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Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 39-51页

作者： Si-Yun Lin Hou Huang Jin-Jie Yu Feng Su Tian Jiang Shao-Yuan Zhang Lu Lv Tao Long Hui-Wen Pan Jun-Qing Qi Qiang Zhou Wei-Feng Tang Guo-Wen ding Li-Ming Wang Li-Jie Tan Jun Yin Department of Thoracic Surgery Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Key Laboratory of Clinical Geriatric Medicine Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Department of Cardiothoracic Surgery The Affiliated People's Hospital of Jiangsu UniversityZhenjiang 212002Jiangsu ProvinceChina Department of Thoracic Surgery Sichuan Cancer Hospital&InstituteChengdu 610042Sichuan ProvinceChina Department of Cardiothoracic Surgery Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Respiratory and Critical Care Medicine Shanghai Xuhui Central HospitalShanghai 200032China

BACKGROUND Transforming growth factor-β(TGF-β)superfamily plays an important role in tumor progression and *** A receptor type 1C(ACVR1C)is a TGF-βtype I receptor that is involved in tumorigenesis through binding to dif-ferent *** To evaluate the correlation between single nucleotide polymorphisms(SNPs)of ACVR1C and susceptibility to esophageal squamous cell carcinoma(ESCC)in Chinese Han *** In this hospital-based cohort study,1043 ESCC patients and 1143 healthy controls were *** SNPs(rs4664229,rs4556933,rs77886248,rs77263459,rs6734630)of ACVR1C were assessed by the ligation detection reaction ***-Weinberg equilibrium test,genetic model analysis,stratified analysis,linkage disequi-librium test,and haplotype analysis were *** Participants carrying ACVR1C rs4556933 GA mutant had significantly decreased risk of ESCC,and those with rs77886248 TA mutant were related with higher risk,especially in older male *** the haplotype analysis,ACVR1C Trs4664229Ars4556933Trs77886248Crs77263459Ars6734630 increased risk of ESCC,while Trs4664229Grs4556933Trs77886248Crs77263459Ars6734630 was associated with lower susceptibility to *** ACVR1C rs4556933 and rs77886248 SNPs were associated with the susceptibility to ESCC,which could provide a potential target for early diagnosis and treatment of ESCC in Chinese Han population.

关键词： Activin A receptor type 1C Single nucleotide polymorphisms Esophageal squamous cell carcinoma Genetic susceptibility Hospital-based cohort study

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Steady-state responses of a belt-drive dynamical system under dual excitations

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Acta Mechanica Sinica 2016年第1期32卷 156-169页

作者： Hu ding Shanghai Institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy EngineeringShanghai UniversityShanghai 200072China

The stable steady-state periodic responses of a belt-drive system with a one-way clutch are studied. For the first time, the dynamical system is investigated under dual excitations. The system is simultaneously excited by the firing pulsations of the engine and the harmonic motion of the foundation. Nonlinear discrete-continuous equations are derived for coupling the transverse vibration of the belt spans and the rotations of the driving and driven pulleys and the accessory pulley. The nonlinear dynamics is studied under equal and multiple relations between the frequency of the fir- ing pulsations and the frequency of the foundation motion. Furthermore, translating belt spans are modeled as axially moving strings. A set of nonlinear piecewise ordinary differ- ential equations is achieved by using the Galerkin truncation. Under various relations between the excitation frequencies, the time histories of the dynamical system are numerically simulated based on the time discretization method. Further- more, the stable steady-state periodic response curves are calculated based on the frequency sweep. Moreover, the convergence of the Galerkin truncation is examined. Numer- ical results demonstrate that the one-way clutch reduces the resonance amplitude of the rotations of the driven pul- ley and the accessory pulley. On the other hand, numerical examples prove that the resonance areas of the belt spans are decreased by eliminating the torque-transmitting in the opposite direction. With the increasing amplitude of the foun- dation excitation, the damping effect of the one-way clutch will be reduced. Furthermore, as the amplitude of the firing pulsations of the engine increases, the jumping phenomena in steady-state response curves of the belt-drive system with or without a one-way clutch both occur.

关键词： Nonlinear vibration One-way clutch Dynamical system Steady-state responses Galerkinmethod

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Biodegradation of jute/poly(lactic acid) composites by fungi

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Science China(Technological Sciences) 2018年第11期61卷 1705-1712页

作者： ding ding YU Tao LI Yan School of Aerospace Engineering and Applied Mechanical Tongji University State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Jiaotong University Key Laboratory of Advanced Civil Engineering Materials Ministry of Education Tongji University

Jute/poly(lactic acid)(PLA) composites were firstly prepared by extrusion and injection molding. Then the composites were exposed to a fungi environment for 28 d which consisted with five fungi according to the American Society of Testing Materials(ASTM) standards. Weight loss, morphology and mechanical properties of the samples with different infected days were measured. Gel permeation chromatography(GPC), scanning electron microscope(SEM) and differential scanning calorimetry(DSC) were utilized to analyze the infected process. Mechanism can be concluded that PLA on the surface of composites slowly degraded under the fungi environment. Then surface fiber were exposed in the air, the interface gap between fiber and matrix enlarged, resulting in the decline of the mechanical properties.

关键词： jute poly(lactic acid) composites biodegradation fungi

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Set Function Optimization

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Journal of the Operations Research Society of China 2019年第2期7卷 183-193页

作者： Wei-Li Wu Zhao Zhang ding-Zhu du Department of Computer Science University of Texas at DallasRichardsonTX 75080USA Department of Computer Science Zhejiang Normal UniversityJinhua 321004ZhejiangChina

This article is an introduction to recent development of optimization theory on set functions,the nonsubmodular optimization,which contains two interesting results,DS(difference of submodular)functions decomposition and sandwich theorem,together with iterated sandwich method and data-dependent *** potential research problems will be mentioned.

关键词： Set function Optimization DS decomposition・Sandwich theorem Iterated sandwich method

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Anaerobic benzene biodegradation by a pure bacterial culture of Bacillus cereus under nitrate reducing conditions

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Journal of Environmental Sciences 2010年第5期22卷 709-715页

作者： Junfeng Dou Aizhong ding Xiang Liu Yongchao du Dong Deng Jinsheng Wang College of Water Sciences Beijing Normal University Engineering Research Center of Groundwater Pollution Control and Remediation Ministry of Education Beifing 100875 China. Department of Environmental Science and Engineering Tsinghua University Beijing 100084 China

A pure culture using benzene as sole carbon and energy sources was isolated by screening procedure from gasoline contaminated *** analysis of the 16S rDNA gene sequence,morphological and physiological characteristics showed that the isolated strain was a member of genus Bacillus *** biodegradation performance of benzene by *** was evaluated,and the results showed that benzene could be efficiently biodegraded when the initial benzene concentration was below 150 mg/*** metabolites of anaerobic nitrate-dependent benzene oxidation by strain *** were identified as phenol and *** results of substrate interaction between binary combinations for benzene,phenol and benzoate showed that the simultaneous presence of benzene stimulated the degradation of benzoate,whereas the addition of benzene inhibited the degradation of *** degradation by *** was enhanced by the addition of phenol and benzoate,the enhanced effects were more pronounced at higher *** our knowledge,this is the first report that the isolated bacterial culture of *** can efficiently degraded benzene under nitrate reducing conditions.

关键词： Bacillus cereus nitrate reduction anaerobic biodegradation substrate interaction phenol benzoate

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Large Piezoresistance and Pressure-Induced Change in Electric Properties in Perovskite-like La_(0.85)Sr_(0.15)MnO_(3)

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Chinese Physics Letters 1996年第11期13卷 870-873页

作者： ZHANG Ning ding Wei-ping GUO Zai-bing XING ding-yu du You-wei LI Gang ZHENG Yi-xin National Laboratory of Solid State Microstructures Nanjing UniversityNanjing 210093 Department of Physics Nanjing Normal UniversityNanjing 210024

Uniaxial pressure dependencies of the electric properties of perovskite-like La_(0.85)Sr_(0.15)MnO_(3)(0.2≤x≤0.6)system have been investigated.A large nonlinear piezoresistance effect and a remarkable pressure-induced change of metal-semiconductor(M-S)transition have been *** La_(0.85)Sr_(0.15)MnO_(3),the piezoresistance value can reach about 86%at 290K under a pressure of 16.8MPa,and the pressure coefficient of Tp,the onset of the M-S transition,is as high as 6.4 K/MPa,which is significantly larger than that of known similar pressure *** pressure effects suggest that the resistivity of the perovskite compounds is relative not only to double exchange but also to the symmetry of *** phenomenon may provide another route in understanding the colossal magnetoresistance behavior in the perovskites.

关键词： resistance perovskite

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CXCL13 shapes tumor immune microenvironment in ovarian cancer with homologous recombination deficiency

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Genes & Diseases 2024年第5期11卷 48-50页

作者： Yue ding Zheng Ye Bo ding Songwei Feng Furong du Xuejiao Ma Xiaoxuan Wang Yang Shen Department of Obstetrics and Gynaecology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210008China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.Ltd.NanjingJiangsu 210042China

Recently,immune checkpoint inhibitors(ICIs)and poly(ADP-ribose)polymerase inhibitors(PARPi)have played a pivotal role in prolonging the recurrence-free survival of patients with ovarian cancer(OC).1,2 Although PARPi have revolutionized the treatment of OC,the absence of reliable predictive biomarkers limits the broad application of ICIs for patients with homologous recombination(HR)deficiency(HRD).3 CXC-chemokine ligand 13(CXCL13)is a cytokine constitutively secreted in the stromal cells of the B-cell region of secondary lymphoid tissue.4 It exclusively binds to the chemokine receptor CXCR5,which is abundantly expressed in subsets of mature circulating B lymphocytes,follicular helper T cells,and skin-derived dendritic cells,and governs the migration of these cells into secondary lymphoid organs in response to the CXCL13 gradient.5 In this study,we aimed to elucidate the role of CXCL13 in shaping the tumor immune microenvironment(TIME)in HR-deficient OC and to explore its relationship with the cGAS-STING signaling pathway.

关键词： CXCL13 cancer organs

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Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第01期 653-664页

作者： Rahul Navik Eryu Wang Xiao ding Huang Yunyi Yiyu Liu Jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

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Smoothness-oriented path optimization for robotic milling processes

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Science China(Technological Sciences) 2020年第9期63卷 1751-1763页

作者： PENG JingFu ding Ye ZHANG Gang ding Han State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai200240China HUST-Wuxi Research Institute Wuxi214174China

Industrial robots are increasingly used for five-axis machining operations, where the rotation of the end effector along the toolaxis direction is functionally redundant. This functional redundancy should be carefully resolved when planning the robot path according to the tool path generated by a computer-aided manufacturing(CAM) system. Improper planning of the redundancy may cause drastic variations of the joint motions, which could significantly decrease the machining efficiency as well as the machining accuracy. To tackle this problem, this paper presents a new optimization-based methodology to globally resolve the functional redundancy for the robotic milling process. Firstly, a global performance index concerning the smoothness of the robot path at the joint acceleration level is proposed. By minimizing the smoothness performance index while considering the avoidance of joint limits and the singularity and the constraint of the stiffness performance, the resolution of the redundancy is formulated as a constrained optimization problem. To efficiently solve the problem, the sequential linearization programming method is employed to improve the initial solution provided by the conventional graph-based method. Then, simulations for a given tool path are presented. Compared with the graph-based method, the proposed method can generate a smoother robot path in which a significant reduction of the magnitude of the maximum joint acceleration is obtained, resulting in a smoother tool-tip feedrate profile. Finally, the experiment on the robotic milling system is also presented. The results show that the optimized robot path of the proposed method obtains better surface quality and higher machining efficiency, which verifies the effectiveness of the proposed method.

关键词： robot milling functional redundancy path optimization smoothness sequential linear programming

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Secure separable reversible data hiding of halftone image in blockchain

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The Journal of China Universities of Posts and Telecommunications 2022年第2期29卷 85-96页

作者： ding Haiyang College of Information Engineering Beijing Institute of Graphic CommunicationBeijing 102600China Information Security Center Beijing University of Posts and TelecommunicationsBeijing 100876China

To realize the distributed storage and management of a secret halftone image in blockchain,a secure separable reversible data hiding(RDH)of halftone image in blockchain(SSRDHB)was proposed.A secret halftone image can be used as the original image to generate multiple share images which can be distributed storage in each point of blockchain,and additional data can be hidden to achieve management of each share ***,the secret halftone image was encrypted through Zu Chongzhi(ZUC)algorithm by using the encryption key(EK).Secondly,the method of using odd or even of share data was proposed to hide data,and a share dataset can be generated by using polynomial ***,multiple share images can be obtained through selecting share data,and different additional data can be hidden through controlling odd or even of share data,and additional data can be protected by using data-hiding key(DK).After sharing process,if the receiver has both keys,the halftone image can be recovered and additional data can be revealed,and two processes are *** results show that multiple share images hidden additional data can be obtained through SSRDHB,and the halftone image can be recovered with 100%by picking any part of share images,and one additional data can be revealed with 100%by picking any one share image.

关键词： separable reversible data hiding(RDH) halftone image secret sharing blockchain additional data

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