检索结果-南通市图书馆

Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

引用

Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang Tian Sanqiao Yao feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia Tian Yanmei Zhao Wenjie Ren institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deletion of the waaf gene affects O antigen synthesis and pathogenicity in Vibrio parahaemolyticus from shellfish

引用

Food science and Human Wellness 2022年第2期11卷 418-426页

作者： feng Zhao Guoying Ding Qilong Wang Huihui du Guosheng Xiao Deqing Zhou College of biology and food engineering Chongqing Three Gorges UniversityWanzhou 404100China Yellow Sea Fisheries Research institute Chinese Academy of Fishery SciencesLaboratory for Marine Drugs and Bioproducts of Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266071China

Vibrio parahaemolyticus is the main cause of foodborne gastroenteritis,which is widely distributed in shellfish and other *** *** are nonpathogenic,and only a few types,such as serotype O3:K6,are pathogenic,which is also the most prevalent strain in ***,the relationship between this serotype and pathogenicity has yet to be *** waaf gene is located in the O antigen synthesis gene ***,we constructed a waaf gene deletion mutant(i.e.,Δwaaf)of wild-type(WT)which isolated from shellfish serotype O3:K6 via chitin-mediated transformation *** then constructed theΔwaaf complementary strain(i.e.,C-△waaf)via the Escherichia coli S17λpir strain by *** basic physiological characteristics,adhesion to Caco2 cells,and pathogenicity of the WT,△waaf,and C-△waaf strains were *** curves showed no remarkable differences between the WT andΔwaaf ***,theΔwaaf strain non-reactive to O3 antisera and other 12 O-group antisera of ***,the number of flgella and extracellular polysaccharides decreased,the adhesion decreased,and the pathogenicity *** characteristics of the C-△waaf strain were similar to those of the WT strain These results indicated that the waaf gene is vital to the serotype in ***,and changes in O antigen could affect the pathogenicity of this *** study will be helpful to understand the pathogenic mechanism of ***.

关键词： Vibrio parahaemolyticus waaf gene LPS O antigen Pathogenicity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

羧酸共聚物与方解石晶体相互作用的MD模拟

引用

化学学报 2006年第17期64卷 1817-1823页

作者：石文艳王风云夏明珠雷武张曙光南京理工大学工业化学研究所

用分子动力学方法,模拟计算了丙烯酸-丙烯酸甲酯共聚物(AA-MAE)、丙烯酸-丙烯酸羟丙酯共聚物(AA-HPA)、丙烯酸-马来酸共聚物(AA-MA)及水解马来酸酐(HPMA)四种聚羧酸类阻垢剂与方解石晶体(110)晶面的相互作用.结果表明,聚羧酸与(110)晶... 详细信息

用分子动力学方法,模拟计算了丙烯酸-丙烯酸甲酯共聚物(AA-MAE)、丙烯酸-丙烯酸羟丙酯共聚物(AA-HPA)、丙烯酸-马来酸共聚物(AA-MA)及水解马来酸酐(HPMA)四种聚羧酸类阻垢剂与方解石晶体(110)晶面的相互作用.结果表明,聚羧酸与(110)晶面结合能的大小排序为AA-MA>HPMA>AA-HPA>AA-MAE;对体系各种相互作用以及径向分布函数的分析表明,结合能主要由库仑作用(包括离子键)提供,并含少量氢键成分.与方解石晶面结合的聚合物发生扭曲变形,但形变能远小于相应的非键作用能.聚合物中不同位置羧基的动力学行为差别很大,链端羧基的运动翻转比链中部羧基剧烈得多,故后者与晶面的结合比前者更牢固而具有更强的阻垢能力.

关键词：分子动力学羧酸共聚物方解石结合能形变能径向分布函数

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

钇二氢化反应热力学函数的研究

引用

化学学报 2008年第2期66卷 170-174页

作者：于桂凤蒋刚徐国亮潘维朱正和青岛农业大学理学院青岛266109 四川大学原子与分子物理研究所成都610065 河南师范大学物理与信息工程学院新乡453007

用密度泛函方法B3LYP/SDD/6-311++G~**计算了YH_2的微观性质.并用分子总能量中的振动能E_V代替固态能量,振动熵S_(Ev)代替固态熵的近似方法,以及考虑到电子能量的变化,计算了固态YH_2(D,T)的焓H和熵S,得到不同温度下Y与H_2,D_2,T_2反应... 详细信息

用密度泛函方法B3LYP/SDD/6-311++G~**计算了YH_2的微观性质.并用分子总能量中的振动能E_V代替固态能量,振动熵S_(Ev)代替固态熵的近似方法,以及考虑到电子能量的变化,计算了固态YH_2(D,T)的焓H和熵S,得到不同温度下Y与H_2,D_2,T_2反应的ΔH~θ,ΔS~θ,ΔG~θ及氢化反应平衡压力,导出了与温度的依赖关系.计算结果表明,YH_2(s)的生成热为199.25 kJ·mol^(-1),与实验值210.00及225.94 KJ·mol^(-1)非常接近,说明近似方法的正确性.

关键词： YH2 分子结构热力学函数

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Atomistic Investigation of Shock-Induced Amorphization within Micro-shear Bands in Hexagonal Close-Packed Titanium

引用

Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1590-1600页

作者： Z.C.Meng K.G.Wang T.Ali D.Li C.G.Bai D.S.Xu S.J.Li A.H.feng G.J.Cao J.H.Yao Q.B.Fan H.Wang R.Yang institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials science and engineering University of Science and Technology of ChinaShenyang 110016China Interdisciplinary Centre for Additive Manufacturing(ICAM) School of Materials and ChemistryUniversity of Shanghai for Science and TechnologyShanghai 200093China School of Materials science and engineering Tongji UniversityShanghai 201804China Key Laboratory for Light-Weight Materials Nanjing Tech UniversityNanjing 210009China National Key Laboratory of science and technology on Materials Under Shock and Impact School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing institute of technology Chongqing Innovation Center Chongqing 401135China

The mechanical response of a single crystal titanium sample against(0001)α surface impact was investigated using molecular dynamics ***,non-uniform plastic deformation was observed in the *** high strain rates,amorphization occurred near the edge of the contact region where severe shear strain induced a large number of stacking faults(SFs)and *** contrast,the central part of the contact region underwent less deformation with significantly fewer ***,instead of amorphization by consuming SFs and dislocations,there was a gradual increase in the density of dislocations and SFs during the process of *** local amorphous regions eventually grew into shear bands.

关键词： Shock compression Amorphization Shear band Titanium molecular dynamics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Isospin dependence of projectile fragmentation at hundreds of MeV/u

引用

Chinese Physics C 2020年第8期44卷 155-163页

作者： Jun su Long Zhu Chenchen Guo feng-Shou Zhang Sino-French institute of Nuclear engineering and technology Sun Yat-sen UniversityZhuhai 519082China The Key Laboratory of Beam technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Beijing Radiation Center Beijing 100875China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion Accelerator of LanzhouLanzhou 730000China

By modeling the fragmentation process using a dynamic model and permitting only evaporation in the statistical code,the main features of a projectile fragmentation at 600 MeV/u were considered in our previous study[***.C,98:014610(2018)].In this study,we extend this to the isospin dependence of a projectile fragmentation at several hundreds of MeV/*** searched for isospin observables related to the isospin fractionation to extract the symmetry energy,and found that at the pre-equilibrium stage of the collisions an isospin diffusion will take place and affect the isospin of the final *** isospin fractionation plays a part during the fragmenting *** to the soft symmetry energy,the stiff symmetry energy provides a smaller repulsive force for neutrons and an attractive force for the protons in a neutron-rich system at a subnormal density,and hence causes a smaller isospin asymmetry of the gas phase,leaving a more neutron-rich liquid *** observable robust isospin is proposed to extract the slope of the symmetry energy at normal density based on the isospin dependence of the projectile fragmentation at hundreds of MeV/u.

关键词： projectile fragmentation symmetry energy isospin-dependent quantum molecular dynamics isospin fractionation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Turning weak into strong: on the CTAB-induced active surface growth

引用

science china chemistry 2022年第7期65卷 1299-1305页

作者： Yonglong Zheng Jianpeng Zong Ting Xiang Quan Ren Dongmeng su Yuhua feng Yawen Wang Hongyu Chen institute of Advanced Synthesis(IAS) School of Chemistry and Molecular EngineeringJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing Tech UniversityNanjing 211816China School of science Westlake UniversityHangzhou 310023China

Discovering new methods and principles in the inequivalent growth of equivalent facets is of great significance for going beyond symmetrical nanocrystals and for out-of-box exploration. In this work, we demonstrate that a middle ground exists between the traditional weak ligands and the strong ligands with unusual growth modes. By modifying the seed concentration during the growth of pentagonal Au nanorods, the typical weak ligand cetyltrimethylammonium bromide(CTAB) is made strong, leading to notches of restricted growth and even the active surface growth mode. In-depth investigation in the link between growth kinetics and ligand packing reveals the principle of their interplay —— that the on-off dynamics of the ligands only allows for a certain limit of materials deposition rate. Beyond this limit, the growth materials build up and are then diverted elsewhere, leading to inequivalent growth. The fact that a freshly grown surface has few ligands promotes the active surface growth, focusing the growth materials onto a few sites. We believe that the knowhow of interfering ligand packing via growth kinetics would offer a powerful tool of synthetic control, where the facet-and curvature-dependent ligand packing is expected to be useful synthetic handles.

关键词： facet control ligand packing active surface growth Au deposition ligand dissociation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimized operation scheme of flash-memory-based neural network online training with ultra-high endurance

引用

Journal of Semiconductors 2024年第1期45卷 33-37页

作者： Yang feng Zhaohui sun Yueran Qi Xuepeng Zhan Junyu Zhang Jing Liu Masaharu Kobayashi Jixuan Wu Jiezhi Chen School of Information science and engineering(ISE) Shandong UniversityQingdao 266200China Neumem Co. LtdHefei 230093China Key Laboratory of Microelectronic Devices and Integrated technology Institute of Microelectronics of Chinese Academy of SciencesBeijing 100084China institute of Industrial science The University of TokyoTokyoJapan

With the rapid development of machine learning,the demand for high-efficient computing becomes more and more *** break the bottleneck of the traditional Von Neumann architecture,computing-in-memory(CIM)has attracted increasing attention in recent *** this work,to provide a feasible CIM solution for the large-scale neural networks(NN)requiring continuous weight updating in online training,a flash-based computing-in-memory with high endurance(10^(9) cycles)and ultrafast programming speed is *** the one hand,the proposed programming scheme of channel hot electron injection(CHEI)and hot hole injection(HHI)demonstrate high linearity,symmetric potentiation,and a depression process,which help to improve the training speed and *** the other hand,the low-damage programming scheme and memory window(MW)optimizations can suppress cell degradation effectively with improved computing *** after 109 cycles,the leakage current(I_(off))of cells remains sub-10pA,ensuring the large-scale computing ability of *** characterizations are done on read disturb to demonstrate its robust *** processing CIFAR-10 tasks,it is evident that~90%accuracy can be achieved after 109 cycles in both ResNet50 and VGG16 *** results suggest that flash-based CIM has great potential to overcome the limitations of traditional Von Neumann architectures and enable high-performance NN online training,which pave the way for further development of artificial intelligence(AI)accelerators.

关键词： NOR flash memory computing-in-memory endurance neural network online training

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lubricating properties of ester oil prepared from bio-based 2,5-furandicarboxylic acid

引用

Friction 2020年第2期8卷 360-369页

作者： Mingjin FAN Jia Al Shuai ZHANG Chenlu YANG Xin du Ping WEN Xiangyuan YE feng ZHOU Weiming LIU Shanxi Key Laboratory of Phytochemistry College of Chemistry&Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China College of chemistry and molecular science Wuhan UniversityWuhan 430072China

The depletion of petroleum resources and the intensification of environmental problems have necessitated the development of renewable products from bio-based chemicals instead of petroleum ***,a new kind of ester lubricating oil,isooctyl furan dicarboxylate(isooctyl-FD),was prepared from bio-based 2,5-furandicarboxylic *** structure of isooctyl-FD was evaluated using nuclear magnetic resonance imaging and high-resolution mass *** physicochemical and tribological properties including thermal and oxidation stabilities,flash point and pour point,viscosity and viscosity index,and friction-reducing and anti-wear properties were systematically *** results show that isooctyl-FD has comparable thermal and oxidation stability to the synthetic ester lubricating oil,isooctyl sebacate(isooctyl-S).Its friction-reducing and anti-wear properties are superior to isooctyl-S;however,its viscosity-temperature and low-temperature properties are inferior to isooctyl-S.

关键词： 2,5-furandicarboxylic acid synthetic ester bio-based platform compound lubricating oil

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Coordination engineering of cobalt phthalocyanine by functionalized carbon nanotube for efficient and highly stable carbon dioxide reduction at high current density

引用

Nano Research 2022年第4期15卷 3056-3064页

作者： Hongdong Li Yue Pan Zuochao Wang Yaodong Yu Juan Xiong Haoyang du Jianping Lai Lei Wang Shouhua feng Key Laboratory of Eco-chemical engineering Taishan scholar advantage and characteristic discipline team of Eco-chemical process and technologyCollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China Shandong engineering Research Center for Marine Environment Corrosion and Safety Protection College of Environment and Safety EngineeringQingdao University of Science and TechnologyQingdao 266042China

Coordination engineering can enhance the activity and stability of the catalyst in heterogeneous ***,the axial coordination engineering between different groups on the carbon carrier and molecular catalysts in the electrocatalytic carbon dioxide reduction reaction(CO_(2)RR)has been studied *** coordination engineering strategy,a series of amino(NH_(2)),hydroxyl(OH),and carboxyl(COOH)groups functionalized carbon nanotubes(CNT)immobilized cobalt phthalocyanine(CoPc)catalysts are *** with no groups,OH groups and COOH groups,NH_(2)groups can effectively change the coordination environment of the central metal Co,thereby significantly increasing the turnover frequency(TOF)(31.4 s^(-1)at-0.6 V ***,CoPc/NH_(2)-CNT>CoPc/OH-CNT>CoPc/COOH-CN>CoPc/CNT).In the flow cell,the CoPc/NH_(2)-CNT catalyst has high carbon monoxide(CO)selectivity at high current density(~100%at-225 mA·cm^(-2),~96%at-351 mA·cm^(-2)).Importantly,the CoPc/NH_(2)-CNT catalyst can operate stably for 100 h at 225 mA·cm^(-2).Theoretical calculations reveal that CoPc/NH_(2)-CNT catalyst is beneficial to the formation of^(*)COOH and desorption of^(*)CO,thus promoting CO_(2)*** work provides an excellent platform for understanding the effect of coordination engineering on electrocatalytic performance and promotes a way to explore efficient and stable catalysts in other applications.

关键词： cobalt phthalocyanine(CoPc) functionalized carbon nanotubes(CNT) coordination engineering highly stable carbon dioxide electroreduction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：