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Total Synthesis of Marine Cyclic Enol-Phosphotriester Salinipostin Compounds

Journal of Ocean University of China 2018年第3期17卷 683-689页

作者： ZHAO Mingliang WEI Xianfeng LIU Xuemeng dong xueyang YU Rilei WAN Shengbiao JIANG Tao Key Laboratory of Marine Drugs The Ministry of Education of China School of Medicine and Pharmacy Ocean University of China Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and Technology

Due to their structural diversity and variety of biological activities, marine natural products have been the subject of extensive study. These compounds, especially phospholipid polycyclic aromatic hydrocarbons, have a wide range of pharmacological applications, including embedded DNA and central nervous system, anti-tumor, anti-virus, anti-parasite, anti-bacterial, and antithrombotic effects. Unfortunately, the insufficient drug sources have limited the development of these compounds. In this study, we isolated salinpostin compounds from a fermentation solution of marine-derived Salinospora sp., which has a common bicyclic enol-phosphotriester core framework, as well as potent and selective antimalarial activities against P. falciparum with EC_(50)=50 nmolL^(-1). The chemical synthesis of these compounds in greater quantities is necessary for their use in bioactivity studies. Thus we explored a short route with high yields and mild reaction conditions, which can generate combinatorial libraries for drug discovery and lead optimization. We developed a new total synthesis method for six cyclic enol-phosphotriester salinipotin compounds and their diastereomers. For the total synthesis of cyclipostin P, we prepared cyclic enol-phosphotriester salinipostin compounds in 10 steps from a readily accessible starting material, 1,3-dihydroxyacetone, and obtained an overall yield of 1.29%. We fully characterized these compounds by proton nuclear magnetic resonance(~1H-NMR), carbon-13 NMR(^(13)C-NMR), and high-resolution mass spectrometry(HRMS) analyses, and found they coincide absolutely with the same compounds reported previously.

关键词： total synthesis Salinipostin enolphosphate trimester

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微型永磁无刷直流电机的设计与优化

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微特电机 2024年第5期52卷 22-26页

作者：左佳赵丽颖商荣翔王浩董雪阳北京七星飞行电子有限公司北京100018

对一款航空用微型永磁无刷直流电机进行了设计,永磁体选用钐钴进行Halbach阵列充磁,并对电机的部分参数进行了优化,与原方案相比,优化了电机的输出转矩。制作了一款实物样机,通过对样机的测试,验证了优化的可行性。

关键词：永磁无刷直流电机钐钴 Halbach阵列

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基于加速度反馈的电机快速换挡方法

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汽车实用技术 2024年第11期49卷 18-21页

作者：左佳赵丽颖商荣翔王浩董雪阳北京七星飞行电子有限公司北京100015

商用车在换挡过程中,会出现短暂的动力中断,电机的调速时间直接影响动力中断时间。而动力中断时间决定了换挡的品质,文章提出了一种基于微分负反馈的变速器快速换挡方法,对驱动电机的转速反馈进行微分处理,从转速反馈信息中提取转速变... 详细信息

商用车在换挡过程中,会出现短暂的动力中断,电机的调速时间直接影响动力中断时间。而动力中断时间决定了换挡的品质,文章提出了一种基于微分负反馈的变速器快速换挡方法,对驱动电机的转速反馈进行微分处理,从转速反馈信息中提取转速变化量的信息。然后经过比例积分控制器调节,输出指令扭矩,从而实现驱动电机的快速转速调节。

关键词：纯电动商用车超调抑制变速器快速换挡方法

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Recent process in developing advanced heterogeneous diatomic-site metal catalysts for electrochemical CO_(2)reduction

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Chinese Chemical Letters 2024年第7期35卷 4-13页

作者： xueyang Zhao Bangwei Deng Hongtao Xie Yizhao Li Qingqing Ye Fan dong Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 611731China Suzhou Industrial Technology Research Institute of Zhejiang University Zhejiang UniversitySuzhou 215159China

Diatomic-site catalysts(DASCs)have emerged as a kind of promising heterogeneous candidate catalysts for electrochemical CO_(2)reduction(ECR),which is considered to retain the advantage of single-atom catalysts(SACs)but also introduce opportunities to exceed the limit of single-atom *** the past few years,tremendous progress has been achieved in this ***,the recent progress in ECR on DASCs has been *** will start with the classification of *** the challenges in the precise fabrication and characterization of DASCs have been *** introducing the advanced ECR performance on DASCs,superior to that on SACs,the synergistic effects of the dual metal atoms are highlighted,as this origin of the advanced ECR performance on DASCs is comprehensively ***,the major challenges and perspectives of DASCs have been proposed to shed light on the development of DASCs for ECR application.

关键词： Diatomic-site metal catalyst Electrochemical CO_(2)reduction Classification CO_(2)activation Synergistic effects

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Ultrafast sodium storage of alkylamine molecule tailored MnPSenabled by quasi-topological intercalation mechanism

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Science China Chemistry 2024年

作者： xueyang Tu Ke Fan Baixin Peng Zhuoran Lv Yiran Hao Wujie dong Wei Zhao Zuocheng Wang Haitao Huang Yuqiang Fang Fuqiang Huang State Key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Research Institute for Smart Energy The Hong Kong Polytechnic University State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Zhangjiang Institute for Advanced Study Shanghai Jiao Tong University Jiangxi Far East Battery Co. Ltd.

Two-dimensional transition metal trithiophosphates （TMPS3,TM=Mn,Fe,Co,etc.） are competitive anode materials for sodium-ion batteries （SIBs） due to their high theoretical capacity (>1,300 mAh g-1) but suffer from limited practical capacity(～300 mAh g-1) and inferior rate capability caused by sluggish Na+intercalation/deintercalation kinetics and severe structural ***,alkylamine molecules are first proposed as intercalation guests to significantly boost the electrochemical activity and stability of *** to MnPS3,C3H9N-MnPS3enlarges the interlayer spacing from 6.48 to 10.23?and shows a 10～5times higher electrical conductivity,which provides fast ion/electron transport and high strain adaptability,realizing a quasi-topological Na+intercalation ***,C3H9N-MnPS3exhibits an ultrahigh reversible capacity of 775m Ah g-1at 0.5 A g-1and superior high-rate cycling stability with～100%capacity retention after 2,500 cycles at 15 A g-1,ranking it among the top metal trithiophosphate-based anode materials *** calculations indicate that the improved sodium storage performance of C3H9N-MnPS3results from the reduced bonding energy of P–S bonds and increased adsorption energy of Na+.This work is expected to provide an efficient strategy for the design of high-performance layered anode materials for SIBs.

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一种笛卡尔积压缩的负表约束上表缩减算法

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吉林大学学报（理学版） 2019年第3期57卷 591-597页

作者：蔡毛毛李占山董学阳吉林大学计算机科学与技术学院符号计算与知识工程教育部重点实验室长春130012 吉林大学公共计算机教学与研究中心长春130012

利用笛卡尔积压缩方法可有效减小负表约束规模的原理,提出一种在压缩负表上维持广义弧相容的高效算法STRC-N,以解决负表约束维持弧相容过程中遍历所有元组导致效率低的问题.实验结果表明,当压缩负表上压缩率较大时,得益于表规模的减小,... 详细信息

利用笛卡尔积压缩方法可有效减小负表约束规模的原理,提出一种在压缩负表上维持广义弧相容的高效算法STRC-N,以解决负表约束维持弧相容过程中遍历所有元组导致效率低的问题.实验结果表明,当压缩负表上压缩率较大时,得益于表规模的减小,新算法相对于主流的负表约束处理算法效率更高,性能更好,从而实现了对负表约束处理算法的改进.

关键词：约束满足问题负表约束表压缩弧相容

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Discovery of active compounds and key targets of Thymus quinquecostatus Celak. based on gastrointestinal metabolism and Gut flora-Compound-Target-Pathway network with TOPSIS method

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Food Science and Human Wellness 2024年

作者： xueyang Ren Jiamu Ma Ying dong Yuan Zheng Rufeng Wang Chongjun Zhao Wei Liu Mingxia Li Mengyu Sun Feng Zhang Yingyu He Xianxian Li Qingyue Deng Gaimei She School of Chinese Materia Medica， Beijing University of Chinese Medicine School of Life Sciences， Beijing University of Chinese Medicine Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medica

Thymus quinquecostatus Celak.， a traditional aromatic edible plant from Lamiaceae， is widely used as food additive， food condiment， spice， and herbal teas. Its polyphenol-rich fraction （PRF） has been proven to be effective protective effect for cerebral ischemia reperfusion injury （CIRI） in our previous study. In this study， we developed a novel “Gut flora-Compound-Target-Pathway” （GCTP） network based on network pharmacology coupled with gastrointestinal metabolism for screening bio-active components， key targets and gut floras through the classical technique for order preference by similarity to ideal solution （TOPSIS） method. This compensates for the lack of gut floras and gastrointestinal metabolism in network pharmacology. Firstly， four incubation models covering simulated gastric juice， simulated intestinal juice， gut floras of normal and transient middle cerebral artery occlusion （tMCAO） rat in vitro were applied to PRF. The 109 proto-components and 64 metabolites were elucidated by UPLC-QE-Orbitrap-MSn. Then， the key targets of MMP9， PTGS2， FYN， ESR1， APP， and EGFR， and gut floras of Enterococcus avium LY1 were selected. Moreover， the selected key proto-components were rosmarinic acid， daidzein， quercetin， luteolin， apigenin， methyl rosmarinate， kaempferol， luteoloside， and caffeic acid， and the key metabolites were isokaempferide， isorhamnetin， isoquercetin， and mangiferin. Binding of compounds to the key proteins was analyzed by molecular docking， and also verified though a AAPH induced oxidative stress zebrafish model and qRT-PCR assays. This study provides a new idea and a better understanding of PRF for its protective effects on CIRI and its underlying mechanisms.

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基于评论的影片个性化推荐方法

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吉林大学学报（理学版） 2018年第4期56卷 965-968页

作者：董学阳郜山权刘磊刘华虓吉林大学公共计算机教学与研究中心长春130012 吉林大学软件学院长春130012 吉林大学计算机科学与技术学院长春130012

针对影片数量较大,观众选择喜欢的影片较难的问题,提出一种基于评论的影片个性化推荐方法.该方法先把电影标签作为主题对观众评论进行分类,再根据主题评估函数计算主题的满意度,然后根据观众喜好为主题设定权重,获得关于影片的个性化评... 详细信息

针对影片数量较大,观众选择喜欢的影片较难的问题,提出一种基于评论的影片个性化推荐方法.该方法先把电影标签作为主题对观众评论进行分类,再根据主题评估函数计算主题的满意度,然后根据观众喜好为主题设定权重,获得关于影片的个性化评价,最后根据评估结果,为观众提供一个可供选择的影片序列.实验结果表明,该基于评论的影片分析方法有效.

关键词：推荐方法评论分析电影评论个性化

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Fufang E’jiao Jiang’s effect on immunity,hematopoiesis,and angiogenesis via a systematic“compound-effect-target”analysis

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Food Science and Human Wellness 2024年第5期13卷 2813-2832页

作者： Xiang Li Xiao Xu Ying dong Shusheng Fan xueyang Ren Yuan Zheng Jiamu Ma Feng Zhang Qingyue Deng Xianxian Li Yingyu He Mengyu Sun Wei Liu Mengxia Li Qing Xia Yan Zhang Gaimei She School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Biology Institute Qilu University of Technology(Shandong Academy of Sciences)Jinan 250103China National Engineering Research Center for Gelatin-based Traditional Chinese Medicine Dong-E-E-Jiao Co.Ltd.Liaocheng 252201China

Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s *** find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were *** on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of *** data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by *** bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and *** studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets.

关键词： Fufang E’jiao Jiang Zebrafish(Danio rerio) Network pharmacology Transcriptome Bibliometrics

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基于Gauss伪谱法的移动机器人非完整运动规划

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北京信息科技大学学报（自然科学版） 2016年第1期31卷 23-27页

作者：董雪仰戈新生陈凯捷北京信息科技大学机电工程学院北京100192 北京信息科技大学理学院北京100192

针对轮式移动机器人中存在的非完整约束导致的系统控制及规划难度较高的问题,采用Gauss伪谱法求解最优控制的数值计算问题。通过建立移动机器人系统模型,确定系统约束及性能指标函数,将状态变量和控制变量在一系列Gauss点上离散,并以这... 详细信息

针对轮式移动机器人中存在的非完整约束导致的系统控制及规划难度较高的问题,采用Gauss伪谱法求解最优控制的数值计算问题。通过建立移动机器人系统模型,确定系统约束及性能指标函数,将状态变量和控制变量在一系列Gauss点上离散,并以这些离散点为节点构造拉格朗日插值多项式来逼近状态变量和控制变量,对于性能指标中的积分项由Gauss积分计算,把非完整运动规划问题转化为一组有约束的非线性规划求解问题。通过建立最优控制输入和控制力矩关系,得到轮式机器人的最优控制力矩,数值仿真验证了方法的有效性。

关键词：轮式机器人非完整运动规划 Gauss伪谱法最优控制

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