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Effect of calcium citrate on bone integration in a rabbit femur defect model

Asian Pacific Journal of Tropical Medicine 2012年第4期5卷 310-314页

作者： Wei Zhang Wei Wang Qing-Yu Chen Zhong-Qin Lin Shao-Wen cheng dong-Quan Kou Xiao-Zhou Ying Yue Shen Xiao-Jie cheng Peng-Fei Nie Xiu-Cui Li Ferdinand An Rompis Hang Huang Hua Zhang Zhong-Lin Mu Lei Peng Department of Orthopaedic Surgery the Second Affiliated Hospital of Wenzhou Medical College Department of Orthopaedic Surgery Hospital of Integrated Traditional Chinese and Western Medicine of Wenzhou Department of Respiratory Medicine Yuying Children's Hospital Affiliated to Wenzhou Medical College Trauma Center of the Affiliated Hospital of Hainan Medical College Haikou 120 Emergency Center International Nursing School of Hainan Medical College Graduate Department of Hainan Medical College The Second Affiliated Hospital of Wenzhou Medical College Trauma Center of the Affiliated Hospital of Hainan Medical College

Objective:To explore effect of calcium citrate on bone integration in a rabbit femur defect model, and to compare the bone formation with different sizes by radiological and histological study. Methods:Twenty-four male Japanese white rabbits were randomly divided into three groups (Group A.B.C)in this *** anesthesia,defects of four sizes(1.2,1.5,2.0 and 2.5 mm) were created in each of the *** pure calcium citrate powder was placed inside the medullary compartment of the femur(Experimental),while in the contralateral femur(Control) nothing was *** defects were analyzed using radiography and histological analysis by using Imagepro-Plus 6.0 software after animal was sacrificed at 4th(Group A),6th(Group B) and 8th(Group C) weeks *** samples were analyzed for each size of defect and each healing ***:The histological and the radiologic evaluation were performed after sacrification of all rabbits on postoperative 4th and 6th weeks,It showed significant difference between the experimental group and the control group when these defects were less than or equal to 2.0 *** statistical difference was observed when these defects were larger than 2.0 mm at all healing periods except at the 4th ***:Calcium citrate affects the early periods of hone defects healing mechanism in Japanese white rabbits positively,especially when the defect is not too large,We suggest further studies on calcium citrate to determine the effects of various dosages,administration ways and the experimental time on the bone defects.

关键词： Experiment Bone Fracture healing Calcium citrate

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Guest Editorial:Intelligent Video Surveillance and Related Technologies

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Journal of Electronic Science and Technology 2017年第2期15卷 113-114页

作者： Chung-Lin Huang cheng-Chang Lien I-cheng Chang Chih-Yang Lin Asia University "Chung-Hua University" dong Hwa University Yuan-Ze University

Due to the increasing demand for developing a secure and smart living environment, the intelligent video surveillance technology has attracted considerable attention. Building an automatic, reliable, secure, and intelligent video surveillance system has spawned large research projects and triggered many popular research topics in several international conferences and workshops recently. This special issue of Journal of ElecWonic Science and Technology （JEST） aims to present recent advances in video surveillance systems which address the observation of people in an environment, leading to a real-time description of their actions and interactions.

关键词： is for been Guest Editorial Intelligent Video Surveillance and Related Technologies of in body that

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哮喘-慢性阻塞性肺疾病重叠综合征的临床研究进展

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中国全科医学 2016年第5期19卷 500-506页

作者：徐飞董竞成复旦大学附属华山医院中西医结合科复旦大学中西医结合研究所上海市200040

哮喘和慢性阻塞性肺疾病(COPD)是两种不同的疾病,两者具有不同的特征,但有时难以将两者区分,尤其当哮喘患者病情加重出现类似COPD症状,而具有吸烟史的COPD患者表现出哮喘特征时,现将同时具备哮喘和COPD临床特征的疾病状态定为哮喘-慢性... 详细信息

哮喘和慢性阻塞性肺疾病(COPD)是两种不同的疾病,两者具有不同的特征,但有时难以将两者区分,尤其当哮喘患者病情加重出现类似COPD症状,而具有吸烟史的COPD患者表现出哮喘特征时,现将同时具备哮喘和COPD临床特征的疾病状态定为哮喘-慢性阻塞性肺疾病重叠综合征(ACOS)。本文从流行病学、病因、病理生理学特征、急性加重情况、生活质量和医疗费用、诊断标准以及治疗等方面,对ACOS近年的临床研究进展做一总结。

关键词：哮喘肺疾病,慢性阻塞性 ACOS 综述

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红外光谱对纺织助剂中烷基酚聚氧乙烯醚的快速定性和定量

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纺织学报 2014年第6期35卷 80-84页

作者：邵敏董锁拽王敏浙江理工大学先进纺织材料与制备技术教育部重点实验室浙江杭州310018 浙江出入境检验检疫局丝类检测中心浙江杭州310012

为快速排查纺织助剂中烷基酚聚氧乙烯醚（APEO）,建立了红外光谱对纺织助剂中APEO的定性和定量方法.应用红外二阶导数谱图中（1 608±4）cm-、（1 510±3） cm-1处一组特征吸收峰筛查纺织助剂中不同分子结构形式的APEO.红外光谱对APEO... 详细信息

为快速排查纺织助剂中烷基酚聚氧乙烯醚（APEO）,建立了红外光谱对纺织助剂中APEO的定性和定量方法.应用红外二阶导数谱图中（1 608±4）cm-、（1 510±3） cm-1处一组特征吸收峰筛查纺织助剂中不同分子结构形式的APEO.红外光谱对APEO的定性方法不需标准品,不需对样品进行分离,简单快速.同时,应用定量软件TQ Analyst中的偏最小二乘法,选择二阶导数红外光谱并选取（1 529.27～1 496.45 cm-1）峰范围建立APEO定量模型,回归系数为0.999 46,均方根误差为0.970.应用该定量模型对APEO定量,结果显示其绝对偏差在-1.56％～3.18％范围,回收率在82％～ 117％之间.

关键词：红外光谱二阶导数光谱烷基酚聚氧乙烯醚特征吸收峰纺织助剂

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改进育种算法在手机键盘字母优化排序中的应用

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东北大学学报（自然科学版） 2009年第9期30卷 1221-1224页

作者：吴成东唐军辉张云洲邹学敏东北大学信息科学与工程学院辽宁沈阳110004 中航世新燃气轮机设计研究所辽宁沈阳110043

针对育种算法虽然能解决手机键盘字母排序优化问题,但存在搜索时间长,收敛速度慢的问题,提出手机不适度模型.该模型引入夭折机制和进化变异系数等改进方法,对育种算法进行改进,很好地解决了这些问题,并将之应用于手机键盘字母优化排序中... 详细信息

针对育种算法虽然能解决手机键盘字母排序优化问题,但存在搜索时间长,收敛速度慢的问题,提出手机不适度模型.该模型引入夭折机制和进化变异系数等改进方法,对育种算法进行改进,很好地解决了这些问题,并将之应用于手机键盘字母优化排序中,极大地提高了中文输入的效率.仿真实验表明,改善算法具有更快的计算速度和更优的收敛值,并能很好地求解手机键盘字母优化排序问题,证明了改进算法的先进性.

关键词：育种算法进化变异系数夭折机制手机键盘字母排序

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RING-OPENING COPOLYMERIZATION OF DL-LACTIDE AND POLY(ETHYLENE GLYCOL) INITIATED BY LANTHANUM ACETATE AND APPLICATION OF THE COPOLYMER AS MATRIX OF MICROSPHERES CONTAINING VIBRIO CHOLERA ANTIGENS

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Chinese Journal of Polymer Science 1999年第3期17卷 265-270页

作者： Xian-mo Deng Xiao-hong Li ming-long Yuan Xiong-wei Li cheng-dong Xiong Zhi-tang Huang Wen-xiang Jia chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, chengdu, 610041, China Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China West China University of Medical Sciences, chengdu, 610041, China Chinese Acad Sci Chengdu Inst Organ Chem Chengdu 610041 Peoples R China Chinese Acad Sci Inst Chem Beijing 100080 Peoples R China W China Univ Med Sci Chengdu 610041 Peoples R China

Poly-dl-lactide-poly(ethylene glycol) (PELA) triblock copolymers were synthesized with lanthanum acetate as the initiator. PELA microspheres with entrapped Vibrio Cholera antigen and outer membrane protein (OMP) were prepared by a double emulsion W/O/W based on solvent extraction methods. The obtained microspheres showed smooth and spherical surface and their size varied between 0.5 and 5.0 mu m, which are suitable for oral targeting delivery system. The distribution tests in rabbits and mice through scanning electronic micrography and fluorescence microscope indicated that microspheres have successfully reached the immunization-related tissues, such as the liver, spleen and intestinal peyer's patches, following oral administration. The PELA microspheres were also evaluated as an efficient antigen delivery system by enhancing a higher protective ratio against live Vibrios Cholera.

关键词： poly-dl-lactide-poly(ethylene glycol) Vibrio Cholera antigen lanthanum acetate microsphere protective ratio

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Metformin inhibits food intake and neuropeptide Y gene expression in the hypothalamus

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Neural Regeneration Research 2013年第25期8卷 2379-2388页

作者： Yale Duan Rui Zhang min Zhang Lijuan Sun Suzhen dong Gang Wang Jun Zhang Zheng Zhao Key Laboratory of Brain Functional Genomics Ministry of EducationShanghai Key Laboratory of Brain Functional GenomicsEast China Normal University Department of Clinical Laboratory Shanghai Public Health Clinical Center Affiliated to Fudan University

Metformin may reduce food intake and body weight, but the anorexigenic effects of metformin are still poorly understood. In this study, Sprague-Dawley rats were administered a single intracere- broventricular dose of metformin and compound C, in a broader attempt to investigate the regula- tory effects of metformin on food intake and to explore the possible mechanism. Results showed that central administration of metformin significantly reduced food intake and body weight gain, par- ticularly after 4 hours. A reduction of neuropeptide Y expression and induction of AMP-activated protein kinase phosphorylation in the hypothalamus were also observed 4 hours after metformin administration, which could be reversed by compound C, a commonly-used antagonist of AMP-activated protein kinase. Furthermore, metformin also improved lipid metabolism by reducing plasma low-density lipoprotein. Our findings suggest that under normal physiological conditions, central regulation of appetite by metformin is related to a decrease in neuropeptide Y gene expres- sion, and that the activation of AMP-activated protein kinase may simply be a response to the anorexigenic effect of metformin.

关键词： neural regeneration metformin food intake body weight gain hypothalamus AMP-activated pro-tein kinase neuropeptide Y grants-supported paper neuroregeneration

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Relation among p130Cas,E-cadherin and β-catenin expression,clinicopathologic significance and prognosis in human hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2008年第5期7卷 490-496页

作者： cheng Guo,Qing-Guang Liu,Wei Yang,Zheng-Liang Zhang and Ying-min Yao Department of Hepatobiliary Surgery,First Affiliated Hospital,School of Medicine,Xi’an Jiaotong University,Xi’an 710061, China Department of Hepatobiliary Surgery First Affiliated Hospital School of Medicine Xi'an Jiaotong University Xi'an 710061 China. guocheng121@***.

BACKGROUND:p130Cas(p130Crk-associated substance) is a junction protein that is important to the adhesion between cytoskeleton and extracellular *** the adhesion molecules E-cadherin andβ-catenin play important roles in the invasiveness of *** study was undertaken to investigate the effects of p130Cas E-cadherin andβ-catenin on the invasion,metastasis and prognosis of hepatocellular carcinoma(HCC). METHODS:Immunohistochemistry was used to evaluate the expression of p130Cas,E-cadherin,andβ-catenin in 40 patients with *** patients were followed up postoperatively,and the relationship between expression and clinicopathological prognostic parameters was analyzed RESULTS:The positive expression rates of p130Cas and E-cadherin in HCC tissue(n=40)were 62.50%and 55.00% but in normal liver tissue 10%,and 100%,respectively (P<0.05).The abnormal expression rate ofβ-catenin in HCC tissue was 70%,while in normal liver tissue it was 13.33%(P<0.05).The positive rate of p130Cas was correlated with lymph node invasion,pathological stage TNM stage,and a worse prognosis,but not with gender age,HBV infection,hepatic cirrhosis,alpha-fetoprotein (AFP)level before operation,and tumor diameter Similarly,the expression of E-cadherin andβ-catenin was correlated with lymph node invasion,pathological stage,TNM stage,and worse prognosis,but not with gender,age,HBV infection,hepatic cirrhosis,AFP level before operation,and tumor *** were found between p130Cas and abnormal E-cadherin/β-catenin expression(P<0.001 and<0.05,respectively).CONCLUSIONS:In HCC,there is a negative correlation between the positive expression of p130Cas and the normal expression of the adhesion molecules E-cadherin/β-catenin, and p130Cas plays important roles in the invasion, metastasis and prognosis of HCC.p130Cas may be involved in alterating the structure and function of E-cadherin/ β-catenin,by regulating tyrosine phosphorylation via the p130Cas-Src signal pathway.

关键词： p130Cas E-cadherin β-catenin hepatocellular carcinoma metastasis

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Inhibition of integrin-linked kinase by angiotensin II receptor antagonist, irbesartan attenuates podocyte injury in diabetic rats

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Chinese Medical Journal 2012年第5期125卷 888-893页

作者： DAI Hou-yong ZHENG min TANG Ri-ning MA Kun-ling NI Jie LIU Bi-cheng Department of Nephrology Zhongda Hospital SoutheastUniversity School of Medicine Nanjing Jiangsu 210009 China Department of Nephrology Affiliated Hospital of NantongUniversity Nantong Jiangsu 226001 China

Background Integrin-linked kinase （ILK） dysregulation is involved in the progression of diabetic nephropathy （DN）. The aim of this study was to investigate the effects of angiotensin II receptor blocker （ARB）, i... 详细信息

关键词： integrin-linked kinase diabetic nephropathy angiotension H receptor blocker podocyte injury

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网络路由基于对策论的资源分配策略

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电子学报 2010年第B02期38卷 143-147页

作者：董军詹聪明舒静华东师范大学软件学院

对策论提供对独立参与者之间冲突进行建模的框架，可用以综合考虑路由选择和拥塞控制问题.经典的对策论不一定直接能应用于网络.本文在路由选择的多Agent系统的基础上，给出具有“惩恶扬善”行为的基于对策论的路由资源分配策略.它奖励... 详细信息

对策论提供对独立参与者之间冲突进行建模的框架，可用以综合考虑路由选择和拥塞控制问题.经典的对策论不一定直接能应用于网络.本文在路由选择的多Agent系统的基础上，给出具有“惩恶扬善”行为的基于对策论的路由资源分配策略.它奖励避免拥塞、惩罚行为不合要求的用户.在用户都是理性的前提下，系统能稳定在纳什均衡状态.

关键词：对策论路由选择拥塞控制多Agent系统资源分配

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