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Ultrastructural changes of rat cortical neurons following ligustrazine intervention for cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2008年第1期3卷 41-43页

作者： Hui Zhang Jianfeng dong Qiuzhen zhao wen Song Aihua Bo Department of Anatomy and Electron Microscopy Hebei North University Zhangjiakou 075029 Hebei Province China

BACKGROUND： Ligustrazine can reduce the production of free radicals and the content of malonaldehyde, and improve the enzymatic activity of adenosine-triphosphate in cerebral anoxia. It also can increase the expression of heat shock protein-70 and Bcl-2, thus alleviating brain tissue injury caused by cerebral ischemia/reperfusion. This study aimed to address the question of whether ligustrazine can protect the membrane structure of neurons. OBJECTIVE： To establish rat models of cerebral ischemia/reperfusion, observe the membrane structure and main organelles of neurons with electron microscope after ligustrazine intervention, and to analyze the dose-dependent effects of ligustrazine on neuronal changes. DESIGN： A randomized controlled study. SETTING： Department of Anatomy Research and Electron Microscopy, Hebei North University. MATERIALS： Forty Wistar rats of SPS grade, weighing 180-250 g and equal proportion of female and male, were provided by Hebei Medical University Animal Center （No. 060126）. The ligustrazine injection （40 g/L, No. 05012） was produced by Beijing Yongkang Yaoye. LKB4 Ultramicrotome was purchased from LKB Company in Sweden. JEM100CXII electron microscope was purchased from JEOL in Japan. METHODS： The experiment was performed in the Laboratory of the Department of Anatomy and Electron Microscopy, Hebei North University from June to August 2006. （1） Wistar rats were allowed to adapt for 3 days, and were then randomly divided into four groups, according to the numeration table method： normal group, model group, low-dose ligustrazine group, and high-dose ligustrazine group. There were 10 rats in each group. （2）Rats in the model group, low-dose ligustrazine group, and high-dose ligustrazine group underwent cerebral ischemia/reperfusion model, according to Bannister＇s method. The carotid artery was opened for reperfusion after 90 minutes of cerebral ischemia. Samples were collected from the cerebral cortex after 24 hours. Animals from the ligustrazine

关键词： cerebral ischemia/reperfusion ligustrazine neuron ultrastructure electron microscope

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Characterization of 17-4PH stainless steel powders produced by supersonic gas atomization

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International Journal of Minerals,Metallurgy and Materials 2012年第1期19卷 83-88页

作者： Xin-ming zhao Jun Xu Xue-xin Zhu Shao-ming Zhang wen-dong zhao Guo-liang Yuan National Engineering and Technological Research Center for Non-ferrous Metals Composites General Research Institute for Non-ferrous Metals Beijing 100088 China Beijing COMPO Advanced Technology Co. Ltd. Beijing 100088 China

17-4PH stainless steel powders were prepared using a supersonic nozzle in a close-coupled gas atomization system. The characteristics of powder particles were carried out by means of a laser particle size analyzer, scanning electron microscopy （SEM）, and the X-ray diffraction （XRD） technique. The results show that the mass median particle diameter is about 19.15 prn. Three main types of surface microstructures are observed in the powders： well-developed dendrite, cellular, and cellular dendrite structure. The XRD measurements show that, as the particle size decreases, the amount of fcc phase gradually decreases and that of bcc phase increases. The cooling rate is inversely related to the particle size, i.e., it decreases with an increase in particle size.

关键词： gas atomization metal powder stainless steel metal injection molding

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Chromosome painting of telomeric repeats reveals new evidence for genome evolution in peanut

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Journal of Integrative Agriculture 2016年第11期15卷 2488-2496页

作者： DU Pei LI Li-na ZHANG Zhong-xin LIU Hua QIN Li HUANG Bing-yan dong wen-zhao TANG Feng-shou QI Zeng-jun ZHANG Xin-you State Key Laboratory of Crop Genetics and Germplasm Enhancement Nanjing Agricultural University Industrial Crops Research Institute Henan Academy of Agricultural Sciences/Key Laboratory of Oil Crops in Huang-Huai-Hai PlainsMinistry of Agriculture/Henan Provincial Key Laboratory for Oil Crops Improvement College of Agriculture Henan University of Science and Technology

Interspecific hybridization is an important approach to improve cultivated peanut varieties. Cytological markers such as tandem repeats will facilitate alien gene introgression in peanut. Telomeric repeats have also been frequently used in chromosome research. Most plant telomeric repeats are（TTTAGGG）n that are mainly distributed at the chromosome ends, although interstitial telomeric repeats（ITRs） are also commonly identified. In this study, the telomeric repeat was chromosomally localized in 10 Arachis species through sequential GISH（genomic in situ hybridization） and FISH（fluorescence in situ hybridization） combined with 4＇,6-diamidino-2-phenylindole（DAPI） staining. Six ITRs were identified such as in the centromeric region of chromosome Bi5 in Arachis ipa？nsis, pericentromeric regions of chromosomes As5 in A. stenosperma, Bho7 in A. hoehnei and Av5 in A. villosa, nucleolar organizer regions of chromosomes As3 in A. stenosperma and Adi3 in A. diogoi, subtelomeric regions of chromosomes Bho9 in A. hoehnei and Adu7 in A. duranensis, and telomeric region of chromosome Es7 in A. stenophylla. The distributions of the telomeric repeat, 5S r DNA, 45 S r DNA and DAPI staining pattern provided not only ways of distinguishing different chromosomes, but also karyotypes with a higher resolution that could be used in evolutionary genome research. The distribution of telomeric repeats, 5S r DNA and 45 S r DNA sites in this study, along with inversions detected on the long arms of chromosomes Kb10 and Bho10, indicated frequent chromosomal rearrangements during evolution of Arachis species.

关键词： Arachis species inversion interstitial telomeric repeats karyotype

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A Comparative Study of the Application of Temporal Method and Current Rate Method

A Comparative Study of the Application of Temporal Method an...

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作者： Gang CHEN wen-dong zhao HuaiYin Institute of Technology North JiangSu Development Institute

The foreign currency statement translation problem has been listed as one of the financial accounting problems since its inception. The conversion methods used by each country in the translation of foreign currency statements vary from country to country, but can be roughly classified into two methods: temporal method and current rate method. The temporal method matches the popular parent company theory, and the current rate method matches the entity theory. Currently the temporal method and the current rate method are two popular but opposite conversion methods. This paper first analyzes and compares the similarities and differences in accounting treatment between the current rate method and the temporal method, and then further argues the negative comments of the temporal method and the positive evaluation of the current rate method, thirdly improves the use of the tense method, finally from the perspective of China’s national conditions, discusses that the use of the tense method is more in line with China’s economic environment.

关键词： Statement conversion Temporal method Current rate method Parent company theory Entity theory

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Study of the vibrational photochemical reation of UF_6+HCl and its isotopic selectivity

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Chinese Journal of Chemistry 1993年第2期11卷 97-104页

作者： XU,Bao-Yu LIU,Yong dong,wen-Bo zhao,Wei HU,Jian-Xun ZHENG,Cheng-Fa Nuclear Science Department,Fudan University,Shanghai 200433 Nuclear Science Department Fudan University Shanghai 200433

The photochemical vibrational reaction of UF_6+HCl was investigated by exciting the ternary overtone of 3ν_3 of UF_6 in an intracavity CO laser *** was found that the rate of the laser-driven reaction was much greater than that of the thermal reaction and this photochemical process had an isotopic *** uranium isotope enrichment factors measured in experiments wore around 1,007 in a single step.

关键词： Study of the vibrational photochemical reation of UF6+HCl and its isotopic selectivity UF HCl

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Development and characterization of new allohexaploid resistant to web blotch in peanut

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Journal of Integrative Agriculture 2021年第1期20卷 55-64页

作者： WANG Si-yu LI Li-na FU Liu-yang LIU Hua QIN Li CUI Cai-hong MIAO Li-juan ZHANG Zhong-xin GAO Wei dong wen-zhao HUANG Bing-yan ZHENG Zheng TANG Feng-shou ZHANG Xin-you DU Pei School of Life Sciences Zhengzhou UniversityZhengzhou 450001P.R.China Industrial Crops Research Institute Henan Academy of Agricultural Sciences/Key Laboratory of Oil Crops in Huang-Huai-HaiPlainsMinistry of Agriculture and Rural Affairs/Henan Provincial Key Laboratory for Oil Crops ImprovementZhengzhou 450002P.R.China

Peanut diseases seriously threaten peanut production, creating disease-resistant materials via interspecific hybridization is an effective way to deal with this problem. In this study, the embryo of an interspecific F1 hybrid was obtained by crossing the Silihong(Slh) cultivar with Arachis duranensis(ZW55), a diploid wild species. Seedlings were generated by embryo rescue and tissue culture. A true interspecific hybrid was then confirmed by cytological methods and molecular markers. After treating seedlings with colchicine during in vitro multiplication, the established interspecific F1 hybrid produced seeds which were named as Am1210. With oligonucleotide fluorescence in situ hybridization(Oligo FISH), molecular marker evaluations, morphological and web blotch resistance characterization, we found that: 1) Am1210 was an allohexaploid between Slh and ZW55;2) the traits of spreading lateral branches, single-seeded or double-seeded pods and red seed coats were observed to be dominant compared to the erect type, multiple-seeded pods and brown seed coats;3) the web blotch resistance of Am1210 was significantly improved than that of Slh, indicating the contribution of the web blotch resistance from the wild parent A. duranensis. In addition, 69 dominant and co-dominant molecular markers were developed which could be both used to verify the hybrid in this study and to identify translocation or introgression lines with A. duranensis chromosome fragments in future studies as well.

关键词： peanut interspecific hybridization allohexaploid Oligo FISH molecular marker web blotch

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少数民族传统体育教学规律研究

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山东体育学院学报 2011年第7期27卷 83-86页

作者：董文梅郭洪光董文朝中央民族大学体育学院北京100081 广西民族大学体育与健康科学学院广西南宁530006

少数民族传统体育作为民族文化的有机载体,是不可多得的课程内容资源,将少数民族传统育活动广泛融入学校体育课程之中,可以弘扬少数民族传统体育文化,增强各民族之间的了解,促进民族团结,进一步探讨少数民族传统体育的教学规律,为初步... 详细信息

少数民族传统体育作为民族文化的有机载体,是不可多得的课程内容资源,将少数民族传统育活动广泛融入学校体育课程之中,可以弘扬少数民族传统体育文化,增强各民族之间的了解,促进民族团结,进一步探讨少数民族传统体育的教学规律,为初步建立少数民族传统体育教学理论奠定基础,为体育教学工作者在实践中提高教学质量提供指导。运用文献资料、行家调查、个案研究等研究方法,对大中小学中已进行教学的少数民族传统体育运动技能进行分类,探讨不同类型运动技能的教学规律。

关键词：少数民族传统体育教学规律会能度运动技能教学方法

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中国苗族人群中细胞色素P450 2C19基因多态性的研究

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遗传 2001年第3期23卷 192-194页

作者：张松周强董兆文国家计生委科学技术研究所分子生物研究室北京100081 贵州省计划生育科研所贵阳550004

为研究细胞色素P45 0 2C19在中国苗族人群中的基因型 ,采用聚合酶链式反应与限制性内切核酸酶片段长度多态性技术分析了 98例无血缘关系苗族人群的基因型。结果显示 5 0人为CYP2C19野生型纯合子 (wt/wt) ;39人为CYP2C19m1杂合子 (wt/m1)... 详细信息

为研究细胞色素P45 0 2C19在中国苗族人群中的基因型 ,采用聚合酶链式反应与限制性内切核酸酶片段长度多态性技术分析了 98例无血缘关系苗族人群的基因型。结果显示 5 0人为CYP2C19野生型纯合子 (wt/wt) ;39人为CYP2C19m1杂合子 (wt/m1) ;9人为CYP2C19m1突变型纯合子 (m1/m1)。与国内外相关报道比较。

关键词：细胞色素P4502C19 基因型聚合酶链式反应性内切核酸酶片段长度多态性苗族人群

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Wave effect of gravitational waves intersected with a microlens field Ⅱ:An adaptive hierarchical tree algorithm and population study

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 241-254页

作者： Xikai Shan Guoliang Li Xuechun Chen wen zhao Bin Hu Shude Mao Department of Astronomy Tsinghua University Purple Mountain Observatory Chinese Academy of Sciences Institute for Frontier in Astronomy and Astrophysics Beijing Normal University School of Physics and Astronomy Beijing Normal University School of Astronomy and Space Science University of Science and Technology of China CAS Key Laboratory for Researches in Galaxies and Cosmology Department of Astronomy University of Science and Technology of ChinaChinese Academy of Sciences

The gravitational lensing wave effect generated by a microlensing field embedded in a lens galaxy is an inevitable phenomenon in strong lensed gravitational waves （SLGWs）.This effect presents both challenges and opportunities for the detection and application of ***,investigating this wave effect requires computing a complete diffraction integral over each microlens in the *** is extremely time-consuming due to the large number of microlenses （10～3-10～6）.Therefore,simply adding all the microlenses is ***,the complexity of the time delay surface makes the lens plane resolution a crucial factor in controlling numerical *** this paper,we propose a trapezoid approximation-based adaptive hierarchical tree algorithm to meet the challenges of calculation speed and *** find that this algorithm accelerates the calculation by four orders of magnitude compared to the simple adding method and is one order of magnitude faster than the fixed hierarchical tree algorithm proposed for electromagnetic *** importantly,our algorithm ensures controllable numerical errors,increasing confidence in the *** with our previous work （***.66,239511,2023）,this paper addresses all numerical issues,including integral convergence,precision,and computational time1).Finally,we conducted a population study on the microlensing wave effect of SLGWs using this algorithm and found that the microlensing wave effect cannot be ignored,especially for Type II SLGWs （from saddle position of the time delay surface） due to their intrinsic geometric structures and their typical intersection with a denser microlensing ***,more than 33%（11%） of SLGWs have a mismatch larger than 1%（3%） compared to the unlensed ***,we found that the mismatch between signal pairs in a doubly imaged GW is generally larger than 10-3,and 61%（25%） of signal pairs have a mismatch larger than 1%（3%）.Therefo

关键词： gravitational lensing diffractional integral algorithm gravitational wave

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Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua Zhang Lian-Lian Wang wen-wen Liu Xin Yang Ming-zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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