检索结果-南通市图书馆

Low-temperature mineralization domain associated with the parallel positions between geochemical steep zones and geophysical gradient zones

在线全文

学校读者我要写书评

暂无评论

chinese Science Bulletin 1999年第S2期44卷 166-168页

作者： zhu bingquan, dong yunpeng, {3. {4. and ZHANG Zhengwei guangzhou institute of geochemistry, chinese Academy of Sciences, guangzhou 51064., china guangzhou institute of geochemistry Chinese Academy of Sciences Guangzhou 510640 China

THE parallel strike of geochemical steep zones and geophysical gradient zones represent geochemicalboundaries with tectonic hiding and almost no magmatism, but there existed great variation of lithosphereor crustal thickness. Tectonically, these areas were located in the foreland basins of craton margin. Thesegeochemical boundaries were usually associated with the low-temperature mineralization and petroleumgeneration. The Nd, Sr and Pb isotopic evidence indicated that there still existed strong crustal-mantle interaction through fluid activation along deep-seated faults at the craton margin. Fig. 1 is the 207Pb/204./sup> Pb-208Pb/204./sup> Pb diagram, which shows the evident crust-mantle mixing for crude oil, chloroform bitumen-A,

关键词： low temperature mineralization domain geochemical steep zones geophysical gradient zones.

Proterozoic copper metaliogenic framework and geochemistry steep zone in central Yunnan Province

在线全文

学校读者我要写书评

暂无评论

chinese Science Bulletin 1999年第S2期44卷 163-164页

作者： chang xiangyang, zhu {3. and {4. guangzhou institute of geochemistry, chinese Academy of Sciences, guangzhou, 51064., china

THE wildly horizontal and vertical chemical heterogeneties, which result from the inchoate core-mantledifferentiation of the globe and the spatio-temporal difference of various regions in the globe, bring on themantle and crust from different landmass and oceans with markedly elemental and isotopic *** these signatures could be used to differentiate the attribute from various landmass or oceans andrecover the scent of kinematics and chemical geodynamics process. It is a quantificational method compared with the division by geotectonics facies and paleontologic fauna. Based on the geochemistry mapping of elements and multi-isotopic systematics of rocks derived frommantle and crust and combined with the studies on geophysical tomographic image, four type geochemicalprovinces can be distinguished. They are: (i) the Pacific (such as N-Pacific, N-Atlantic, the

关键词： Proterozoic copper metallogenesis geochemical steep zone Yunnan.

Relation of Isotope Geochemical Steep Zones with Geophysical Fields and Tectonics in the Junction Area of the Cathaysian,Yangtze and Indochina Plates

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2000年第2期74卷 236-240页

作者： zhu bingquan dong yunpeng {3. {4. ZHANG Zhengwei guangzhou institute of geochemistry Chinese Academy of SciencesGuangzhou 510640Guangdong

Through lead isotope geochemical mapping in the Yunnan-Guizhou area geochemical steep zones (GSZ) have been established, which clearly reveal the junction relationship of the Cathaysian, Yangtze and Indo-china plates. GSZ are closey related to gravity Moho gradient zones and lithospheric thickness. The GSZ between the Yangtze and Cathaysian plates is consistent with the Shizong-Mile tectonic belt, where island are basalts are well developed. The Yangtze-Indo-china GSZ is parallel to the Jingdong-Mojiang volcanic belt in rift-island are environments. The evidence of geology, geophysics and {3. all indicates that Cathaysia was subducted towards the Yangtze plate and that the Yangtze plate was underthrust beneath the Indo-china, which took place from the Early Carboniferous to the Early Triassic.

关键词： junction relationship of the Cathaysia Yangtze and Indo-china plates geochemical steep zone gradient zone of gravity Moho

重离子储存环CSRe上类钠Kr^(25+)离子的双电子复合精密谱学实验研究

在线全文

学校读者我要写书评

暂无评论

物理学报 2024年第12期73卷 147-158页

作者：邵林黄忠魁汶伟强汪书兴黄厚科马万路刘畅汪寒冰陈冬阳刘鑫周晓鹏赵冬梅张少锋朱林繁马新文华南师范大学物理学院量子调控工程与材料重点实验室广州510006 中国科学院近代物理研究所兰州730000 中国科学技术大学近代物理系合肥230026

高电荷态离子的双电子复合精密谱学实验研究,不仅对天体等离子体和聚变等离子体的研究具有重要意义,而且可以作为一种新的精密谱学工具,用来检验强场量子电动力学效应、测量同位素移动及提取原子核电荷半径等.在兰州重离子储存环CSRe上... 详细信息

高电荷态离子的双电子复合精密谱学实验研究,不仅对天体等离子体和聚变等离子体的研究具有重要意义,而且可以作为一种新的精密谱学工具,用来检验强场量子电动力学效应、测量同位素移动及提取原子核电荷半径等.在兰州重离子储存环CSRe上,安装了专门用于电子-离子复合精密谱学实验的电子束能量调制系统,质心系下电子-离子碰撞能量的调制范围达到0—1 keV.在CSRe电子冷却器下游安装了自主研制的塑料闪烁体探测器和多丝正比探测器,用于探测复合离子.在此基础上,使用Kr^(25+)离子在CSRe上进行了首次双电子复合测试实验,实验测量了质心系能量0—70 eV的双电子复合速率系数.为了更好地理解实验测量结果,利用FAC(flexible atomic code)程序计算了Kr^(25+)离子的双电子复合速率系数,并与实验做了细致对比,整体符合很好,而且发现3.→4.(△n=1)的共振跃迁对实验谱线有很大的贡献.实验结果表明,CSRe双电子复合实验平台具有非常好的稳定性和可重复性,能够为下一步开展更高电荷态离子的双电子复合精密谱学实验、检验强场量子电动力学效应以及原子核性质精密测量等前沿实验提供支持.

关键词：双电子复合储存环CSRe 电子冷却器多丝正比探测器

ARHGAP4.variants are associated with X-linked early-onset temporal lobe epilepsy

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第8期20卷 859-867页

作者： Yuan-Yuan Hu Wang Song Zhi-Gang Liu Xing-Guang Ye Hong-Wei Zhang Xin Li Jun-Xia Luo Peng-Yu Wang Jie Wang Xiao-Fei Lin Hong-Li zhu Wei-Ping Liao Bin Li Xu-Qin Chen Department of Neurology Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of ChinaInstitute of Neuroscience and the Second Affiliated Hospital of Guangzhou Medical UniversityChang-gang-dong RoadGuangzhou510260China Epilepsy Center and Neurology Department of Children’s Hospital of Soochow University Suzhou215000JiangsuChina Department of pediatrics Foshan Women and Children HospitalFoshan528000China Children’s Hospital Affiliated to Shandong University Jinan250000ShandongChina Second Hospital of Shandong University Jinan250000China Huai’an Maternity&Child Healthcare Hospital Huai’an223001China institute of Neuroscience of guangzhou Medical University and Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of{3. Chang-gang-dong Road 250Guangzhou510260GuangdongChina

The ARHGAP4.gene(OMIM*3.0,023.,also known as Rho GTPase activating protein 4.encodes a protein that has an essential role in the regulation of small ***4.message RNA(mRNA)is highly expressed during the developing and adult nervous *** the protein level,ARHGAP4.is exclusively present in certain brain regions,such as the mesial temporal lobe,specifically the stratum lucidum of the CA3.region[1].ARHGAP4.enhances the GTPase activity of Rho proteins,which modulate morphological alterations in neuron development and synaptic plasticity by interacting with the actin cytoskeleton[2].

关键词： epilepsy alterations stratum

Optical Information Storage in Poly [3.Methyl-4.Bis(N,N-Oxyethylene)Imino-4.Nitro-Azobenzene Sebacoyl] Film by Degenerate Four-Wave Mixing

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Physics Letters 1997年第4期14卷 284-286页

作者： BI dong-ying ZHANG Ling-zhi LIANG Zhao-xi XIE Zhong-hui LIN Wei-zhu LIAO chang-jun LIU Song-hao Department of Physics University of Science and Technology of ChinaHefei 230026 institute of Polymer Science Zhongshan UniversityGuangzhou 510275 Department of Physics Zhongshan UniversityGuangzhou 510275 institute of Quantum Electronics South China Normal UniversityGuangzhou 510631

Optical storage caused by photo-induced anisotropy in poly[3.methyl-4.bis(N,N-oxyethylene)imino-4.nitro-azobenzene sebacoyl]film is studied by degenerate four-wave *** orientation gratings which are stable for three months are *** grating in the sample can be“erased”by using circular polarized *** an azobenzene polymer thin film can be used many times to restore optical information.

关键词： film Optical Storage

Cardiotoxicity of 5-fluorouracil and capecitabine in chinese patients: a prospective study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2018年第1期38卷 247-253页

作者： Jianjun Peng Chao dong chang Wang Weihua Li Hao Yu Min Zhang Qun Zhao Bo zhu Jun Zhang Wenliang Li Fenghua Wang Qiong Wu Wenhao Zhou Ying Yuan Meng Qiu Gong Chen Center of Gastrointestinal Surgery First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongP.R.China Department of the Second Medical Oncology The 3rd Affiliated Hospital of Kunming Medical UniversityYunnan Tumor HospitalKunming 650118YunnanP.R.China Department of Oncology The First Hospital of Jilin UniversityChangchun 130021JilinP.R.China Department of Surgical Oncology Fujian Provincial HospitalFuzhou 350014FujianP.R.China Department of Biological Statistics School of Public HealthNanjing Medical UniversityNanjing 211166JiangsuP.R.China Department of Cardiology Shanghai Jiaotong UniversityShanghai 200030P.R.China The Third Surgery Department the Fourth Hospital of Hebei Medical UniversityTumor Hospital of Hebei ProvinceShijiazhuang 050011HebeiP.R.China institute of Cancer Xinqiao Hospital of Third Military Medical UniversityChongqing 400037P.R.China Oncology Department Shanghai Ruijin HospitalShanghai 200025P.R.China Oncology Department First Affiliated Hospital of Kunming Medical UniversityKunming 650032YunnanP.R.China Department of Internal Medicine Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Medical Oncology The first Affiliated Hospital of Bengbu Medical CollegeBengbu 233004AnhuiP.R.China Department of Colorectal Surgery Sun Yat-sen University Cancer Center651 Donfeng RdEastGuangzhou 510060GuangdongP.R.China Medical Oncology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009ZhejiangP.R.China Department of Medical Oncology Cancer CenterThe State Key Laboratory of BiotherapyWest China HospitalWest China Medical SchoolSichuan UniversityNo.37Guo Xue XiangChengdu 610041SichuanP.R.China

Background:5-Fluorouracil(5-FU)and capecitabine-associated cardiotoxicity ranging from asymptomatic electro-cardiography(ECG)abnormalities to severe myocardial infarction has been reported in a number of studies,but such cardiotoxicity in chinese patients with malignant diseases has not been investigated to *** the present study,we aimed to prospectively evaluate the incidence rates and clinical manifestations of 5-FU-and capecitabine-associated cardiotoxicity in cancer patients recruited from multiple centers in ***:Among the 527 patients who completed the study,196 received 5-FU-based chemotherapy and 3.1 received capecitabine-based chemotherapy as either first-line or adjuvant *** events were reported during the treatment and up to 28 days of *** measures included ECG,myocardial enzymes,cardiac troponin,brain natriuretic peptide and *** analysis and logistic regression were performed for subgroup analysis and identification of significant independent variables that are associated with cardiotoxicity of both ***:In total,161 of 527 patients(3..6%)experienced *** incidence rate of cardiotoxicity was 3..8%(112/3.1)in the capecitabine group,which was significantly higher than the rate of 25%(4./196)in the 5-FU group(P=0.004.).110/527 patients(20.9%)suffered arrhythmia,105/527(19.9%)developed ischemic changes,while only 20/527 patients(3.8%)presented heart failure and 6/527 patients(1.1%)had myocardial ***-existing cardiac disease,hypertension,capecitabine-based chemotherapy and duration of treatment were identified as sig-nificant risk factors associated with *** odds ratio were 15.7(prior history of cardiac disease versus no history),1.86(capecitabine versus 5-FU),1.06(5-8 versus 1-4.chemotherapy cycles)and 1.58(hypertension versus no hypertension),***:Cardiotoxicity induced by fluoropyrimidines in the chinese population may be und

关键词： 5-Fluorouracil Capecitabine Cardiotoxicity

Effect of Kuanxiong Aerosol(宽胸气雾剂)on Patients with Angina Pectoris:A Non-inferiority Multi-center Randomized Controlled Trial

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

chinese Journal of Integrative Medicine 2018年第5期24卷 336-342页

作者： YANG Qiao-ning1 BAI Rui-na1 dong Guo-ju1 GE chang-jiang2 ZHOU Jing-min3.HUANG Li4.HE Yan 5 WANG Jun6 REN Ai-hua7 HUANG Zhan-quan8 zhu Guang-li9 LU Shu10 XlONG Shang-quan11 XlAN Shao-xiang12 zhu Zhi-jun13.SIll Da-zhuo1 LU Shu-zheng2 LI Li-zhi1 CHEN Ke-ji1 Cardiovascular Diseases Center Xiyuan Hospital China Academy of Chinese Medical Sciences Department of Cardiology Beijing Anzhen Hospital Beijing Institute of Respiratory Medicine Capital Medical University Department of Cardiology Zhongshan Hospital Fudan University Department of Cardiology China-Japan Friendship Hospital Department of Cardiology Longhua Hospital Shanghai University of Traditional Chinese Medicine Department of Cardiology Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine Department of Cardiology Zhejiang Hospital Department of Cardiology The First Affiliated Hospital of Zhejiang Chinese Medical University Department of Cardiology Guangxing Hospital Affiliated to Zhejiang Chinese Medical University Department of Cardiology Wuxi Traditional Chinese Medicine Hospital Nanjing University of Traditional Chinese Medicine Department of Cardiology People's Hospital Affiliated Fujian University of Traditional Chinese Medicine Department of Cardiology The First Affiliated Hospital of Guangzhou University of Chinese Medicine Department of Cardiology The 117th Hospital of People's Liberation Army of China

Objective： To evaluate the effect and safety of Kuanxiong Aerosol （宽胸气雾剂, KA） on patients with angina pectoris. Methods： Block randomization was performed to randomly allocate 750 patients into KA （3.6 cases） and control groups （3.4.cases）. During an angina attack, the KA group received 3.consecutive sublingual sprays of KA （0.6 mL per spray）. The control group received 1 sublingual nitroglycerin tablet （NT, 0.5 rag/tablet）. Log-rank tests and Kaplan-Meier estimations were used to estimate the angina remission rates at 6 time-points after treatment （1,2, 3. 4. 5, and 〉5 min）. Logistic regression analysis was performed to observe the factors influencing the rate of effective angina remission, and the remission rates and incidences of adverse reactions were compared for different Canadian Cardiovascular Society （CCS） classes of angina. Results： The 5-min remission rates in the KA and control groups were not significantly different （94.4.% vs. 90.64., P〉0.05）. The angina CCS class significantly influenced the rate of remission （95% confidence interval = 0.4.3.0.74., P〈0.01）. In the CCS subgroup analysis, the 3. and 5-min remission rates for KA and NT were similar in the CCS I and IV subgroups （P〉0.05）, while they were significantly better for KA in the CCS Ⅱ and Ⅲ subgroups （P〈0.05 or P〈0.01）. Furthermore, the inciden0ce of adverse reactions was significantly lower in the KA group than in the control group for the CCS Ⅱ and Ⅲ subgroups （9.29% vs. 26.22%, 10.13. vs. 20.88%, P〈0.05 or P〈0.01）. Conclusions： KA is not inferior to NT in the remission of angina. Furthermore, in CCS Ⅱ and Ⅲ patients, KA is superior to NT, with a lower incidence of adverse reactions. （Registration No. ChiCTR- IPR-15007204.

关键词： Kuanxiong Aerosol angina pectoris Canadian Cardiovascular Society classification of angina randomized controlled trial chinese medicine

Famitinib versus placebo in the treatment of refractory metastatic colorectal cancer:a multicenter,randomized,double-blinded,placebo-controlled,phaseⅡclinical trial

在线全文

学校读者我要写书评

暂无评论

chinese Journal of Cancer 2017年第12期36卷 677-685页

作者： Rui-Hua Xu Lin Shen Ke-Ming Wang Gang Wu Chun-Mei Shi Ke-Feng Ding Li-zhu Lin Jin-Wan Wang Jian-Ping Xiong chang-Ping Wu Jin Li Yun-Peng Liu dong Wang Yi Ba Jue-Ping Feng Yu-Xian Bai Jing-Wang Bi Li-Wen Ma Jian Lei Qing Yang Hao Yu Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060GuangdongP.R.China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteNo 52Fucheng RoadHaidian DistrictBeijing 100142P.R.China Department of Medical Oncology Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011JiangsuP.R.China Cancer Center of Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiP.R.China Department of Medical Oncology Fujian Medical University Union HospitalFuzhou 350001FujianP.R.China Department of Surgical Oncology Second Hospital Affiliated to Zhejiang University School of MedicineHangzhou 310009ZhejiangP.R.China Department of Oncology First Affiliated Hospital of Guangzhou Medical University of Chinese MedicineGuangzhou 510405GuangdongP.R.China Department of Medical Oncology Chinese Academy of Medical Sciences Cancer HospitalBeijing 100021P.R.China Department of Medical Oncology First Affiliated Hospital of Nanchang UniversityNanchang 330006JiangxiP.R.China Department of Medical Oncology First People’s Hospital of ChangzhouChangzhou 213003JiangsuP.R.China Department of Medical Oncology Fudan University Cancer HospitalShanghai 200032P.R.China Department of Medical Oncology First Hospital of China Medical UniversityShenyang 110001LiaoningP.R.China Cancer Center Daping Hospital and Institute of Surgery ResearchThird Military Medical UniversityChongqing 400042P.R.China Department of Gastrointestinal Medical Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060P.R.China Department of Oncology PuAi Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430032HubeiP.R.China Department of Medical Oncology Harbin Medical University Cancer Hospit

Background: Metastatic colorectal cancer(mCRC) patients with progressive disease after all available standard therapies need new medication for further treatment. Famitinib is a small-molecule multikinase inhibitor, with promising anticancer activities. This multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial was designed to evaluate the safety and efficacy of famitinib in ***: Famitinib or placebo was administered orally once daily. The primary endpoint was progression-free survival(PFS). Secondary endpoints included objective response rate(ORR), disease control rate(DCR), overall survival(OS), quality-of-life(QoL), and ***: Between July 18,2012 and Jan 22,2014. a total of 167 patients were screened, and 154.patients were randomized in a 2:1 ratio to receive either famitinib(n = 99) or placebo(n = 55). The median PFS was 2.8 and 1.5 months in the famitinib and placebo groups(hazard ratio = 0.60,95% confidence interval = 0.4.-0.86, P = 0.004.. The DCR was 59.8% and 3..4.(P = 0.002) and the ORR was 2.2% and 0.0%(P = 0.54.) in the famitinib and placebo groups,respectively. The most frequent grade 3.4.adverse events were hypertension(11.1%), hand-foot syndrome(10.1%),thrombocytopenia(10.1%) and neutropenia(9.1%). Serious adverse events occurred in 11(11.1%) patients in the famitinib group and 5(9.1%) in the placebo group(P = 0.788). The median OS of the famitinib and placebo groups was 7.4.and 7.2 months(P = 0.657).Conclusion: Famitinib prolonged PFS in refractory mCRC patients with acceptable *** registration This study was registered on ***(NCT01762293. and was orally presented in the 2015 ASCO-Gastrointestinal

关键词： Colorectal cancer Famitinib Efficacy Safety