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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 423-429页

作者： douglas Bastos-Neves Paolo Rogerio de Oliveira Salvalaggio Marcio Dias de Almeida Digestive and Hepatobiliary Surgery Hospital Sao Vicente de PauloRio de JaneiroBrazil Liver Transplant Unit Hospital Israelita Albert EinsteinSao PauloBrazil

Background: Early allograft dysfunction (EAD) is a severe complication after liver transplantation. The associated risk factors and complications have re-gained recent interest. This study investigated risk factors, survival and complications associated with EAD in a large liver transplant center in Latin America. Methods: Retrospective, unicenter, cohort, based on data from adult patients undergoing first deceaseddonor liver transplant from January 2009 to December 2013. EAD was defined by one or more of the following:(i) bilirubin ≥10 mg/dL on postoperative day 7;(ii) international normalized ratio ≥1.6 on postoperative day 7, and (iii) alanine aminotransferase or aspartate aminotransferase > 2000 IU/L within the first seven days after transplant. Results: A total of 602 patients were included;of these 34.2% developed EAD. Donor risk factors were male ( P = 0.007), age between 50 and 59 years ( P = 0.034), overweight ( P = 0.028) or grade I obesity ( P = 0.012), sodium > 157 mmol/L ( P = 0.002) and grade IV ischemia/reperfusion injury ( P = 0.002). Cold ischemia time ≥10 h ( P = 0.008) and warm ischemia time ≥40 min ( P = 0.013) were the surgical factors. Male ( P 157 mmol/L and grade Ⅳ ischemia/reperfusion injury. Cold ischemia time ≥10 h and warm ischemia time ≥40 min were the surgical risk factors. Male was the only recipient protective factor. Patients with EAD had higher reoperations and graft loss rates.

关键词： Graft survival Liver transplantation Primary graft dysfunction Donor evaluation

Identification of cancer stem cells provides novel tumor models for drug discovery

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Frontiers of Medicine 2012年第2期6卷 112-121页

作者： douglas D.Fang Danyi Wen Yajun Xu Shanghai ChemPartner Co. Ltd.998 Halei RoadZhangjiang Hi-Tech ParkPudong New DistrictShanghai 201203China

Cancer stem cells(CSCs)have received considerable attention from the research community since they were first reported in human acute myeloid leukemia 15 years *** evidence suggests that CSCs are responsible for tumor initiation and progression,drug resistance,and metastasis in both liquid and solid *** findings lead to the development of novel compounds targeting CSC populations that is becoming increasingly important for eradicating CSCs in heterogeneous tumor masses and to cure the *** 2003,we have participated in CSC studies and encountered crucial early events in the *** article reviews the history of CSC biology,clarifies the term and its definition,and further addresses the issue of how to utilize CSCs in therapeutic target discovery and drug development based on our substantial experience.

关键词： cancer stem cell tumor model drug discovery

The hamster egg penetration test may decrease intracytoplasmic sperm injection utilization while maintaining high conventional fertilization rates

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Asian Journal of Andrology 2021年第1期23卷 11-15页

作者： Yetunde Ibrahim Brett Einerson douglas T Carrell Benjamin R Emery Erica Johnstone Division of Reproductive Endocrinology and Infertility Department of Obstetrics and GynecologyUniversity of UtahSchool of MedicineSalt Lake CityUT 84132USA Division of Maternal-Fetal Medicine Department of Obstetrics and GynecologyUniversity of UtahSchool of MedicineSalt Lake CityUT 84132USA Division of Urology Department of SurgeryUniversity of UtahSchool of MedicineSalt Lake CityUT 84132USA Department of Human Genetics University of UtahSchool of MedicineSalt Lake CityUT 84132USA

This was a cohort study of in vitro fertilization(IVF)subjects at the University of Utah,Salt Lake City(UT,USA)utilizing partner *** where both the hamster egg penetration test(HEPT)and semen analysis were performed within 2 years prior to IVF cycles were stratified into four groups based on a normal or an abnormal HEPT and *** mean conventional and intracytoplasmic sperm injection(ICSI)fertilization rates were calculated in each *** performed a univariate analysis on the primary outcome comparing clinically interesting *** performed a cost-effectiveness analysis of a policy of HEPT versus universal ICSI in couples with an abnormal *** patients with a normal HEPT,there was no difference in the mean conventional fertilization rates between those with a normal and an abnormal *** was no difference in the mean conventional fertilization rates between subjects with a normal morphology without a hamster test and those with a normal HEPT without a morphology *** 1000 simulated cycles with an abnormal morphology,a policy of HEPT was cost saving compared to universal ICSI,yet produced similar fertilization *** HEPT is similar to the World Health Organization edition 5(WHO-5)morphology in predicting successful conventional fertilization while allowing decreased utilization of ICSI.A policy of HEPT for males with abnormal morphology saves cost in selecting couples for a fertilization method.

关键词： conventional fertilization hamster egg penetration test intracytoplasmic sperm injection semen analysis sperm penetration assay

Decision Making for Managing Community Flood Risks:Perspectives of United States Floodplain Managers

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International Journal of Disaster Risk Science 2021年第5期12卷 649-660页

作者： Jenna Tyler Abdul-Akeem Sadiq douglas S.Noonan Rebecca M.Entress School of Public Administration University of Central FloridaOrlandoFL 32801USA O'Neill School of Public and Environmental Affairs Indiana University–Purdue University IndianapolisIN 46202USA

To reduce flood losses,floodplain managers make decisions on how to effectively manage their community’s flood *** there is a growing body of research that examines how individuals and households make decisions to manage their flood risks,far less attention has been directed at understanding the decision-making processes for flood management at the community *** study aimed to narrow this research gap by examining floodplain managers’perceptions of the quality of their community’s flood management decision-making *** gathered from interviews with 200 floodplain managers in the United States indicate that most floodplain managers perceive their community’s flood management decision-making processes to be *** results also indicate that communities participating in the Federal Emergency Management Agency’s Community Rating System,as well as communities with a higher level of concern for flooding and a lower poverty rate,are significantly more likely to report better flood management decision-making processes.

关键词： Community flood risk management Decision making Floodplain managers United States

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Work in hand

Work in hand

作者： (1961-)douglas Aileen

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Earth meets spirit

Earth meets spirit

Key Facts about “Abuse-Deterrent” Opioids

作者： photography douglas Beasley

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Journal of Chinese Pharmaceutical Sciences 2016年第11期25卷 855-856页

作者： douglas C.Throckmorton FDA’s Center for Drug Evaluation and Research

Here at FDA, we work diligently to be part of our nation＇s solution to the opioid abuse epidemic. While there is no single solution to this complex problem, we continue to encourage efforts to develop new opioid form... 详细信息

关键词：药物滥用美国食品药品管理局药物制剂

Erratum to “A gyroscope-based system for intraoperative measurement of tibia coronal plane alignment in total knee arthroplasty” [Med Nov Technol Dev, 13, 2022, 100112]

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Medicine in Novel Technology and Devices 2024年第1期21卷 120-120页

作者： Michael A.Kokko Ryan M.Chapman Martin W.Roche douglas W.Van Citters Thayer School of Engineering at Dartmouth College 14 Engineering DriveHanoverNH03755USA Department of Kinesiology College of Health SciencesUniversity of Rhode Island25 W.Independence WayKingstonRI02881USA Orthopedic Research Institute Holy Cross Hospital 4725 N Federal Hwy.FtLauderdaleFL33308USA

The publisher would like to include the Ethical approval and informed consent statement for this *** study did not involve human subjects or animal research,and was therefore not subject to institutional ethics approval and did not require informed *** single cadaveric specimen used in ex vivo evaluation was obtained from Science Care(https://***/)and was handled in accordance with applicable Science Care policy.

关键词： approval statement alignment

JDIS Special Issue on Networked Knowledge Organization Systems(NKOS)

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Journal of Data and Information Science 2020年第1期5卷 1-2页

作者： Joseph Busch douglas Tudhope Taxonomy Strategies Washington D.CUSA University of South Wales PontypriddUK

NKOSis devoted to the discussion of the functional and data model for enabling knowledge organization systems/services(KOS),such as classification systems,thesauri,gazetteers,and ontologies,as networked interactive information services to support the description and retrieval of diverse information resources through the *** tools help to model the underlying semantic structure of a domain for purposes of information retrieval,knowledge discovery,language engineering,and the Semantic *** workshops have been held since 1997 in conjunction with related professional and digital library meetings in the U.S.,Europe and *** purpose of the workshops is to bring together KOS researchers and practitioners to share work on projects,good practices and innovations,and to discuss and critique this *** focus on topics including domain modeling,terminology development,validation,automated indexing,annotation and enrichment,and *** JDIS special issue includes a selection of papers developed from presentations at the NKOS Workshop held at the Korean National Library in Seoul on September 26,2019 as part of the International Conference on Dublin Core and Metadata Applications 2019(DCMI-2019).In the spirit of the NKOS workshops,these papers include research in process,reports on projects,and“thought experiments”.

关键词： Special Issue Systems

Assessing the effects of surface-bound humic acid on the phototoxicity of anatase and rutile TiO_2 nanoparticles in vitro

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Journal of Environmental Sciences 2016年第4期28卷 50-60页

作者： Xiaojia He Sabrieon Sanders Winfred G.Aker Yunfeng Lin Jessica douglas Huey-min Hwang Department of Biology Jackson State University Department of Biological Sciences Alcorn State University Environmental Science Ph.D.Program Jackson State University Department of Chemistry and Biochemistry Jackson State University School of Polymers and High Performance Materials The University of Southern Mississippi

In this study,the cytotoxicity of two different crystal phases of TiO2 nanoparticles,with surface modification by humic acid（HA）,to Escherichia coli,was *** physicochemical properties of TiO2 nanoparticles were thoroughly *** different initial concentrations,namely 50,100,and 200 ppm,of HA were used for synthesis of HA coated TiO2 nanoparticles（denoted as A/RHA50,A/RHA100,and A/RHA200,respectively）.Results indicate that rutile（LC50（concentration that causes 50%mortality compared the control group）=6.5）was more toxic than anatase（LC50=278.8）under simulated sunlight（SSL）irradiation,possibly due to an extremely narrow band *** is noted that HA coating increased the toxicity of anatase,but decreased that of ***,AHA50 and RHA50had the biggest differences compared to uncoated anatase and rutile with LC50of 201.9 and21.6,*** then investigated the formation of reactive oxygen species（ROS）by TiO2 nanoparticles in terms of hydroxyl radicals（OH）and superoxide anions（O2^-）.Data suggested that O2^- was the main ROS that accounted for the higher toxicity of rutile upon SSL *** also observed that HA coating decreased the generation of OH and O2^- on rutile,but increased O2^- formation on *** from TEM analysis also indicated that HA coated rutile tended to be attached to the surface of *** more than anatase.

关键词： TiO2nanoparticles Escherichia coli Humic acid Crystallinity Surface coating