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Moxifloxacin:cardiovascular effects in conscious,jacketed cynomolgus monkeys following oral(nasogastric intubation) administration

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Moxifloxacin:cardiovascular effects in conscious,jacketed cy...

Genetic etiologies associated with infantile hydrocephalus in a Chinese infantile cohort

作者： HU Miao-miao XING Guo-zhen Matthew SKINNER YU Hong WANG shao-dong ZHAO Li ZHENG Wei-jun REN Jin Centre for Drug Safety Evaluation and Research Shanghai Institute of Materia Medica AstraZeneca R&D Alderley Park

OBJECTIVE Moxifloxacin is a fluoroquinolone with a broad spectrum of antibacterial *** aim of this study was to investigate the cardiovascular effects of moxifloxacin,administered to conscious,jacketed cynomolgus monkeys as single oral *** was a validation study performed to assess the new DSI Jacketed External Telemetry (JET) system recently installed at *** There were 6 animals(3 males and 3 females) in two groups. Animals of the same gender were group-housed in the same *** received 4 doses of vehicle control(3 fe- males) or vehicle control followed by moxifloxacin(3 males) with single ascending doses at 15,45 and 135 mg·kg~(-1).All animals had at least 3 to 4 dose-free days between each dose *** JET system(Data Science International,US), including two receivers and 6 devices,was used for continuous ECG data and body temperature(surface) collection for approximately 1 h before,until 24 h after each *** Administration of moxifloxacin to group-housed conscious male primates was associated with a dose-dependent prolongation of QTc interval(increase of 9 and 16%vs timematched vehicle data after 45 and 135 mg·kg~(-1),respectively).In female monkeys,administered multiple doses of vehicle, QTc was comparable across consecutive dosing *** results demonstrate the usefulness of the JET system in conscious monkeys for evaluating the cardiovascular effects of drugs under normal physiological conditions.

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World Journal of Pediatrics 2021年第3期17卷 305-316页

作者： Hong-Fang Mei Xin-Ran dong Hui-Yao Chen Yu-Lan Lu Bing-Bing Wu Hui-jun Wang Guo-Qiang Cheng Lai-Shuan Wang Yun Cao Lin Yang Wen-Hao Zhou Department of Neonatology Children's Hospital of Fudan UniversityNational Children's Medical CenterShanghaiChina Key Laboratory of Birth Defects Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Center for Molecular Medicine of Children’s Hospital of Fudan University Institutes of Biomedical SciencesFudan UniversityShanghaiChina Clinical Genetic Center Children’s Hospital of Fudan UniversityNational Children's Medical Center399 Wan Yuan RoadShanghai 201102China

Background Infantile hydrocephalus(IHC)is commonly related to other central nervous system diseases,which may have adverse effects on *** causes of IHC are heterogeneous,and the genetic etiologies are not fully *** study aimed to analyze the genetic etiologies of an IHC *** The data for 110 IHC patients who had received exome sequencing at the Clinical Genetic Center of the Children's Hospital of Fudan University between 2016 and 2019 were reviewed and analyzed *** exome-wide association analysis(EWAS)was performed within this cohort using IHC as the study *** Of the 110 IHC patients,a pathogenic or likely pathogenic variant was identified in 16(15%)patients,spanning 13 *** genes were mainly associated with metabolic disorders,brain abnormalities,and genetic *** patients who had unclear clinical etiology were more likely to possess a genetic *** on previous studies and on our EWAS results,ZEB1,SBF2,and GNAI2 were over-represented among IHC patients and might alfect the signaling pathways involved in IHC *** Our study showed heterogeneous genetic etiologies in an IHC *** is essential to perform genetic testing on IHC patients who have unclear clinical etiology,and genes associated with metabolic disorders,brain abnormalities,and genetic syndromes should he *** addition,when aiming to discover IHC susceptibility genes,genes that might influence the signaling pathways involved in IHC formation should be prioritized.

关键词： Etiology Genetic Hydrocephalus Infantile

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松花江吉林段土壤有机组分的雄激素干扰效应

环境科学研究 2014年第8期27卷 898-903页

作者：李剑李沫蕊孔东东韩绍伦北京师范大学水科学研究院地下水污染控制与修复教育部工程研究中心北京100875

利用重组AR（雄激素受体）基因酵母,结合土壤样品索氏提取、富集和净化方法,开展松花江流域吉林段土壤有机组分雄激素干扰效应及其分布特征研究.结果表明：所有样品均未检测出显著的AR诱导活性;部分样品检测出AR抑制活性,检出率为62.50%... 详细信息

利用重组AR（雄激素受体）基因酵母,结合土壤样品索氏提取、富集和净化方法,开展松花江流域吉林段土壤有机组分雄激素干扰效应及其分布特征研究.结果表明：所有样品均未检测出显著的AR诱导活性;部分样品检测出AR抑制活性,检出率为62.50%,最大抑制率为61.74%;采用RIC20（抑制率为20.00%时,96孔板每孔所需要的土壤当量,单位为mgwell）表征样品的抑制活性,RIC20在1.01-9.03 mgwell之间,表明松花江吉林段土壤中存在AR抑制活性物质,可能具有潜在的环境危害.研究区土壤雄激素干扰效应的分布特征表明,干扰效应分布与产业布局呈一定的相关性;工业区的AR抑制活性明显高于农田区,表明化工原料及产品的生产和使用及工业废水的排放可能是该地区土壤中AR抑制活性的重要来源.

关键词：雄激素受体重组基因酵母土壤有机组分雄激素干扰效应

B Cell Epitopes within VP1 of Type O Foot-and-mouth Disease Virus for Detection of Viral Antibodies

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Virologica Sinica 2010年第1期25卷 18-26页

作者： Shan-dian GAO jun-zheng DU Hui-yun CHANG Guo-zheng CONG jun-jun shao Tong LIN Shuai SONG Qing-ge XIE National Foot-and-mouth Disease Reference Laboratory Key Laboratory of Animal Virology of Ministry of Agriculture State Key Laboratory of Veterinary Etiologieal Biology Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou 730046 China

In this study, the coding region of type O FMDV capsid protein VP1 and a series of codon optimized DNA sequences coding for VP1 amino acid residues 141-160 （epitopel）, tandem repeat 200-213 （epitope2 （＋2）） and the combination of two epitopes （epitopel-2） was genetically cloned into the prokaryotic expression vector PPRoExHTb and pGEX4T-1, respectively. VP1 and the fused epitopes GST-E1, GST-E2 （＋2） and GST-E1-2 were successfully solubly expressed in the cytoplasm of Escherichia coli and Western blot analysis demonstrated they retained antigenicity. Indirect VP1-ELISA and epitope ELISAs were subsequently developed to screen a panel of 80 field pig sera using LPB-ELISA as a standard test. For VP1-ELISA and all the epitope ELISAs, there were clear distinctions between the FMDV-positive and the FMDV-negative samples. Cross-reactions with pig sera positive to the viruses of swine vesicular disease virus that produce clinically indistinguishable syndromes in pigs or guinea pig antisera to FMDV strains of type A, C and Asia1 did not occur. The relative sensitivity and specificity for the GST-E1 ELISA, GST-E2 （＋2）, GST-E1-2 ELISA and VP1-ELISA in comparison with LPB-ELISA were 93.3% and 85.0%, 95.0% and 90%, 100% and 81.8%, 96.6% and 80.9% respectively. This study shows the potential use of the aforementioned epitopes as alternatives to the complex antigens used in current detection for antibody to FMDV structural proteins.

关键词： Foot-and-mouth disease virus ( FMDV) Serology Epitope ELISA

Water regime-nitrogen fertilizer incorporation interaction：Field study on methane and nitrous oxide emissions from a rice agroecosystem in Harbin, China

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Journal of Environmental Sciences 2018年第2期30卷 289-297页

作者： Wenjun dong Jia Guo Lijun Xu Zhifeng Song jun Zhang Ao Tang Xijuan Zhang Chunxu Leng Youhong Liu Lianmin Wang Lizhi Wang Yang Yu Zhongliang Yang Yilei Yu Ying Meng Yongcai Lai Heilongjiang Academy of Agricultural Sciences Postdoctoral Programme Harbin 150086 China Cultivation and Farming Research Institute Heilongjiang Academy of Agricultural Sciences Harbin 150086 China Northern Japonica Rice Molecular Breeding Joint Research Center Chinese Academy of Sciences Harbin 250086 China Scientific Observing and Experimental Station of Crop Cultivation in Northeast China Ministry of Agriculture Harbin 150086 China Institute of Wetland Research Chinese Academy of Forestry Beijing 100091 China Beijing Key Laboratory of Wetland Services and Restoration Beijing 100091 China Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences Beijing 100081 China Jilin Academy of Agricultural Sciences ChangchunJilin 130124 China Institute of Crop Science Chinese Academy of Agricultural Sciences Beijing 100081 China Rice Institute of Wuchang Heilongjiang Academy of Agricultural Sciences Wuchang 150229 China

Water regime and nitrogen（N） fertilizer are two important factors impacting greenhouse gases（GHG） emission from paddy field, whereas their effects have not been well studied in cold region. In this study, we conducted a two-year field experiment to study the impacts of water regime and N fertilizer on rice yields and GHG emissions in Harbin, China, a cold region located in high latitudes. Our results showed that intermittent irrigation significantly decreased methane（CH4） emission compared with continuous flooding, however,the decrement was far lower than the global average level. The N2O emissions were very small when flooded but peaked at the beginning of the disappearance of floodwater. The N fertilizer treatments increased CH4 emissions at low level（75 kg N/ha）. But both CH4 and N2O emissions were uninfluenced at the levels of 150 kg N/ha and 225 kg N/ha. Rice yields increased under intermittent irrigation and were highest at the level of 150 kg N/ha. From our results, we recommended that the intermittent irrigation and 150 kg N/ha as the ideal water regime-nitrogen fertilizer incorporation for this area to achieve low GHG emissions without impacting rice yields.

关键词： Methane(CH4) Nitrous oxide(N2O) Rice ecosystem Cold region Global warming potential

冷轧对Fe-Al合金层组织及高温氧化性能的影响

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材料热处理学报 2010年第6期31卷 84-88页

作者：丛伟姚正军包卫军邵斌南京航空航天大学材料科学与技术学院江苏南京211100 江苏地龙管业有限公司江苏宜兴214200

利用热浸镀铝后真空扩散的方法在Q235钢板表面制备FeAl合金层,并进行形变量为20.5%、34.1%、40.9%的冷轧试验。采用金相、SEM、EDS、XRD分析了冷轧前后合金层的组织结构,测试了不同冷轧形变量试样的高温抗氧化性能。结果表明,冷轧后合... 详细信息

利用热浸镀铝后真空扩散的方法在Q235钢板表面制备FeAl合金层,并进行形变量为20.5%、34.1%、40.9%的冷轧试验。采用金相、SEM、EDS、XRD分析了冷轧前后合金层的组织结构,测试了不同冷轧形变量试样的高温抗氧化性能。结果表明,冷轧后合金层与基体结合良好,未出现脆裂、剥落。冷轧过程中剧烈的塑性变形使FeAl相发生部分无序化转变,微观应变随冷轧形变量的增大缓慢增大,最大微观应变达0.40%。冷轧后合金层依然具有良好的高温抗氧化性能,经最大冷轧形变量40.9%时,高温抗氧化性能仅下降8.4%。

关键词： FeAl合金层组织高温氧化性冷轧

Global stability coefficient of large underground caverns under static loading and earthquake wave condition

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Journal of Central South University 2024年第8期31卷 2826-2843页

作者： CHEN Peng-fei JIANG Quan LIU Jian LI shao-jun CHEN Tao HE Ben-guo State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Power China Chengdu Engineering Corporation Limited Chengdu 610072China Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110819China

Underground energy and resource development,deep underground energy storage and other projects involve the global stability of multiple interconnected cavern groups under internal and external dynamic *** evaluation method of the global stability coefficient of underground caverns based on static overload and dynamic overload was ***,the global failure criterion for caverns was defined based on its band connection of plastic-strain between ***,overloading calculation of the boundary geostress and seismic intensity on the caverns model was carried out,and the critical unstable state of multi-caverns can be identified,if the plastic-strain band appeared between caverns during these overloading ***,the global stability coefficient for the multi-caverns under static loading and earthquake was obtained based on the corresponding overloading *** analysis for the Yingliangbao(YLB)hydraulic caverns indicated that this method can not only effectively obtain the global stability coefficient of caverns under static and dynamic earthquake conditions,but also identify the caverns’high-risk zone of local instability through localized plastic strain of surrounding *** study can provide some reference for the layout design and seismic optimization of underground cavern group.

关键词： underground caverns global stability coefficient static-dynamic overload local instability

Clinical features and microsurgical reconstruction of congenital unilateral absence of the vas deferens with obstructive azoospermia:a tertiary care center experience

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Asian Journal of Andrology 2023年第1期25卷 73-77页

作者： Yi-Hong Zhou Jian-jun dong Er-Lei Zhi Chen-Cheng Yao Yu-Hua Huang Ru-Hui Tian Hui-Xing Chen Ying-Bo Dai Yu-Xin Tang Na-Chuan Liu Hui-Rong Chen Fu-jun Zhao Zheng Li Peng Li Department of Andrology The Center for Men's HealthUrologic Medical CenterShanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 200080China Department of Urology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China Department of Andrology Jiaozuo Maternity and Infant Health HospitalJiaozuo 454000China

Patients with congenital unilateral absence of the vas deferens(CUAVD)manifest diverse symptoms from normospermia to *** for CUAVD patients with obstructive azoospermia(OA)is complicated,and there is a lack of relevant *** this study,we describe the clinical features and evaluate the treatments and outcomes of CUAVD patients with *** December 2015 to December 2020,33 patients were diagnosed as CUAVD with OA in Shanghai General Hospital(Shanghai,China).Patient information,ultrasound findings,semen analysis,hormone profiles,and treatment information were collected,and the clinical outcomes were *** 33 patients,29 patients were retrospectively ***(VE)or cross VE was performed in 12 patients,the patency rate was 41.7%(5/12),and natural pregnancy was achieved in one of the *** other 17 patients underwent testicular sperm extraction as the distal vas deferens(contralateral side)was *** findings showed that VE or cross VE remains an alternative treatment for CUAVD patients with OA,even with a relatively low rate of patency and natural pregnancy.

关键词： congenital unilateral absence of the vas deferens natural pregnancy obstructive azoospermia patency vasoepididymostomy

Irradiation study of liquid crystal variable retarder for Full-disk Magneto-Graph payload onboard ASO-S mission

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Chinese Physics B 2020年第7期29卷 346-355页

作者： jun-Feng Hou Hai-Feng Wang Gang Wang Yong-Quan Luo Hong-Wei Li Zhen-Long Zhang dong-Guang Wang Yuan-Yong Deng Key Laboratory of Solar Activity National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Institute of Fluid Physics China Academy of Engineering PhysicsMianyang 621900China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China

The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed by the Chinese Solar Physics Commu*** one of the three payloads of ASO-S,the Full-disc Magneto-Graph(FMG)will measure the photospheric magnetic fields of the entire solar disk with high spatial and temporal resolution,and high magnetic sensitivity,where liquid crystal variable retarder(LCVR)is the key to whether FMG can achieve its scientific *** far,there is no space flight experience for ***,irradiation study for LCVRs becomes more important and urgent in order to make sure their safety and reliability in space *** this paper,γirradiation,proton irradiation,and ultra-violet(UV)irradiation are tested for LCVRs *** optical and chemical properties during irradiation tests are measured and *** optical properties,there is no significant change in those parameters FMG payload concerned except the *** there is no drastic degradation in the retardation versus voltage during irradiations,the amount of retardation variation is much higher than the instrument ***,an in-flight retardation versus voltage should be added in FMG payload,reducing or even avoiding the impact of retardation *** chemical properties,the clearing point and birefringence of the LC materials almost have no change;the ion density dose not change below 60 krad[Si],but begin to increase dramatically above 60 krad[Si].

关键词： solar telescope liquid crystal variable retarder(LCVR) irradiation