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Effects of interleukin-10 treated macrophages on bone marrow mesenchymal stem cells via signal transducer and activator of transcription 3 pathway

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World Journal of Stem Cells 2024年第5期16卷 560-574页

作者： Meng-Hao Lyu Ce Bian Yi-ping dou Kang Gao Jun-Ji Xu Pan Ma Department of Periodontics School of StomatologyCapital Medical UniversityBeijing 100050China Department of Orthodontics School of StomatologyCapital Medical UniversityBeijing 100050China Department of Dental Implantology School of StomatologyCapital Medical UniversityBeijing 100050China Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction School of StomatologyCapital Medical UniversityBeijing 100050China Beijing Laboratory of Oral Health Capital Medical UniversityBeijing 100050China

BACKGROUND Alveolar bone defects caused by inflammation are an urgent issue in oral implant surgery that must be *** the various phenotypes of macrophages to enhance the inflammatory environment can significantly affect the progression of diseases and tissue engineering repair *** To assess the influence of interleukin-10(IL-10)on the osteogenic differentiation of bone marrow mesenchymal stem cells(BMSCs)following their interaction with macrophages in an inflammatory *** IL-10 modulates the differentiation of peritoneal macrophages in Wistar rats in an inflammatory *** this study,we investigated its impact on the proliferation,migration,and osteogenesis of *** expression levels of signal transducer and activator of transcription 3(STAT3)and its activated form,phos-phorylated-STAT3,were examined in IL-10-stimulated ***,a specific STAT3 signaling inhibitor was used to impede STAT3 signal activation to further investigate the role of STAT3 *** IL-10-stimulated macrophages underwent polarization to the M2 type through substitution,and these M2 macrophages actively facilitated the osteogenic differentiation of ***,STAT3 signaling plays a crucial role in the process by which IL-10 influences ***,IL-10 stimulated the activation of the STAT3 signaling pathway and reduced the macrophage inflammatory response,as evidenced by its diminished impact on the osteogenic differentiation of *** Stimulating macrophages with IL-10 proved effective in improving the inflammatory environment and promoting the osteogenic differentiation of *** IL-10/STAT3 signaling pathway has emerged as a key regulator in the macrophage-mediated control of BMSCs’osteogenic differentiation.

关键词： Macrophages Interleukin-10 Bone marrow mesenchymal stem cells Signal transducer and activator of transcription 3 Inflammatory response

MicroRNAs as novel molecular targets of green tea polyphenol epigallocatechin-3-gallate(EGCG): relevance and importance to nutrition sciences and cancer prevention

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Food Science and Human Wellness 2024年

作者： Yu Li Q.ping dou Bo Li Yongli Wang Xiushan Wang Hui Guan Dapeng Li Feng Li College of Food Science and Engineering， Shandong Agricultural University Key Laboratory of Food Nutrition and Human Health in Universities of Shandong Barbara Ann Karmanos Cancer Institute， Departments of Oncology， Pharmacology and Pathology， Wayne State University School of Medicine Jinan Vocational College of Nursing

MicroRNAs (miRNAs) are a class of single-stranded and non-coding endogenous RNAs with 18-25 nucleotides in length. By binding to the complementary sequences in the 3’untranslated region (3’UTR) of protein coding genes， miRNAs regulate posttranscriptionally the mRNA expression of target genes and enzymes involved in various biological processes. The application of high-throughput sequencing， bioinformatics analysis， and novel detection methods has high-lighted promising roles of miRNAs as both novel biomarkers for tumor diagnosis and critical regulators involved in almost all stages of carcinogenesis including cancer initiation， promotion and progression. Epigallocatechin-3-gallate (EGCG)， the most investigated active catechin in green tea， has been linked to various health-promoting benefits including chemoprevention and treatment of cancers. In this review， we first present a brief description of EGCG and its major metabolic pathway. It is followed by reviewing the roles of EGCG in the modulation of oncogenic and tumor suppressing miRNAs in some common cancers. These findings suggest that the capacity of EGCG to regulate expression of specific miRNAs provides insights of its new mechanisms of action underlying its chemopreventive and potential beneficial activities against various cancers.

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俯冲带水岩相互作用:来自西南天山(超)高压变质岩的矿物学证据

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地球科学 2024年第8期49卷 2751-2765页

作者：窦萍肖媛媛林晋炎姚永祥西北大学地质学系陕西西安710069 中国科学院海洋研究所海洋地质与环境重点实验室山东青岛266071 崂山实验室山东青岛266061 中国科学院海洋大科学研究中心山东青岛266071 中国科学院大学北京100049

西南天山(超)高压变质带内发育有大规模被流体交代的变质岩,其脉体和围岩记录了重要的俯冲带流体信息.在以往对有脉体发育的俯冲带变质岩全岩地球化学研究的基础上,进一步对该样品脉体和围岩中的石榴石、帘石、绿辉石、多硅白云母等矿... 详细信息

西南天山(超)高压变质带内发育有大规模被流体交代的变质岩,其脉体和围岩记录了重要的俯冲带流体信息.在以往对有脉体发育的俯冲带变质岩全岩地球化学研究的基础上,进一步对该样品脉体和围岩中的石榴石、帘石、绿辉石、多硅白云母等矿物成分进行原位分析,对比同一矿物在脉体和围岩中的成分区别,以深入理解脉体和围岩的全岩成分差异、俯冲带水岩相互作用中相关元素的地球化学行为及流体性质.根据岩石学特征,该样品分为富蓝闪石脉体、富帘石和碳酸盐的过渡部分及富绿辉石内部.元素储库计算揭示全岩的元素组成和元素赋存矿物及其丰度具有一致性,脉体中更高的中重稀土元素(MHREE)含量显示该部分更多的石榴石对M-HREE的赋存,过渡部分更高的REE-Th-U-Pb-Sr等元素含量反映了大量存在的帘石族矿物、碳酸盐对这些元素的控制,富绿辉石内部更高的K-Rb-Ba-Cs等元素含量则反映了这部分更多的白云母对这些元素的控制.另外,同一矿物在样品不同部分的成分差异可直接反映元素在不同变质阶段和不同水化程度下的地球化学变化,相较于受流体改造较少的富绿辉石内部,富蓝闪石脉体和过渡部分的多硅白云母和绿辉石丰度降低但更富集K-Rb-Ba-Cs等元素;石榴石丰度升高但其所含的HREE含量更低;帘石丰度升高但其所含的Th-U-轻稀土元素(LREE)含量更低.结合过渡部分出现的大量碳酸盐矿物,推测外来流体为含碳酸盐的蛇纹岩衍生流体.水岩相互作用后,流体的LILE含量显著升高,碳酸盐组分明显降低,其余元素含量变化不大.

关键词：西南天山俯冲变质作用流体活动赋存矿物元素地球化学行为地球化学

基于注意力机制和不确定性损失的太阳磁图超分

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天文学报 2024年第4期65卷 63-78页

作者：窦凤平徐龙赵栋中国科学院国家空间科学中心北京100190 中国科学院大学北京100049

为了全面了解太阳活动规律,需要连续观测时长覆盖多个太阳活动周的、高质量数据.太阳磁图是研究太阳活动的重要数据,连续、长时间和高空间分辨率的太阳磁图能够提供更精细的太阳磁场演化信息,有助于更准确地预报太阳活动和空间天气事件... 详细信息

为了全面了解太阳活动规律,需要连续观测时长覆盖多个太阳活动周的、高质量数据.太阳磁图是研究太阳活动的重要数据,连续、长时间和高空间分辨率的太阳磁图能够提供更精细的太阳磁场演化信息,有助于更准确地预报太阳活动和空间天气事件.因此,提出一种基于深度学习的超分率算法,对MDI(Michelson Doppler Imager)磁图进行超分,取得与日震和磁成像仪(Helioseismic and Magnetic Imager,HMI)磁图一致的分辨率,从而能够获得持续时长将近两个太阳活动周的高质量太阳磁图数据库.为了引导网络学习磁图中有效的特征信息,将注意力机制引入到网络中,学习注意力权重图.此外,采用了不确定性损失作为模型训练的损失函数,该方法能够对于带有磁场变化的纹理和边缘分配更大的权重,同时不增加网络参数和计算量.实验证明,提出的算法显著提高了超分太阳磁图的质量,在峰值信噪比(Peak Signal-to-Noise Ratio,PSNR:33.3168)、结构相似性(Structure Similarity Index Measure,SSIM:0.8754)、相关性(Correlation Coefficient,CC:0.9323)和均方根误差(Root Mean Square Error,RMSE:21.8544)等指标上取得了最优的结果.

关键词：太阳:磁图超分方法:不确定性方法:注意力机制

能源电力特色高校“大思政课”实践育人:关键要素、特色优势与实施进路

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河北大学成人教育学院学报 2024年第3期26卷 83-91页

作者：巩建宇窦雅萍华北电力大学党委宣传部北京102206

“大思政课”是新时代高校育人格局的拓展与创新,对于促进学生知行合一、学以致用具有重要作用。从“大思政课”之“大”的三重思维向度切入,在分析高校“大思政课”实践育人存在的薄弱环节以及需把握的三个关键要素基础上,以华北电力... 详细信息

“大思政课”是新时代高校育人格局的拓展与创新,对于促进学生知行合一、学以致用具有重要作用。从“大思政课”之“大”的三重思维向度切入,在分析高校“大思政课”实践育人存在的薄弱环节以及需把握的三个关键要素基础上,以华北电力大学为例,系统凝练能源电力特色高校在思想价值引领、特色人才培养、实践教学内容、行业资源融入等方面的特色优势,并从课程教学体系、实践教学基地、校企师资联动、特色文化建设、智慧平台保障五个维度,提出能源电力高校“大思政课”实践育人的路径,为高校全面推进“大思政课”建设和新形势新境遇下思政课改革创新提供新的思路。

关键词： “大思政课”建设能源电力特色高校实践育人

伴GATA2基因突变的急性髓系白血病患者的临床特征及预后分析

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中国实验血液学杂志 2024年第2期32卷 327-334页

作者：单若琪黄赛谷振阳王楠刘代红窦立萍南开大学医学院天津300071 中国人民解放军总医院第五医学中心血液科北京100071 解放军医学院北京100853

目的:探讨伴有GATA2基因突变的急性髓系白血病(AML)患者的临床特征、共存突变基因及其对预后的影响。方法:回顾性分析2008年1月至2021年1月就诊于解放军总医院第一医学中心血液科的370例初诊AML患者的临床资料,应用二代基因测序技术检... 详细信息

目的:探讨伴有GATA2基因突变的急性髓系白血病(AML)患者的临床特征、共存突变基因及其对预后的影响。方法:回顾性分析2008年1月至2021年1月就诊于解放军总医院第一医学中心血液科的370例初诊AML患者的临床资料,应用二代基因测序技术检测其突变基因,分析AML中GATA2突变患者的临床特征、GATA2突变的共变基因及GATA2突变对预后的影响。结果:370例AML患者中,共23例(6.2%)患者检测到GATA2突变。与GATA2未突变组相比,GATA2突变组患者多属于正常核型(P=0.037)且多处于低危细胞遗传学分层(P=0.028),CEBPAdm、NRAS在GATA2突变组的发生率显著高于GATA2未突变组(P=0.010,P=0.009),两组在性别、年龄、白细胞数、血小板数、血红蛋白、原始细胞数、诱导方案、CR率方面的差异均无统计学意义(P>0.05)。23例伴有GATA2突变的患者中主要共存基因突变依次为CEBPAdm、NRAS(均为39.1%),NPM1、FLT3、TET2、WT1(均为17.4%),ASXL1、IDH1(均为13.0%)。生存分析结果显示,在整个队列中,伴GATA2突变组患者与不伴GATA2突变组患者5年总生存(OS)及无白血病生存(LFS)率无统计学差异(P=0.306,P=0.308);在306例不伴CEBPAdm的患者中,GATA2突变组患者较GATA2未突变组患者5年OS率及LFS率均有提高趋势,但差异未达统计学意义(P2=0.092,P=0.056);而在64例伴CEBPAdm的患者中,GATA2突变组患者与GATA未突变组患者5年OS率无统计学差异(P=0.104),但GATA2突变组患者5年LFS率显著降低(P=0.047)。23例GATA2突变患者中,16例接受“3+7”诱导方案,其中12例接受异基因造血干细胞移植;7例接受“PDCAG”诱导方案,其中3例接受移植。“3+7”方案组与“DCAG”方案组相比,CR率无统计学差异(=1.000)。移植组较化疗组5年OS率及LFS率显著提高(P=0.021,P=0.020)。结论:GATA2突变显著多见于核型正常及低危细胞遗传学分层的m AML患者,与CEBPAdm、NRAS共突变显著相关。GATA2对预后的意义受CEBPAd共突变影响。GATA2突变患者诱导方案选择“3+7”方案或“DCAG”方案不影响其CR率,而选择异基因造血干细胞移植相较于化疗能显著改善预后。

关键词：急性髓系白血病 GATA2基因突变 CEBPAdm 造血干细胞移植预后

外泌体MicroRNA在抗病毒免疫中的功能分析

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生物技术通报 2024年第5期40卷 48-57页

作者：窦金萍高维崧韦双高新桃李轶女中国农业科学院生物技术研究所北京100081

外泌体是一种细胞外囊泡,内含有多种蛋白质和细胞调节因子,参与细胞间的信息传递并调控细胞的生长和生理过程。由于外泌体的功能差异性与分泌其细胞的类型和状态密切相关,因此在细胞水平的免疫研究中,外泌体可在一定程度上反映细胞的基... 详细信息

外泌体是一种细胞外囊泡,内含有多种蛋白质和细胞调节因子,参与细胞间的信息传递并调控细胞的生长和生理过程。由于外泌体的功能差异性与分泌其细胞的类型和状态密切相关,因此在细胞水平的免疫研究中,外泌体可在一定程度上反映细胞的基因表达水平。病毒个体微小、结构简单,在感染宿主细胞,完成自身复制以及逃逸宿主免疫等过程中涉及到复杂的免疫调控网络,其中外泌体作为信息交流的新兴关注点,在这一免疫调控网络中的“使者”作用值得关注。MicroRNA在细胞间信息交流中也具有重要的调控作用,作为外泌体装载的货物,被选择性的分选到外泌体后,外泌体microRNA能够更加稳定的靶向调节生物功能,参与调控病毒免疫。本文介绍了外泌体的组成、发生机制以及内容物的成分,并以其中研究范围较广,研究内容较多的外泌体miRNA为出发点,重点阐述其在病毒免疫中的双重作用,通过了解外泌体miRNA在同种病毒或不同病毒中的调控作用,对进一步解析病毒入侵宿主的机理具有重要意义。

关键词：外泌体细胞外囊泡 microRNA 病毒免疫

Morphodynamic Characteristics and Medium-Term Simulation of the North-South Passage Under the Impact of the Yangtze Estuary Deepwater Navigation Channel Project

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China Ocean Engineering 2020年第2期34卷 198-209页

作者： JIAO Jian dou Xi-ping GAO Xiang-yu DING Lei YANG Xiao-yu Key Laboratory of Port Waterway and Sedimentation Engineering of MOTNanjing Hydraulic Research InstituteNanjing 210029China College of Water Conservancy and Hydropower Engineering Hohai UniversityNanjing 210098China

The morphological evolution characteristics of the North-South Passage area since the construction of the Yangtze Estuary Deepwater Navigation Channel Project(DNCP)are analyzed on the basis of the measured data.A twodimensional morphodynamics numerical model of the Yangtze Estuary is established to verify the morphological evolution of the North-South Passage under the influence of the DNCP and to predict the future evolution in the next 40 *** analysis shows that the North Passage has experienced rapid adjustment stages and adaptive stages after the construction of the *** erosion occurred along the main channel,and slow siltation could be observed in the area between the *** South Passage showed a state of upper section erosion and down section *** present,the whole South Passage is in a slight erosion *** to the numerical model,the eroding and silting speed of the North Passage will slow down in the *** present state that erosion occurs in the main channel and siltation occurs between the groins will *** South Passage will still maintain upper section erosion and down section deposition in the *** to the main channel erosion of the North Passage and siltation of the South Passage,the sediment division ratio of the North Passage will increase in the future but still be smaller than 50%.After morphological evolution of 40 years,the direction of residual sediment transport caused by M2 and M4 tidal components in the North Passage has not changed,but the transport rate will *** is considered that the morphological evolution of the North-South Passage could reach a relatively stable state after 40 years.

关键词： Yangtze Estuary numerical model morphology tidal current sediment transport deepwater navigation channel project(DNCP)

New C(21) steroidal glycoside from Cynanchum paniculatum

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Chinese Chemical Letters 2007年第3期18卷 300-302页

作者： Jing dou ping Li Zhi Ming Bi Jian Liang Zhou Ministry of Education Key Laboratory of Modern Chinese Medicines Department of Pharmacognosy China Pharmaceutical University Nanjing 210038 China

A new C21 steroidal glycoside, neocynapanogenin F 3-O-β-D-thevetoside 1, as well as its known aglycone neocynapanogenin F 2, which have an aberrant 13, 14：14, 15-disecopregnane-type skeleton were isolated from the root of Cynanchum paniculatum. Their structures were elucidated on the basis of spectroscopic data analysis. These compounds showed certain cytotoxic activities in vitro.

关键词： Neocynapanogenin F 3-O-β-D-thevetoside Neocynapanogenin F Cynanchum paniculatum