts due to their excellent combination of mechanical properties and chemical *** study utilised NaOH anodising method to create micro-rough titanium surfaces for enhancing adhesive bonding between titanium alloy and CFRP laminates.A special and simple technique named Resin Pre-Coating(RPC)was also employed to improve the surface wetting of anodised titanium and grinded CFRP *** influences of anodising temperature and duration on the surface morphology,wettability and adhesive bond strength were *** single lap shear test results showed that the bond strength of specimens anodised at 20℃for 15 min improved by 135.9%and 95.4%,respectively,in comparison with that of acid pickled and grinded specimens(without RPC treatment).Although increasing the anodising temperature and duration produced rougher titanium surfaces,the adhesively bonded joints were not strong enough due to relatively friable titanium oxide layers.

关键词： Carbon Fibre Reinforced Polymer(CFRP) Titanium alloy Anodising Resin pre-coating Adhesive joints

Effect of Central Multiphase Microstructure of Thick Plates on Work Hardening and Crack Propagation

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 325-338页

作者： Lei hu Liqin Zhang Feng hu Kuan Zheng Guohong Zhang Collaborative Innovation Center for Advanced Steels Wuhan University of Science and TechnologyWuhan430081China Department of Applied Physics Wuhan University of Science and TechnologyWuhan430081China Analysis and Testing Center Wuhan University of Science and TechnologyWuhan430081China

The effect of multiphase microstructure in the center segregation zones(CSZ)of high-strength steel thick plates on work hardening characteristics and crack initiation/propagation were *** was correlated with deformation damage behavior by using Taylor factor(TF)gradients,kernel average misorientation(KAM),and geometric necessary dislocation(GND)*** results show that the segregation leads to a mixed structure of ferrite(soft phase)and martensite/bainite(hard phase)in the center of the thick *** to the 1/4 thickness(1/4 T)region,grain refinement occurred in the CSZ,with KAM values increasing from 0.24 to 0.49 and a decrease in the proportion of high-angle grain boundaries(>15°)from 77.4 to 51.8%.In the process of deformation,due to the influence of grain refinement and adjacent martensite/bainite,ferrite grains were divided into structural units with different TF *** higher KAM value and GND density at the interface between soft/hard phases resulted in severe work *** addition,the presence of micron-sized inclusions in the CSZ caused local strain concentration and non-continuous deformation of the matrix,which induced crack *** fracture surface showed a mixed mode of brittle cleavage fracture and ductile fracture.

关键词： Thick plate Center segregation zone Multiphase microstructure Taylor factor Crack propagation