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Journal of Advanced Ceramics 2024年第7期13卷 1002-1010页

作者： Xiaocui Rao Xueling Yang Renbing Sun peng du Hai Jiang Yao Huang Laihui Luo Department of Microelectronics Science and Engineering School of Physical Science and TechnologyNingbo UniversityNingbo 315211China College of Materials Science and Engineering Ningbo University of TechnologyNingbo 315016China

0-3 type ferroelectric-phosphor composite ceramics cannot be prepared by the traditional solid-state sintering(SSS)method due to the strong chemical reaction between ferroelectrics and phosphors during high-temperature *** cold sintering process(CSP)may solve this issue by densifying ceramics at ultralow sintering *** this work,dense 0-3 type 0.8BaTiO_(3)-0.2CaTiO_(3):Pr^(3+)(0.8BT-0.2CT:Pr^(3+))binary composite ceramics were fabricated at an ultralow temperature of 225℃via CSP with the Ba(OH)2·8H2O hydrated *** effects of the Ba(OH)_(2)·8H2O content,sintering temperature,and sintering time on the microstructure and densification of the ceramics were *** density of the composite ceramics prepared by the optimized sintering parameters reaches 89%.Both energy-dispersive X-ray(EDX)spectroscopy and X-ray diffraction(XRD)confirm the existence of BT and CT:Pr^(3+)phases in the prepared ceramics.A strong ferroelectric performance is obtained,and the luminescent properties of CT:Pr^(3+)are preserved for the ***,the 0.8BT-0.2CT:Pr^(3+)composite ceramics prepared by CSP have stronger photoluminescence and photo-stimulated luminescence than their counterparts prepared by cold sintering assistance(CSA)and SSS ***,CSP is a promising method for combining luminescent and ferroelectric properties into 0-3 type composite ceramics.

关键词： single-step densification cold sintering composite ceramics ferroelectric luminescence

Aβ-Aggregation-Generated Blue Autofluorescence Illuminates Senile Plaques as well as Complex Blood and Vascular Pathologies in Alzheimer’s Disease

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Neuroscience Bulletin 2024年第8期40卷 1115-1126页

作者： Hualin Fu Jilong Li Chunlei Zhang peng du Guo Gao Qiqi Ge Xinping Guan Daxiang Cui Institute of Nano Biomedicine and Engineering School of Sensing Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Institute of Marine Equipment Shanghai Jiao Tong UniversityShanghai 200240China National Center for Translational Medicine Shanghai Jiao Tong UniversityShanghai 200240China Department of Colorectal Surgery School of MedicineXinhua HospitalShanghai Jiao Tong UniversityShanghai 200092China Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China The Key Laboratory of System Control and Information Processing Ministry of EducationShanghai 200240China

Senile plaque blue autofluorescence was discovered around 40 years ago,however,its impact on Alzheimer’s disease(AD)pathology has not been fully *** analyzed senile plaques with immunohistochemistry and fluorescence imaging on AD brain sections and also Aβ aggregation in *** DAPI or Hoechst staining,the nuclear blue fluorescence could only be correctly assigned after subtracting the blue plaque *** flower-like structures wrapping dense-core blue fluorescence formed by cathepsin D staining could not be considered central-nucleated neurons with defective lysosomes since there was no nuclear staining in the plaque core when the blue autofluorescence was *** Aβ self-oligomers and Aβ/hemoglobin heterocomplexes generated blue *** Aβ amyloid blue autofluorescence not only labels senile plaques but also illustrates red cell aggregation,hemolysis,cerebral amyloid angiopathy,vascular plaques,vascular adhesions,and *** summary,we conclude that Aβ-aggregation-generated blue autofluorescence is an excellent multi-amyloidosis marker in Alzheimer’s disease.

关键词： Senile plaque Blue autofluorescence Aβ Amyloid aggregation Hemoglobin Cathepsin D.Microaneurysm Alzheimer's disease

Enhanced measurement precision with continuous interrogation during dynamical decoupling

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Chinese Physics B 2024年第3期33卷 88-94页

作者：张军杜鹏敬雷徐鹏尤力张文献 Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education and School of Physics and TechnologyWuhan UniversityWuhan 430072China State Key Laboratory of Low-Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China Wuhan Institute of Quantum Technology Wuhan 430206China

Dynamical decoupling(DD)is normally ineffective when applied to DC *** its straightforward implementation,DD nulls out DC signal as well while suppressing *** work proposes a phase relay method that is capable of continuously interrogating the DC signal over many DD *** illustrate its efficacy when applied to the measurement of a weak DC magnetic field with an atomic spinor Bose-Einstein *** approaching standard quantum limit or Heisenberg limit are potentially realizable for a coherent spin state or a squeezed spin state of 10000 atoms,respectively,while ambient laboratory level noise is suppressed by *** work offers a practical approach to mitigate the limitations of DD to DC measurement and would find other applications for resorting coherence in quantum sensing and quantum information processing research.

关键词： quantum sensing continuous interrogation quantum magnetometer dynamical decoupling Heisenberg limit

Research progress in CALPHAD assisted metal additive manufacturing

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China Foundry 2024年第4期21卷 295-310页

作者： Ya-qing Hou Xiao-qun Li Wei-dong Cai Qing Chen Wei-ce Gao du-peng He Xue-hui Chen Hang Su China Iron&Steel Research Institute Group Beijing 100081China Thermo-Calc Software AB SolnaSE-169Sweden KTH Royal Institute of Technology StockholmSE-100Sweden Central Iron and Steel Research Institute Beijing 100081China

Metal additive manufacturing(MAM)technology has experienced rapid development in recent *** both equipment and materials progress towards increased maturity and commercialization,material metallurgy technology based on high energy sources has become a key factor influencing the future development of *** calculation of phase diagrams(CALPHAD)is an essential method and tool for constructing multi-component phase diagrams by employing experimental phase diagrams and Gibbs free energy models of simple *** combining with the element mobility data and non-equilibrium phase transition model,it has been widely used in the analysis of traditional metal *** development of CALPHAD application technology for MAM is focused on the compositional design of printable materials,the reduction of metallurgical imperfections,and the control of microstructural *** endeavor carries considerable theoretical and practical *** paper summarizes the important achievements of CALPHAD in additive manufacturing(AM)technology in recent years,including material design,process parameter optimization,microstructure evolution simulation,and properties ***,the limitations of applying CALPHAD technology to MAM technology are discussed,along with prospective research directions.

关键词： metal additive manufacturing CALPHAD integrated computational material engineering powder bed fusion material design microstructure simulation

Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3964-3982页

作者： Weilian Bao Jiaren Lyu Guize Feng Linfeng Guo Dian Zhao Keyuan You Yang Liu Haidong Li peng du Daofeng Chen Xiaoyan Shen Department of Pharmacology&the Key Laboratory of Smart Drug Delivery Ministry of Education School of PharmacyFudan UniversityShanghai 201210China Department of Natural Medicine School of PharmacyFudan UniversityShanghai 201210China Department of Colorectal and Anal Surgery Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China Shanghai Colorectal Cancer Research Center Shanghai 200092China

The proper differentiation and reorganization of the intestinal epithelial cell population is critical to mucosal regeneration post *** retaining cells(LRCs)expressing SRY-box transcription factor 9(SOX9)promote epithelial repair by replenishing LGR5 t intestinal stem cells(ISCs).While,LRCs are also considered precursor cells for enteroendocrine cells(EECs)which exacerbate mucosal damage in inflammatory bowel disease(IBD).The factors that determine LRC-EEC differentiation and the effect of intervening in LRC-EEC differentiation on IBD remain *** this study,we investigated the effects of a natural anthraquinone called aloe emodin(derived from the Chinese herb rhubarb)on mucosal healing in IBD *** findings demonstrated that aloe emodin effectively interfered with the differentiation to EECs and preserved a higher number of SOX9t LRCs,thereby promoting mucosal ***,we discovered that aloe emodin acted as an antagonist of free fatty acid receptors(FFAR1),suppressing the FFAR1-mediated Gbg/serine/threonine-protein kinase(AKT)pathway and promoting the translocation of forkhead box protein O1(FOXO1)into the nucleus,ultimately resulting in the intervention of differentiation *** findings reveal the effect of free fatty acid accessibility on EEC differentiation and introduce a strategy for promoting mucosal healing in IBD by regulating the FFAR1/AKT/FOXO1 signaling pathway.

关键词： LRCs ISCs EECs IBD SOX9 Aloe emodin FFAR1 FOXO1

Game Analysis of Regulation for Online Prescription Drugs under Customer Feedback Mechanism

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Asian Journal of Social Pharmacy 2024年第2期19卷 147-158页

作者： du peng Huang Zhe Dong Li School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China

Objective To study the way to better regulate the online sales of prescription drugs,and to provide reference for the adjustment of relevant policies since the online sales of prescription drugs has become an inevitable *** A game model was constructed for the strategy choice of pharmaceutical e-commerce platform,customers and government departments based on differential game theory and Nash equilibrium game model to analyze the pure strategy Nash equilibrium,Nash equilibrium dominant strategy of each subject and the mixed strategy Nash equilibrium under different ***,Matlab was used to carry out simulation *** and Conclusion The study shows that:(1)Improving the credibility of the government and reducing the cost of government regulation can not only make the pharmaceutical e-commerce platform operate with high quality,but also give greater play to government functions;(2)The greater the influence of social evaluation on pharmaceutical e-commerce platforms,the lower the cost of high-quality operation of pharmaceutical e-commerce platform,and the greater the probability of customer choosing real evaluation strategy;(3)The greater the customers’perception of potential risk,the greater the compensation,and the lower the cost of ***,the greater the probability that government departments will choose strict ***,the model solution and simulation analysis are combined to provide countermeasures and suggestions for the safety regulation of online sales of prescription drugs.

关键词： online prescription drug sale Nash equilibrium simulation analysis mixed strategy game

制造边界:家庭代际关系的情感分流与现代调适

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社会科学研究 2024年第2期 120-134页

作者：杜鹏南开大学社会学院天津300350

家庭代际关系的现代转型改变了情感伦理化的依附性表达路径,赋予情感以自主的实践空间。情感实践兼有理性面向和伦理底色。结合鄂西的田野调查经验,文章建构了代际互动中的情感分流路径,揭示了以制造边界为核心的情感调适逻辑。情感分... 详细信息

家庭代际关系的现代转型改变了情感伦理化的依附性表达路径,赋予情感以自主的实践空间。情感实践兼有理性面向和伦理底色。结合鄂西的田野调查经验,文章建构了代际互动中的情感分流路径,揭示了以制造边界为核心的情感调适逻辑。情感分流主要包含三个维度:一是伦理轨道中代际互动过程的分化,基于“父子之别”构造了生活本位的情感实践路径;二是在伦理轨道之外激活情感轨道,基于“嫁娶之别”构造了以资源流动为媒介的情感实践路径;三是面对代际互动的双轨格局,子代家庭基于“夫妻之别”构造了灵活的场景转换机制,维系了双轨格局的均衡稳定。“制造边界”的目标不是伦理的封存,而是理顺理性、情感和伦理的关系,进而在底线伦理之基础上拓展代际互动空间,塑造灵活、自由且富有弹性的代际关系。伦理、理性在融入情感实践的过程中赋予转型期家庭制度以开放性和包容性,展现了农民家庭秩序重建的可能路径。

关键词：伦理理性情感实践代际关系情感分流

乡村秩序的空间基础:一个人地关系的分析框架

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华南农业大学学报（社会科学版） 2024年第5期23卷 107-117页

作者：杜鹏南开大学社会学院天津300350

村落空间不仅是村庄社会关系运作的背景,而且定义了乡村秩序再生产的底层架构。人地关系是村落空间的基础,且在农民土地利用实践中推动村落空间的功能分化,并逐渐形成生产空间与生活空间的分化与融合、公共空间与私人空间的分化与互通... 详细信息

村落空间不仅是村庄社会关系运作的背景,而且定义了乡村秩序再生产的底层架构。人地关系是村落空间的基础,且在农民土地利用实践中推动村落空间的功能分化,并逐渐形成生产空间与生活空间的分化与融合、公共空间与私人空间的分化与互通。村落空间兼有自然底色与社会面向,集体土地制度调控维系了村落空间结构的有机整合。城市化进程推动村落空间转型,生产空间与生活空间的分离、公共空间与私人空间的断裂可能导致村落空间的秩序紊乱。为此,须将人地关系纳入集体土地制度调控,在农民流动的社会场景中建构富有包容性和适应性的村落空间秩序。

关键词：村落空间乡村秩序人地关系城市化集体制度

“效用”与“情感”——论莫言新剧《鳄鱼》的两个象征维度

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当代作家评论 2024年第1期 99-103页

作者：杜鹏山东大学文化传播学院

《鳄鱼》1是莫言在继《晚熟的人》之后拿出的又一部新作。莫言虽然以小说创作闻名,但是他多年来一直尝试着进行不同文体的写作,无论是散文,还是诗歌、戏剧。在莫言的文学创作中,戏剧创作一直占有非常重要的位置。其话剧作品《霸王别姬... 详细信息

《鳄鱼》1是莫言在继《晚熟的人》之后拿出的又一部新作。莫言虽然以小说创作闻名,但是他多年来一直尝试着进行不同文体的写作,无论是散文,还是诗歌、戏剧。在莫言的文学创作中,戏剧创作一直占有非常重要的位置。其话剧作品《霸王别姬》《我们的荆轲》都已被搬上舞台,在国内外先后上演了百余场。

关键词：戏剧创作莫言《霸王别姬》《我们的荆轲》文学创作新剧《鳄鱼》小说创作

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考虑运行图抽线调整的城际铁路动车周转计划编制

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交通运输系统工程与信息 2024年第5期24卷 148-159,184页

作者：杜鹏张路瑶北京交通大学交通运输学院北京100044

针对现有城际铁路动车组周转计划编制方法未考虑运行线客座率分布,导致抽线调整时难以单独停运低客座率车次而不影响高客座率车次的问题,本文提出一种适用于运行图抽线调整的动车组周转计划优化编制方法。以最小化动车组使用数量及交路... 详细信息

针对现有城际铁路动车组周转计划编制方法未考虑运行线客座率分布,导致抽线调整时难以单独停运低客座率车次而不影响高客座率车次的问题,本文提出一种适用于运行图抽线调整的动车组周转计划优化编制方法。以最小化动车组使用数量及交路中运行线客座率差异为目标,考虑满足一级修等约束条件,构建非线性整数规划模型;通过线性化处理并结合Hierholzer's算法筛选合格解的方式,高效求解模型。案例分析表明:相较于只考虑动车组使用数量的传统方法,该模型在不增加动车组使用数量的情况下,可以显著降低各交路中运行线客座率的差异。优化后的交路中运行线客座率极差提高了68.67%,交路中运行线客座率方差之和降低至对比方案的66.27%。抽线调整时,采用优化方案能够更精确地优先取消低客座率运行线,有效保留高客座率运行线。在抽线条数分别设定为1,2,3的情况下,优化方案停开的运行线中,客座率低于60%的运行线的占比均保持在77%以上,而对比方案中该比例均未超过45%;优化方案中被取消车次的平均客座率比对比方案分别降低了4.48%、5.88%和6.01%。

关键词：铁路运输动车组非线性规划模型动车组周转计划客座率运行图调整