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丹酚酸B调控脂质代谢改善非酒精性脂肪肝实验研究

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中国药理学通报 2025年第1期41卷 107-115页

作者：张佳健郭梦茹梅金玉陈明安徽医科大学基础医学院药理学教研室安徽合肥230032 安徽医科大学第二附属医院耳鼻喉科安徽合肥230601

目的探讨丹酚酸B(SalB)可能通过调控Lcn2改善非酒精性脂肪肝的作用。方法体内实验,8周龄♂C57BL/6J小鼠用普通维持饲料喂养,作为对照组,8周龄ApoE-/-小鼠用高脂饲料喂养,随机分为模型组和SalB组。在饲养8周后,SalB组小鼠用SalB灌胃,低... 详细信息

目的探讨丹酚酸B(SalB)可能通过调控Lcn2改善非酒精性脂肪肝的作用。方法体内实验,8周龄♂C57BL/6J小鼠用普通维持饲料喂养,作为对照组,8周龄ApoE-/-小鼠用高脂饲料喂养,随机分为模型组和SalB组。在饲养8周后,SalB组小鼠用SalB灌胃,低剂量为15 mg·kg^(-1)·d^(-1),高剂量为30 mg·kg^(-1)·d^(-1),对照组和模型组用等剂量生理盐水灌胃。肝脏转录组测序结果揭示模型组和SalB组的差异表达基因,HE染色、油红O染色观察肝组织的病理变化,试剂盒检测血清和肝组织的脂质、氧化应激和炎症指标,RT-qPCR检测Lcn2、SREBP-1C以及脂质合成相关酶的mRNA水平。体外实验,用棕榈酸(PA)诱导L02和LX-2细胞24 h建立NAFLD模型,用SalB(30μmol·L^(-1))和PA(0.2 mmol·L^(-1))共孵育检测SalB体外改善NAFLD的情况。试剂盒检测L02细胞TC、TG的含量,细胞油红O染色试剂盒检测L02细胞的脂质积累,RT-qPCR检测LX-2细胞Lcn2、SREBP-1C以及脂质合成相关酶基因的mRNA水平。结果模型组血清、肝脏的生化指标异常,肝组织脂质、炎症和氧化应激水平升高,出现大面积脂肪空泡和大量的脂质沉积,PA诱导的L02细胞也出现大量的脂质积累,在SalB干预后均有明显改善。转录组测序结果表明SalB可以调控肝脏脂质代谢和炎症。肝脏和LX-2细胞mRNA水平显示模型组Lcn2、SREBP-1C以及脂质合成相关酶基因表达明显上调,SalB干预后均能降低这些基因的表达。结论丹酚酸B可以明显改善非酒精性脂肪肝,其机制可能是通过下调Lcn2、SREBP-1C和脂质合成酶的表达。

关键词： SalB 非酒精性脂肪肝脂质代谢 Lcn2 SREBP-1C 脂质合成相关酶

Numerical Simulation on the Impact of A Liquid Square on Rigid Plate and Liquid Layer

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China Ocean Engineering 2020年第3期34卷 362-373页

作者： guo chun-yu guo Hang LIU Li-chao HU jian WANG Wei College of Shipbuilding Engineering Harbin Engineering UniversityHarbin 150001China

Fluids and structures impact is one of the common phenomena in nature, and it widely exists in engineering practice,including ship hydrodynamic slamming, wave impact on offshore platforms, plunging wave on coastal structures,emergency landing of aircrafts at sea as well as impact of ultra-cold droplets and ice lumps under aviation *** this paper, a two dimensional (2-D) solver for Navier-Stokes equations is developed and applied in the numerical simulation of the impact on a rigid plate by a liquid square. The computational domain is discretized by Finite Volume Method (FVM). The Volume of Fluid (VOF) technique is used to track the free surface and the PiecewiseLinear Interface Construction (PLIC) is used for reconstruction. The Continuum Surface Force (CSF) model is used to account for the surface tension. The convective term and the diffusive term are upwind and centrally differenced respectively. The Inner Doubly Iterative Efficient Algorithm for Linked Equations (IDEAL) is used to decouple the pressure and velocity. Based on the proposed techniques, collapse of water column is simulated and convergence study is performed for the validation of the numerical solver. Then the impact of a free falling liquid body is simulated, and the effect of volume and initial height of the liquid body is analyzed. In addition, the impact on a plate with a liquid layer is also simulated to study the effect of falling height on a liquid floor.

关键词： fluid impact VOF liquid square free surface evolution pressure distribution impact force

Genetic parameters for somatic cell score and production traits in the fi rst three lactations of Chinese Holstein cows

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Journal of Integrative Agriculture 2015年第1期14卷 125-130页

作者： ZHAO Fu-ping guo Gang WANG Ya-chun guo Xiang-yu zhang yuan du Li-xin National Center for Molecular Genetics and Breeding of Animal Institute of Animal SciencesChinese Academy of Agricultural Sciences Beijing Sanyuan Dairy Cattle Breeding Center College of Animal Science and Technology China Agricultural University

The objectives of this study were to estimate genetic parameters of lactation average somatic cell scores （LSCS） and examine genetic associations between LSCS and production traits in the first three lactations of Chinese Holstein cows using single-parity multi-trait animal model and multi-trait repeatability animal model. There were totally 273605 lactation records of Chinese Holstein cows with first calving from 2001 to 2012. Heritability estimates for LSCS ranged from 0.144 to 0.187. Genetic correlations between LSCS and 305 days milk, protein percentage and fat percentage were -0.079, -0.082 and -0.135, respectively. Phenotypic correlation between LSCS and 305 days milk yield was negative （-0.103 to -0.190）. Genetic correlation between 305 days milk and fat percentage or protein percentage was highly negative. Genetic correlation between milk fat percentage and milk protein percentage was highly favorable. Heritabilities of production traits decreased with increase of parity, whereas heritability of LSCS increased with increase of parity.

关键词： somatic cell score genetic parameters Chinese Holstein single-parity multi-trait animal model multi-traitrepeatability animal model

Effect of cross wedge rolling on the microstructure of GH4169 alloy

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International Journal of Minerals,Metallurgy and Materials 2012年第9期19卷 836-842页

作者： Ning zhang Bao-yu Wang jian-guo Lin School of Mechanical Engineering University of Science and Technology Beijing Beijing 100083 China Deparment of Mechanical Engineering Imperial College London SW7 2AZ UK

The metal microstructure during the hot forming process has a significant effect on the mechanical properties of final products. To study the microstructural evolution of the cross wedge rolling （CWR） process, the microstructural model of GH4169 alloy was programmed into the user subroutine of DEFORM-3D by FORTRAN. Then, a coupled thermo-mechanical and microstructural simulation was performed under different conditions of CWR, such as area reduction, rolling temperature, and roll speed. Comparing experimental data with simulation results, the difference in average grain size is from 11.2% to 33.4% so it is verified that the mierostructural model of GH4169 alloy is reliable and accurate. The fine grain of about 12-15 p.m could be obtained by the CWR process, and the grain distribution is very homogeneous. For the symmetry plane, increasing the area reduction is helpful to refine the grain and the value should be around 61%. Moreover, when the roiling temperature changes from 1000 to 1100℃ and the roll speed from 6 to 10 ***-1, the grain size of the rolled piece decreases first and then increases. The temperature may be better to choose the value around 1050℃ and the speed less than 10 r-min-1.

关键词： superalloys nickel alloys cross wedge rolling microstructural evolution grain size numerical analysis

Influence of bias voltage on structure,mechanical and corrosion properties of reactively sputtered nanocrystalline TiN films

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Journal of Iron and Steel Research International 2017年第12期24卷 1223-1230页

作者： chun-lin He Jin-lin zhang guo-feng Ma Zhao-fu du jian-ming Wang Dong-liang Zhao Liaoning Provincial Key Laboratory of Advanced Materials Shenyang UniversityShenyang 110044LiaoningChina Research Institute of Functional Materials Central Iron&Steel Research InstituteBeijing 100081China

Nanocrystalline TiN films were prepared by DC reactive magnetron *** influence of substrate biases on structure,mechanical and corrosion properties of the deposited films was studied using X-ray diffraction,field emission scanning electron microscopy,nanoindentation and electrochemical *** deposited films have a columnar structure,and their preferential orientation strongly depends on bias *** preferential orientations change from（200）plane at low bias to（111）plane at moderate bias and then to（220）plane at relatively high *** H,elastic modulus E,H/E＊and H3/E＊2 ratios,and corrosion resistance of the deposited films increase first and then decrease with the increase in bias *** the best values appear at bias of-120 V,attributing to the film with a fine,compact and less defective *** demonstrates that there is a close relation among microstructure,mechanical and corrosion properties of the TiN films,and the film with the best mechanical property can also provide the most effective corrosion protection.

关键词： TiN film Nanocrystalline Bias voltage Microstructure Mechanical property Corrosion resistance

Functional Cellulose Materials Fabricated by Using Ionic Liquids as the Solvent

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Chinese Journal of Polymer Science 2023年第4期41卷 483-499,I0005页

作者： Yi-Rong Wang chun-chun Yin Jin-Ming zhang Jin Wu jian yu Jun zhang CAS Key Laboratory of Engineering Plastics and CAS Research/Education Center for Excellence in Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing100190China College of Chemistry University of Chinese Academy of SciencesBeijing100049China

Cellulose is one of the most abundant natural polymers in the nature,which has many attractive advantages,such as renewability,biodegradability,and ***,due to the strong hydrogen bond network and hierarchical structure,cellulose is extremely difficult to be dissolved and *** recently,a class of novel eco-friendly solvents,ionic liquids,have been found to be able to efficiently dissolve cellulose,providing a versatile platform for cellulose processing and ***,we highlight recent advances in efficiently fabricating functional cellulose derivatives via the homogeneous chemical modification and developing all-biomass materials via controlling the dissolution-regeneration process in ionic *** effective and environmentally-friendly utilization of cellulose not only reduces dependence on fossil resources but also protects the environment.

关键词： Cellulose Ionic liquids Homogeneous modification Functional materials Cellulose derivatives

Low-Cycle Fatigue and Creep-Fatigue Behaviors of a Second-Generation Nickel-Based Single-Crystal Superalloy at 760℃

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Acta Metallurgica Sinica(English Letters) 2020年第10期33卷 1423-1432页

作者： jian zhang yuan-yuan guo Mai zhang Zhen-yu Yang yu-Shi Luo Beijing Institute of Aeronautical Materials Beijing 100095China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

Low-cycle fatigue(LCF)behaviors of a second-generation nickel-based single-crystal superalloys with[001]orientation at 760℃ have been *** strain amplitudes were introduced to investigate the creep-fatigue *** LCF life of none tensile holding(NTH)was higher than that of the 60-s tensile hold(TH)at any strain *** the strain amplitude was 0.7%,the stacking and cross-slip dislocations appeared together at the γ/γ’coherent microstructure in both TH and NTH *** the strain amplitude of 0.9%,plenty of the cross-slip dislocations appeared inγchannel and other dislocations were stacking at γ/γ’***,the SFs still appeared in γ’phase with 60-s TH which caused cyclic *** the strain amplitude increased up to 1.2%,the dislocations are piling up at the γ/γ’interfaces and cutting through the γ’phase in both TH and NTH tests,which caused cyclic *** influences of strain amplitude and holding time were *** stress response behaviors occurred in different loading *** surface characteristic and fracture mechanism were observed by scanning electron *** result is helpful for building the relationship of various blade fatigue failure modes,cyclic stress response and microstructure deformation under different strain amplitudes.

关键词： Low-cycle fatigue Cyclic stress response behavior Dislocation morphologies

Delay of planet formation at large radius and the outward decrease in mass and gas content of Jovian planets

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Research in Astronomy and Astrophysics 2015年第9期15卷 1597-1603页

作者： Li-Ping Jin chun-jian Liu yu zhang College of Physics Jilin University

A prominent observation of the solar system is that the mass and gas content of Jovian planets decrease outward with orbital radius, except that, in terms of these properties, Neptune is almost the same as Uranus. In previous studies, the solar nebula was assumed to preexist and the formation process of the solar nebula was not considered. It was therefore assumed that planet formation at different radii started at the same time in the solar nebula. We show that planet formation at different radii does not start at the same time and is delayed at large radii. We suggest that this delay might be one of the factors that causes the outward decrease in the masses of Jovian planets. The nebula starts to form from its inner part because of the inside-out collapse of its progenitorial molecular cloud core. The nebula then expands outward due to viscosity. Material first reaches a small radius and then reaches a larger radius, so planet formation is delayed at the large radius. The later the material reaches a planet＇s location, the less time it has to gain mass and gas content. Hence, the delay tends to cause the outward decrease in mass and gas content of Jovian planets. Our nebula model shows that the material reaches Jupiter, Saturn, Uranus and Neptune at t = 0.40, 0.57, 1.50 and 6.29 × 10^6 yr, respectively. We discuss the effects of time delay on the masses of Jovian planets in the framework of the core accretion model of planet formation. Saturn＇s formation is not delayed by much time relative to Jupiter so that they both reach the rapid gas accretion phase and become gas giants. However, the delay in formation of Uranus and Neptune is long and might be one of the factors that cause them not to reach the rapid gas accretion phase before the gas nebula is dispersed. Saturn has less time to go through the rapid gas accretion, so Saturn＇s mass and gas content are significantly less than those of Jupiter.

关键词： planetary systems -- planets and satellites: formation -- planets and satellites: gaseous planets -- planets and satellites: individual (Jovian planets) -- protoplanetary disks

Analysis of Genetic Effects for Heterosis of Erucic Acid and Glucosinolate Contents in Rapeseed (Brassica napus L.)

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Agricultural Sciences in China 2011年第10期10卷 1525-1531页

作者： zhang Hai-zhen SHI chun-hai WU jian-guo Department of Agronomy College of Agriculture and Biotechnology Zhejiang University Hangzhou 310029 P.R.China Key Laboratory of Genetic and Breeding for Landscape Plant Hangzhou Botanical Garden Hangzhou 310012. P.R. China

The embryo, cytoplasmic, and maternal heterosis for erucic acid content （EAC） and glucosinolate content （GLS） of rapeseed （Brassica napus L.） were studied by using the genetic models for quantitative traits of seeds in diploid crops. Eight parents were included in a diallel mating design in two years. It was found that the heterosis of EAC and GLS was simultaneously controlled by genetic main effects and genotype×environment （GE） interaction effects. The general heterosis of most crosses for EAC was significantly positive, while it was not for GLS. The general heterosis was more important for two quality traits of rapeseed because of the low GE interaction heterosis in both years, especially for GLS. Among different genetic systems, significant positive embryo general heterosis and the negative maternal general heterosis were found for EAC and GLS in most hybrid crosses. Some hybrids with significant negative interaction heterosis were detected for either of EAC or GLS. In general, maternal general and interaction heterosis was more important for reducing EAC and GLS of rapeseed.

关键词： rapeseed quality general heterosis GE interaction heterosis