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Weak interaction-steered evolution of polyoxovanadate-based metal-organic polyhedra from transformation via interlock to packing

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Chinese Chemical Letters 2024年第2期35卷 527-533页

作者： Yan-Hu Wang Ke-Wei Tong Chao-Qin Chen jing du Peng Yang College of Chemistry and Chemical Engineering Advanced Catalytic Engineering Research Center of the Ministry of EducationHunan UniversityChangsha 410082China College of Chemistry and Materials Science Testing and Analysis CenterHebei Normal UniversityShijiazhuang 050024China

A bottleneck in biomimetic synthesis consists in the full copy of,for example,the hierarchical structure of proteins directed by weak *** contrast with covalent bonds bearing definite orientation and high stability,weak intermolecular forces within a continuous dynamic equilibrium can be hardly tamed for molecular *** this endeavor,a ligand-dominated strategy that embodies tunable electrostatic repulsion andπ···πstacking was first employed to shape polyoxovanadate-based metal-organic polyhedra(VMOPs).Structural evolution involving transformation,interlock,and discovery of an unprecedented prototype of the Star of David was hence *** only as a handy tool for the primary structural control over VMOPs,these weak forces allow for an advanced management on the spatial distribution of such manmade macromolecules as well as the associated physicochemical behaviors,representing an ideal model for simulating and interpreting the conformation-function relationship of proteins.

关键词： Polyoxometalates Polyoxovanadates Metal-organic polyhedron Interlock Weak intermolecular forces

A new production component method for natural gas development planning

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Energy Geoscience 2024年第1期5卷 283-292页

作者： Fanliao Wang Jiangchen Han Shucheng Liu Yanqing Liu Kun Su jing du Liru Wang Petroleum Exploration and Production Research Institute SINOPECBeijing102206China Research Institute of Petroleum Exploration&Development PetroChinaBeijing100083China

Based on an analysis of the limitations of conventional production component methods for natural gas development planning,this study proposes a new one that uses life cycle models for the trend fitting and prediction of *** this new method,the annual production of old and new wells is predicted by year first and then is summed up to yield the production for the planning *** shows that the changes in the production of old wells in old blocks can be fitted and predicted using the vapor pressure model(VPM),with precision of 80%e95%,which is 6.6%e13.2%higher than that of other life cycle ***,a new production prediction process and method for new wells have been established based on this life cycle model to predict the production of medium-to-shallow gas reservoirs in western Sichuan Basin,with predication error of production rate in 2021 and 2022 being 6%and 3%*** new method can be used to guide the medium-and long-term planning or annual scheme preparation for gas *** is also applicable to planning for large single gas blocks that require continuous infill drilling and adjustment to improve gas recovery.

关键词： Production component method Production prediction Life cycle model Gas development planning Western Sichuan Basin

Production forecasting methods for different types of gas reservoirs

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Energy Geoscience 2024年第3期5卷 275-283页

作者： Fanliao Wang Shucheng Liu Ying Jia Anrong Gao Kun Su Yanqing Liu jing du Liru Wang Petroleum Exploration and Production Research Institute SINOPECBeijing102206China

Hydrocarbon production in oil and gas fields generally progresses through stages of production ramp-up,plateau(peak),and decline during field development,with the whole process primarily modeled and forecasted using lifecycle ***'s conventional gas reservoirs are dominated by carbonates,low-permeability tight sandstone,condensate,volcanic rocks,and medium-to-high-permeability *** study identifies the optimal production forecasting models by comparing the fitting coefficients of different models and calculating the relative errors in technically recoverable *** improve forecast precision,it suggests substituting exponential smoothing method-derived predictions for anomalous data caused by subjective influences like market dynamics and maintenance *** preferred models for carbonate gas reservoir production forecasts are the generalized Weng's,Beta,Class-I generalized mathematical,and Hu-Chen *** Vapor pressure and Beta models are optimal for forecasting the annual productivity of wells(APW)from gas-bearing low-permeability tight sandstone *** Wang-Li,Beta,and Yu QT tb models are apt for moderate-to-small-reserves,single low-permeability tight sandstone gas *** Rayleigh,Hu-Chen,and generalized Weng's models are suitable for condensate gas *** medium-to-high-permeability sandstone gas reservoirs,the lognormal,generalized gamma,and Beta models are recommended.

关键词： Production prediction Life cycle model Carbonate gas reservoir Low-permeability tight sandstone gas reservoir

Optical vortex array:generation and applications[Invited]

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Chinese Optics Letters 2024年第2期22卷 3-16页

作者：杜竫权志强李康王健 Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Optics Valley Laboratory Wuhan 430074China

Optical vortex arrays,with their unique wavefront structures,find extensive applications in fields such as optical communications,trapping,imaging,metrology,and *** methods used to generate these vortex beam arrays are crucial for their *** this review,we begin with introducing the fundamental concepts of optical vortex ***,we present three methods for generating them,including diffractive optical elements,metasurfaces,and integrated optical *** then explore the applications of optical vortex beam arrays in five different ***,we conclude with a summary and outlook for the research on optical vortex beam arrays.

关键词： optical vortex array topological charge number orbital angular momentum vector beam

Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第1期25卷 51-64页

作者： Mingming XU Zhaoliang LIU Wenhua HU Ying HAN Zhen WU Sufeng CHEN Peng XIA jing du Xumin ZHANG Piliang HAO Jun XIA Shuang YANG Center for Clinical Mass Spectrometry College of Pharmaceutical SciencesSoochow UniversitySuzhou215123China School of Life Science and Technology ShanghaiTech UniversityShanghai201210China State Key Laboratory of Genetic Engineering Department of BiochemistrySchool of Life SciencesFudan UniversityShanghai200438China Department of Clinical Laboratory Center Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou310014China

Pancreatic cancer is among the most malignant cancers,and thus early intervention is the key to better survival ***,no methods have been derived that can reliably identify early precursors of development into ***,it is urgent to discover early molecular changes during pancreatic *** aberrant glycosylation is closely associated with cancer progression,numerous efforts have been made to mine glycosylation changes as biomarkers for diagnosis;however,detailed glycoproteomic information,especially site-specific N-glycosylation changes in pancreatic cancer with and without drug treatment,needs to be further ***,we used comprehensive solid-phase chemoenzymatic glycoproteomics to analyze glycans,glycosites,and intact glycopeptides in pancreatic cancer cells and patient *** profiling of N-glycans in cancer cells revealed an increase in the secreted glycoproteins from the primary tumor of MIA PaCa-2 cells,whereas human sera,which contain many secreted glycoproteins,had significant changes of glycans at their specific *** results indicated the potential role for tumor-specific glycosylation as disease *** also found that AMG-510,a small molecule inhibitor against Kirsten rat sarcoma viral oncogene homolog(KRAS)G12C mutation,profoundly reduced the glycosylation level in MIA PaCa-2 cells,suggesting that KRAS plays a role in the cellular glycosylation process,and thus glycosylation inhibition contributes to the anti-tumor effect of AMG-510.

关键词： Pancreatic cancer Glycosylation Biomarker Glycoproteomics Mass spectrometry

Dimensional regulation in gigantic molybdenum blue wheels featuring{(W)Mo_(5)}motifs for enhanced proton conductivity

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Nano Research 2024年第9期17卷 8261-8268页

作者： Yu-Lun Wu jing du Hai-Ying Zhang Ming-Jun Hou Qiao-Yue Li Wei-Chao Chen Kui-Zhan Shao Bo Zhu Chao Qin Xin-Long Wang Zhong-Min Su Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Department of ChemistryNortheast Normal UniversityChangchun 130024China Hebei Key Laboratory of Organic Functional Molecules National Demonstration Center for Experimental Chemistry EducationTesting and Analysis CenterCollege of Chemistry and Materials ScienceHebei Normal UniversityShijiazhuang 050024China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchun 130021China

Dimensional regulation in polyoxometalates is an effective strategy during the design and synthesis of polyoxometalates-based high proton conductors,but it is not available to ***,the precise regulation of dimensionality has been realized in an unprecedented gigantic molybdenum blue wheel family featuring pentagonal{(W)Mo5}motifs through optimizing the molar ratio of Mo/W,including[Gd_(2)Mo_(124)W_(14)O_(422)(H_(2)O)62]38-(0D-{Mo_(124)W_(14)},1),[Mo_(126)W_(14)O441(H_(2)O)51]^(70-)(1D-{Mo_(126)W_(14)}n,2),and[Mo_(124)W_(14)O_(430)(H_(2)O)50]60-(2D-{Mo_(124)W_(14)}n,3).Such important{(W)Mo5}structural motif brings new reactivity into gigantic Mo blue *** are different numbers and sites of{Mo2}defects in each wheel-shaped monomer in 1-3,which leads to the monomers of 2 and 3 to form 1D and 2D architectures via Mo-O-Mo covalent bonds driven by{Mo2}-mediated H_(2)O ligands substitution process,respectively,thus achieving the controllable dimensional *** expected,the proton conductivity of 3 is 10 times higher than that of 1 and 1.7 times higher than that of *** continuous proton hopping sites in 2D network are responsible for the enhanced proton conductivity with lower activation *** study highlights that this dimensional regulation approach remains great potential in preparing polyoxometalates-based high proton conductive materials.

关键词： polyoxometalate molybdenum blue wheels Mo/W mixed-addenda polyoxometalates dimensional regulation proton conduction

Composition analysis of Compound Shenhua Tablet,a seven-herb Chinese medicine for IgA nephropathy:evaluation of analyte-capacity of the assays

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Chinese Journal of Natural Medicines 2024年第2期22卷 178-192页

作者： ZHANG Haiyan WANG Qiuyue WANG Jianan ZHANG Sichao JIA Weiwei HE Ning XIA Xiaoyan WANG Ting LAI Liyu LI Jiaying du jing OLALEYE Olajide E CHEN Xiangmei YANG Junling LI Chuan Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China School of Pharmacy University of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100049China Department of Nephrology First Medical Center of Chinese PLA General HospitalNephrology Institute of the Chinese People’s Liberation ArmyNational Key Laboratory of Kidney DiseasesNational Clinical Research Center for Kidney DiseasesBeijing Key Laboratory of Kidney Disease ResearchBeijing 100853China Zhongshan Institute for Drug Discovery Zhongshan 528400China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China

Compound Shenhua Tablet,a medicine comprising seven herbs,is employed in treating IgA *** study aimed to meticulously analyze its chemical *** on a list of candidate compounds,identified through extensive literature review pertinent to the tablet’s herbal components,the composition analysis entailed the systematic identification,characterization,and quantification of the *** analyte-capacity of LC/ESI-MS-based and GC/EI-MS-based assays was *** identified and characterized constituents were quantified to determine their content levels and were ranked based on the constituents’daily doses.A total of 283 constituents,classified into 12 distinct categories,were identified and characterized in the Compound Shenhua *** constituents exhibited content levels of 1−10982μg·g^(−1),with daily doses of 0.01−395μmol·d^(−1).The predominant constituents,with daily doses of≥10μmol·d^(−1),include nine organic acids(citric acid,quinic acid,chlorogenic acid,cryptochlorogenic acid,gallic acid,neochlorogenic acid,isochlorogenic acid C,isochlorogenic acid B,and linoleic acid),five iridoids(specnuezhenide,nuezhenoside G13,nuezhenidic acid,secoxyloganin,and secologanoside),two monoterpene glycosides(paeoniflorin and albiflorin),a sesquiterpenoid(curzerenone),a triterpenoid(oleanolic acid),and a phenylethanoid(salidroside).Additionally,there were 83,126,and 55 constituents detected in the medicine with daily doses of 1–10,0.1–1,and 0.01–0.1μmol·d^(−1),*** combination of the LC/ESI-MS-based and GC/EI-MS-based assays demonstrated a complementary relationship in their analyte-capacity for detecting the constituents present in the *** comprehensive composition analysis establishes a solid foundation for further pharmacological research on Compound Shenhua Tablet and facilitates the quality evaluation of this complex herbal medicine.

关键词： Compound Shenhua Tablet Composition analysis Analyte-capacity

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基于连通度的作战体系结构可靠性分析方法

系统工程与电子技术 2024年第9期46卷 3112-3117页

作者：丁泽柳季明杜静军事科学院战略评估咨询中心北京100091

具备坚实可靠的组成结构是作战体系有效执行作战任务的基础和充分发挥体系效能的前提。为了判断评价作战体系结构在遭到打击破坏或出现故障损耗情况下的持续运行能力,基于体系结构要素之间的相互连通程度,从点连通度和边连通度两个角度... 详细信息

具备坚实可靠的组成结构是作战体系有效执行作战任务的基础和充分发挥体系效能的前提。为了判断评价作战体系结构在遭到打击破坏或出现故障损耗情况下的持续运行能力,基于体系结构要素之间的相互连通程度,从点连通度和边连通度两个角度入手,研究给出一种作战体系结构可靠性分析方法,利用算例对所提方法进行了检验,可服务于作战体系设计与建设。

关键词：连通度作战体系结构可靠性

“乡村医疗社会”的生成与显现——基于一个农村老人生病、治疗与护理的医学人类学观察与思考

同方期刊数据库博看期刊评论

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青海民族研究 2024年第1期35卷 45-54页

作者：杜靖杜若桑青岛大学山东青岛266071 首都医科大学北京100069

乡村居家治疗与照护中的疾病不仅是科学的存在,也是宇宙论意义的存在以及在世的存在。就科学的存在而言,疾病是自然界的物质与病者的身体相遇而互构出来的一种界面,现代医学和传统医学在这个界面上实施干预。就宇宙论意义的存在而言,疾... 详细信息

乡村居家治疗与照护中的疾病不仅是科学的存在,也是宇宙论意义的存在以及在世的存在。就科学的存在而言,疾病是自然界的物质与病者的身体相遇而互构出来的一种界面,现代医学和传统医学在这个界面上实施干预。就宇宙论意义的存在而言,疾病是宇宙神秘力量的显象,需要借助秘术和民俗医疗手段进行救治。就在世的存在而言,疾病创建了以病人为核心的医疗社会,该类医疗社会是各种医学知识观念显象、具身与交流的场域,即科学的存在和宇宙论的存在在其中存在。然而,按照西方医学科学模式开展救治和护理的城镇医院则把上述诸多内容屏蔽在外。

关键词：乡村居家医疗照护乡村医疗社会医疗人类学在世